Movement Function Assessment Based on Human Pose Estimation from Multi-View

Human pose estimation is a basic and critical task in the field of computer vision that involves determining the position(or spatial coordinates)of the joints of the human body in a given image or video.It is widely used in motion analysis,medical evaluation,and behavior monitoring.In this paper,the authors propose a method for multi-view human pose estimation.Two image sensors were placed orthogonally with respect to each other to capture the pose of the subject as they moved,and this yielded accurate and comprehensive results of three-dimensional(3D)motion reconstruction that helped capture their multi-directional poses.Following this,we propose a method based on 3D pose estimation to assess the similarity of the features of motion of patients with motor dysfunction by comparing differences between their range of motion and that of normal subjects.We converted these differences into Fugl–Meyer assessment(FMA)scores in order to quantify them.Finally,we implemented the proposed method in the Unity framework,and built a Virtual Reality platform that provides users with human–computer interaction to make the task more enjoyable for them and ensure their active participation in the assessment process.The goal is to provide a suitable means of assessing movement disorders without requiring the immediate supervision of a physician.

AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

Electrostatic Attraction and Repulsion Explained and Modelled Mathematically Using Classical Physics—A Detailed Mechanism Based on Particle Wave Functions

The phenomenon of electrical attraction and repulsion between charged particles is well known, and described mathematically by Coulomb’s Law, yet until now there has been no explanation for why this occurs. There has been no mechanistic explanation that reveals what causes the charged particles to accelerate, either towards or away from each other. This paper gives a detailed explanation of the phenomena of electrical attraction and repulsion based on my previous work that determined the exact wave-function solutions for both the Electron and the Positron. It is revealed that the effects are caused by wave interactions between the wave functions that result in Electromagnetic reflections of parts of the particle’s wave functions, causing a change in their momenta.

Mathematical Wave Functions and 3D Finite Element Modelling of the Electron and Positron

The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles.

Ultrathin poly(cyclocarbonate-ether)-based composite electrolyte reinforced with high-strength functional skeleton

Composite polymer electrolytes(CPEs)are considered to be the most promising to break through the performance and safety limitations of traditional lithium-ion batteries because of their excellent electrochemical and mechanical properties.Aiming at the performance limitations of the most common polyether matrix such as poly(ethylene oxide)(PEO),a novel poly(cyclocarbonate-ether)polymer matrix was prepared by in-situ thermal curing,the weaker interaction between its C=O bond and Li^(+)can promote the rapid transport of Li^(+).Adding ionic liquid and active filler LLZTO to the matrix can synergistically reduce the crystallinity of matrix and promote the dissociation of lithium salts.In addition,a 3D functional skeleton made of polyacrylonitrile(PAN)and lithium fluoride(LiF)can greatly improve the mechanical strength of polymer matrix after cold pressing,and Li F is also conducive to interface stability.The thickness of the optimal sample(VP6L/CPL)was only 25μm,and its ionic conductivity,lithium ion transference number,and electrochemical stability window were as high as 7.17×10^(-4)S cm^(-1)(25℃),0.54 and 5.4 V,respectively,while the mechanical strength reaches 6.1 MPa,which can fully inhibit the growth of lithium dendrites.The excellent electrochemical performance and mechanical strength enable the assembled Li|VP6L/CPL|Li battery to be continuously charged for over 200 h and cycled stably for more than 2300 h,and Li|VP6L/CPL|LFP battery can be stably cycled for more than 400 and 550 cycles at 1 C(40℃)and 0.5 C(25℃),respectively.

Prevalence of Ventilatory Function Abnormalities in Residents of Attecoube Lagune, Abidjan (Côte d’Ivoire)

