Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer.In addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the...Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer.In addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis.Transplant oncology is an emerging field that addresses oncological challenges in transplantation.In this context,a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients.Double-negative T cells(DNTs)are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor(TCR)type.Among them,TCRαβ^(+)DNTs are considered to induce immune suppression in immune-mediated diseases,while TCRγδ^(+)DNTs are widely recognized as tumor killers.As a composite cell therapy,healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the host.In this work,we summarized the biological characteristics and functions of DNTs in oncology,immunology,and transplantation.Based on the multiple roles of DNTs,we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy(ACT).展开更多
DNT细胞（CD4^-CD8^-double—negative T cells）是新发现的一种免疫细胞，其特点是细胞表面既不表达CD4分子同时也不表达CD8分子。近年来，通过免疫疗法可以使肿瘤患者的愈后及生存质量得到很大的改善和提高。免疫细胞可以通过免疫调...DNT细胞（CD4^-CD8^-double—negative T cells）是新发现的一种免疫细胞，其特点是细胞表面既不表达CD4分子同时也不表达CD8分子。近年来，通过免疫疗法可以使肿瘤患者的愈后及生存质量得到很大的改善和提高。免疫细胞可以通过免疫调节或直接杀伤的途径作用于肿瘤细胞，因此研究DNT细胞对肿瘤细胞的作用将有重要意义。展开更多
基金supported by the Key Research&Development Plan of Zhejiang Province(Nos.2019C03050 and 2021C03118)the National Key Research and Development Program of China(No.2021YFA1100500)the National Natural Science Foundation of China(No.92159202)。
文摘Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer.In addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis.Transplant oncology is an emerging field that addresses oncological challenges in transplantation.In this context,a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients.Double-negative T cells(DNTs)are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor(TCR)type.Among them,TCRαβ^(+)DNTs are considered to induce immune suppression in immune-mediated diseases,while TCRγδ^(+)DNTs are widely recognized as tumor killers.As a composite cell therapy,healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the host.In this work,we summarized the biological characteristics and functions of DNTs in oncology,immunology,and transplantation.Based on the multiple roles of DNTs,we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy(ACT).
文摘DNT细胞（CD4^-CD8^-double—negative T cells）是新发现的一种免疫细胞，其特点是细胞表面既不表达CD4分子同时也不表达CD8分子。近年来，通过免疫疗法可以使肿瘤患者的愈后及生存质量得到很大的改善和提高。免疫细胞可以通过免疫调节或直接杀伤的途径作用于肿瘤细胞，因此研究DNT细胞对肿瘤细胞的作用将有重要意义。
