The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free de...The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free deuterated benzene C6D6 liquid scintillation detectors,in the ES#2 experiment station on the beam line,at a distance of about 76 m from the neutron-production assembly.The total energy detection principle in combination with the pulse height weighting technique(PHWT)was applied to analyze the measured data.Results of the ^(232)Th(n,γ)reaction cross section in the unresolved resonance region from 4 keV to 100 keV were obtained,which shows a good agreement with the existing experimental data from EXFOR,as well as with the evaluated data from the ENDF/B-VIII.0 and CENDL-3.1.In addition,the excitation function of ^(232)Th(n,γ)^(233)Th reaction in the unresolved resonance region was theoretically calculated by using the code TALYS-1.95.By fitting the experimental cross section and theoretical data,the average parameters in the unresolved resonance region were extracted.展开更多
Petroleum, the most important energy source in the world, plays an essential role in securing economic development. If a petroleum shortage happens, it will severely disrupt production and life. Cross-regional emergen...Petroleum, the most important energy source in the world, plays an essential role in securing economic development. If a petroleum shortage happens, it will severely disrupt production and life. Cross-regional emergency scheduling can effectively alleviate a petroleum shortage and further enhance the efficiency of the emergency response. Considering the general lack of focus on cross-regional petroleum dispatching management, we propose a three-layer emergency scheduling network for petroleum based on a supernetwork model that can increase the regional emergency correlation by adding a transfer management process. Then, we compare the total demand for petroleum and the emergency costs considered in the petroleum emergency scheduling supernetwork model(the single-region and the cross-region scenarios).The result shows that the cross-regional emergency scheduling pattern can effectively enhance the efficiency of the emergency preparations and reduce the emergency costs in most cases. However, when the vulnerabilities in the crossregional link grow or the regional linkage decreases, the effect of single-regional scheduling is better. In addition, the advantages of the cross-regional emergency scheduling network will be strengthened with an increase in its maximum emergency capability. Nonetheless, this advantage will disappear when the petroleum demand in the crisis layer reaches the maximum emergency response capacity. Finally, according to the comparative analysis simulation among scenarios,certain strategic policy recommendations are suggested to improve the petroleum emergency scheduling ability in regions.These recommendations include strengthening the cross-regional coordination mechanism, increasing the modes of petroleum transportation and enhancing the carrying capacity of regional emergency routes.展开更多
We have measured the cross-section ratios of helium induced by Cq+ and Oq+ (q = 1-4) in an energy range from 20 keV/amu to 500 keV/amu, and obtained the two-dimensional spectra by employing the coincidence method ...We have measured the cross-section ratios of helium induced by Cq+ and Oq+ (q = 1-4) in an energy range from 20 keV/amu to 500 keV/amu, and obtained the two-dimensional spectra by employing the coincidence method combined with the MPA-3 data acquisition system. Hence, we obtain the ratios of total single-ionization cross-sections (SI, SC, SLSI, and DLSI), total double-ionization cross-sections (DI, DC, TI, SLDI, and DLDI) and cross-sections of every process (SI, SC, SLSI, DLSI, DI, DC, TI, SLDI, and DLDI), which induce the single-ionization and double-ionization, to the total cross sections respectively. The competitive relations between the reaction-channels and the experimental data law of each reaction-channel are revealed explicitly, and the qualitative explanations involved in those results are also presented accordingly.展开更多
The amount of solar PV installed capacity has steadily increased to 44.5 GW at the end of FY2017,since the introduction of the Feed in Tariff(FiT)to Japan in 2012.On the other hand,since the first curtailment of solar...The amount of solar PV installed capacity has steadily increased to 44.5 GW at the end of FY2017,since the introduction of the Feed in Tariff(FiT)to Japan in 2012.On the other hand,since the first curtailment of solar PV was conducted on October 13th,2018 in the Kyushu area,the curtailment has been frequently executed including wind power after that.In this study,cross-regional interconnector and pumped hydro energy storage(PHES)are focused on mitigating curtailment.In Japan,there are 9 electric power areas which connected each other by cross-regional interconnectors.According to the historical operation,cross-regional interconnectors were secured as emergency flexible measures,but after the implicit auction was started from October 2018,it is used on merit order.Regarding a PHES in Japan,they have been built with nuclear power plants for several decades.Because the output of nuclear power generation is constant,so the PHES is used to absorb the surplus at nighttime when the demand declines.All nuclear power