Biodegradable shape memory polymers( SMPs) are a class of intelligent materials with great potential for imparting biomaterial scaffolds multifunctionality in the field of tissue engineering and regenerative medicine....Biodegradable shape memory polymers( SMPs) are a class of intelligent materials with great potential for imparting biomaterial scaffolds multifunctionality in the field of tissue engineering and regenerative medicine.In this study,the biodegradable SMP poly( D,L-lactide-co-trimethylene carbonate)( PLMC) incorporated with the dexamethasone( Dex),which was a kind of synthetic bone-formation inducing factor,was fabricated into nanofibers via electrospinning.The morphology,constituent,thermal and mechanical properties of the produced Dex / PLMC composite nanofibers were characterized by scanning electron microscopy( SEM), Fourier transform infrared spectroscopy( FTIR), differential scanning calorimetry( DSC),and tensile testing,respectively.Then,ultrasound was employed as a remote stimulus to regulate the Dex releasing behavior from the composite nanofibers.It was found that the generated Dex /PLMC composite nanofibers had a uniform and smooth morphology with a diameter of ca.564 nm.Mechanical testing results showed that incorporation of the Dex gave rise to improved mechanical performance with the tensile strength,Young's modulus and strainat-break increased by 18.2%,20.0% and 64.4%,respectively.DSC data revealed that the glass transition temperature( Tg) of the composite nanofibers, i.e., the thermal transition temperature( Ttrans) for activating shape memory effect, was 39.7 ℃.Moreover, the release kinetics of the encapsulated Dex in the nanofibers could be manipulated by varying the acoustic power and insonation duration.These results suggested that the newly developed Dex / PLMC nanofibers could be a promising drug delivery system for applications in bone tissue engineering( BTE).展开更多
Dear Editor,We present a case of dexamethasone（DEX）intravitreal implantation（Ozurdex~;Allergan,Irvine,CA,USA）to treat diabetic macular edema（DME）during pregnancy.According to Pescosolido et al,pregnancy may prom...Dear Editor,We present a case of dexamethasone（DEX）intravitreal implantation（Ozurdex~;Allergan,Irvine,CA,USA）to treat diabetic macular edema（DME）during pregnancy.According to Pescosolido et al,pregnancy may promote the onset of diabetic retinopathy in about 10%of cases and may contribute to its worsening when already present,causing macular edema.Although one report has indicated that DME during pregnancy spontaneously regresses after delivery,others have reported that DME can persist and be associated with severe and persistent visual dysfunction.展开更多
ore deposits and a large number of ore occurrences cluster in Dexing ore field which is 20 km long and 12 km wide. The tectonic evolution, magmatism, as well as the metallogeny are controlled by the Northeast Jiangxi...ore deposits and a large number of ore occurrences cluster in Dexing ore field which is 20 km long and 12 km wide. The tectonic evolution, magmatism, as well as the metallogeny are controlled by the Northeast Jiangxi deep seated fracture belt (NJDFB). The source is believed to have been derived from the Meso-Neoproterozoic marine volcanism. The magmatic activity of Mesozoic I type granite could have provided the metal elements, thermal fluid, heat, and the space for ore forming processes. A unified geological model is proposed, which combines the tectonism, magmatism and metallogeny as the basic control of the giant metal mineralizations.展开更多
Since Dalvik Executable （DEX） files are prone to be reversed to the Java source code using some decompiling tools, how- to protect the DEX files from attackers becomes an important re- search issue. The traditional ...Since Dalvik Executable （DEX） files are prone to be reversed to the Java source code using some decompiling tools, how- to protect the DEX files from attackers becomes an important re- search issue. The traditional way to protect the DEX files from reverse engineering is to encrypt the entire DEX file, but after the complete plain code has been loaded into the memory while the application is running, the attackers can re- trieve the code by using memory dump attack. This paper presents a novel DEX protection scheme to withstand memory dump attack on the Android platform with the name of Dex- Defender, which adopts the dynamic class-restoration method to ensure that the complete plain DEX data not appear in the memolT while the application is being loaded into the memory. Experimental results show- that the proposed scheme can protect the DEX files from both reverse engineering and mem- ory dump attacks with an acceptable performance.展开更多
Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder patients.Methods: A total of 60 elder patients who were admitte...Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder patients.Methods: A total of 60 elder patients who were admitted in our hospital from November 2016 to October 2017 for selective painless fiber colonoscopy were included in the study and divided into the low dose group and high dose group according to Dex dose. The micro-infusion pump was used to inject Dex 10 min before examination. The load capacity in the low dose group was 0.25 μg/kg, while in the high dose group was 0.75 μg/kg. The pump injection was completed within 10 min, then a continuous pump injection was performed in a speed of 0.5 μg/kg/h until the check off. After the completion of Dex pumping, propofol (1-1.5 mg/kg) was slowly injected. MAP, HR, and SpO2 before medication (T0), 5 min after inserting the endoscope (T1), and the time after the examination being finished (T2) were recorded, respectively. The bioelectrical impedance technique was used to continuously monitor SV, CO, and SVR. The awakening time, propofol dose, and discharge time were recorded.Results: The comparison of MAP, HR, and SpO2 at T0 between the two groups was not statistically significant. MAP, HR, SV, CO, and SVR at T1 and T2 were significantly lower than those at T0, while the comparison of SpO2 was not significantly changed. MAP at T1 in the high dose group was significantly higher than that in the low dose group, while HR at T1 and T2 was significantly lower than that in the low dose group. SV, CO, and SVR at T1 and T2 in the high dose group was significantly higher than those in the low dose group. The awakening time in the high dose group was significantly shorter than that in the low dose group, and the propofol dose was significantly less than that in the low dose group, while the comparison of discharge time was not significantly different. Conclusions: Application of Dex in a high dose in the painless colonoscopy in the elder patients can reduce the propofol dose, and will not increase the inhibiting effect on respiration and circulation.展开更多
