Altered synaptic currents,mitophagy,mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai capsules intervention

Emerging research suggests a potential association of progression of Alzheimer's disease(AD)with alterations in synaptic currents and mitochondrial dynamics.However,the specific associations between these pathological changes remain unclear.In this study,we utilized Aβ42-induced AD rats and primary neural cells as in vivo and in vitro models.The investigations included behavioural tests,brain magnetic resonance imaging(MRI),liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis,Nissl staining,thioflavin-S staining,enzyme-linked immunosorbent assay,Golgi-Cox staining,transmission electron microscopy(TEM),immunofluorescence staining,proteomics,adenosine triphosphate(ATP)detection,mitochondrial membrane potential(MMP)and reactive oxygen species(ROS)assessment,mitochondrial morphology analysis,electrophysiological studies,Western blotting,and molecular docking.The results revealed changes in synaptic currents,mitophagy,and mitochondrial dynamics in the AD models.Remarkably,intervention with Dengzhan Shengmai(DZSM)capsules emerged as a pivotal element in this investigation.Aβ42-induced synaptic dysfunction was significantly mitigated by DZSM intervention,which notably amplified the frequency and amplitude of synaptic transmission.The cognitive impairment observed in AD rats was ameliorated and accompanied by robust protection against structural damage in key brain regions,including the hippocampal CA3,primary cingular cortex,prelimbic system,and dysgranular insular cortex.DZSM intervention led to increased IDE levels,augmented long-term potential(LTP)amplitude,and enhanced dendritic spine density and length.Moreover,DZSM intervention led to favourable changes in mitochondrial parameters,including ROS expression,MMP and ATP contents,and mitochondrial morphology.In conclusion,our findings delved into the realm of altered synaptic currents,mitophagy,and mitochondrial dynamics in AD,concurrently highlighting the therapeutic potential of DZSM intervention.

Probabilistic Calculation of Tidal Currents forWind Powered Systems Using PSO Improved LHS

This paper introduces the Particle SwarmOptimization(PSO)algorithmto enhance the LatinHypercube Sampling(LHS)process.The key objective is to mitigate the issues of lengthy computation times and low computational accuracy typically encountered when applying Monte Carlo Simulation(MCS)to LHS for probabilistic trend calculations.The PSOmethod optimizes sample distribution,enhances global search capabilities,and significantly boosts computational efficiency.To validate its effectiveness,the proposed method was applied to IEEE34 and IEEE-118 node systems containing wind power.The performance was then compared with Latin Hypercubic Important Sampling(LHIS),which integrates significant sampling with theMonte Carlomethod.The comparison results indicate that the PSO-enhanced method significantly improves the uniformity and representativeness of the sampling.This enhancement leads to a reduction in data errors and an improvement in both computational accuracy and convergence speed.

Absolute Wall Thickness Measurement of Conducting Plates Using Pulsed Eddy Currents

The method using pulsed eddy currents to determine the thickness of a conduction plate is extended to enable the simultaneous measurement of the plate thickness and material properties. For optimal performance, a probe must be designed depending on the thickness range that should be accessible. The need for a calibration of the material properties of a conducting plate to enable the measurement of its thickness has been removed. All that is needed is a probe with known dimensions and suitable hardware to create a current pulse and measure a transient magnetic induction.

On the functions of astrocyte-mediated neuronal slow inward currents

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of astrocytes.These events are significantly slower than the excitatory postsynaptic currents.Parameters of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto rs.Astrocytes are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback loop.Mostly as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological conditions.There is a growing body of evidence on the roles of slow inward currents on a single neuron or local network level.These events often occur in synchro ny on neurons located in the same astrocytic domain.Besides synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic plasticity.In addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory inputs.Of note,there might be important regionspecific differences in the roles and actions triggering slow inward currents.In greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological ones.Slow inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural networks.Slow inward currents are significant contributors to paroxysmal depolarizational shifts/interictal spikes.These events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive functions.Events with features overlapping with slow inward currents(excitatory,N-methyl-Daspartate-receptor mediated currents with astrocytic contribution) as ischemic currents and spreading depolarization also have a well-known pathophysiological role in worsening consequences of stroke,traumatic brain injury,or epilepsy.One might assume that slow inward currents occurring with low frequency under physiological conditions might contribute to synaptic plasticity and memory formation.However,to state this,more experimental evidence from greater neuronal networks or the level of the individual is needed.In this review,I aimed to summarize findings on slow inward currents and to speculate on the potential functions of it.