Introduction: Studies of abnormal ventilatory function in Côte d’Ivoire have been carried out in the workplace and in schools. The objective of this study was to determine the prevalence of respiratory symptoms and ventilatory function abnormalities in the population of the lagoon district of Attécoubé in Abidjan. Material and Methods: A cross-sectional study was carried out on 170 people in the municipality of Attécoubé Lagune. A questionnaire was used to collect information on sociodemographic, clinical, and environmental characteristics. A basic spirometry and a beta mimetic test were carried out on all the subjects surveyed. Data analysis was done with the stata 15.1 software. Results: The study population was composed of 103 women and 67 men with a sex ratio (M/F) of 0.65. The average age was 35.92 ± 15.28 years. The most frequent respiratory symptoms were chest tightness (29.41%), dyspnea (28.82%), sneezing (22.94%) and cough (22.35%). The prevalence of ventilatory function abnormalities was 43.24% among residents of Attécoubé Lagune and the most frequent abnormality was ventilatory restriction (35.15%) followed by obstruction (4.85%). The risk factor for ventilatory function abnormalities was heavy pollution [OR = 2.66;IC: 1.053 - 6.743;P = 0.038]. Conclusion: Residents of the Attécoubé Lagune district had many respiratory symptoms and a high prevalence of ventilatory function abnormalities. Improving air quality is urgently needed in this municipality.

Effects of C2 hemisection on respiratory and cardiovascular functions in rats

High ce rvical spinal co rd injuries induce permanent neuromotor and autonomic deficits.These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system.So far,cardiovascular studies have focused on models of complete contusion or transection at the lower cervical and thoracic levels and diaphragm activity evaluations using invasive methods.The present study aimed to evaluate the impact of C2 hemisection on different parameters representing vital functions(i.e.,respiratory function,cardiovascular,and renal filtration parameters)at the moment of injury and 7 days post-injury in rats.No ventilatory parameters evaluated by plethys mography were impacted during quiet breathing after 7 days post-injury,whereas permanent diaphragm hemiplegia was observed by ultrasound and confirmed by diaphragmatic electromyography in anesthetized rats.Interestingly,the mean arterial pressure was reduced immediately after C2 hemisection,with complete compensation at 7 days post-injury.Renal filtration was unaffected at 7 days post-injury;however,remnant systolic dysfunction chara cterized by a reduced left ventricular ejection fraction persisted at 7 days post-injury.Taken together,these results demonstrated that following C2 hemisection,diaphragm activity and systolic function are impa cted up to 7 days post-injury,whereas the respiratory and cardiovascular systems display vast ada ptation to maintain ventilatory parameters and blood pressure homeostasis,with the latter likely sustained by the remaining descending sympathetic inputs spared by the initial injury.A better broad characterization of the physiopathology of high cervical spinal cord injuries covering a longer time period post-injury could be beneficial for understanding evaluations of putative therapeutics to further increase cardiorespiratory recovery.

Green's functions of two-dimensional piezoelectric quasicrystal in half-space and bimaterials

In this paper,we obtain Green’s functions of two-dimensional(2D)piezoelectric quasicrystal(PQC)in half-space and bimaterials.Based on the elastic theory of QCs,the Stroh formalism is used to derive the general solutions of displacements and stresses.Then,we obtain the analytical solutions of half-space and bimaterial Green’s functions.Besides,the interfacial Green’s function for bimaterials is also obtained in the analytical form.Before numerical studies,a comparative study is carried out to validate the present solutions.Typical numerical examples are performed to investigate the effects of multi-physics loadings such as the line force,the line dislocation,the line charge,and the phason line force.As a result,the coupling effect among the phonon field,the phason field,and the electric field is prominent,and the butterfly-shaped contours are characteristic in 2D PQCs.In addition,the changes of material parameters cause variations in physical quantities to a certain degree.

Status of Renal and Liver Function in Rheumatoid Arthritis (RA) Patients of Chattogram, Bangladesh Treated with Methotrexate (MTX)