基金the Fundamental Research Funds for the Central Universities,China(No.14D110519)Pujiang Talent Program Funded by the Science and Technology Commission of Shanghai Municipality,China(No.10PJ1400200)National Natural Science Foundation of China(No.51073032)
文摘Biodegradable shape memory polymers( SMPs) are a class of intelligent materials with great potential for imparting biomaterial scaffolds multifunctionality in the field of tissue engineering and regenerative medicine.In this study,the biodegradable SMP poly( D,L-lactide-co-trimethylene carbonate)( PLMC) incorporated with the dexamethasone( Dex),which was a kind of synthetic bone-formation inducing factor,was fabricated into nanofibers via electrospinning.The morphology,constituent,thermal and mechanical properties of the produced Dex / PLMC composite nanofibers were characterized by scanning electron microscopy( SEM), Fourier transform infrared spectroscopy( FTIR), differential scanning calorimetry( DSC),and tensile testing,respectively.Then,ultrasound was employed as a remote stimulus to regulate the Dex releasing behavior from the composite nanofibers.It was found that the generated Dex /PLMC composite nanofibers had a uniform and smooth morphology with a diameter of ca.564 nm.Mechanical testing results showed that incorporation of the Dex gave rise to improved mechanical performance with the tensile strength,Young's modulus and strainat-break increased by 18.2%,20.0% and 64.4%,respectively.DSC data revealed that the glass transition temperature( Tg) of the composite nanofibers, i.e., the thermal transition temperature( Ttrans) for activating shape memory effect, was 39.7 ℃.Moreover, the release kinetics of the encapsulated Dex in the nanofibers could be manipulated by varying the acoustic power and insonation duration.These results suggested that the newly developed Dex / PLMC nanofibers could be a promising drug delivery system for applications in bone tissue engineering( BTE).
基金Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI)funded by the Ministry of Health&Welfare(No.HI14C1872)
文摘Dear Editor,We present a case of dexamethasone（DEX）intravitreal implantation（Ozurdex~;Allergan,Irvine,CA,USA）to treat diabetic macular edema（DME）during pregnancy.According to Pescosolido et al,pregnancy may promote the onset of diabetic retinopathy in about 10%of cases and may contribute to its worsening when already present,causing macular edema.Although one report has indicated that DME during pregnancy spontaneously regresses after delivery,others have reported that DME can persist and be associated with severe and persistent visual dysfunction.
文摘ore deposits and a large number of ore occurrences cluster in Dexing ore field which is 20 km long and 12 km wide. The tectonic evolution, magmatism, as well as the metallogeny are controlled by the Northeast Jiangxi deep seated fracture belt (NJDFB). The source is believed to have been derived from the Meso-Neoproterozoic marine volcanism. The magmatic activity of Mesozoic I type granite could have provided the metal elements, thermal fluid, heat, and the space for ore forming processes. A unified geological model is proposed, which combines the tectonism, magmatism and metallogeny as the basic control of the giant metal mineralizations.
基金supported by ZTE Industry-Academia-Research Cooperation Funds
文摘Since Dalvik Executable （DEX） files are prone to be reversed to the Java source code using some decompiling tools, how- to protect the DEX files from attackers becomes an important re- search issue. The traditional way to protect the DEX files from reverse engineering is to encrypt the entire DEX file, but after the complete plain code has been loaded into the memory while the application is running, the attackers can re- trieve the code by using memory dump attack. This paper presents a novel DEX protection scheme to withstand memory dump attack on the Android platform with the name of Dex- Defender, which adopts the dynamic class-restoration method to ensure that the complete plain DEX data not appear in the memolT while the application is being loaded into the memory. Experimental results show- that the proposed scheme can protect the DEX files from both reverse engineering and mem- ory dump attacks with an acceptable performance.
文摘Objective:To explore the anesthetic effect of dexmedetomidine (Dex) in different doses in combined with propofol on the painless colonoscopy in the elder patients.Methods: A total of 60 elder patients who were admitted in our hospital from November 2016 to October 2017 for selective painless fiber colonoscopy were included in the study and divided into the low dose group and high dose group according to Dex dose. The micro-infusion pump was used to inject Dex 10 min before examination. The load capacity in the low dose group was 0.25 μg/kg, while in the high dose group was 0.75 μg/kg. The pump injection was completed within 10 min, then a continuous pump injection was performed in a speed of 0.5 μg/kg/h until the check off. After the completion of Dex pumping, propofol (1-1.5 mg/kg) was slowly injected. MAP, HR, and SpO2 before medication (T0), 5 min after inserting the endoscope (T1), and the time after the examination being finished (T2) were recorded, respectively. The bioelectrical impedance technique was used to continuously monitor SV, CO, and SVR. The awakening time, propofol dose, and discharge time were recorded.Results: The comparison of MAP, HR, and SpO2 at T0 between the two groups was not statistically significant. MAP, HR, SV, CO, and SVR at T1 and T2 were significantly lower than those at T0, while the comparison of SpO2 was not significantly changed. MAP at T1 in the high dose group was significantly higher than that in the low dose group, while HR at T1 and T2 was significantly lower than that in the low dose group. SV, CO, and SVR at T1 and T2 in the high dose group was significantly higher than those in the low dose group. The awakening time in the high dose group was significantly shorter than that in the low dose group, and the propofol dose was significantly less than that in the low dose group, while the comparison of discharge time was not significantly different. Conclusions: Application of Dex in a high dose in the painless colonoscopy in the elder patients can reduce the propofol dose, and will not increase the inhibiting effect on respiration and circulation.