Observation of Arctic surface currents using data from a surface drifting buoy

During the 10th Chinese Arctic scientific expedition carried out in the summer of 2019,the surface current in the high-latitude areas of the Arctic Ocean was observed using a self-developed surface drifting buoy,which was initially deployed in the Chukchi Sea.The buoy traversed the Chukchi Sea,Chukchi Abyssal Plain,Mendeleev Ridge,Makarov Basin,and Canada Basin over a period of 632 d.After returning to the Mendeleev Ridge,it continued to drift toward the pole.Overall,the track of the buoy reflected the characteristics of the transpolar drift and Chukchi Slope Current,as well as the inertial flow,cross-ridge surface flow,and even the surface disorganized flow for some time intervals.The results showed that:(1)the transpolar drift mainly occurs in the Chukchi Abyssal Plain,Mendeleev Ridge,and western Canada Basin to the east of the ridge where sea ice concentration is high,and the average northward flow velocity in the region between 79.41°N and 86.32°N was 5.1 cm/s;(2)the average surface velocity of the Chukchi Slope Current was 13.5 cm/s,and while this current moves westward along the continental slope,it also extends northwestward across the continental slope and flows to the deep sea;and(3)when sea ice concentration was less than 50%,the inertial flow was more significant(the maximum observed inertial flow was 26 cm/s,and the radius of the inertia circle was 3.6 km).

Suppressing Leakage Currents and Improving Performance of Indoor Organic Photovoltaic Devices

Organic photovoltaic(OPV) devices hold great promise for indoor light harvesting,offering a theoretical upper limit of power conversion efficiency that surpasses that of other photovoltaic technologies.However,the presence of high leakage currents in OPV devices commonly constrains their effective performance under indoor conditions.In this study,we identified that the origin of the high leakage currents in OPV devices lay in pinhole defects present within the active layer(AL).By integrating an automated spin-coating strategy with sequential deposition processes,we achieved the compactness of the AL and minimized the occurrence of pinhole defects therein.Experimental findings demonstrated that with an increase in the number of deposition cycles,the density of pinhole defects in the AL underwent a marked reduction.Consequently,the leakage current experienced a substantial decrease by several orders of magnitude which achieved through well-calibrated AL deposition procedures.This enabled a twofold enhancement in the power conversion efficiency(PCE) of the OPV devices under conditions of indoor illumination.

A study of impact of the reclamation and artificial island projects on tidal currents and sediment concentration in radial sand ridge field of the South Yellow Sea

The two-dimensional hydrodynamic model, MIKE21, is applied to simulate the tidal currents and sediment concentration in the radial sand ridges of the South Yellow Sea. Results are in accordance with in situ observations. Then the variations of tidal currents and suspended sediment concentration caused by reclamation and artificial islands projects are simulated. The results show that the impacts are limited around the project areas. After the projects, the fan-shaped, Jianggang centered tidal current pattern would be replaced by a pattern which is formed by two tidal paths. One locates at the Xiyang channel in north-south direction, and the other locates at the Huangshayang channel in east-west direction. The reclamation of Tiaozini separates the waters into south portion and north portion. The changes of sediment concentrations coincide with those of currents. Both the sediment concentrations and tidal currents increase at the northwest of Dongsha and the south of Gaoni, while both decrease at the north and south of Tiaozini, and the east and southwest of Dongsha.