plants in Japan have been shut down after the accident at the Fukushima Daiichi Nuclear Power Plant following the Great East Japan Earthquake that occurred on March 11th,2011.There are several nuclear power plants that have been restarted(9 reactors,as of August 2019).In this study,the amount of curtailment for solar PV in the Kyushu area is sent to the Chugoku area using the cross-regional interconnector(Kanmon line).Then,the PHES in the Chugoku area is pumping with low price.Because the spot price in the market is low when the curtailment is executed.After that,the PHES is generating at night with high price when the solar PV is not generating.It makes a profit by the deference for the cost of pumping and the revenue of generating by the PHES.As a calculation result,for one week from May 2nd to 8th,2019,a profit becomes 152.2 million JPY(about 1.22 million EUR).For this purpose,it is necessary to raise the operation capacity of the cross-regional interconnector up to the rated capacity with the frequency control function of solar PV instead of the capacity to keep frequency in the event of an accident.This will allow the further introduction of solar PV in Japan.展开更多
As an effective environment governance tool,environment governance performance evaluation is an important content and method to promote the modernization of environment governance system and governance ability.The env...As an effective environment governance tool,environment governance performance evaluation is an important content and method to promote the modernization of environment governance system and governance ability.The environmental pollution of the Beijing-Tianjin-Hebei region has typical cross-administrative characteristics.Based on the analysis of the major environmental pollution problems in the Beijing-Tianjin-Hebei region,according to the international environment governance PSR model,a performance evaluation system that applies to the environment governance of Beijing-Tianjin-Hebei region is established.Meanwhile,the principal component analysis method is applied to conduct an empirical analysis of the environmental governance panel data for the 13 major cities in the Beijing-Tianjin-Hebei region from 2014 to 2016.The results show that most of the cities in the Beijing-Tianjin-Hebei region attach great importance to reduction of emission and pollutants,continuously alleviating the stress of environmental governance.However,the overall improvement of the environment governance performance in Beijing-Tianjin-Hebei region has presented a polarization imbalance.There is a clear tendency for subjective biases in the implementation of environment governance and a lack of comprehensive and systematic governance.According to the environment governance performance evaluation result of Beijing-Tianjin-Hebei region,the cross-administrative regional environment governance should improve the environment governance performance evaluation system as soon as possible,strengthen the consistency of the environment governance objectives,and implement comprehensive and systematic governance for the regional environment.展开更多
Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of dif...Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of different interpolation methods in meteorological data of Xinjiang Uygur Autonomous Region (Xinjiang). Actually, it has importantly practical significance to as far as possibly improve the accuracy of interpolation results for meteorological data, especially in mountainous Xinjiang. There- fore, this paper focuses on the performance of different spatial interpolation methods for monthly temperature data in Xinjiang. The daily observed data of temperature are collected from 38 meteorological stations for the period 1960- 2004. Inverse distance weighting (IDW), ordinary kriging (OK), temperature lapse rate method (TLR) and multiple linear regressions (MLR) are selected as interpolated methods. Two rasterized methods, multiple regression plus space residual error and directly interpolated observed temperature (DIOT) data, are used to analyze and compare the performance of these interpolation methods respectively. Moreover, cross-validation is used to evaluate the performance of different spatial interpolation methods. The results are as follows: 1) The method of DIOT is unsuitable for the study area in this paper. 2) It is important to process the observed data by local regression model before the spatial interpolation. 3) The MLR-IDW is the optimum spatial interpolation method for the monthly mean temperature based on cross-validation. For the authors, the reliability of results and the influence of measurement accuracy, density, distribution and spatial variability on the accuracy of the interpolation methods will be tested and analyzed in the future.展开更多
The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network calculations.The neutron capture cross section...The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network calculations.The neutron capture cross section in the resonance range of isotopes and even natural selenium samples has not been measured.Promptγ-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator detectors at the Back-n facility of China Spallation Neutron Source(CSNS).The pulse height weighting technique(PHWT)was used to analyze the data in the 1 e V to 100 ke V region.The deduced neutron capture cross section was compared with ENDF/B-VIII.0,JEFF-3.2,and JENDL-4.0,and some differences were found.Resonance parameters were extracted by the R-matrix code SAMMY in the 1 e V-1 ke V region.All the cross sections ofnatSe and resonance parameters are given in the datasets.The datasets are openly available at http://www.doi.org/10.11922/sciencedb.j00113.00019.展开更多