Rheumatoid Arthritis (RA) is a chronic autoimmune disorder that is usually manifested as inflammation in multiple joints and several extra-articular symptoms, involving the liver, kidney, eye, skin, blood, blood vessels, heart, lungs, nervous system, and other organs. Methotrexate (MTX) is the anchor drug that treats RA. As renal and liver abnormalities are more common during disease conditions as well as during the treatment period, we tried to find out if there is any impact of MTX in these organs during the treatment of RA patients. Once the disease complications are developed, it is quite difficult to reverse the disease, and treatment in this situation is not very effective. Consequently, patients suffer a lot. So, early evaluation of renal and liver function is essential for the treatment of RA patients and it might also help prevent different complications which are usually very frequently observed. This was a cross-sectional study. A total of 150 RA patients treated with MTX were evaluated for the study where female and male respondents were 115 and 35 respectively. In this study, we found that 82% of RA patients had creatinine levels ≤ 1.1 mg/dL although the normal range of serum creatinine is below 1.4 mg/dL. Usually, a 15% increase in Serum creatinine level from the baseline is considered renal impairment. We found 4% of such cases. Moreover, 2% of RA patients had creatinine levels above the normal range of 1.4 mg/dL and those patients were hypertensive as well. So, a total (4 + 2 = 6)% had renal impairments. Among them, 5% had diabetes mellitus. On the other hand, the ultrasonogram (USG) of RA patients with kidney disease showed signs of renal parenchymal disease and 3% of RA patients having renal problems whose serum creatinine level was within the normal range showed signs of chronic kidney disease (CKD). On the other hand, 2% of RA patients showed signs of hepatic parenchymal disease. In this study, 69% of RA patients had ALT levels ≤ 50 mg/dL, 23% had 50 - 100 mg/dL, and 5% had 101 - 150 mg/dL. The remaining 3% of RA patients had ALT levels above 150 mg/dL. All those patients with ALT levels above 100 mg/dL used Nonsteroidal anti-inflammatory drugs (NSAIDs) concomitantly. Different parameters of liver and renal function should be monitored strongly in RA patients treated with MTX and NSAIDs. MTX should not be given for a prolonged period without monitoring renal and liver function. As MTX, Diabetes Mellitus, Hypertension, etc., may cause renal complications, we could not concretely conclude which one is the actual causative agent.

新生儿GBS感染所致化脓性脑膜炎中血清维生素D和炎性细胞因子的表达及意义

目的检测新生儿B族链球菌(group B streptococcus,GBS)感染所致化脓性脑膜炎(purulent meningitis,PM)血清中维生素D、白细胞介素(interleukin,IL)-6、IL-10、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和C反应蛋白(c-reactive protein,CRP)的表达水平,并探讨其临床价值。方法选取2017年5月至2020年5月在秦皇岛市第一医院出生的59例GBS感染的PM新生儿纳入观察组,同期59例非GBS感染的PM新生儿(晚发败血症)纳入对照组。检测所有受试者血清维生素D、CRP、IL-6、IL-10和TNF-α水平,并进行Pearson相关性分析;利用受试者操作特征(receiver operating characteristic,ROC)曲线分析血清维生素D和炎性细胞因子对新生儿GBS感染所致PM的诊断价值。统计学方法采用t检验、χ^(2)检验和Pearson相关性分析。结果观察组与对照组孕产妇胎膜早破[47.5%(28/59)与5.1%(3/59),χ^(2)=27.345]、产时窒息[52.5%(31/59)与18.6%(11/59),χ^(2)=14.787]和产褥感染[(44.1%(26/59)与(22.0%(13/59)),χ^(2)=6.473]的发生率比较,观察组明显高于对照组(P<0.05)。观察组血清维生素D水平显著低于对照组[(13.3±2.1)μg/L与(21.1±5.0)μg/L,t=11.345],IL-6[(87.1±14.5)μg/L与(63.9±11.9)μg/L,t=9.507]、IL-10[(49.6±15.2)μg/L与(29.3±10.0)μg/L,t=8.596]、TNF-α[(76.8±19.0)μg/L与(50.0±10.8)μg/L,t=9.410]和CRP[(21.5±5.0)μg/L与(13.7±3.7)μg/L,t=9.702]水平显著高于对照组(P值均<0.05)。Pearson相关性分析结果显示,观察组血清维生素D水平分别与IL-6、IL-10、TNF-α和CRP水平呈负相关(r=-0.662、-0.644、-0.564、-0.643,P<0.05);血清维生素D、IL-6、IL-10、TNF-α和CRP单独诊断GBS感染新生儿PM的曲线下面积(area under the curve,AUC)分别为0.831(95%CI:0.757~0.904)、0.887(95%CI:0.830~0.944)、0.859(95%CI:0.793~0.925)、0.888(95%CI:0.821~0.955)、0.879(95%CI:0.820~0.938),5项联合检测的AUC为0.991(95%CI:0.978~1.000)。结论GBS感染所致的PM新生儿血清中维生素D水平降低,炎性细胞因子水平增加,对于GBS感染所致的PM具有一定的辅助诊断价值。

