ABSTRACT Objective： To explore clinical short and long-term effect of combining Dalitong Granule （达立通颗粒） and electroacupuncture group （EA） in the treatment of functional dyspepsia. Methods： Totally 640 pati...ABSTRACT Objective： To explore clinical short and long-term effect of combining Dalitong Granule （达立通颗粒） and electroacupuncture group （EA） in the treatment of functional dyspepsia. Methods： Totally 640 patients with confirmed functional dyspepsia were randomly divided into 4 groups using a randomized digital table： the DG group, the EA group, the combined group and the control group, 160 cases in each group. The DG group was treated with 6 g DG 3 times daily; the EA group was treated with puncture of points Zusanli （ST36）, Zhongwan （CV12）, Neiguan （PC6）, Taichong （LR3） and Gongsun （SP4） twice daily; the combined group with above-mentioned DG and EA; and the control group with 5 mg mosapride 3 times, 20 mg pantoprazole and 25 mg amitriptylines twice daily. The treatment course was 4 weeks for all groups. The symptom score, quality of life score by Short Form 36 Health Survey Ouestionnaires （SF-36）, plasma motilin by radioimmunoassay, electrogastrographic frequencies by electrogastrogram （EGG） and gastric emptying by B-sonography were examined, and adverse reactions were observed before, at the end of treatment and 60 weeks post-treatment. Results： In the DG group 1 case dropped out for not taking medicine strictly and 1 case was lost to follow-up, while 1 case in the EA group and 2 cases in the combined therapy group were lost to follow-up. Compared with pre-treatment, quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all increased significantly, while symptom score was decreased significantly at the end of treatment in each group （P〈0.01）; in the combined group quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all significantly higher than those in the other groups, while symptom score was significantly lower than in the other groups （P〈0.05）. Compared with at the end of treatment, these indices changed insignificantly in the combined group and the EA group 60 weeks post-treatment （P〉0.05）, but the 4 increased indices were all decreased significantly, and symptom score was increased significantly in the DG and the control groups （P〉0.05）. The short and long-term total effective rates in the combined group were all significantly higher than those in the other treatment groups （P〈0.05 or P〈0.01）. No serious adverse reaction occurred in the four groups. Conclusion： Combined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect.展开更多
目的:总结泮托拉唑肠溶片联合达立通颗粒对根治性近端胃切除术后反流性食管炎的维持治疗效果。方法:回顾分析河南省肿瘤医院普外科2009年3月—2010年3月48例因根治性近端胃切除术后经胃镜确诊为反流性食管炎患者的临床资料,评价泮托拉...目的:总结泮托拉唑肠溶片联合达立通颗粒对根治性近端胃切除术后反流性食管炎的维持治疗效果。方法:回顾分析河南省肿瘤医院普外科2009年3月—2010年3月48例因根治性近端胃切除术后经胃镜确诊为反流性食管炎患者的临床资料,评价泮托拉唑肠溶片、达立通颗粒单独用药和联合用药的疗效。并对患者术后3个月、6个月、1年进行生活质量调查问卷(quality of life questionnaire of stomach 22,QLQ-STO22)评分。结果:单独应用泮托拉唑肠溶片或达立通颗粒即可明显改善患者病情,但联合用药在改善患者生活质量方面更具优势。结论:联合应用泮托拉唑肠溶片和达立通颗粒有助于提高根治性近端胃切除术后反流性食管炎的疗效。展开更多
目的探讨达立通颗粒对胆囊切除术后胆汁反流性胃炎(bile reflux gastritis,BRG)患者胃动力和胃肠激素的影响。方法选取2018-01至2020-04武警安徽总队医院的114例胆囊切除术后BRG患者,随机分为研究组和对照组,每组57例。对照组给予雷贝...目的探讨达立通颗粒对胆囊切除术后胆汁反流性胃炎(bile reflux gastritis,BRG)患者胃动力和胃肠激素的影响。方法选取2018-01至2020-04武警安徽总队医院的114例胆囊切除术后BRG患者,随机分为研究组和对照组,每组57例。对照组给予雷贝拉唑、铝镁加混悬液治疗,研究组在对照组治疗的基础上,给予达立通颗粒治疗,两组疗程均为4周;比较两组治疗前后临床有效率和胃排空率、胃电的平均收缩频率(mean frequency of contraction,MFC)和收缩振幅值(amplitude of contraction,AC)、胃动素(motilin,MTL)和胆囊收缩素(cholecystokinin,CCK)水平。结果治疗4周后,研究组有效率(92.98%)显著升高,与对照组(77.19%)比较,差异有统计学意义(P<0.05);治疗后研究组的胃排空率[(67.4±7.5)%]、MFC[(4.99±0.51)次/min]、AC[(227.63±24.12)μV]、MTL[(331.32±38.07)pg/ml]明显升高,CCK[(4.66±0.54)pg/ml]明显下降,与对照组的胃排空率[(37.0±8.8)%]、MFC[(2.90±0.39)次/min]、AC[(168.11±24.65)μV]、MTL[(300.44±35.39)pg/ml]、CCK[(6.04±0.69)pg/ml]比较,差异有统计学意义(P<0.05)。结论达立通颗粒可升高MTL水平,降低CCK水平,提高胃排空率,达立通颗粒联合治疗胆囊切除术后BRG,疗效优于单纯的雷贝拉唑、铝镁加混悬液治疗。展开更多
