Due to their high density,the ilmenite-bearing cumulates(IBC)(with or without KREEP)formed during the late-stage lunar magma ocean solidification are thought to sink into the underlying lunar mantle and trigger lunar ...Due to their high density,the ilmenite-bearing cumulates(IBC)(with or without KREEP)formed during the late-stage lunar magma ocean solidification are thought to sink into the underlying lunar mantle and trigger lunar mantle overturn.Geophysical evidence implied that IBC may descend deep inside the Moon and remain as a partially molten layer at the core-mantle boundary(CMB).However,partial melting may have occurred on the mixed mantle cumulates during the sinking of IBC/KREEP and the silicate melt may be positively buoyant,thus preventing the IBC/KREEP layer from sinking to the CMB.Here,we perform thermodynamic simulation on the stability of lunar mantle cumulates at different depths mixed with different amounts of IBC/KREEP from an updated LMO model.The modeling results suggest that the sinking of IBC/KREEP will cause at least 5 wt%partial melting in the shallow(~120 km)and a much larger degree of partial melting in the deep lunar mantle(~420 km).Due to the density contrast with the surrounding mantle,IBC/KREEP-bearing melts could potentially decouple under certain conditions.The modified lunar mantle by sinking of IBC/KREEP can better explain the formation of different kinds of lunar basaltic magma than the primary lunar mantle formed through differentiation of lunar magma ocean.Sinking of IBC/KREEP back into the lunar mantle may introduce plagioclase,clinopyroxene,garnet,and incompatible radioactive elements into the deep lunar mantle,which will further affect the thermal and chemical evolution of the lunar interior.展开更多
The G?ksun(Kahramanmaras)ophiolite(GKO),cropping out in a tectonic window bounded by the Malatya metamorphic unit on both the north and south,is located in the EW-trending lower nappe zone of the southeast Anatolian o...The G?ksun(Kahramanmaras)ophiolite(GKO),cropping out in a tectonic window bounded by the Malatya metamorphic unit on both the north and south,is located in the EW-trending lower nappe zone of the southeast Anatolian orogenic belt(Turkey).It exhibits a complete oceanic lithospheric section and overlies the Middle Eocene Maden Group/Complex with a tectonic contact at its base.The ophiolitic rocks and the tectonically overlying Malatya metamorphic(continental)unit were intruded by I-type calc-alkaline Late Cretaceous granitoid(~81-84 Ma).The ultramafic to cumulates in the GKO are represented by wehrlite,plagioclase wehrlite,olivine gabbro and gabbro.The crystallization order for the cumulate rocks is as follows:olivine±chromian spinel→clinopyroxene→plagioclase.The major and trace element geochemistry as well as the mineral chemistry of the ultramafic to mafic cumulate rocks suggest that the primary magma generating the GKO is compositionally similar to that observed in the modern island-arc tholeiitic sequences.The mineral chemistry of the ultramafic to mafic cumulates indicates that they were derived from a mantle source that was previously depleted by earlier partial melting events.The highly magnesian olivine(Fo77-83),clinopyroxene(Mg#of 82-90)and the highly Ca-plagioclase(An81-89)exhibit a close similarity to those,which formed in a supra-subduction zone(SSZ)setting.The field and the geochemical evidence suggest that the GKO formed as part of a much larger sheet of oceanic lithosphere,which accreted to the base of the Tauride active continental margin,including the ispendere,K?mürhan and the Guleman ophiolites.The latter were contemporaneous and genetically/tectonically related within the same SSZ setting during the closure of the Neotethyan oceanic basin(Berit Ocean)between the Taurides to the north and the Bitlis-Pütürge massif to the south during the Late Cretaceous.展开更多
Objective Sulfide inclusions within natural mineral phases play important roles in exploring the origin of magmatic sulfides ores,tracing the distribution of sulfur in mantle or crust and understanding continental man...Objective Sulfide inclusions within natural mineral phases play important roles in exploring the origin of magmatic sulfides ores,tracing the distribution of sulfur in mantle or crust and understanding continental mantle evolution(partial melting and metasomatism in upper mantle).Until now,varieties of sulfide inclusions have been extensively discovered in the ultramafic or mafic phenocrysts.展开更多
The Late Cretaceous Sabzevar ophiolite represents one of the largest and most complete fragments of Tethyan oceanic lithosphere in the NE Iran.It is mainly composed of serpentinized mantle peridotites slices;nonethele...The Late Cretaceous Sabzevar ophiolite represents one of the largest and most complete fragments of Tethyan oceanic lithosphere in the NE Iran.It is mainly composed of serpentinized mantle peridotites slices;nonetheless,minor tectonic slices of all crustal sequence constituents are observed in this ophiolite.The crustal sequence contains a well-developed ultramafic and mafic cumulates section,comprising plagioclase-bearing wehrlite,olivine clinopyroxenite,olivine gabbronorite,gabbronorite,amphibole gabbronorite and quartz gabbronorite with adcumulate,mesocumulate,heteradcumulate and orthocumulate textures.The crystallization order for these rocks is olivine±chromian spinel→clinopyroxene→plagioclase→orthopyroxene→amphibole.The presence of primary magmatic amphiboles in the cumulate rocks shows that the parent magma evolved under hydrous conditions.Geochemically,the studied rock units are characterized by low TiO2(0.18-0.57 wt.%),P2 O5(<0.05 wt.%),K2 O(0.01-0.51 wt.%)and total alkali contents(0.12-3.04 wt.%).They indicate fractionated trends in the chondrite-normalized rare earth element(REE)plots and multi-element diagrams(spider diagrams).The general trend of the spider diagrams exhibit slight enrichment in large ion lithophile elements(LILEs)relative to high field strength elements(HFSEs)and positive anomalies in Sr,Pb and Eu and negative anomalies in Zr and Nb relative to the adjacent elements.The REE plots of these rocks display increasing trend from La to Sm,positive Eu anomaly(Eu/Eu*=1.06-1.54)and an almost flat pattern from medium REE(MREE)to heavy REE(HREE)region[(Gd/Yb)N=1-1.17].Moreover,clinopyroxenes from the cumulate rocks have low REE contents and show marked depletion in light REE(LREE)compared to MREE and HREE[(La/Sm)N=0.10-0.27 and(La/Yb)N=0.08-0.22].The composition of calculated melts in equilibrium with the clinopyroxenes from less evolved cumulate samples are closely similar to island arc tholeiitic(IAT)magmas.Modal mineralogy,geochemical features and REE modeling indicate that Sabzevar cumulate rocks were formed by crystal accumulation from a hydrous depleted basaltic melt with IAT affinity.This melt has been produced by moderate to high degree(~15%)of partial melting a depleted mantle source,which partially underwent metasomatic enrichment from subducted slab components in an intra-oceanic arc setting.展开更多