老年血液透析病人衰弱与血清瘦素及25-羟维生素D的相关性研究

目的探究老年血液透析病人血清瘦素及25-羟维生素D[25(OH)D]水平,并分析其与透析病人衰弱的相关性。方法选取2021年4月至2023年4月我院收治的150例老年血液透析病人,依据Fried表型评价病人的衰弱情况,分为非衰弱组(51例),衰弱前期组(74例)和衰弱组(25例)。比较3组一般资料、血清瘦素、25(OH)D及心功能。采用多因素Logistic回归分析老年血液透析病人衰弱的影响因素。结果3组年龄、糖尿病比例、透析龄、左室舒张末期内径,以及白蛋白、镁、IL-6、瘦素、25(OH)D水平比较,差异均有统计学意义(P<0.01)。多因素有序Logistic回归分析显示,年龄、透析龄、糖尿病、镁、IL-6、白蛋白、瘦素、25(OH)D、左室舒张末期内径是老年血液透析病人衰弱的独立影响因素(P<0.05)。结论针对白蛋白水平低、瘦素水平高、25(OH)D水平低的老年血液透析病人采取积极干预措施,有利于延缓衰弱的进展。

血清CX3CL1、CCL17与类风湿关节炎相关间质性肺疾病患者肺功能及预后的关系研究

目的分析血清C-X3-C基序趋化因子配体1(CX3CL1)、C-C基序趋化因子配体17(CCL17)与类风湿关节炎相关间质性肺疾病(RA-ILD)患者肺功能及预后的关系。方法选取2017年1月—2018年1月上海中医药大学附属龙华医院风湿科收治RA患者295例,根据是否合并ILD分为ILD组115例和非ILD组180例,根据预后情况将RA-ILD患者分为预后不良亚组和预后良好亚组。检测血清CX3CL1、CCL17水平及肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC和肺一氧化碳弥散量(DLCO)]。采用Pearson相关性分析RA-ILD患者血清CX3CL1、CCL17水平与肺功能指标的相关性,多因素Logistic回归分析RA-ILD患者预后不良的影响因素,受试者工作特征(ROC)曲线分析血清CX3CL1、CCL17水平预测RA-ILD患者预后不良的价值。结果与非ILD组比较,ILD组血清CX3CL1、CCL17水平升高,FEV_(1)、FVC、FEV_(1)/FVC、DLCO降低(t/P=14.359/<0.001、13.855/<0.001、12.015/<0.001、2.732/0.007、14.749/<0.001、14.010/<0.001)。Pearson相关性分析显示,RA-ILD患者血清CX3CL1、CCL17水平与FEV_(1)、FVC、FEV_(1)/FVC、DLCO呈负相关(r=-0.762、-0.711、-0.577、-0.534、-0.707、-0.692、-0.735、-0.672,P均<0.001)。随访5年,115例RA-ILD患者预后不良发生率为46.96%。多因素Logistic回归分析显示,普通型间质性肺炎和高分辨率电子计算机断层扫描(HRCT)评分、CX3CL1、CCL17升高为RA-ILD患者预后不良的独立危险因素[OR(95%CI)=3.745(1.245~11.264)、1.051(1.008~1.095)、1.008(1.003~1.012)、1.037(1.012~1.062)],FEV_(1)、FEV_(1)/FVC、DLCO升高为独立保护因素[OR(95%CI)=0.952(0.896~0.988)、0.892(0.867~0.981)、0.857(0.789~0.949)]。ROC曲线分析显示,血清CX3CL1、CCL17水平联合预测RA-ILD患者预后不良的曲线下面积为0.875,大于CX3CL1、CCL17单独预测的0.783、0.788(Z=2.807、2.698,P=0.005、0.007)。结论RA-ILD患者血清CX3CL1、CCL17水平升高,与肺功能降低和预后不良有关,血清CX3CL1、CCL17水平联合检测对RA-ILD患者预后具有较高的预测价值。