Cross border traders make a major contribution to the growth of economies in Southern Africa. Cross border trade is a source of livelihood for many poor people, especially women. However, few studies examined challeng...Cross border traders make a major contribution to the growth of economies in Southern Africa. Cross border trade is a source of livelihood for many poor people, especially women. However, few studies examined challenges facing cross border traders and future business prospects.The aim of this paper is to examine the challenges that face Zimbabwean cross border traders in South Africa. The paper goes further to review existing literature as well as empirical studies in order to identify the major challenges that face Zimbabwean cross border traders. Among the challenges noted are crime, harassment due to xenophobia, traders are often stigmatized as "prostitutes" or "smugglers", accommodation problems, extortion and bribery by the South African Police and municipal police officials, delays at the border post during peak periods and banks that close early and also do not operate on Sundays. The Zimbabwean Cross Border Traders Association should build office in Musina and Johannesburg so that members can easily consult with the association in times of problems and also help with marketing information like distribution of brochures showcasing Zimbabwean products sold by cross border traders and also organize fairs where Zimbabwean traders can display their products. Furthermore cases of harassment by police officials should be investigated and dealt with. Banks that do have branches at the border posts are also urged to provide 24 hour service to cross border traders.展开更多
The spatial-temporal evolution of coherent structures (CS) is significant for turbulence control and drag re- duction. Among the CS, low and high speed streak structures show typical burst phenomena. The analysis wa...The spatial-temporal evolution of coherent structures (CS) is significant for turbulence control and drag re- duction. Among the CS, low and high speed streak structures show typical burst phenomena. The analysis was based on a time series of three-dimensional and three-component (3D-3C) velocity fields of the flat plate turbulent boundary layer (TBL) measured by a Tomographic and Time-resolved PIV (Tomo TRPIV) system. Using multi-resolution wavelet transform and conditional sampling method, we extracted the intrinsic topologies and found that the streak structures appear in bar-like patterns. Furthermore, we seized locations and velocity information of transient CS, and then calculated the propagation velocity of CS based on spatial-temporal cross-correlation scanning. This laid a foundation for further studies on relevant dynamics properties.展开更多
AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the disease.METHODS:Sixteen rep...AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the disease.METHODS:Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients.Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis,18 with chronic hepatitis and 16 with liver cirrhosis patients were studied.RESULTS:The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68,which was signif icantly lower than in those with chronic hepatitis(5.44 ± 3.93,P < 0.05) and liver cirrhosis(7.44 ± 3.90,P < 0.01).No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient's age,infection time,serum alanine aminotransferase activity,or serum HCV-RNA concentration.It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease.CONCLUSION:The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus,which results in persistent infection in patients with chronic hepatitis.展开更多
Identification of precise hypocenter location is useful in order to improve the faults plane orientation and seismic zone analysis. In the study area, relocated hypocenter of earthquakes in Koyna-Warna region (KWR) fr...Identification of precise hypocenter location is useful in order to improve the faults plane orientation and seismic zone analysis. In the study area, relocated hypocenter of earthquakes in Koyna-Warna region (KWR) from the short period recorded data from 6th January 2010 to 28th May 2010 by using Cross-Correlation waveform results in Double Difference Hypocenter method [1]. The results show the significant improvement in hypocenter location and orientation in earthquake hypocenters, which is correlated with local faults plane orientation in study region. From the observations the earthquake hypocenters are lying in the depth between 3 to 8 km. The result which identified three faults plane orientation in NNW-SSE direction and also identified new fractures in NE-SW directions between the faults plane orientation with short duration data sets the first time in India.展开更多
基金supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(Grant No.XDA02010000)the National Natural Science Foundation of China(Grant No.11790321).