The Neotethys plays an important role in shaping the Gangdese magmatic belt,southern Tibet.However,the initial time of spreading and subduction of the Neotethys remains contentious.In this study,a suite of late Triass...The Neotethys plays an important role in shaping the Gangdese magmatic belt,southern Tibet.However,the initial time of spreading and subduction of the Neotethys remains contentious.In this study,a suite of late Triassic cumulate hornblende gabbro was identified in the southern margin of the Gangdese magmatic belt.The gabbro exhibits cumulate structure,with hornblende and plagioclase as the primary mineral phases.Isotopic data indicate a hydrous magma source derived from a depleted mantle wedge that has been modified by slab dehydration.Geochemical discriminations suggest that the gabbro was formed in an intraoceanic arc setting,with crystallization ages of ca.220-213 Ma.Hornblende,hornblendelagioclase and ilmenite thermometers reveal that the crystallization temperature of 900-750°C for the gabbro.Hornblende and hornblende-plagioclase geobarometers yield an emplacement depth at ca.14.5-19.5 km.This gabbro constitutes a line of evidence for an intraoceanic arc magmatism that is coeval with the counterparts in the southern Turkey,revealing an intraoceanic subduction system within the Neotethys from west to east in the Late Triassic and that the oceanization of the Neotethys was much earlier than previous expectation.展开更多
Mafic enclaves in granites are generally considered to represent coeval mafic melts that derived from metasomatized mantle,which can provide valuable information about crust-mantle interaction.Exploring the genetic li...Mafic enclaves in granites are generally considered to represent coeval mafic melts that derived from metasomatized mantle,which can provide valuable information about crust-mantle interaction.Exploring the genetic links between the mafic enclaves and their host monzogranite from the Triassic Zhashui Pluton,Qinling orogenic belt.The enclaves(220±4.6 Ma)and the monzogranite(220±2.8 Ma)display identical zircon U-Pb ages,and they also share similar trace element and zircon Lu-Hf isotopes,indicating a cognate source.The monzogranite displays zirconεHf(t)values of−0.99 to+1.98,while the mafic enclaves show similar values of−0.45 to+3.26;however,differences in mineral chemistry reveal different crystallization conditions.The amphibole from the mafic enclaves has higher temperature and pressure(757℃;2.65 kbar)compared to those of the host monzogranite(733℃;1.96 kbar),suggesting that mafic minerals in the enclaves crystallized at an early stage.Moreover,apatite in the mafic enclaves displays slightly higher volatile contents(0.72 wt%)than those of the monzogranite(0.66 wt%),indicating a volatile-rich condition.These results suggest that the mafic enclaves represent early hydrous mafic cumulates in the granitic chamber,and subsequent magma convection would have led to the formation of the mafic enclaves.展开更多
Cyclic impact induces ongoing fatigue damage and performance degradation in anchoring structures,ser-ving as a critical factor leading to the instability of deep roadways.This paper takes the intrinsic spatio-temporal...Cyclic impact induces ongoing fatigue damage and performance degradation in anchoring structures,ser-ving as a critical factor leading to the instability of deep roadways.This paper takes the intrinsic spatio-temporal relationship of macro-microscopic cumulative damage in anchoring structures as the main thread,revealing the mechanism of bearing capacity degradation and progressive instability of anchoring structure under cyclic impact.Firstly,a set of impact test devices and methods for the prestressed solid anchor bolt anchoring structure were developed,effectively replicating the cyclic impact stress paths in situ.Secondly,cyclic impact anchoring structure tests and simulations were conducted,which clarifies the damage evolution mechanism of the anchoring structure.Prestress loss follows a cubic decay func-tion as the number of impacts increases.Under the same impact energy and pretension force,the impact resistance cycles of extended anchoring and full-length anchoring were increased by 186.7%and 280%,respectively,compared to end anchoring.The rate of internal damage accumulation is positively corre-lated with impact energy and negatively correlated with anchorage length.Internal tensile cracks account for approximately 85%.Stress transmission follows a fluctuating pattern.Compared to the extended anchoring,the maximum vibration velocity of the exposed end particles in the full-length anchoring was reduced by 59.31%.Damage evolution exhibits a pronounced cumulative mutation effect.Then,a three-media,two-interface mechanical model of the anchoring structure was constructed.It has been clarified that the compressive stress,tensile stress,and oscillation effect arising from rapid transi-tions between compression and tension are the primary internal factors responsible for the degradation of the anchoring structure’s bearing capacity.Finally,the progressive instability mechanism of the anchoring structure under cyclic impact was elucidated.The mutual feedback and superposition of media rupture,interface debonding,and bearing capacity degradation result in overall failure.The failure pro-cess involves stages dominated by oscillation-compression,tensile stress,and compression failure.A tar-geted control strategy was further proposed.This provides a reference for maintaining the long-term stability of deep roadways under dynamic impact loads.展开更多
Metabasites consisting of metamorphic ultra-mafic rocks, cumulate gabbro, gabbro (diabase), basalt, and plagiogranite are exposed at the Taoxinghu area in central Qiangtang, northern Tibetan Plateau. Zircon SHRIMP U-P...Metabasites consisting of metamorphic ultra-mafic rocks, cumulate gabbro, gabbro (diabase), basalt, and plagiogranite are exposed at the Taoxinghu area in central Qiangtang, northern Tibetan Plateau. Zircon SHRIMP U-Pb dating for the cumulate gabbro yields a weighted mean age of 467±4 Ma, which is the oldest and most reliable magmatic age in this area. Zircon 176Hf/177Hf ratios range from 0.282615 to 0.282657, with εHf(t) values of 5.02±0.28, indicating that the cumulate gabbro was mainly derived from the depleted mantle. In addition, geochemical data of metabasites suggest that they have similar characteristics to those in the mid-ocean ridge basalts (MORB). The Taoxinghu metabasites may represent the fragment of Early Paleozoic ophiolite in the "Central Uplift" of the Qiangtang, northern Tibetan Plateau.展开更多