感染性肺炎新生儿的血清25-羟基维生素D与炎症因子的相关性分析

目的分析感染性肺炎新生儿的血清25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]与炎症因子干扰素-γ(infectious pneumonia-γ,IFN-γ)、C-反应蛋白(C-reactive protein,CRP)、白细胞介素-2(interleukin-2,IL-2)水平的相关性。方法选取河北省秦皇岛市第一医院2018年12月至2020年12月收治的100例感染性肺炎新生儿,根据血清25(OH)D水平分为缺乏组(≤15.0μg/L,18例)、不足组(15.1~20.0μg/L,42例)、充足组(>20.0μg/L,40例)。统计3组性别、胎龄、血清25(OH)D水平、出生体重、分娩方式等一般资料和临床资料,比较3组IFN-γ、CRP及IL-2水平,分析新生儿血清25(OH)D水平与IFN-γ、CRP、IL-2水平的相关性。结果3组胎龄、性别、出生体质量、分娩方式比较差异无统计学意义(P>0.05);缺乏组、不足组、充足组新生儿的血清25(OH)D水平逐渐升高,差异有统计学意义(P<0.05)。缺乏组IFN-γ、CRP及IL-2水平均高于不足组、充足组(P<0.05),不足组IFN-γ、CRP及IL-2水平高于充足组(P<0.05)。经Pearson相关分析,感染性肺炎新生儿血清25(OH)D水平与IFN-γ、CRP、IL-2水平呈负相关(P<0.05)。结论新生儿血清25(OH)D越低,维生素D越缺乏,IFN-γ、CRP及IL-2水平越高,感染性肺炎的风险越高。

D-二聚体与C反应蛋白对Stanford A型主动脉夹层动脉瘤患者术后远期预后的预测价值

目的分析D-二聚体(D-D)与C反应蛋白(CRP)在Stanford A型主动脉夹层动脉瘤(ADA)患者术后远期预后中的预测价值。方法选取76例胸痛患者为研究对象,所有患者均行心脏超声或主动脉CT血管成像检查,将45例Stanford A型ADA患者纳入观察组,均行手术治疗;非Stanford A型ADA的31例患者纳入对照组。对比2组发生胸痛72 h内的D-D与CRP水平。术后对观察组随访3年,按临床结局分成死亡组(n=10)与存活组(n=35),对比2组D-D与CRP水平;另绘制受试者工作曲线(ROC),分析D-D、CRP单独与联合预测Stanford A型ADA患者的远期预后临床价值。结果观察组的D-D[(1.31±0.35)mg/L]与CRP[(16.59±2.34)mg/L]水平高于对照组[(0.68±0.13)mg/L、(7.53±1.26)mg/L],差异有统计学意义(P<0.05);ADA患者中死亡组的D-D[(1.78±0.49)mg/L]与CRP[(30.46±4.77)mg/L]水平高于存活组[(1.03±0.26)mg/L、(13.59±2.36)mg/L],差异有统计学意义(P<0.05)。ROC结果显示,D-D与CRP联合检测预测Stanford A型ADA患者远期预后的曲线下面积(AUC)[0.909(95%CI:0.823~0.994)]高于D-D与CRP单独预测[0.806(95%CI:0.680~0.931)、0.840(95%CI:0.727~0.953)]。结论Stanford A型ADA患者血清内的D-D与CRP水平呈高表达,且表达水平越高,患者预后越差,两项指标联合可有效预测患者的远期预后,临床应用价值较高。

机械臂多目标最优轨迹的自适应惩罚MOEA/D规划

为了减少机械臂的工作时间和工作过程中的冲击量,提出了基于自适应惩罚MOEA/D算法的时间-冲击多目标规划方法。介绍了PUMA560机械臂结构,并建立了机械臂的连杆坐标系。建立了以减小机械臂工作时间和冲击为综合目标的优化模型,并分析了5次多项式插值函数。通过编码和建立适应度函数,将轨迹规划问题转化为最优基因搜索问题。根据邻域内解的密度设置了自适应惩罚因子,提出了机械臂轨迹的自适应惩罚MOEA/D规划方法。经仿真验证,自适应惩罚MOEA/D算法搜索的Pareto前沿解质量高于标准MOEA/D算法、文献[10]新型MOEA/D算法。且经过优化,机械臂工作时间减少了7.68%,冲击减少了17.32%。实验结果表明,自适应惩罚MOEA/D算法在机械臂轨迹规划中具有优越性。