An Analysis of Observed Ocean Currents Data and Numerical Simulation in the Offshore Area of Jiaonan

Based on the diurnal consecutively observed data in the offshore area of Jiaonan in 2005, the paper tries to make a preliminary analysis of the specificity of ocean currents, tidal current property and residual current property in the area in observing dates. Then on the basis of observed data analysis and by employing the split-step method, the paper conducts a numerical simulation of the tidal current field, which can show the M2 tidal constituent tidal wave system, current ellipse distribution, maximum current velocity distribution and time-dependent current field. The calculated results agree well with the observed data, which can on the one hand reflect the basic specificities of temporal and spatial distribution of the M2 tidal constituent current field to some extent, and, on the other hand, offer more information about the hydrodynamic condition. So the paper would provide a scientific basis for the making of sea environment protection plans in the offshore area of Jiaonan under certain conditions.

Variations in tidal currents and suspended sediment concentration of the upper part of the North Channel of Changjiang Estuary over the past 10 years

The tidal current duration （TCD） and velocity （TCV） and suspended sediment concentration （SSC） were measured in the dry season in December, 2011 and in the flood season in June, 2012 at the upper part of the North Channel of Changjiang Estuary. They were assimilated with the measured data in 2003, 2004, 2006 and 2007, using the tidal range＇s proportion conversion. Variations in TCD and TCV, preferential flow and SSC have been calculated. Influences of typical engineering projects such as Qingcaosha fresh water reservoir, Yangtze River Bridge, and land reclamation on the ebb and flood TCD, TCV and SSC in the North Channel for the last 10 years are discussed. The results show that： （1） currently, in the upper part of North Channel, the ebb tide dominates; after the construction of the typical projects, ebb TCD and TCV tends to be larger and the vertical average ebb and flood SSC decrease during the flood season while SSC increases during the dry season; （2） changes in the vertical average TCV are mainly contributed by seasonal runoff variation during the flood season, which is larger in the flood season than that in the dry season; the controlling parameters of increasing ebb TCD and TCV are those large-scale engineering projects in the North Channel; variation in SSC may result mainly from the reduction of basin annual sediment loads, large-scale nearshore projects and so on.

Analysis of tidal and residual currents across semi-enclosed bay mouth based on shipboard ADCP measurements

Based on 25 hours shipboard ADCP measurements across semi-enclosed bay mouth（Kemen Channel）, time series of tidal currents over 12 sites, which distribute evenly along the transect, were constructed to improve our understanding of tidal characteristics and residuals in this region. The tidal currents in Kemen Channel were identified as the regular semidiurnal and reversing tidal flows, with its behaviour more like standing waves. Moreover, the flood currents in the lower layers were found to be ahead of that in the upper layers and vice versa for ebb tides. The major of tidal ellipse for M2 constituent was found to be larger close to the southern side of the channel, with its incline also increasing toward the south. The signs of M4 constituent were also found mainly nearby the end points of this transect, indicating the importance of nonlinearity in tidal dynamics due to the shallower topography. A two-layer structure was found for the residual currents in Kemen Channel, flowing northeastwardly out of the Bay in upper 20m and southwestwardly into the bay in the lowers. Besides approximate 4.81×10^8 m^3 water exchanges were determined between the Luoyuan Bay and outer seas by the calculation of tidal flux through Kemen Channel.