Mafic xenoliths occur in Mesozoic diorites from nine localities in eastern Inner Mongolia from the Da Hinggan Mrs. to Huabei craton. Their petrologic and geochemical features suggest that they are an intact suite of c...Mafic xenoliths occur in Mesozoic diorites from nine localities in eastern Inner Mongolia from the Da Hinggan Mrs. to Huabei craton. Their petrologic and geochemical features suggest that they are an intact suite of cumulate complex whose mineral assemblages contain typical patent mantle metasomatism minerals such as pargosite, phlogopite and apatite. Their REEs and trace element characteristics suggest a comagmatic relationship in these cumulates with different compositions. Isotopic dating of the xenoliths indicates that they are products of the mantle magmatic underplating in the Early Mesozoic (237—224 Ma), and they may provide direct evidence for the crust-mantle interaction and vertical accretion of continental crust under a background of the mantle upwelling in the Early Mesozoic in Huabei region.展开更多
BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations ...BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.展开更多
Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and failure.This study develops an experimental device designed to test AS under triaxial loads.The device enables the inves...Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and failure.This study develops an experimental device designed to test AS under triaxial loads.The device enables the investigation of the mechanical response,failure mode,instability assessment criteria,and anchorage effect of AS subjected to combined cyclic dynamic-static triaxial stress paths.The results show that the peak bearing strength is positively correlated with the anchoring matrix strength,anchorage length,and edgewise compressive strength.The bearing capacity decreases significantly when the anchorage direction is severely inclined.The free face failure modes are typically transverse cracking,concave fracturing,V-shaped slipping and detachment,and spallation detachment.Besides,when the anchoring matrix strength and the anchorage length decrease while the edgewise compressive strength,loading rate,and anchorage inclination angle increase,the failure intensity rises.Instability is determined by a negative tangent modulus of the displacement-strength curve or the continued deformation increase against the general downward trend.Under cyclic loads,the driving force that breaks the rock mass along the normal vector and the rigidity of the AS are the two factors that determine roadway stability.Finally,a control measure for surrounding rock stability is proposed to reduce the internal driving force via a pressure relief method and improve the rigidity of the AS by full-length anchorage and grouting modification.展开更多
Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by drought.Understanding the impact of droughts on different types of vegetation...Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by drought.Understanding the impact of droughts on different types of vegetation GPP provides insight into the spatiotemporal variation of terrestrial carbon sinks,aiding efforts to mitigate the detrimental effects of climate change.In this study,we utilized the precipitation and temperature data from the Climatic Research Unit,the standardized precipitation evapotranspiration index(SPEI),the standardized precipitation index(SPI),and the simulated vegetation GPP using the eddy covariance-light use efficiency(EC-LUE)model to analyze the spatiotemporal change of GPP and its response to different drought indices in the Mongolian Plateau during 1982-2018.The main findings indicated that vegetation GPP decreased in 50.53% of the plateau,mainly in its northern and northeastern parts,while it increased in the remaining 49.47%area.Specifically,meadow steppe(78.92%)and deciduous forest(79.46%)witnessed a significant decrease in vegetation GPP,while alpine steppe(75.08%),cropland(76.27%),and sandy vegetation(87.88%)recovered well.Warming aridification areas accounted for 71.39% of the affected areas,while 28.53% of the areas underwent severe aridification,mainly located in the south and central regions.Notably,the warming aridification areas of desert steppe(92.68%)and sandy vegetation(90.24%)were significant.Climate warming was found to amplify the sensitivity of coniferous forest,deciduous forest,meadow steppe,and alpine steppe GPP to drought.Additionally,the drought sensitivity of vegetation GPP in the Mongolian Plateau gradually decreased as altitude increased.The cumulative effect of drought on vegetation GPP persisted for 3.00-8.00 months.The findings of this study will improve the understanding of how drought influences vegetation in arid and semi-arid areas.展开更多
The non-Gaussianity of quantum states incarnates an important resource for improving the performance of continuous-variable quantum information protocols.We propose a novel criterion of non-Gaussianity for single-mode...The non-Gaussianity of quantum states incarnates an important resource for improving the performance of continuous-variable quantum information protocols.We propose a novel criterion of non-Gaussianity for single-mode rotationally symmetric quantum states via the squared Frobenius norm of higher-order cumulant matrix for the quadrature distribution function.As an application,we study the non-Gaussianities of three classes of single-mode symmetric non-Gaussian states:a mixture of vacuum and Fock states,single-photon added thermal states,and even/odd Schr¨odinger cat states.It is shown that such a criterion is faithful and effective for revealing non-Gaussianity.We further extend this criterion to two cases of symmetric multi-mode non-Gaussian states and non-symmetric single-mode non-Gaussian states.展开更多
Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects an...Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.展开更多
To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive t...To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive the general evolution formula of the Wigner function, and its relation to Weyl correspondence is also discussed. The method of integration within the ordered product of operators is essential to our discussion.展开更多
In order to investigate the fatigue performance of orthotropic anisotropic steel bridge decks,this study realizes the simulation of the welding process through elastic-plastic finite element theory,thermal-structural ...In order to investigate the fatigue performance of orthotropic anisotropic steel bridge decks,this study realizes the simulation of the welding process through elastic-plastic finite element theory,thermal-structural sequential coupling,and the birth-death element method.The simulated welding residual stresses are introduced into the multiscale finite element model of the bridge as the initial stress.Furthermore,the study explores the impact of residual stress on crack propagation in the fatigue-vulnerable components of the corroded steel box girder.The results indicate that fatigue cracks at the weld toe of the top deck,the weld root of the top deck,and the opening of the transverse diaphragm will not propagate under the action of a standard vehicle load.However,the inclusion of residual stress leads to the propagation of these cracks.When considering residual stress,the fatigue crack propagation paths at the weld toe of the transverse diaphragm and the U-rib weld toe align with those observed in actual bridges.In the absence of residual stress,the cracks at the toe of the transverse diaphragm with a 15%mass loss rate are categorized as type I cracks.Conversely,when residual stress is considered,these cracks become I-II composite cracks.Residual stress significantly alters the cumulative energy release rate of the three fracturemodes.Therefore,incorporating the influence of residual stress is essential when assessing the fatigue performance of corroded steel box girders in long-span bridges.展开更多
Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop production.The widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop w...Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop production.The widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water status.With three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water availability.The Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different parameters.The equation Nc=6.43T0.24 established a consistent relationship across varying irrigation regimes.Independent test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root absorption.Additionally,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller AIC.The novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation conditions.These findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.展开更多
Acute myocardial infarction is a deadly disease, and in the Indian context, it occurs at a younger age, even below the age of 40 years, and sometimes even below 30 years. These young MI patients have high mortality ra...Acute myocardial infarction is a deadly disease, and in the Indian context, it occurs at a younger age, even below the age of 40 years, and sometimes even below 30 years. These young MI patients have high mortality rates, and many of them are not able to reach the hospital. The pathophysiology of AMI is very well understood. AMI is a multifactorial disease and has several risk factors, like dyslipidemia, diabetes, hypertension, smoking, diet, etc. However, low-density lipoprotein cholesterol (LDL-C) has a very strong causal relationship with atherosclerosis. Reducing LDL-C to <70 results in the arrest of the progression of atherosclerosis, and slashing its level to below 50 produces the regression of atherosclerosis. The cumulative exposure of LDL-C to the arterial wall is a very strong determinant of atherosclerosis and the development of AMI. The coronary heart disease (CHD) threshold target of LDL-C for the development of AMI is roughly 7000 mg/year. If LDL-C is 100 mg/dL from an early age, the CHD threshold target for the development of AMI will reach 70 years of age. However, if LDL-C target is <70 mg/dL from an early age, the patients will reach the CHD threshold of LDL-C at the age of 100 years. Based on the current science, this is an emerging concept to postpone AMI by several years, even up to 100 years. The goal of LDL-C <70 mg/dL can be achieved by available oral or injectable drugs. Gene editing with CRISPR technology is emerging as a very exciting modality for lowering LDL-C to a very low level for the rest of life.展开更多
This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularl...This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.展开更多
Cumulative assessment is a tool for the project developer to try and take into consideration not only their contribution to cumulative impacts but also other projects and external factors that may place their developm...Cumulative assessment is a tool for the project developer to try and take into consideration not only their contribution to cumulative impacts but also other projects and external factors that may place their developments at risk.This study assessed the cumulative impacts of air emissions from 22 major power plants in southeast Bangladesh planned to generate 21,550 MW of electricity.It also includes anticipated growth in small to medium size industries,brickfields,highway traffic,inland water transport,transhippers,jetty,and vessel transports used for transporting fuel resources for these power plants.A 50 km by 50 km airshed is considered for air quality modeling.Cumulative analysis indicates that predicted MGLCs(Maximum Ground Level Concentrations)of NO2 and CO are complying with both Bangladesh NAAQS(National Ambient Air Quality Standards)and WBG(World Bank Group)Guidelines.The daily average MGLC of PM_(2.5)(62.45µg/m^(3))from all sources complies with NAAQS,however,exceeds the WBG Guidelines.Annual PM_(2.5) concentration(15.45µg/m^(3))exceeds NAAQS and WBG Guidelines.The PM10 concentration complies with the NAAQS for both 24-hour and annual averaging times.Annual average concentration(23.12µg/m^(3))exceeds WBG Guidelines.Daily average SO2 concentration(102.49µg/m^(3))complies with the NAAQS however,it exceeds the WBG guideline values.High concentrations of PM_(2.5) and SO2 are due to the contribution of transboundary emissions and secondary pollutants in the atmosphere.This dispersion modeling outcome can be used by the policymakers for the pollution reduction strategy.展开更多
基金funded by the National Natural Science Foundation of China(41773052,41973058)。
文摘Due to their high density,the ilmenite-bearing cumulates(IBC)(with or without KREEP)formed during the late-stage lunar magma ocean solidification are thought to sink into the underlying lunar mantle and trigger lunar mantle overturn.Geophysical evidence implied that IBC may descend deep inside the Moon and remain as a partially molten layer at the core-mantle boundary(CMB).However,partial melting may have occurred on the mixed mantle cumulates during the sinking of IBC/KREEP and the silicate melt may be positively buoyant,thus preventing the IBC/KREEP layer from sinking to the CMB.Here,we perform thermodynamic simulation on the stability of lunar mantle cumulates at different depths mixed with different amounts of IBC/KREEP from an updated LMO model.The modeling results suggest that the sinking of IBC/KREEP will cause at least 5 wt%partial melting in the shallow(~120 km)and a much larger degree of partial melting in the deep lunar mantle(~420 km).Due to the density contrast with the surrounding mantle,IBC/KREEP-bearing melts could potentially decouple under certain conditions.The modified lunar mantle by sinking of IBC/KREEP can better explain the formation of different kinds of lunar basaltic magma than the primary lunar mantle formed through differentiation of lunar magma ocean.Sinking of IBC/KREEP back into the lunar mantle may introduce plagioclase,clinopyroxene,garnet,and incompatible radioactive elements into the deep lunar mantle,which will further affect the thermal and chemical evolution of the lunar interior.