维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效

目的:探讨维生素C辅助阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎(MPP)疗效及其对免疫功能的影响。方法:选取106例MPP患儿为研究对象,按照治疗方式不同分为观察组和对照组,每组各53例。观察组患者采用维生素C辅助阿奇霉素序贯疗法治疗;对照组采用阿奇霉素治疗,疗程均为7 d。比较两组患儿临床疗效、症状缓解时间、肺功能、免疫功能及不良反应发生情况。结果:观察组患儿临床总有效率高于对照组(98.11%vs.86.79%,P<0.05)。治疗后,观察组患儿高热、咳嗽、肺啰音、胸片缓解时间短于对照组(P<0.05)。治疗前,两组患儿用力呼气肺活量占预计值百分比(FVC)、第1秒用力呼气肺活量(FEVl)、FEVl/FVC无统计学差异(P>0.05);治疗后,两组患儿FVC、FEVl、FEVl/FVC均升高,且观察组高于对照组(P<0.05)。治疗前,两组患儿外周血免疫球蛋白IgA、IgM、IgG水平无统计学差异(P>0.05);治疗后,两组患儿外周血IgA、IgG水平均升高,且观察组高于对照组(P<0.05);IgM水平均降低,且观察组低于对照组(P<0.05)。两组患儿治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿奇霉素序贯疗法联合维生素C治疗儿童肺炎支原体肺炎能够提高疗效和免疫功能,值得临床推广。

维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效及对认知功能的保护作用研究

目的探讨维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效及对认知功能的保护作用。方法收集140例老年慢阻肺合并睡眠障碍患者作为研究对象,随机分为对照组和研究组,每组70例。对照组给予右佐匹克隆治疗,研究组给予维生素D联合右佐匹克隆治疗。采用匹茨堡睡眠质量指数(PSQI)评估睡眠质量。采用简易精神状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估认知功能。比较两组睡眠障碍临床疗效、睡眠监测指标、PSQI评分、认知功能和神经营养因子水平。结果研究组睡眠障碍治疗总有效率高于对照组(92.8%vs 80.0%,P<0.05)。睡眠监测指标显示,研究组治疗后总睡眠时间长于对照组[(371.77±27.22)min vs(334.71±28.80 min)],觉醒时间和觉醒次数少于对照组[(32.51±3.89)min vs(46.88±7.32)min,(1.36±0.51)次vs(3.11±0.77)次,P<0.05]。治疗前、治疗后1月和治疗后3月时,不同时间点PSQI评分差异有统计学意义(P<0.05),研究组与对照组PSQI评分变化趋势差异有统计学意义,研究组降低更明显[(15.78±2.02)分vs(15.67±2.05)分,(9.31±2.01)分vs(11.60±2.04)分,(7.60±0.95)分vs(9.40±1.21)分,P<0.05]。研究组治疗后MMSE评分和MoCA评分高于对照组[(28.24±0.92)分vs(26.24±1.53)分,(27.88±1.23)分vs(25.21±1.02)分],脑源性神经生长因子(BDNF)和神经生长因子(NGF)水平高于对照组[(672.29±66.60)pg/mL vs(626.89±55.46)pg/mL,(31.49±5.62)pg/mL vs(23.75±5.18)pg/mL,P<0.05]。结论维生素D联合右佐匹克隆治疗老年慢阻肺合并睡眠障碍疗效良好,而且对认知功能具有一定程度的保护作用。