Numerical study of the tides and residual currents in the Qiongzhou Strait

Based on the three-dimensional ECOM model,the tide,tide-induced residual current,wind-driven and density currents in the Beibu (Tonkin) Gulf and Qiongzhou Strait are diagnostically computed in fine grid.The tides and tidal currents in the Beibu Gulf and Qiongzhou Strait are well reproduced.The model results show that the semidiurnal tidal wave propagates eastward from the Beibu Gulf through Qiongzhou Strait,while diurnal tidal waves enter the strait from both the eastern and western sides and interact on the southeast coast of the strait.The formation processes of the residual currents in Qiongzhou Strait in summer (August) and winter (January) are mainly discussed.It is shown that the total residual currents (coupling effect of wind,tide and density) in the strait are westward in both summer and winter.The water volume transported from the east to west into the Beibu Gulf is 0.026 Sv in summer and 0.116 Sv in winter.Numerical experiments indicate that the dominant factor affecting the residual currents in the strait is not the wind stress but the tidal rectification.The westward tide-induced residual current,driven by the tidal rectification,is rather strong in the strait with water volume transport of 0.063 Sv.The wind in summer only reduces the westward tide-induced residual current to a certain extent,and the wind in winter approximately doubles the westward tide-induced residual current through the strait.The density current contributes little to the total residual current in both summer and winter.

Numerical simulation of tides, tidal currents and residual currents in the Yellow River estuary

A 3-D Finite-Volume Coastal Ocean Model was applied in the Bohai Sea,especially near the Yellow River estuary, to simulate the tides, tidal currents, residualcurrents and shear fronts, using unstructured triangular grids. In the case of anaccurate simulation of the tides and tidal currents in the Bohai Sea, this article focuseson the Yellow River mouth. The type of tides is irregular semi-diurnal and the type oftidal currents is the reciprocating flow, mostly parallel to the coastline. The tide inducedeulerian residual currents are a couple of eddies on each side of the river mouth, withthe anticlockwise on the left side and clockwise on the other side, and both of theeddies are enhanced by the Yellow River runoff. Two patterns of shear fronts areidentified at the conversion between the flood and ebb tidal phase. The results suggestthat the shear fronts be generated in the shallow water because the tidal phase of thecoastal area is ahead of the deeper seaward area, then moves seaward and finallydisappears 1-2 hours later.

Analysis of Equatorial Currents Observed by Eastern Indian Ocean Cruises in 2010 and 2011

Hydrographic and direct current measurements were made in the Eastern Equatorial Indian Ocean in May 2010 and April 2011 as part of the Eastern Indian Ocean Cruises(EIOC) organized by the South China Sea Institute of Oceanology(SCSIO).Analyses of the shipdrift Acoustic Doppler Current Profiler(ADCP) data indicate that the equatorial currents observed in May 2010 are characterized by a strongly eastward surface current(Wyrtki Jets,WJs) with a maximum velocity of 0.9 m s 1,while that observed in April 2011 is weak and without a consistent direction.The strongly eastward WJ transports the surface water eastward,resulting in a deeper upper mixed layer,as shown in the temperature and salinity profiles.However,it was found that the Equatorial Undercurrent(EUC) in the Eastern Indian Ocean is strong in April 2011 and weak in May 2010.The EUC was located approximately at the position of the thermocline,and it had higher salinity(up to approximately 35.5 psu) than the upper and lower waters.

Currents in the Luzon Strait during the spring of 2002: observation and computation by modified inverse model