基金supported by TüBITAK (YDABCAG199Y011) and the Cukurova University Scientific Research Projects (MMF2002BAP41)the Open Fund (GPMR201702) of State Key Lab of Geological Processes and Mineral Resources,China University of Geosciences,Wuhansubsidy by the Russian Government to support the Program of competitive growth of Kazan Federal University
文摘The G?ksun(Kahramanmaras)ophiolite(GKO),cropping out in a tectonic window bounded by the Malatya metamorphic unit on both the north and south,is located in the EW-trending lower nappe zone of the southeast Anatolian orogenic belt(Turkey).It exhibits a complete oceanic lithospheric section and overlies the Middle Eocene Maden Group/Complex with a tectonic contact at its base.The ophiolitic rocks and the tectonically overlying Malatya metamorphic(continental)unit were intruded by I-type calc-alkaline Late Cretaceous granitoid(~81-84 Ma).The ultramafic to cumulates in the GKO are represented by wehrlite,plagioclase wehrlite,olivine gabbro and gabbro.The crystallization order for the cumulate rocks is as follows:olivine±chromian spinel→clinopyroxene→plagioclase.The major and trace element geochemistry as well as the mineral chemistry of the ultramafic to mafic cumulate rocks suggest that the primary magma generating the GKO is compositionally similar to that observed in the modern island-arc tholeiitic sequences.The mineral chemistry of the ultramafic to mafic cumulates indicates that they were derived from a mantle source that was previously depleted by earlier partial melting events.The highly magnesian olivine(Fo77-83),clinopyroxene(Mg#of 82-90)and the highly Ca-plagioclase(An81-89)exhibit a close similarity to those,which formed in a supra-subduction zone(SSZ)setting.The field and the geochemical evidence suggest that the GKO formed as part of a much larger sheet of oceanic lithosphere,which accreted to the base of the Tauride active continental margin,including the ispendere,K?mürhan and the Guleman ophiolites.The latter were contemporaneous and genetically/tectonically related within the same SSZ setting during the closure of the Neotethyan oceanic basin(Berit Ocean)between the Taurides to the north and the Bitlis-Pütürge massif to the south during the Late Cretaceous.
基金financially supported by the National Natural Science Foundation of China(grant No. 41302062)the China Geological Survey(grant No. 12120115034401)
文摘Objective Sulfide inclusions within natural mineral phases play important roles in exploring the origin of magmatic sulfides ores,tracing the distribution of sulfur in mantle or crust and understanding continental mantle evolution(partial melting and metasomatism in upper mantle).Until now,varieties of sulfide inclusions have been extensively discovered in the ultramafic or mafic phenocrysts.
文摘The Late Cretaceous Sabzevar ophiolite represents one of the largest and most complete fragments of Tethyan oceanic lithosphere in the NE Iran.It is mainly composed of serpentinized mantle peridotites slices;nonetheless,minor tectonic slices of all crustal sequence constituents are observed in this ophiolite.The crustal sequence contains a well-developed ultramafic and mafic cumulates section,comprising plagioclase-bearing wehrlite,olivine clinopyroxenite,olivine gabbronorite,gabbronorite,amphibole gabbronorite and quartz gabbronorite with adcumulate,mesocumulate,heteradcumulate and orthocumulate textures.The crystallization order for these rocks is olivine±chromian spinel→clinopyroxene→plagioclase→orthopyroxene→amphibole.The presence of primary magmatic amphiboles in the cumulate rocks shows that the parent magma evolved under hydrous conditions.Geochemically,the studied rock units are characterized by low TiO2(0.18-0.57 wt.%),P2 O5(<0.05 wt.%),K2 O(0.01-0.51 wt.%)and total alkali contents(0.12-3.04 wt.%).They indicate fractionated trends in the chondrite-normalized rare earth element(REE)plots and multi-element diagrams(spider diagrams).The general trend of the spider diagrams exhibit slight enrichment in large ion lithophile elements(LILEs)relative to high field strength elements(HFSEs)and positive anomalies in Sr,Pb and Eu and negative anomalies in Zr and Nb relative to the adjacent elements.The REE plots of these rocks display increasing trend from La to Sm,positive Eu anomaly(Eu/Eu*=1.06-1.54)and an almost flat pattern from medium REE(MREE)to heavy REE(HREE)region[(Gd/Yb)N=1-1.17].Moreover,clinopyroxenes from the cumulate rocks have low REE contents and show marked depletion in light REE(LREE)compared to MREE and HREE[(La/Sm)N=0.10-0.27 and(La/Yb)N=0.08-0.22].The composition of calculated melts in equilibrium with the clinopyroxenes from less evolved cumulate samples are closely similar to island arc tholeiitic(IAT)magmas.Modal mineralogy,geochemical features and REE modeling indicate that Sabzevar cumulate rocks were formed by crystal accumulation from a hydrous depleted basaltic melt with IAT affinity.This melt has been produced by moderate to high degree(~15%)of partial melting a depleted mantle source,which partially underwent metasomatic enrichment from subducted slab components in an intra-oceanic arc setting.