文摘The neutron capture cross section of ^(232)Th was measured at the neutron time-of-flight facility Back-n of China Spallation Neutron Source(CSNS)for the first time.The measurement was performed with 4 hydrogen-free deuterated benzene C6D6 liquid scintillation detectors,in the ES#2 experiment station on the beam line,at a distance of about 76 m from the neutron-production assembly.The total energy detection principle in combination with the pulse height weighting technique(PHWT)was applied to analyze the measured data.Results of the ^(232)Th(n,γ)reaction cross section in the unresolved resonance region from 4 keV to 100 keV were obtained,which shows a good agreement with the existing experimental data from EXFOR,as well as with the evaluated data from the ENDF/B-VIII.0 and CENDL-3.1.In addition,the excitation function of ^(232)Th(n,γ)^(233)Th reaction in the unresolved resonance region was theoretically calculated by using the code TALYS-1.95.By fitting the experimental cross section and theoretical data,the average parameters in the unresolved resonance region were extracted.
基金supported by the Fundamental Research Funds for the Central Universities (Grant No. 2014XT06)
文摘Petroleum, the most important energy source in the world, plays an essential role in securing economic development. If a petroleum shortage happens, it will severely disrupt production and life. Cross-regional emergency scheduling can effectively alleviate a petroleum shortage and further enhance the efficiency of the emergency response. Considering the general lack of focus on cross-regional petroleum dispatching management, we propose a three-layer emergency scheduling network for petroleum based on a supernetwork model that can increase the regional emergency correlation by adding a transfer management process. Then, we compare the total demand for petroleum and the emergency costs considered in the petroleum emergency scheduling supernetwork model(the single-region and the cross-region scenarios).The result shows that the cross-regional emergency scheduling pattern can effectively enhance the efficiency of the emergency preparations and reduce the emergency costs in most cases. However, when the vulnerabilities in the crossregional link grow or the regional linkage decreases, the effect of single-regional scheduling is better. In addition, the advantages of the cross-regional emergency scheduling network will be strengthened with an increase in its maximum emergency capability. Nonetheless, this advantage will disappear when the petroleum demand in the crisis layer reaches the maximum emergency response capacity. Finally, according to the comparative analysis simulation among scenarios,certain strategic policy recommendations are suggested to improve the petroleum emergency scheduling ability in regions.These recommendations include strengthening the cross-regional coordination mechanism, increasing the modes of petroleum transportation and enhancing the carrying capacity of regional emergency routes.
基金Project supported by the National Natural Science Foundation of China(Grant No.10775063)
文摘We have measured the cross-section ratios of helium induced by Cq+ and Oq+ (q = 1-4) in an energy range from 20 keV/amu to 500 keV/amu, and obtained the two-dimensional spectra by employing the coincidence method combined with the MPA-3 data acquisition system. Hence, we obtain the ratios of total single-ionization cross-sections (SI, SC, SLSI, and DLSI), total double-ionization cross-sections (DI, DC, TI, SLDI, and DLDI) and cross-sections of every process (SI, SC, SLSI, DLSI, DI, DC, TI, SLDI, and DLDI), which induce the single-ionization and double-ionization, to the total cross sections respectively. The competitive relations between the reaction-channels and the experimental data law of each reaction-channel are revealed explicitly, and the qualitative explanations involved in those results are also presented accordingly.