On the basis of the current measurements at 200,500 and 800 m from moored current meters with the time series data from March 17 to April 15 at the mooring station (20°49′57″N, 120°48′ 12″E) and the hydrographic data obtained in the Luzon Strait during the spring of 2002 cruise, the circulation in the investigated area is computed by using the modified inverse method. The major observed results are as follows: (1) the average velocity and the flow direction in the observing days are (47.4 cm/s, 346°) at the 200 m level. The average velocity in the observing days is (20.3 cm/s, 350? at the 500 m level. These mean that the Kuroshio intrudes into the South Chin Sea to flow northwestward through the Luzon Strait at 200 and 500 m levels. (2) The average velocity in the observing days is (1.2 cm/s, 35°) at the 800 m level, i. e., its direction is northeastward. This means that the flow condition at the 800 m level very differs from mat at the 200 and 500 m levels. (3) There is the high density and cold water (HDCW) in the middle of western part of in the investigated region, and its center is located near the hydrological station 3 at Section A. (4) There is the lower density and warm water (LDWW) in the southeastern part of investigated region. (5) The currents in April 2002 are stronger than those in March 2002.The major computed results are as follows: (1) The northwestward and southeastward VTs through Section B are 32.48×106 m3/s (inclusive of VT of anticyclonic eddy) and 3.34×106m3/s, respectively. The net northwestward VT through Section B in the investigated area is about 29.14×106 m3/s. (2) The eastern and western VTs through Section A are about 16.71×106 and 8.57×106 m3/s, respectively. Thus, the net eastward VT through Section A is about 8.14×106 m3/s. (3) The net northward VT through Section M is about 24.68×106 m3/s. (4) After about 24.68×106 m3/s flows through Section M, most of it, about 16.54×106 m3/s, flows northward through the eastern part of Section C and then flows northward into the region east Taiwan Island. The other part of it, about 8.14×106 m3/s, branches out from the main Kuroshio and then flows meanderingly through the western part of Section C. Thus, the Kuroshio has the two cores of current at Section C. (5) The direction of the computed current near the mooring station M agrees with the direction of the current measurements at 200 and 500 m from moored current meters, i.e., their directions both are northwestward. (6) About 3.34×106 m3/s of the South Chin Sea water probably flows slowly from the northwest to the southeast in the layer below 550 m at the western part of Section B.

The Theory of Field-Effect Transistors:XI. The Bipolar Electrochemical Currents(1-2-MOS-Gates on Thin-Thick Pure-Impure Base)

The field-effect transistor is inherently bipolar, having simultaneously electron and hole surface and volume channels and currents. The channels and currents are controlled by one or more externally applied transverse electric fields. It has been known as the unipolar field-effect transistor for 55-years since Shockley＇s 1952 invention,because the electron-current theory inevitably neglected the hole current from over-specified internal and boundary conditions, such as the electrical neutrality and the constant hole-electrochemical-potential, resulting in erroneous solutions of the internal and terminal electrical characteristics from the electron channel current alone, which are in gross error when the neglected hole current becomes comparable to the electron current, both in subthreshold and strong inversion. This report presents the general theory, that includes both electron and hole channels and currents. The rectangular （ x, y, z） parallelepiped transistors,uniform in the width direction （z-axis）,with one or two MOS gates on thin and thick,and pure and impure base, are used to illustrate the two-dimensional effects and the correct internal and boundary conditions for the electric and the electron and hole electrochemical potentials. Complete analytical equations of the DC current-voltage characteristics of four common MOS transistor structures are derived without over-specification： the 1-gate on semi-infinite-thick impure-base （the traditional bulk transistor）, the 1-gate on thin impure-silicon layer over oxide-insulated silicon bulk （SOI） ,the 1-gate on thin impure-silicon layer deposited on insulating glass （SOI TFT）, and the 2-gates on thin pure-base （FinFETs）.

Thermoelectric Currents of Earth’s Core Generate the Earth’s Magnetic Field

The geotemperature gradient is considered as taking main part in generating the Earth’s magnetic field. It is shown that geotemperature gradient functions as a generator of both nuclear and mantle thermoelectrical currents thanks to the great temperature difference between the core and the mantle. The movement of those currents is close to the radial direction towards the Earth’s crust. However, the nuclear thermocurrents movement tends to cyclically change into opposite one. If the mantle and core thermocurrents move oppositely, the Earth’s crust cools down globally and ice age comes, but if they move unidirectionally then global warming comes. The calculation show that the Earth’s surface can warm up to not more than 10°C. The latter, considering how human factor affects the warming of Earth, is incomparably great. There are calculations that show power of the Earth’s thermocurrents being enough to generate and maintain the Earth’s magnetic field, its modern dynamics and the poles inversion.

