Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxy...Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxylate（2a）, were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid（l） and 7-（N,N＇-diethylamino）-coumarin-3-carboxylic acid（2）, against the SGC-7901 cell lines were determined by Sulforhodamine B（SRB） assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound la according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.展开更多
基金Supported by the National Natural Science Foundation of China(No.60776006)the Research Fund of Lanzhou Jiaotong University,China(No.40745)
文摘Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate（la）, PEG （600） dibenzo[5,6]coumarin-3-carboxylate（1b）, triethylene-glycol di[7-（N,N＇-diethylamino）]-coumarin-3-carboxylate（2a）, were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid（l） and 7-（N,N＇-diethylamino）-coumarin-3-carboxylic acid（2）, against the SGC-7901 cell lines were determined by Sulforhodamine B（SRB） assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound la according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.