文摘The amount of solar PV installed capacity has steadily increased to 44.5 GW at the end of FY2017,since the introduction of the Feed in Tariff(FiT)to Japan in 2012.On the other hand,since the first curtailment of solar PV was conducted on October 13th,2018 in the Kyushu area,the curtailment has been frequently executed including wind power after that.In this study,cross-regional interconnector and pumped hydro energy storage(PHES)are focused on mitigating curtailment.In Japan,there are 9 electric power areas which connected each other by cross-regional interconnectors.According to the historical operation,cross-regional interconnectors were secured as emergency flexible measures,but after the implicit auction was started from October 2018,it is used on merit order.Regarding a PHES in Japan,they have been built with nuclear power plants for several decades.Because the output of nuclear power generation is constant,so the PHES is used to absorb the surplus at nighttime when the demand declines.All nuclear power plants in Japan have been shut down after the accident at the Fukushima Daiichi Nuclear Power Plant following the Great East Japan Earthquake that occurred on March 11th,2011.There are several nuclear power plants that have been restarted(9 reactors,as of August 2019).In this study,the amount of curtailment for solar PV in the Kyushu area is sent to the Chugoku area using the cross-regional interconnector(Kanmon line).Then,the PHES in the Chugoku area is pumping with low price.Because the spot price in the market is low when the curtailment is executed.After that,the PHES is generating at night with high price when the solar PV is not generating.It makes a profit by the deference for the cost of pumping and the revenue of generating by the PHES.As a calculation result,for one week from May 2nd to 8th,2019,a profit becomes 152.2 million JPY(about 1.22 million EUR).For this purpose,it is necessary to raise the operation capacity of the cross-regional interconnector up to the rated capacity with the frequency control function of solar PV instead of the capacity to keep frequency in the event of an accident.This will allow the further introduction of solar PV in Japan.
基金financially supported by Youth Project of National Social Science Fund of China(Grant No.17CZZ021).
文摘As an effective environment governance tool,environment governance performance evaluation is an important content and method to promote the modernization of environment governance system and governance ability.The environmental pollution of the Beijing-Tianjin-Hebei region has typical cross-administrative characteristics.Based on the analysis of the major environmental pollution problems in the Beijing-Tianjin-Hebei region,according to the international environment governance PSR model,a performance evaluation system that applies to the environment governance of Beijing-Tianjin-Hebei region is established.Meanwhile,the principal component analysis method is applied to conduct an empirical analysis of the environmental governance panel data for the 13 major cities in the Beijing-Tianjin-Hebei region from 2014 to 2016.The results show that most of the cities in the Beijing-Tianjin-Hebei region attach great importance to reduction of emission and pollutants,continuously alleviating the stress of environmental governance.However,the overall improvement of the environment governance performance in Beijing-Tianjin-Hebei region has presented a polarization imbalance.There is a clear tendency for subjective biases in the implementation of environment governance and a lack of comprehensive and systematic governance.According to the environment governance performance evaluation result of Beijing-Tianjin-Hebei region,the cross-administrative regional environment governance should improve the environment governance performance evaluation system as soon as possible,strengthen the consistency of the environment governance objectives,and implement comprehensive and systematic governance for the regional environment.
文摘Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of different interpolation methods in meteorological data of Xinjiang Uygur Autonomous Region (Xinjiang). Actually, it has importantly practical significance to as far as possibly improve the accuracy of interpolation results for meteorological data, especially in mountainous Xinjiang. There- fore, this paper focuses on the performance of different spatial interpolation methods for monthly temperature data in Xinjiang. The daily observed data of temperature are collected from 38 meteorological stations for the period 1960- 2004. Inverse distance weighting (IDW), ordinary kriging (OK), temperature lapse rate method (TLR) and multiple linear regressions (MLR) are selected as interpolated methods. Two rasterized methods, multiple regression plus space residual error and directly interpolated observed temperature (DIOT) data, are used to analyze and compare the performance of these interpolation methods respectively. Moreover, cross-validation is used to evaluate the performance of different spatial interpolation methods. The results are as follows: 1) The method of DIOT is unsuitable for the study area in this paper. 2) It is important to process the observed data by local regression model before the spatial interpolation. 3) The MLR-IDW is the optimum spatial interpolation method for the monthly mean temperature based on cross-validation. For the authors, the reliability of results and the influence of measurement accuracy, density, distribution and spatial variability on the accuracy of the interpolation methods will be tested and analyzed in the future.
