BACKGROUND： This paper describes histomorphologic studies on arachnoid granulations in rats, which have not been investigated in China to our knowledge. OBJECTIVE： To observe the distribution of intracranial arachno...BACKGROUND： This paper describes histomorphologic studies on arachnoid granulations in rats, which have not been investigated in China to our knowledge. OBJECTIVE： To observe the distribution of intracranial arachnoid granulations in rats. DESIGN, TIME AND SETTING： The observational experiment was performed in the Academy of Life Sciences of Shandong Taishan Medical College from May to August 2004. MATERIALS： Thirty healthy adult Wistar rats （3-4 months old） of SPF grade, equal numbers of each sex, were selected for this study. Methylene blue parenteral solution was provided by Jiangsu Jichuan Pharmaceutical Company （China）, and an optical microscope （Type： CH20; Olympus Co. Ltd., Japan） was used for observation of the histomorphology of the arachnoid granulations. METHOD： Injection of methylene blue parenteral solution into the cerebellomedullary cistern of rats. MAIN OUTCOME MEASURE： The blue stained parts of the lateral sinus were sectioned, stained by hematoxylin and eosin, and then observed under the microscope. RESULTS： The cavitas subarachnoidealis had extensive blue staining after methylene blue injection, while the arachnoid and dura were without dye accumulation. The blue dye indicated the location of the arachnoid granulations. The location of these granulations was fixed, mainly in the lateral sinus at both sides of confluence within 4 mm of the internal jugular vein. CONCLUSION： The arachnoid granulations of the rat were located mainly in the lateral sinuses of the dura mater.展开更多
Background In the chronic stage of cerebral venous sinus thrombosis （CVST）, recanalization can result in disparate MR appearances. We aimed to prospectively investigate the diagnostic accuracy of magnetic resonance ...Background In the chronic stage of cerebral venous sinus thrombosis （CVST）, recanalization can result in disparate MR appearances. We aimed to prospectively investigate the diagnostic accuracy of magnetic resonance venography （MRV） in the evaluation of the recanalization of CVST. Methods This study prospectively evaluated the diagnostic performance of 2-dimensional time-of-flight （2D-TOF） MRV in thirty-two consecutive patients during a threeto six-month follow-up for CVST. Both 2D-TOF MRV and digital substraction angiography （DSA） were undertaken. Diagnostic accuracy of 2D-TOF MRV in the detection of recanalized thrombus was evaluated using DSA as the reference standard. Results MRV and DSA were completed without complications in all 32 patients. The sensitivity, specificity, positive predictive value, and negative predictive value of 2D-TOF MRV for the detection of recanalization on a segmental basis were 91% （62/68）, 93% （37/40）, 95% （62/65）, and 86% （37/43） respectively. Conclusion 2D-TOF MRV provides high sensitivity and specificity for the diagnosis of recanalized CVST segments.展开更多
文摘BACKGROUND： This paper describes histomorphologic studies on arachnoid granulations in rats, which have not been investigated in China to our knowledge. OBJECTIVE： To observe the distribution of intracranial arachnoid granulations in rats. DESIGN, TIME AND SETTING： The observational experiment was performed in the Academy of Life Sciences of Shandong Taishan Medical College from May to August 2004. MATERIALS： Thirty healthy adult Wistar rats （3-4 months old） of SPF grade, equal numbers of each sex, were selected for this study. Methylene blue parenteral solution was provided by Jiangsu Jichuan Pharmaceutical Company （China）, and an optical microscope （Type： CH20; Olympus Co. Ltd., Japan） was used for observation of the histomorphology of the arachnoid granulations. METHOD： Injection of methylene blue parenteral solution into the cerebellomedullary cistern of rats. MAIN OUTCOME MEASURE： The blue stained parts of the lateral sinus were sectioned, stained by hematoxylin and eosin, and then observed under the microscope. RESULTS： The cavitas subarachnoidealis had extensive blue staining after methylene blue injection, while the arachnoid and dura were without dye accumulation. The blue dye indicated the location of the arachnoid granulations. The location of these granulations was fixed, mainly in the lateral sinus at both sides of confluence within 4 mm of the internal jugular vein. CONCLUSION： The arachnoid granulations of the rat were located mainly in the lateral sinuses of the dura mater.
文摘Background In the chronic stage of cerebral venous sinus thrombosis （CVST）, recanalization can result in disparate MR appearances. We aimed to prospectively investigate the diagnostic accuracy of magnetic resonance venography （MRV） in the evaluation of the recanalization of CVST. Methods This study prospectively evaluated the diagnostic performance of 2-dimensional time-of-flight （2D-TOF） MRV in thirty-two consecutive patients during a threeto six-month follow-up for CVST. Both 2D-TOF MRV and digital substraction angiography （DSA） were undertaken. Diagnostic accuracy of 2D-TOF MRV in the detection of recanalized thrombus was evaluated using DSA as the reference standard. Results MRV and DSA were completed without complications in all 32 patients. The sensitivity, specificity, positive predictive value, and negative predictive value of 2D-TOF MRV for the detection of recanalization on a segmental basis were 91% （62/68）, 93% （37/40）, 95% （62/65）, and 86% （37/43） respectively. Conclusion 2D-TOF MRV provides high sensitivity and specificity for the diagnosis of recanalized CVST segments.
