Objective： To investigate the relationship between the appearances of digital subtraction angiography （DSA） and the serum level of vascular endothelial growth factor （VEGF） in patients with primary hepatocellular...Objective： To investigate the relationship between the appearances of digital subtraction angiography （DSA） and the serum level of vascular endothelial growth factor （VEGF） in patients with primary hepatocellular carcinoma （HCC）. Methods： 24 HCC patients, 30 times DSA were examined, serum VEGF level was measured with the quantitative enzyme linked immunosorbent assay （ELISA） in patients and healthy control subjects in this study. Results： Among DSA for 24 patients with HCC, 18 of 24 cases showed hepatic artery blood supply of tumor. Four of 24 cases showed portal vein blood supply of tumor, 1 of 24 cases showed superior mesenteric artery blood supply of tumor and artery-venous shunt formation, and there was no blood supply to tumor in one case. Serum VEGF level in HCC[（χ＋s）194.5±14.2] ng/L was significant elevated to those in patients comparing with those of the normal controls （132.4±47.9） ng/L and marked differences （P〈0.01）. Conclusion： During the cases for plenty blood supply or arteryvenous shunt formation in patients with HCC, serum VEGF level markedly elevated in the patients of HCC. VEGF expression was significantly related to intrahepatic dissemination, recurrence and metastasis in patients with HCC.展开更多
Acute ischemic stroke has the characteristics of high disability,lethality and recurrence rate,which seriously threatens the health of middle-aged and elderly people.This article describes the acute ischemic stroke wi...Acute ischemic stroke has the characteristics of high disability,lethality and recurrence rate,which seriously threatens the health of middle-aged and elderly people.This article describes the acute ischemic stroke with internal carotid artery occlusion as the main clinical feature and discusses its treatment strategy.Treatment remedies:clinical diagnosis was carried out based on the present medical history,physical examination and craniocerebral CT(computed tomography).Neurological function was improved by intravenous thrombolysis,cerebrovascular angiography was used to clarify cerebrovascular occlusion,cerebral blood supply was identified by CT perfusion,and neurological function recovery was followed up.After intravenous thrombolysis,the patient’s consciousness turned clear and the right limb muscle strength recovery was not obvious,but the patient did not receive bridging therapy.Cerebral angiography showed about 90%stenosis at the beginning of the left internal carotid artery,and the blood flow terminated at the C7 segment.Cerebral CT perfusion imaging showed decreased perfusion in the left cerebral hemisphere,but the patient did not receive carotid endarterectomy and vascular bypass treatment.Post treatment evaluating:follow-up showed that NIHSS(National Institute of Health stroke scale)score was significantly decreased and limb function was significantly restored.Conclusion:early intravenous thrombolytic therapy can help reduce the area of ischemic penumbra and improve long-term prognosis.Severe vascular stenosis can stimulate vascular compensation,significantly reduce the range of ischemia when thrombus occurs,and effectively reduce the disability rate without bridging therapy.Whether vascular stenosis and occlusion are treated by vascular bypass,etc.,individualized plans should be made according to vascular compensation.展开更多
Cogan’s syndrome is rare.The purpose of this article is to describe a Cogan’s syndrome case characterized by bilateral internal carotid artery occlusion and to review the literature.Treatment remedies:we showed a pa...Cogan’s syndrome is rare.The purpose of this article is to describe a Cogan’s syndrome case characterized by bilateral internal carotid artery occlusion and to review the literature.Treatment remedies:we showed a patient with vertigo,nausea and retching,blurred vision,unclear speech.And the whole cerebral angiogram of the patient showed bilateral internal carotid artery occlusion without obvious neurological deficit.After differential diagnosis,compared with classic Cogan’s syndrome,granulomatous polyvasculitis(GPA),rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),the patient was considered as Cogan’s syndrome.Post treatment evaluating:the patient did not significantly improve vertigo after vascular bypass therapy.Conclusions:Cogan’s syndrome may cause severe vascular occlusion.The patient had no clinical symptoms;and the chronic occlusion caused by vascular inflammation may be the reason,so that there was enough time for compensation.展开更多
Fibromuscular dysplasia(FMD)is a rare disease with a typical clinical manifestations.This article will describe the clinical features of a FMD case with severe headache misdiagnosed as cerebral artery dissection(CAD)....Fibromuscular dysplasia(FMD)is a rare disease with a typical clinical manifestations.This article will describe the clinical features of a FMD case with severe headache misdiagnosed as cerebral artery dissection(CAD).Treatment remedies:we collected the clinical data of a patient with severe headache and performed brain MRI(magnetic resonance imaging)and cerebral arteriovenous MRA(magnetic resonance angiography).The preliminary diagnosis was considered as right vertebral artery dissection,and then cerebral DSA(digital subtraction angiography)was performed for further diagnosis.Post treatment evaluating:cerebral angiography showed that the vessel wall was stiff,with multiple(insect phagocytic)-like changes,and severe stenosis of local long segments.Some vessels showed“double lumen sign”,which was consistent with the performance of FMD.After anticoagulant treatment,the patient’s condition was improved.Conclusions:for severe headache,in addition to common diseases,the possibility of FMD should also be paid great attention.Early cerebrovascular screening is conducive to early diagnosis and timely treatment.展开更多