Morphology and Frictional Characteristics Under Electrical Currents of Al_2O_3/Cu Composites Prepared by Internal Oxidation

Two Al2O3/Cu composites containing 0.24 wt.% Al2O3 and 0.60 wt.% Al2O3 separately are prepared by internal oxidation. Effects of sliding speed and pressure on the frictional characteristics of the composites and copper against brass are investigated and compared. The changes in morphology of the sliding surface and subsurface are examined with scanning electron microscope （SEM） and energy dispersive X-ray spectrum （EDS）. The results show that the wear resistance of the Al2O3/Cu composites is superior to that of copper under the same conditions, Under a given electrical current, the wear rate of Al2O3/Cu composites decreases as the Al2O3-content increases, However, the wear rates of the Al2O3/Cu composites and copper increase as the sliding speed and pressure increase under dry sliding condition. The main wear mechanisms for Al2O3/Cu composites are of abrasion and adhesion; for copper, it is adhesion, although wear by oxidation and electrical erosion can also be observed as the speed and pressure rise.

Numerical study of pollutant movement in waves and wave-induced long-shore currents in surf zone

Water waves, wave-induced long-shore currents and movement of pollutants in waves and currents have been numerically studied based on the hyperbolic mild-slope equation, the shallow water equation , as well as the pollutant movement equation, and the numerical results have also been validated by experimental data. It is shown that the long-shore current velocity and wave set-up increase with the increasing incident wave amplitude and slope steepness of the shore plane ; the wave set-up increases with the in- creasing incident wave period;and the pollutant morement proceeds more quiekly with the increasing incident wave amplitude and slope steepness of the shore palane. In surf zones, the long-shore currents induced by the inclined incident waves have effectively affected the pollutant movement.

Evaluation of Mid-Depth Currents of NCEP Reanalysis Data in the Tropical Pacific Using ARGO Float Position Information

The global project of the Array for Real-time Geostrophic Oceanography （ARGO） provides a unique opportunity to observe the absolute velocity in mid-depths of the world oceans. A total of 1597 velocity vectors at 1000 （2000） db in the tropical Pacific derived from the ARGO float position information during the period November 2001 to October 2004 are used to evaluate the intermediate currents of the National Centers for Environmental Prediction reanalysis. To derive reliable velocity information from ARGO float trajectory points, a rigorous quality control scheme is applied, and by virtue of a correction method for reducing the drift error on the surface in obtaining the velocity vectors, their relative errors are less than 25%. Based on the comparisons from the quantitative velocity vectors and from the space-time average currents, some substantial discrepancies are revealed. The first is that the velocities of the reanalysis at mid-depths except near the equator are underestimated relative to the observed velocities by the floats. The average speed difference between NCEP and ARGO values ranges from about -2.3cm s^-1 to -1.8 cm s^-1. The second is that the velocity difference between the ocean model and the observations at 2000 dB seems smaller than that at 1000 dB. The third is that the zonal flow in the reanalysis is too dominant so that some eddies could not be simulated, such as the cyclonic eddy to the east of 160°E between 20°N and 30°N at 2000 dB. In addition, it is noticeable that many floats parking at 1000 dB cannot acquire credible mid-depth velocities due to the time information of their end of ascent （start of descent） on the surface in the trajectory files. Thus, relying on default times of parking, descent and ascent in the metadata files gravely confines their application to measuring mid-depth currents.

Ocean surface currents retrieval based on the satellite remote sensing data

The ocean surface currents are reconstructed from the satellite remote sensing data containing altimeter-derived sea surface height and QuikSCAT satellite-derived wind data. Based on the method proposed by Lagerloef, a global weekly 0.5°×0.5°ocean surface current product was obtained over the period 2000 - 2008 by combining the geostrophic currents estimated from sea surface height with Ekman current estimated from the wind stress. Particularly, weight functions were introduced when calculating the Ekman currents to eliminate the discontinuity near 25°S and 25°N. These satellite-derived currents have been compared with TAO current meter and the SCUD product, respectively. The comparison showed that satellite-derived currents not only could capture the characteristics of ocean surface currents but also had high accuracy and reliability. The result showed that this innovatory method was effective.