This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends t...This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].展开更多
In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term ...In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.展开更多
AIM: To study the effects of aminoguanidine (AG) and two L-arginine analogues N(omega)-nitro-L-arginine methyl ester (L-NAME) and N(omega)-nitro-L-arginine (L-NNA) on nitric oxide (NO) production induced by cytokines ...AIM: To study the effects of aminoguanidine (AG) and two L-arginine analogues N(omega)-nitro-L-arginine methyl ester (L-NAME) and N(omega)-nitro-L-arginine (L-NNA) on nitric oxide (NO) production induced by cytokines (TNF-alpha, IL-1 beta, and IFN-gamma) and bacterial lipopolysaccharide (LPS) mixture (CM) in the cultured rat hepatocytes, and examine their mechanisms action. METHODS: Rat hepatocytes were incubated with AG, L-NAME, L-NNA, Actinomycin D (ActD) and dexamethasone in a medium containing CM (LPS plus TNF-alpha, IL-1 beta, and IFN-gamma) for 24h. NO production in the cultured supernatant was measured with the Griess reaction. Intracellular cGMP level was detected with radioimmunoassy. RESULTS: NO production was markedly blocked by AG and L-NAME in a dose-dependent manner under inflammatory stimuli condition triggered by CM in vitro. The rate of the maximum inhibitory effects of L-NAME (38.9%) was less potent than that obtained with AG(53.7%, P 【 0.05). There was no significant difference between the inhibitory effects of AG and two L-arginine analogues on intracellular cGMP accumulation in rat cultured hepatocytes. Non-specific NOS expression inhibitor dexamethasone (DEX)and iNOS mRNA transcriptional inhibitor ActD also significantly inhibited CM-induced NO production. AG(0.1 mmol x L(-1)) and ActD (0.2 ng x L(-1)) were equipotent in decreasing NO production induced by inflammatory stimuli in vitro, and both effects were more potent than that induced by non-selectivity NOS activity inhibitor L-NAME (0.1 mmol x L(-1)) under similar stimuli conditions (P【0.01). CONCLUSION: AG is a potent selective inhibitor of inducible isoform of NOS,and the mechanism of action may be not only competitive inhibition in the substrate level, but also the gene expression level in rat hepatocytes.展开更多
Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were con...Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were conducting lectures in English, as the students listen carefully and occasionally answered the questions posed in fluent English.If hearing their voices only, audiences might easily mistake that they were in a university in an English-speaking country.'展开更多
The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the cor...The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions).展开更多
In the mid-19th century, out of their dissatisfaction with the neglect of the economic theories about other countries’ experiences in the British classic economics, the economists in the German Historical School wo...In the mid-19th century, out of their dissatisfaction with the neglect of the economic theories about other countries’ experiences in the British classic economics, the economists in the German Historical School worked hard to construct an economic theory that was congruent to the developmental stage in their own country’s culture and history. Their deeply-cherished concern about the reality in a transitional era when Germany was approaching modernization drove them to propose that the living condition of the working class be improved by the power of the state. In the late 80’s of the same century, the Methodenstreit of German Historical School versus the Austrian School broke out, after which the mainstream economics was well on its way in terms of theoretical refinement and scrutiny, whereas the influence from the Historical School gradually subsided. Even so, the lessons from the Historical School are still enlightening to research in contemporary social sciences. This paper describes the unique basics in the theory building of the Historical School; explains the background and meaning of its academic origin, research methodology, and the Methodenstreit; and from there, discusses implications for contemporary social sciences.展开更多
In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The p...In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes).展开更多
The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13...The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13). Moreover, peace is the most fundamental value in the Qur'an and Islam. The majority of the classical Muslim jurists, especially Hanafi school, emphasised that the reason for Muslims' fight against non-Muslims is Muslims' defense themselves against attacks, not non-Muslims' faith. Bediuzzaman Said Nursi (d. 1960) states that the only kind of jihad that is appropriate for the present age is spiritual or moraljihad. Furthermore, regarding Qur'anic approach to relations between Muslims and the People of the Book, Muslim scholars, in general, advocate sincere relations and trust between Muslims and the People of the Book. In addition, Said Nursi is one of the great Muslim scholars in interfaith dialogue in the 20th century. Finally, there is the need for establishing culture of coexistence, which practised before within a religious tradition such as Islamic tradition for many centuries in the history. Through achieving a culture of coexistence and peace, most conflicts can be resolved.展开更多
This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein...This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness.展开更多
This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was use...This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine.展开更多