文摘The Neotethys plays an important role in shaping the Gangdese magmatic belt,southern Tibet.However,the initial time of spreading and subduction of the Neotethys remains contentious.In this study,a suite of late Triassic cumulate hornblende gabbro was identified in the southern margin of the Gangdese magmatic belt.The gabbro exhibits cumulate structure,with hornblende and plagioclase as the primary mineral phases.Isotopic data indicate a hydrous magma source derived from a depleted mantle wedge that has been modified by slab dehydration.Geochemical discriminations suggest that the gabbro was formed in an intraoceanic arc setting,with crystallization ages of ca.220-213 Ma.Hornblende,hornblendelagioclase and ilmenite thermometers reveal that the crystallization temperature of 900-750°C for the gabbro.Hornblende and hornblende-plagioclase geobarometers yield an emplacement depth at ca.14.5-19.5 km.This gabbro constitutes a line of evidence for an intraoceanic arc magmatism that is coeval with the counterparts in the southern Turkey,revealing an intraoceanic subduction system within the Neotethys from west to east in the Late Triassic and that the oceanization of the Neotethys was much earlier than previous expectation.
基金supported by the National Natural Science Foundation of China(Grant Nos.42372071,41421002)the Foundation for the Author of National Excellent Doctoral Dissertation of China(Grant No.201324)a research grant of the State Key Laboratory of Continental Dynamics(Grant No.SKLCD-04).
文摘Mafic enclaves in granites are generally considered to represent coeval mafic melts that derived from metasomatized mantle,which can provide valuable information about crust-mantle interaction.Exploring the genetic links between the mafic enclaves and their host monzogranite from the Triassic Zhashui Pluton,Qinling orogenic belt.The enclaves(220±4.6 Ma)and the monzogranite(220±2.8 Ma)display identical zircon U-Pb ages,and they also share similar trace element and zircon Lu-Hf isotopes,indicating a cognate source.The monzogranite displays zirconεHf(t)values of−0.99 to+1.98,while the mafic enclaves show similar values of−0.45 to+3.26;however,differences in mineral chemistry reveal different crystallization conditions.The amphibole from the mafic enclaves has higher temperature and pressure(757℃;2.65 kbar)compared to those of the host monzogranite(733℃;1.96 kbar),suggesting that mafic minerals in the enclaves crystallized at an early stage.Moreover,apatite in the mafic enclaves displays slightly higher volatile contents(0.72 wt%)than those of the monzogranite(0.66 wt%),indicating a volatile-rich condition.These results suggest that the mafic enclaves represent early hydrous mafic cumulates in the granitic chamber,and subsequent magma convection would have led to the formation of the mafic enclaves.
基金supported by National Key Research and Development Program of China(No.2023YFC2907600)the National Natural Science Foundation of China(Nos.52074263,52274145 and 52034007)+1 种基金the Postdoctoral Fellowship Program(Grade C)of China Postdoctoral Science Foundation(No.GZC20241925)the Fundamental Research Funds for the Central Universities(No.2024QN11002).
文摘Cyclic impact induces ongoing fatigue damage and performance degradation in anchoring structures,ser-ving as a critical factor leading to the instability of deep roadways.This paper takes the intrinsic spatio-temporal relationship of macro-microscopic cumulative damage in anchoring structures as the main thread,revealing the mechanism of bearing capacity degradation and progressive instability of anchoring structure under cyclic impact.Firstly,a set of impact test devices and methods for the prestressed solid anchor bolt anchoring structure were developed,effectively replicating the cyclic impact stress paths in situ.Secondly,cyclic impact anchoring structure tests and simulations were conducted,which clarifies the damage evolution mechanism of the anchoring structure.Prestress loss follows a cubic decay func-tion as the number of impacts increases.Under the same impact energy and pretension force,the impact resistance cycles of extended anchoring and full-length anchoring were increased by 186.7%and 280%,respectively,compared to end anchoring.The rate of internal damage accumulation is positively corre-lated with impact energy and negatively correlated with anchorage length.Internal tensile cracks account for approximately 85%.Stress transmission follows a fluctuating pattern.Compared to the extended anchoring,the maximum vibration velocity of the exposed end particles in the full-length anchoring was reduced by 59.31%.Damage evolution exhibits a pronounced cumulative mutation effect.Then,a three-media,two-interface mechanical model of the anchoring structure was constructed.It has been clarified that the compressive stress,tensile stress,and oscillation effect arising from rapid transi-tions between compression and tension are the primary internal factors responsible for the degradation of the anchoring structure’s bearing capacity.Finally,the progressive instability mechanism of the anchoring structure under cyclic impact was elucidated.The mutual feedback and superposition of media rupture,interface debonding,and bearing capacity degradation result in overall failure.The failure pro-cess involves stages dominated by oscillation-compression,tensile stress,and compression failure.A tar-geted control strategy was further proposed.This provides a reference for maintaining the long-term stability of deep roadways under dynamic impact loads.
