BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interes...BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interest.High scores on the JH scale and cynicism measures correlate with an increased risk of cardiovascular disease.High cynicism is also a hallmark of burnout syndrome,another known risk factor for heart disease.AIM To evaluate possible interactions between JH and cynicism hoping to clarify risk factors of burnout.METHODS We analyzed genetic and psychological data available from the Database of Genotypes and Phenotypes for genome-wide associations with these traits.We split the total available samples and used plink to perform the association studies on the discovery set(n=1852,80%)and tested for replication using the validation set(n=465).We used scikit-learn to perform supervised machine learning for developing genetic risk algorithms.RESULTS We identified 2,727,and 204 genetic associations for scores on the JH,cynicism and cynical distrust(CD)scales,respectively.We also found 173 associations with high cynicism,109 with high CD,but no associations with high JH.We also produced polygenic classifiers for high cynicism using machine learning with areas under the receiver operator characteristics curve greater than 0.7.CONCLUSION We found significant genetic components to these traits but no evidence of an interaction.Therefore,while there may be a genetic risk,JH is not likely a burnout risk factor.展开更多
In this thesis,compared with pioneer ladies,Alexandra and Antonia,the lost ladies Mrs.Forrest and Myra Henshawe worshipped mammonism as its slaves,hypocritical Christians rather than devoted disciples,unbuttoned hedon...In this thesis,compared with pioneer ladies,Alexandra and Antonia,the lost ladies Mrs.Forrest and Myra Henshawe worshipped mammonism as its slaves,hypocritical Christians rather than devoted disciples,unbuttoned hedonists rather than weather-beaten and down-to-earth innovators.Cynically fear of poverty,those depraved ladies elegized the previous ostenta tious years contrasted to those industrious pioneers of anti-temptation,immune to hedonism and materialism,and died nameless ly,a symbol of decadence of the pioneering age.展开更多
According to Angelica Duran and Yuhan Huang, Mo Yan＇s ＂artistic works＂ are ＂towering within the literatures of the world.＂ His novel Si shi yi pao （Pow!, 2o12） offers one of the clearest recent examples of what...According to Angelica Duran and Yuhan Huang, Mo Yan＇s ＂artistic works＂ are ＂towering within the literatures of the world.＂ His novel Si shi yi pao （Pow!, 2o12） offers one of the clearest recent examples of what Shelley W. Chan calls Mo＇s ＂postmodern playfulness.＂ In his afterword to Pow! Mo says that the story ＂gives way to an improvisation that swings between reality and illusion,＂ thus suggesting the notion of ＂hallucinatory realism＂ as a ＂blending＂ or ＂merging＂ of the illusory and the real. This article examines the ideology--that is, the class politics of consciousness--of this swingy postmodern storytelling, taking a critical view of Mo＇s playfully bold assertion： ＂I＇ve always taken pride in my lack of ideology, especially when I＇m writing.＂ I argue that the swinginess of ＂imagination＂ in Pow! embodies what Marx calls a ＂happy confusion＂ that （re）articulates the ＂post＂-class doctrine of ＂combine two into one.＂展开更多
文摘BACKGROUND John Henryism(JH)is a strategy for dealing with chronic psychological stress characterized by high levels of physical effort and work.Cynicism is a belief that people are motivated primarily by self-interest.High scores on the JH scale and cynicism measures correlate with an increased risk of cardiovascular disease.High cynicism is also a hallmark of burnout syndrome,another known risk factor for heart disease.AIM To evaluate possible interactions between JH and cynicism hoping to clarify risk factors of burnout.METHODS We analyzed genetic and psychological data available from the Database of Genotypes and Phenotypes for genome-wide associations with these traits.We split the total available samples and used plink to perform the association studies on the discovery set(n=1852,80%)and tested for replication using the validation set(n=465).We used scikit-learn to perform supervised machine learning for developing genetic risk algorithms.RESULTS We identified 2,727,and 204 genetic associations for scores on the JH,cynicism and cynical distrust(CD)scales,respectively.We also found 173 associations with high cynicism,109 with high CD,but no associations with high JH.We also produced polygenic classifiers for high cynicism using machine learning with areas under the receiver operator characteristics curve greater than 0.7.CONCLUSION We found significant genetic components to these traits but no evidence of an interaction.Therefore,while there may be a genetic risk,JH is not likely a burnout risk factor.
文摘In this thesis,compared with pioneer ladies,Alexandra and Antonia,the lost ladies Mrs.Forrest and Myra Henshawe worshipped mammonism as its slaves,hypocritical Christians rather than devoted disciples,unbuttoned hedonists rather than weather-beaten and down-to-earth innovators.Cynically fear of poverty,those depraved ladies elegized the previous ostenta tious years contrasted to those industrious pioneers of anti-temptation,immune to hedonism and materialism,and died nameless ly,a symbol of decadence of the pioneering age.
文摘According to Angelica Duran and Yuhan Huang, Mo Yan＇s ＂artistic works＂ are ＂towering within the literatures of the world.＂ His novel Si shi yi pao （Pow!, 2o12） offers one of the clearest recent examples of what Shelley W. Chan calls Mo＇s ＂postmodern playfulness.＂ In his afterword to Pow! Mo says that the story ＂gives way to an improvisation that swings between reality and illusion,＂ thus suggesting the notion of ＂hallucinatory realism＂ as a ＂blending＂ or ＂merging＂ of the illusory and the real. This article examines the ideology--that is, the class politics of consciousness--of this swingy postmodern storytelling, taking a critical view of Mo＇s playfully bold assertion： ＂I＇ve always taken pride in my lack of ideology, especially when I＇m writing.＂ I argue that the swinginess of ＂imagination＂ in Pow! embodies what Marx calls a ＂happy confusion＂ that （re）articulates the ＂post＂-class doctrine of ＂combine two into one.＂