This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invari...This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invariant 1 s/s rate of time. This is the Fundamental Direction of Evolution, FDE. There is also an evolution down time dilation gradients, the Gravitational Direction of Evolution, GDE. These evolutions are gravity, which is the evolutionary force in time. Gravitational velocities are compensation for the difference in the rate of time, dRt, in a dilation field, and the dRtis equal to the compensatory velocity’s percentage of c, and is a measure of the force in time inducing the velocity. In applied force induced velocities, the dRt is a measure of the resistance in time to the induced velocity, which might be called “anti-gravity” or “negative gravity”. The two effects keep the continuum uniformly evolving forward at c. It is demonstrated that gravity is already a part of the electromagnetic field equations in way of the dRt element contained in the TDC velocity formula. Einstein’s energy formula is defined as a velocity formula and a modified version is used for charged elementary particle solutions. A time dilation-based derivation of the Lorentz force ties gravity directly to the electromagnetic field proving the unified field of gravity and the EMF. It is noted how we could possibly create gravity drives. This is followed by a discussion of black holes, proving supermassive objects, like massive black hole singularities, are impossible, and that black holes are massless Magnetospheric Eternally Collapsing Objects (MECOs) that are vortices in spacetime. .展开更多
The phenomenon of aphasia in Chinese culture is serious.The existing English teaching materials emphasize too much Western culture education and lack traditional Chinese cultural elements.Therefore,this paper takes th...The phenomenon of aphasia in Chinese culture is serious.The existing English teaching materials emphasize too much Western culture education and lack traditional Chinese cultural elements.Therefore,this paper takes the Guangdong Maritime Silk Road as an example to study the specific application of traditional Chinese culture in cross-cultural English education.This paper first summarizes the significance of cross-cultural integration into college English education and then points out the serious phenomenon of Chinese cultural aphasia.Next,the paper focuses on English education,using English textbooks as a starting point to explore and integrate strategies related to excellent traditional Chinese culture from the Guangdong Maritime Silk Road.By integrating traditional Chinese culture into business English classes(with the Guangdong Maritime Silk Road as an example),the study explores the influence of such cultural integration on students’cross-cultural communication skills,cultural identity,and learning effects.The results showed that the P value of the experimental group and the control group was<0.05,that is,cultural integration had a positive effect on improving the effect of cross-cultural English education.The overall scores and cultural confidence of the experimental group are higher than those of the control group,which proves that cross-cultural teaching has a positive effect on the improvement of students’scores.展开更多
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.展开更多
文摘This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].
文摘In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.
基金Project supported by the National Natural Science Foundation of China,No.39770861.and JANSSEN Science Research Foundation.
文摘AIM: To study the effects of aminoguanidine (AG) and two L-arginine analogues N(omega)-nitro-L-arginine methyl ester (L-NAME) and N(omega)-nitro-L-arginine (L-NNA) on nitric oxide (NO) production induced by cytokines (TNF-alpha, IL-1 beta, and IFN-gamma) and bacterial lipopolysaccharide (LPS) mixture (CM) in the cultured rat hepatocytes, and examine their mechanisms action. METHODS: Rat hepatocytes were incubated with AG, L-NAME, L-NNA, Actinomycin D (ActD) and dexamethasone in a medium containing CM (LPS plus TNF-alpha, IL-1 beta, and IFN-gamma) for 24h. NO production in the cultured supernatant was measured with the Griess reaction. Intracellular cGMP level was detected with radioimmunoassy. RESULTS: NO production was markedly blocked by AG and L-NAME in a dose-dependent manner under inflammatory stimuli condition triggered by CM in vitro. The rate of the maximum inhibitory effects of L-NAME (38.9%) was less potent than that obtained with AG(53.7%, P 【 0.05). There was no significant difference between the inhibitory effects of AG and two L-arginine analogues on intracellular cGMP accumulation in rat cultured hepatocytes. Non-specific NOS expression inhibitor dexamethasone (DEX)and iNOS mRNA transcriptional inhibitor ActD also significantly inhibited CM-induced NO production. AG(0.1 mmol x L(-1)) and ActD (0.2 ng x L(-1)) were equipotent in decreasing NO production induced by inflammatory stimuli in vitro, and both effects were more potent than that induced by non-selectivity NOS activity inhibitor L-NAME (0.1 mmol x L(-1)) under similar stimuli conditions (P【0.01). CONCLUSION: AG is a potent selective inhibitor of inducible isoform of NOS,and the mechanism of action may be not only competitive inhibition in the substrate level, but also the gene expression level in rat hepatocytes.
文摘Although it was frigid outside mid-winter, classrooms in the Business School of Beijing International Studies University are still as warm as spring,because of the passionate teachers and students. Professors were conducting lectures in English, as the students listen carefully and occasionally answered the questions posed in fluent English.If hearing their voices only, audiences might easily mistake that they were in a university in an English-speaking country.'