基金supported by National Natural Science Foundation of China (Grants Nos. 40872146 and 40672147)China Geological Survey (Grant Nos. 1212010561605 and 1212010911070)Institute of Geology, Chinese Academy of Geological Sciences (Grant No. J0910)
文摘Metabasites consisting of metamorphic ultra-mafic rocks, cumulate gabbro, gabbro (diabase), basalt, and plagiogranite are exposed at the Taoxinghu area in central Qiangtang, northern Tibetan Plateau. Zircon SHRIMP U-Pb dating for the cumulate gabbro yields a weighted mean age of 467±4 Ma, which is the oldest and most reliable magmatic age in this area. Zircon 176Hf/177Hf ratios range from 0.282615 to 0.282657, with εHf(t) values of 5.02±0.28, indicating that the cumulate gabbro was mainly derived from the depleted mantle. In addition, geochemical data of metabasites suggest that they have similar characteristics to those in the mid-ocean ridge basalts (MORB). The Taoxinghu metabasites may represent the fragment of Early Paleozoic ophiolite in the "Central Uplift" of the Qiangtang, northern Tibetan Plateau.
文摘Mafic xenoliths occur in Mesozoic diorites from nine localities in eastern Inner Mongolia from the Da Hinggan Mrs. to Huabei craton. Their petrologic and geochemical features suggest that they are an intact suite of cumulate complex whose mineral assemblages contain typical patent mantle metasomatism minerals such as pargosite, phlogopite and apatite. Their REEs and trace element characteristics suggest a comagmatic relationship in these cumulates with different compositions. Isotopic dating of the xenoliths indicates that they are products of the mantle magmatic underplating in the Early Mesozoic (237—224 Ma), and they may provide direct evidence for the crust-mantle interaction and vertical accretion of continental crust under a background of the mantle upwelling in the Early Mesozoic in Huabei region.
基金National Natural Science Foundation of China,No.72101236China Postdoctoral Science Foundation,No.2022M722900+1 种基金Collaborative Innovation Project of Zhengzhou City,No.XTCX2023006Nursing Team Project of the First Affiliated Hospital of Zhengzhou University,No.HLKY2023005.
文摘BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.
基金This paper is financially supported by the National Natural Science Foundation of China(Grant Nos.52074263 and 52034007)the Postgraduate Research and Practice Innovation Program of Jiangsu Province(Grant No.KYCX21_2332).
文摘Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and failure.This study develops an experimental device designed to test AS under triaxial loads.The device enables the investigation of the mechanical response,failure mode,instability assessment criteria,and anchorage effect of AS subjected to combined cyclic dynamic-static triaxial stress paths.The results show that the peak bearing strength is positively correlated with the anchoring matrix strength,anchorage length,and edgewise compressive strength.The bearing capacity decreases significantly when the anchorage direction is severely inclined.The free face failure modes are typically transverse cracking,concave fracturing,V-shaped slipping and detachment,and spallation detachment.Besides,when the anchoring matrix strength and the anchorage length decrease while the edgewise compressive strength,loading rate,and anchorage inclination angle increase,the failure intensity rises.Instability is determined by a negative tangent modulus of the displacement-strength curve or the continued deformation increase against the general downward trend.Under cyclic loads,the driving force that breaks the rock mass along the normal vector and the rigidity of the AS are the two factors that determine roadway stability.Finally,a control measure for surrounding rock stability is proposed to reduce the internal driving force via a pressure relief method and improve the rigidity of the AS by full-length anchorage and grouting modification.
基金jointly supported by the National Natural Science Foundation of China(42361024,42101030,42261079,and 41961058)the Talent Project of Science and Technology in Inner Mongolia of China(NJYT22027 and NJYT23019)the Fundamental Research Funds for the Inner Mongolia Normal University,China(2022JBBJ014 and 2022JBQN093)。
文摘Gross primary productivity(GPP)of vegetation is an important constituent of the terrestrial carbon sinks and is significantly influenced by drought.Understanding the impact of droughts on different types of vegetation GPP provides insight into the spatiotemporal variation of terrestrial carbon sinks,aiding efforts to mitigate the detrimental effects of climate change.In this study,we utilized the precipitation and temperature data from the Climatic Research Unit,the standardized precipitation evapotranspiration index(SPEI),the standardized precipitation index(SPI),and the simulated vegetation GPP using the eddy covariance-light use efficiency(EC-LUE)model to analyze the spatiotemporal change of GPP and its response to different drought indices in the Mongolian Plateau during 1982-2018.The main findings indicated that vegetation GPP decreased in 50.53% of the plateau,mainly in its northern and northeastern parts,while it increased in the remaining 49.47%area.Specifically,meadow steppe(78.92%)and deciduous forest(79.46%)witnessed a significant decrease in vegetation GPP,while alpine steppe(75.08%),cropland(76.27%),and sandy vegetation(87.88%)recovered well.Warming aridification areas accounted for 71.39% of the affected areas,while 28.53% of the areas underwent severe aridification,mainly located in the south and central regions.Notably,the warming aridification areas of desert steppe(92.68%)and sandy vegetation(90.24%)were significant.Climate warming was found to amplify the sensitivity of coniferous forest,deciduous forest,meadow steppe,and alpine steppe GPP to drought.Additionally,the drought sensitivity of vegetation GPP in the Mongolian Plateau gradually decreased as altitude increased.The cumulative effect of drought on vegetation GPP persisted for 3.00-8.00 months.The findings of this study will improve the understanding of how drought influences vegetation in arid and semi-arid areas.
基金Project supported by the Natural Science Foundation of Hunan Province of China(Grant No.2021JJ30535)。
文摘The non-Gaussianity of quantum states incarnates an important resource for improving the performance of continuous-variable quantum information protocols.We propose a novel criterion of non-Gaussianity for single-mode rotationally symmetric quantum states via the squared Frobenius norm of higher-order cumulant matrix for the quadrature distribution function.As an application,we study the non-Gaussianities of three classes of single-mode symmetric non-Gaussian states:a mixture of vacuum and Fock states,single-photon added thermal states,and even/odd Schr¨odinger cat states.It is shown that such a criterion is faithful and effective for revealing non-Gaussianity.We further extend this criterion to two cases of symmetric multi-mode non-Gaussian states and non-symmetric single-mode non-Gaussian states.