Standford B型主动脉夹层腔内治疗围手术期超敏C反应蛋白等相关指标应用意义的临床研究

目的探讨超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、降钙素原(PCT)对Standford B型主动脉夹层(TBAD)患者胸主动脉腔内修复术预后的影响。方法选取2017年4月至2022年3月抚州市第一人民医院行胸主动脉腔内修复术(TEVAR)的80例TBAD患者作为研究对象,于术前1 d和术后7 d检测hs-CRP、D-D、PCT水平。根据患者预后分为预后良好组和预后不良组,比较两组患者术前1 d和术后7 d的血清hs-CRP、D-D、PCT水平,分析血清hs-CRP、D-D、PCT水平与患者预后的关联性。结果80例患者中预后良好(预后良好组)63例(78.75%),预后不良(预后不良组)17例(21.25%)。两组患者术后7 d血清hs-CRP、D-D、PCT水平高于本组术前1 d,差异有统计学意义(P<0.05);预后良好组患者术前1 d和术后7 d的血清hs-CRP、D-D、PCT水平低于预后不良组,差异有统计学意义(P<0.05);logistic回归模型分析结果显示,术前1 d血清hs-CRP(β=0.617,OR=1.854,95%CI=1.217~2.696)、D-D(β=0.639,OR=1.895,95%CI=1.841~2.635)、PCT(β=0.554,OR=1.741,95%CI=1.547~3.052)和术后7 d hs-CRP(β=0.892,OR=2.440,95%CI=1.251~4.761)、D-D(β=0.797,OR=2.219,95%CI=1.669~3.141)、PCT(β=0.604,OR=1.829,95%CI=1.058~2.969)水平是接受TEVAR治疗的TBAD患者预后的影响因素,差异有统计学意义(P<0.05)。结论监测围手术期血清hs-CRP、D-D、PCT水平对接受TEVAR治疗的TBAD患者预后判断具有一定的参考价值。

关节镜联合C型臂X线机治疗胫骨平台骨折的疗效

目的探讨关节镜联合C型臂X线机治疗胫骨平台骨折的效果。方法方便选择2017年1月—2022年12月丹阳市人民医院收治的78例胫骨平台骨折患者为研究对象,以随机双盲法分为两组,每组39例。对照组行常规切开复位内固定术,观察组行关节镜联合C型臂X线机微创内固定术,对两组手术疗效、手术指标、膝关节功能恢复与并发症发生情况进行分析比较。结果观察组手术优良率(97.44%)明显高于对照组(82.05%),差异有统计学意义(χ^(2)=5.014,P<0.05);观察组手术治疗相关指标优于对照组,差异有统计学意义(P均<0.05)。术后6个月两组患者Lysholm、纽约特种外科医院(Hospital for Special Surgery,HSS)评分均升高,且观察组Lysholm、HSS评分明显高于对照组,差异有统计学意义(P均<0.05)。观察组术后并发症总发生率低于对照组,差异有统计学意义(P均<0.05)。结论胫骨平台骨折患者采用关节镜联合C型臂X线机治疗的疗效确切,患者创伤小、术后恢复快、并发症少,且对患者膝关节功能的恢复有着明显的促进作用。

通督调神针法治疗阴虚动风型脑梗死偏瘫疗效及对患者血清Hcy、CRP水平的影响

目的:探讨通督调神针法治疗阴虚动风型脑梗死偏瘫患者疗效及对患者血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)水平的影响。方法:选取脑梗死偏瘫患者76例,1∶1随机分为观察组(西医治疗+通督调神针法)与对照组(常规西医治疗)各38例。持续治疗1个月后,评估两组临床疗效,比较两组治疗前后中医证候积分、血清炎症因子(Hcy、CRP)水平、运动功能[Fugl-Meyer评定量表(FMA)]、平衡功能[Berg平衡量表(BBS)]和移动功能[功能性步态评价表(FGA)]变化情况,并记录两组不良事件发生率。结果:观察组总有效率更高(P<0.05);观察组治疗后中医证候积分降低程度比对照组更明显(P<0.05)。观察组治疗后FMA、FGA和BBS评分升高水平均比对照组更明显(P<0.05),观察组治疗后Hcy、CRP水平下降程度均比对照组更明显(P<0.05)。治疗期间两组均无不良事件发生。结论:阴虚动风型脑梗死偏瘫患者应用通督调神针法联合常规西医治疗具有较好的增益效果,可有效提高临床疗效,缓解患者临床症状,提高运动、平衡和移动能力,降低炎症反应。