基金supported by the National Natural Science Foundation of China(Grant Nos.11875311,11905274,11705156,11605097,and U2032146)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB34030000)。
文摘The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network calculations.The neutron capture cross section in the resonance range of isotopes and even natural selenium samples has not been measured.Promptγ-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator detectors at the Back-n facility of China Spallation Neutron Source(CSNS).The pulse height weighting technique(PHWT)was used to analyze the data in the 1 e V to 100 ke V region.The deduced neutron capture cross section was compared with ENDF/B-VIII.0,JEFF-3.2,and JENDL-4.0,and some differences were found.Resonance parameters were extracted by the R-matrix code SAMMY in the 1 e V-1 ke V region.All the cross sections ofnatSe and resonance parameters are given in the datasets.The datasets are openly available at http://www.doi.org/10.11922/sciencedb.j00113.00019.
文摘Cross border traders make a major contribution to the growth of economies in Southern Africa. Cross border trade is a source of livelihood for many poor people, especially women. However, few studies examined challenges facing cross border traders and future business prospects.The aim of this paper is to examine the challenges that face Zimbabwean cross border traders in South Africa. The paper goes further to review existing literature as well as empirical studies in order to identify the major challenges that face Zimbabwean cross border traders. Among the challenges noted are crime, harassment due to xenophobia, traders are often stigmatized as "prostitutes" or "smugglers", accommodation problems, extortion and bribery by the South African Police and municipal police officials, delays at the border post during peak periods and banks that close early and also do not operate on Sundays. The Zimbabwean Cross Border Traders Association should build office in Musina and Johannesburg so that members can easily consult with the association in times of problems and also help with marketing information like distribution of brochures showcasing Zimbabwean products sold by cross border traders and also organize fairs where Zimbabwean traders can display their products. Furthermore cases of harassment by police officials should be investigated and dealt with. Banks that do have branches at the border posts are also urged to provide 24 hour service to cross border traders.
基金supported by the National Natural Science Foundation of China(11332006,11272233,and 11411130150)the National Basic Research Programm of China(2012CB720101)
文摘The spatial-temporal evolution of coherent structures (CS) is significant for turbulence control and drag re- duction. Among the CS, low and high speed streak structures show typical burst phenomena. The analysis was based on a time series of three-dimensional and three-component (3D-3C) velocity fields of the flat plate turbulent boundary layer (TBL) measured by a Tomographic and Time-resolved PIV (Tomo TRPIV) system. Using multi-resolution wavelet transform and conditional sampling method, we extracted the intrinsic topologies and found that the streak structures appear in bar-like patterns. Furthermore, we seized locations and velocity information of transient CS, and then calculated the propagation velocity of CS based on spatial-temporal cross-correlation scanning. This laid a foundation for further studies on relevant dynamics properties.
基金Supported by The National Natural Science Foundation of China, No 30500476The National High-Tech Science Foundation of China, No 2008AA02Z434+1 种基金National S and T Major Projects for Infectious Disease Control, No 2008ZX10002-013 and 2009ZX09103-621Beijing Natural Science Foundation, No 7082048
文摘AIM:To evaluate the presence and cross-reactive anti-bodies against hypervariable region 1(HVR1) in hepatitis C virus(HCV) infected patients and its relationship with the progression of the disease.METHODS:Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients.Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis,18 with chronic hepatitis and 16 with liver cirrhosis patients were studied.RESULTS:The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3.09 ± 2.68,which was signif icantly lower than in those with chronic hepatitis(5.44 ± 3.93,P < 0.05) and liver cirrhosis(7.44 ± 3.90,P < 0.01).No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient's age,infection time,serum alanine aminotransferase activity,or serum HCV-RNA concentration.It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease.CONCLUSION:The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus,which results in persistent infection in patients with chronic hepatitis.
文摘Identification of precise hypocenter location is useful in order to improve the faults plane orientation and seismic zone analysis. In the study area, relocated hypocenter of earthquakes in Koyna-Warna region (KWR) from the short period recorded data from 6th January 2010 to 28th May 2010 by using Cross-Correlation waveform results in Double Difference Hypocenter method [1]. The results show the significant improvement in hypocenter location and orientation in earthquake hypocenters, which is correlated with local faults plane orientation in study region. From the observations the earthquake hypocenters are lying in the depth between 3 to 8 km. The result which identified three faults plane orientation in NNW-SSE direction and also identified new fractures in NE-SW directions between the faults plane orientation with short duration data sets the first time in India.