Recent research progress from biological perspective on the mechanism of formation of osteoarthritis after anterior cruciate ligament injury

The anterior cruciate ligament(ACL)mainly plays a role in stabilizing the knee joint by limiting the forward translation of tibial force and rotational force at the tibial joint,and if this ligament is damaged,it will cause joint pain,limited mobility,knee instability,etc.According to related studies,the incidence of traumatic osteoarthritis(PTOA)after ACL injury is as high as 87%,although many studies have shown that patients with ACL injury are susceptible to PTOA,but the exact mechanism is currently unknown.This may be related to biological,structural,and mechanical factors caused by the ligament injury.Previous studies have shown that elevated inflammatory mediators in the joint cavity following ACL injury can lead to chondrocytes necrosis and degradation of the cartilage matrix.These potential biochemical mediators contribute to PTOA formation,and early intervention can reduce future episodes of PTOA.In recent years,many scholars have devoted themselves to studying the potential important factors and signaling pathways involved in the formation of osteoarthritis after ACL injury,and exploring its molecular mechanism,which has led to great progress in this field.This paper mainly studies and discusses the mechanism of osteoarthritis formation after ACL injury from the biological perspective.

Closed patella fracture combined with cruciate ligament injury： a case control study

Background Patellar fracture and cruciate ligament injury are a common consequence of traumatic knee injury. Patellar fracture combined with cruciate ligament injury is rarely reported, although the mechanisms of two things are similar. This study aimed to evaluate the incidence of closed patella fracture combined with cruciate ligament injury.

Research Progress of Anterior Cruciate Ligament Reconstruction under Arthroscopy

As an important means to treat anterior cruciate ligament (ACL) injury, the reconstruction technology under arthroscopy has made remarkable progress in recent years, evolving gradually from the early traditional open surgery to the minimally invasive surgery under full arthroscopy. At present, it is widely used. Different graft choices (such as autologous hamstring, peroneus longus, artificial tendon, and allogeneic tendon, etc.) and fixation methods (such as metal suspension fixation, interference screw, etc.) have their own characteristics. However, this technology still faces some challenges, such as postoperative complications and the long-term stability of the graft. In terms of future trends, it will develop in a more accurate and personalized direction. New materials and technologies are expected to emerge continuously to improve the surgical effect and the rehabilitation quality of patients, providing stronger support for clinical application and research. This article will conduct a comprehensive review from aspects such as surgical methods, graft selection, fixation methods, ligamentization of the graft, challenges faced, and future trends in ACL reconstruction surgery.