文摘Objective： To investigate the relationship between the appearances of digital subtraction angiography （DSA） and the serum level of vascular endothelial growth factor （VEGF） in patients with primary hepatocellular carcinoma （HCC）. Methods： 24 HCC patients, 30 times DSA were examined, serum VEGF level was measured with the quantitative enzyme linked immunosorbent assay （ELISA） in patients and healthy control subjects in this study. Results： Among DSA for 24 patients with HCC, 18 of 24 cases showed hepatic artery blood supply of tumor. Four of 24 cases showed portal vein blood supply of tumor, 1 of 24 cases showed superior mesenteric artery blood supply of tumor and artery-venous shunt formation, and there was no blood supply to tumor in one case. Serum VEGF level in HCC[（χ＋s）194.5±14.2] ng/L was significant elevated to those in patients comparing with those of the normal controls （132.4±47.9） ng/L and marked differences （P〈0.01）. Conclusion： During the cases for plenty blood supply or arteryvenous shunt formation in patients with HCC, serum VEGF level markedly elevated in the patients of HCC. VEGF expression was significantly related to intrahepatic dissemination, recurrence and metastasis in patients with HCC.
文摘Acute ischemic stroke has the characteristics of high disability,lethality and recurrence rate,which seriously threatens the health of middle-aged and elderly people.This article describes the acute ischemic stroke with internal carotid artery occlusion as the main clinical feature and discusses its treatment strategy.Treatment remedies:clinical diagnosis was carried out based on the present medical history,physical examination and craniocerebral CT(computed tomography).Neurological function was improved by intravenous thrombolysis,cerebrovascular angiography was used to clarify cerebrovascular occlusion,cerebral blood supply was identified by CT perfusion,and neurological function recovery was followed up.After intravenous thrombolysis,the patient’s consciousness turned clear and the right limb muscle strength recovery was not obvious,but the patient did not receive bridging therapy.Cerebral angiography showed about 90%stenosis at the beginning of the left internal carotid artery,and the blood flow terminated at the C7 segment.Cerebral CT perfusion imaging showed decreased perfusion in the left cerebral hemisphere,but the patient did not receive carotid endarterectomy and vascular bypass treatment.Post treatment evaluating:follow-up showed that NIHSS(National Institute of Health stroke scale)score was significantly decreased and limb function was significantly restored.Conclusion:early intravenous thrombolytic therapy can help reduce the area of ischemic penumbra and improve long-term prognosis.Severe vascular stenosis can stimulate vascular compensation,significantly reduce the range of ischemia when thrombus occurs,and effectively reduce the disability rate without bridging therapy.Whether vascular stenosis and occlusion are treated by vascular bypass,etc.,individualized plans should be made according to vascular compensation.
文摘Cogan’s syndrome is rare.The purpose of this article is to describe a Cogan’s syndrome case characterized by bilateral internal carotid artery occlusion and to review the literature.Treatment remedies:we showed a patient with vertigo,nausea and retching,blurred vision,unclear speech.And the whole cerebral angiogram of the patient showed bilateral internal carotid artery occlusion without obvious neurological deficit.After differential diagnosis,compared with classic Cogan’s syndrome,granulomatous polyvasculitis(GPA),rheumatoid arthritis(RA),systemic lupus erythematosus(SLE),the patient was considered as Cogan’s syndrome.Post treatment evaluating:the patient did not significantly improve vertigo after vascular bypass therapy.Conclusions:Cogan’s syndrome may cause severe vascular occlusion.The patient had no clinical symptoms;and the chronic occlusion caused by vascular inflammation may be the reason,so that there was enough time for compensation.
文摘Fibromuscular dysplasia(FMD)is a rare disease with a typical clinical manifestations.This article will describe the clinical features of a FMD case with severe headache misdiagnosed as cerebral artery dissection(CAD).Treatment remedies:we collected the clinical data of a patient with severe headache and performed brain MRI(magnetic resonance imaging)and cerebral arteriovenous MRA(magnetic resonance angiography).The preliminary diagnosis was considered as right vertebral artery dissection,and then cerebral DSA(digital subtraction angiography)was performed for further diagnosis.Post treatment evaluating:cerebral angiography showed that the vessel wall was stiff,with multiple(insect phagocytic)-like changes,and severe stenosis of local long segments.Some vessels showed“double lumen sign”,which was consistent with the performance of FMD.After anticoagulant treatment,the patient’s condition was improved.Conclusions:for severe headache,in addition to common diseases,the possibility of FMD should also be paid great attention.Early cerebrovascular screening is conducive to early diagnosis and timely treatment.