基金supported by the National Natural Science Foundation of China(Grant No.12372356)Postgraduate Scientific Research In-novation Project of Hunan Province(Grant No.CX20221044).
文摘Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.
基金Project supported by the Foundation for Young Talents in College of Anhui Province, China (Grant Nos. gxyq2021210 and gxyq2019077)the Natural Science Foundation of the Anhui Higher Education Institutions, China (Grant Nos. 2022AH051580 and 2022AH051586)。
文摘To conveniently calculate the Wigner function of the optical cumulant operator and its dissipation evolution in a thermal environment, in this paper, the thermo-entangled state representation is introduced to derive the general evolution formula of the Wigner function, and its relation to Weyl correspondence is also discussed. The method of integration within the ordered product of operators is essential to our discussion.
基金supported by a grant from the Key Technologies Research and Development Program(No.2021YFF0602005)Jiangsu Key Research and Development Plan(Nos.BE2022129,BE2022134)the Fundamental Research Funds for the Central Universities(Nos.2242022k30031,2242022k30033),which are gratefully acknowledged.
文摘In order to investigate the fatigue performance of orthotropic anisotropic steel bridge decks,this study realizes the simulation of the welding process through elastic-plastic finite element theory,thermal-structural sequential coupling,and the birth-death element method.The simulated welding residual stresses are introduced into the multiscale finite element model of the bridge as the initial stress.Furthermore,the study explores the impact of residual stress on crack propagation in the fatigue-vulnerable components of the corroded steel box girder.The results indicate that fatigue cracks at the weld toe of the top deck,the weld root of the top deck,and the opening of the transverse diaphragm will not propagate under the action of a standard vehicle load.However,the inclusion of residual stress leads to the propagation of these cracks.When considering residual stress,the fatigue crack propagation paths at the weld toe of the transverse diaphragm and the U-rib weld toe align with those observed in actual bridges.In the absence of residual stress,the cracks at the toe of the transverse diaphragm with a 15%mass loss rate are categorized as type I cracks.Conversely,when residual stress is considered,these cracks become I-II composite cracks.Residual stress significantly alters the cumulative energy release rate of the three fracturemodes.Therefore,incorporating the influence of residual stress is essential when assessing the fatigue performance of corroded steel box girders in long-span bridges.
基金supported by the National Key Research and Development Program of China(2022YFD2001005)the Key Research&Development Program of Jiangsu province(BE2021358)+2 种基金the National Natural Science Foundation of China(32271989)the Natural Science Foundation of Jiangsu province(BK20220146)the Jiangsu Independent Innovation Fund Project of Agricultural Science and Technology[CX(23)3121].
文摘Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop production.The widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water status.With three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water availability.The Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different parameters.The equation Nc=6.43T0.24 established a consistent relationship across varying irrigation regimes.Independent test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root absorption.Additionally,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller AIC.The novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation conditions.These findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.
文摘Acute myocardial infarction is a deadly disease, and in the Indian context, it occurs at a younger age, even below the age of 40 years, and sometimes even below 30 years. These young MI patients have high mortality rates, and many of them are not able to reach the hospital. The pathophysiology of AMI is very well understood. AMI is a multifactorial disease and has several risk factors, like dyslipidemia, diabetes, hypertension, smoking, diet, etc. However, low-density lipoprotein cholesterol (LDL-C) has a very strong causal relationship with atherosclerosis. Reducing LDL-C to <70 results in the arrest of the progression of atherosclerosis, and slashing its level to below 50 produces the regression of atherosclerosis. The cumulative exposure of LDL-C to the arterial wall is a very strong determinant of atherosclerosis and the development of AMI. The coronary heart disease (CHD) threshold target of LDL-C for the development of AMI is roughly 7000 mg/year. If LDL-C is 100 mg/dL from an early age, the CHD threshold target for the development of AMI will reach 70 years of age. However, if LDL-C target is <70 mg/dL from an early age, the patients will reach the CHD threshold of LDL-C at the age of 100 years. Based on the current science, this is an emerging concept to postpone AMI by several years, even up to 100 years. The goal of LDL-C <70 mg/dL can be achieved by available oral or injectable drugs. Gene editing with CRISPR technology is emerging as a very exciting modality for lowering LDL-C to a very low level for the rest of life.
文摘This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.
文摘Cumulative assessment is a tool for the project developer to try and take into consideration not only their contribution to cumulative impacts but also other projects and external factors that may place their developments at risk.This study assessed the cumulative impacts of air emissions from 22 major power plants in southeast Bangladesh planned to generate 21,550 MW of electricity.It also includes anticipated growth in small to medium size industries,brickfields,highway traffic,inland water transport,transhippers,jetty,and vessel transports used for transporting fuel resources for these power plants.A 50 km by 50 km airshed is considered for air quality modeling.Cumulative analysis indicates that predicted MGLCs(Maximum Ground Level Concentrations)of NO2 and CO are complying with both Bangladesh NAAQS(National Ambient Air Quality Standards)and WBG(World Bank Group)Guidelines.The daily average MGLC of PM_(2.5)(62.45µg/m^(3))from all sources complies with NAAQS,however,exceeds the WBG Guidelines.Annual PM_(2.5) concentration(15.45µg/m^(3))exceeds NAAQS and WBG Guidelines.The PM10 concentration complies with the NAAQS for both 24-hour and annual averaging times.Annual average concentration(23.12µg/m^(3))exceeds WBG Guidelines.Daily average SO2 concentration(102.49µg/m^(3))complies with the NAAQS however,it exceeds the WBG guideline values.High concentrations of PM_(2.5) and SO2 are due to the contribution of transboundary emissions and secondary pollutants in the atmosphere.This dispersion modeling outcome can be used by the policymakers for the pollution reduction strategy.