We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without e...We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without elucidation of its absolute configuration.The concise five-step route with a chirally poor and regioselective strategy starting from monosaccharides was established,and the absolute structure of the natural crotonine was determined by comparison of the NMR spectra and optical rotations of the synthetic products.展开更多
One name of Chinese Croton L., Croton olivaceus Y. T. Chang & P. T. Li is corrected as Croton sanyaensis Z. L. Xu. Another illegitimate name, Sauropus pierrei (Beille) Webster is corrected based on St. Louis Code.
目的研究大孔树脂分离纯化巴豆总生物碱的工艺。方法采用分光光度法测定总生物碱,筛选HPD400、AB-8、NKA-9、ADS-17、D101树脂对巴豆总生物碱的吸附和解吸附能力,并优化分离纯化条件。结果优选出D101树脂,上样液浓度为生药1.5 g mL-1,...目的研究大孔树脂分离纯化巴豆总生物碱的工艺。方法采用分光光度法测定总生物碱,筛选HPD400、AB-8、NKA-9、ADS-17、D101树脂对巴豆总生物碱的吸附和解吸附能力,并优化分离纯化条件。结果优选出D101树脂,上样液浓度为生药1.5 g mL-1,吸附流速1.5 BV h-1,药材量:树脂量=9:2,4 BV水除杂后用4 BV 30%乙醇冲洗收集目标滤液。结论该方法简便易行,适合于巴豆总生物碱的分离纯化。展开更多
To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. （family Euphorbiaceae）, its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and prepara...To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. （family Euphorbiaceae）, its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were identified based on 1D, 2D NMR and mass spectral analysis. A total of 10 phorbol esters were obtained. Among them, compound 1 （12-O-（2-methyl）butyryl-4ct-deoxyphorbol-β-isobutyrate） and compound 10 （20-formyl-4a-deoxyphorbol- β-acetate） were two new compounds, and the other eight were known compounds.展开更多
基金This work was supported financially and inspired scientifically by Prof.Yongxian Cheng of State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,and Prof.Baomin Fan of Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission&Ministry of Education,Yunnan University of Nationalities.
文摘We report the first total synthesis of four possible absolute configurations and four other regional isomers of a naturally occurring alkaloid crotonine,which was isolated from Croton tiglium L.(Euphoriaceae)without elucidation of its absolute configuration.The concise five-step route with a chirally poor and regioselective strategy starting from monosaccharides was established,and the absolute structure of the natural crotonine was determined by comparison of the NMR spectra and optical rotations of the synthetic products.
文摘One name of Chinese Croton L., Croton olivaceus Y. T. Chang & P. T. Li is corrected as Croton sanyaensis Z. L. Xu. Another illegitimate name, Sauropus pierrei (Beille) Webster is corrected based on St. Louis Code.
基金National Natural Science Foundation of China(Grant No.81172943)
文摘To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. （family Euphorbiaceae）, its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were identified based on 1D, 2D NMR and mass spectral analysis. A total of 10 phorbol esters were obtained. Among them, compound 1 （12-O-（2-methyl）butyryl-4ct-deoxyphorbol-β-isobutyrate） and compound 10 （20-formyl-4a-deoxyphorbol- β-acetate） were two new compounds, and the other eight were known compounds.
