Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that ...Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer's disease. Calcium channel blockers are effective therapeutics for treating Alzheimer's disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer's disease theraov.展开更多
目的:观察“筋骨并重”理念下等速肌力训练联合玻璃酸钠膝关节腔注射治疗膝骨关节炎的临床疗效。方法:选取2018年1月至2021年10月入住北京积水潭医院贵州医院的膝骨关节炎患者88例,随机分为对照组与观察组各44例。对照组给予膝关节腔注...目的:观察“筋骨并重”理念下等速肌力训练联合玻璃酸钠膝关节腔注射治疗膝骨关节炎的临床疗效。方法:选取2018年1月至2021年10月入住北京积水潭医院贵州医院的膝骨关节炎患者88例,随机分为对照组与观察组各44例。对照组给予膝关节腔注射玻璃酸钠,观察组在对照组基础上联合等速肌力训练。比较两组的临床疗效、治疗前后的膝关节疼痛视觉模拟量表(visual analogue scale,VAS)评分、膝关节lysholm量表评分、步速测定结果及起立行走计时测试(time up and go test,TUGT)结果。结果:观察组的临床总有效率(88.64%)明显高于对照组(72.73%),P<0.05。治疗后,观察组的VAS、lysholm评分、步速测定及TUGT结果均优于对照组,P<0.05。结论:等速肌力训练联合玻璃酸钠膝关节腔注射治疗膝骨关节炎的临床疗效确切,可使患者的疼痛减轻,膝关节功能得以改善。展开更多
基金supported by the National Natural Science Foundation of China, No. 81171206
文摘Alzheimer's disease is characterized by two pathological hallmarks: amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer's disease. Calcium channel blockers are effective therapeutics for treating Alzheimer's disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer's disease theraov.
文摘目的:观察“筋骨并重”理念下等速肌力训练联合玻璃酸钠膝关节腔注射治疗膝骨关节炎的临床疗效。方法:选取2018年1月至2021年10月入住北京积水潭医院贵州医院的膝骨关节炎患者88例,随机分为对照组与观察组各44例。对照组给予膝关节腔注射玻璃酸钠,观察组在对照组基础上联合等速肌力训练。比较两组的临床疗效、治疗前后的膝关节疼痛视觉模拟量表(visual analogue scale,VAS)评分、膝关节lysholm量表评分、步速测定结果及起立行走计时测试(time up and go test,TUGT)结果。结果:观察组的临床总有效率(88.64%)明显高于对照组(72.73%),P<0.05。治疗后,观察组的VAS、lysholm评分、步速测定及TUGT结果均优于对照组,P<0.05。结论:等速肌力训练联合玻璃酸钠膝关节腔注射治疗膝骨关节炎的临床疗效确切,可使患者的疼痛减轻,膝关节功能得以改善。