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A multi-enzymatic cascade reaction for the synthesis of bioactive C-oligosaccharides
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作者 Kebo Xie Qian Zhang +1 位作者 Fei Ye Jungui Dai 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第6期451-455,共5页
C-Oligosaccharides are rare in nature and possess diverse bioactivities.However,their chemical synthesis faces many challenges.In this work,enzymatic introduction of C-linked sugar chains to target aglycones was succe... C-Oligosaccharides are rare in nature and possess diverse bioactivities.However,their chemical synthesis faces many challenges.In this work,enzymatic introduction of C-linked sugar chains to target aglycones was successfully achieved by multi-enzymatic cascade reactions.A C-glycosyltransferase from Aloe barbadensis was employed to introduce the first C-linked glucose and then a cyclomaltodextrin glucanotransferase from Bacillus licheniformis was used to extend the sugar chain.A total of twenty C-oligosaccharides with 2-6 sugars were synthesized from scale-up reactions and exhibited good water solubility and sodium-dependent glucose transporter 2(SGLT2)inhibitory activity.Furthermore,a glucoamylase was used to control the length of the sugar chain and the C-maltosides were efficiently synthesized.These findings not only expanded the structural diversity of C-oligosaccharides,but also provided a strategy for the modification of C-glycoside drugs to improve the druggability. 展开更多
关键词 C-Oligosaccharides C-Glycosyltransferase cyclomaltodextrin glucanotransferase GLUCOAMYLASE Enzymatic synthesis SGLT2 inhibitory activity
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