文摘The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions).
文摘In the mid-19th century, out of their dissatisfaction with the neglect of the economic theories about other countries’ experiences in the British classic economics, the economists in the German Historical School worked hard to construct an economic theory that was congruent to the developmental stage in their own country’s culture and history. Their deeply-cherished concern about the reality in a transitional era when Germany was approaching modernization drove them to propose that the living condition of the working class be improved by the power of the state. In the late 80’s of the same century, the Methodenstreit of German Historical School versus the Austrian School broke out, after which the mainstream economics was well on its way in terms of theoretical refinement and scrutiny, whereas the influence from the Historical School gradually subsided. Even so, the lessons from the Historical School are still enlightening to research in contemporary social sciences. This paper describes the unique basics in the theory building of the Historical School; explains the background and meaning of its academic origin, research methodology, and the Methodenstreit; and from there, discusses implications for contemporary social sciences.
文摘In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes).
文摘The Qur'an embraces cultural pluralism, emphasising that “People, We created you all from a single man and a single woman, and made you into races and tribes so that you should recognize one another. ”(Q. 49: 13). Moreover, peace is the most fundamental value in the Qur'an and Islam. The majority of the classical Muslim jurists, especially Hanafi school, emphasised that the reason for Muslims' fight against non-Muslims is Muslims' defense themselves against attacks, not non-Muslims' faith. Bediuzzaman Said Nursi (d. 1960) states that the only kind of jihad that is appropriate for the present age is spiritual or moraljihad. Furthermore, regarding Qur'anic approach to relations between Muslims and the People of the Book, Muslim scholars, in general, advocate sincere relations and trust between Muslims and the People of the Book. In addition, Said Nursi is one of the great Muslim scholars in interfaith dialogue in the 20th century. Finally, there is the need for establishing culture of coexistence, which practised before within a religious tradition such as Islamic tradition for many centuries in the history. Through achieving a culture of coexistence and peace, most conflicts can be resolved.
文摘This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness.
文摘This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine.
文摘This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invariant 1 s/s rate of time. This is the Fundamental Direction of Evolution, FDE. There is also an evolution down time dilation gradients, the Gravitational Direction of Evolution, GDE. These evolutions are gravity, which is the evolutionary force in time. Gravitational velocities are compensation for the difference in the rate of time, dRt, in a dilation field, and the dRtis equal to the compensatory velocity’s percentage of c, and is a measure of the force in time inducing the velocity. In applied force induced velocities, the dRt is a measure of the resistance in time to the induced velocity, which might be called “anti-gravity” or “negative gravity”. The two effects keep the continuum uniformly evolving forward at c. It is demonstrated that gravity is already a part of the electromagnetic field equations in way of the dRt element contained in the TDC velocity formula. Einstein’s energy formula is defined as a velocity formula and a modified version is used for charged elementary particle solutions. A time dilation-based derivation of the Lorentz force ties gravity directly to the electromagnetic field proving the unified field of gravity and the EMF. It is noted how we could possibly create gravity drives. This is followed by a discussion of black holes, proving supermassive objects, like massive black hole singularities, are impossible, and that black holes are massless Magnetospheric Eternally Collapsing Objects (MECOs) that are vortices in spacetime. .
基金Research on the Cultural Inheritance of Guangdong Maritime Silk Road Enabled by AI(CXXL2024249)。
文摘The phenomenon of aphasia in Chinese culture is serious.The existing English teaching materials emphasize too much Western culture education and lack traditional Chinese cultural elements.Therefore,this paper takes the Guangdong Maritime Silk Road as an example to study the specific application of traditional Chinese culture in cross-cultural English education.This paper first summarizes the significance of cross-cultural integration into college English education and then points out the serious phenomenon of Chinese cultural aphasia.Next,the paper focuses on English education,using English textbooks as a starting point to explore and integrate strategies related to excellent traditional Chinese culture from the Guangdong Maritime Silk Road.By integrating traditional Chinese culture into business English classes(with the Guangdong Maritime Silk Road as an example),the study explores the influence of such cultural integration on students’cross-cultural communication skills,cultural identity,and learning effects.The results showed that the P value of the experimental group and the control group was<0.05,that is,cultural integration had a positive effect on improving the effect of cross-cultural English education.The overall scores and cultural confidence of the experimental group are higher than those of the control group,which proves that cross-cultural teaching has a positive effect on the improvement of students’scores.
基金supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL)the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH)+2 种基金the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH)the Sino-German Center for Research Promotion,No.M-0759(to YH)a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
文摘Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.