文摘ABSTRACT Objective： To explore clinical short and long-term effect of combining Dalitong Granule （达立通颗粒） and electroacupuncture group （EA） in the treatment of functional dyspepsia. Methods： Totally 640 patients with confirmed functional dyspepsia were randomly divided into 4 groups using a randomized digital table： the DG group, the EA group, the combined group and the control group, 160 cases in each group. The DG group was treated with 6 g DG 3 times daily; the EA group was treated with puncture of points Zusanli （ST36）, Zhongwan （CV12）, Neiguan （PC6）, Taichong （LR3） and Gongsun （SP4） twice daily; the combined group with above-mentioned DG and EA; and the control group with 5 mg mosapride 3 times, 20 mg pantoprazole and 25 mg amitriptylines twice daily. The treatment course was 4 weeks for all groups. The symptom score, quality of life score by Short Form 36 Health Survey Ouestionnaires （SF-36）, plasma motilin by radioimmunoassay, electrogastrographic frequencies by electrogastrogram （EGG） and gastric emptying by B-sonography were examined, and adverse reactions were observed before, at the end of treatment and 60 weeks post-treatment. Results： In the DG group 1 case dropped out for not taking medicine strictly and 1 case was lost to follow-up, while 1 case in the EA group and 2 cases in the combined therapy group were lost to follow-up. Compared with pre-treatment, quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all increased significantly, while symptom score was decreased significantly at the end of treatment in each group （P〈0.01）; in the combined group quality of life score, plasma motilin, electrogastrographic frequencies and gastric emptying were all significantly higher than those in the other groups, while symptom score was significantly lower than in the other groups （P〈0.05）. Compared with at the end of treatment, these indices changed insignificantly in the combined group and the EA group 60 weeks post-treatment （P〉0.05）, but the 4 increased indices were all decreased significantly, and symptom score was increased significantly in the DG and the control groups （P〉0.05）. The short and long-term total effective rates in the combined group were all significantly higher than those in the other treatment groups （P〈0.05 or P〈0.01）. No serious adverse reaction occurred in the four groups. Conclusion： Combined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect.
文摘目的:总结泮托拉唑肠溶片联合达立通颗粒对根治性近端胃切除术后反流性食管炎的维持治疗效果。方法:回顾分析河南省肿瘤医院普外科2009年3月—2010年3月48例因根治性近端胃切除术后经胃镜确诊为反流性食管炎患者的临床资料,评价泮托拉唑肠溶片、达立通颗粒单独用药和联合用药的疗效。并对患者术后3个月、6个月、1年进行生活质量调查问卷(quality of life questionnaire of stomach 22,QLQ-STO22)评分。结果:单独应用泮托拉唑肠溶片或达立通颗粒即可明显改善患者病情,但联合用药在改善患者生活质量方面更具优势。结论:联合应用泮托拉唑肠溶片和达立通颗粒有助于提高根治性近端胃切除术后反流性食管炎的疗效。
文摘目的探讨达立通颗粒对胆囊切除术后胆汁反流性胃炎(bile reflux gastritis,BRG)患者胃动力和胃肠激素的影响。方法选取2018-01至2020-04武警安徽总队医院的114例胆囊切除术后BRG患者,随机分为研究组和对照组,每组57例。对照组给予雷贝拉唑、铝镁加混悬液治疗,研究组在对照组治疗的基础上,给予达立通颗粒治疗,两组疗程均为4周;比较两组治疗前后临床有效率和胃排空率、胃电的平均收缩频率(mean frequency of contraction,MFC)和收缩振幅值(amplitude of contraction,AC)、胃动素(motilin,MTL)和胆囊收缩素(cholecystokinin,CCK)水平。结果治疗4周后,研究组有效率(92.98%)显著升高,与对照组(77.19%)比较,差异有统计学意义(P<0.05);治疗后研究组的胃排空率[(67.4±7.5)%]、MFC[(4.99±0.51)次/min]、AC[(227.63±24.12)μV]、MTL[(331.32±38.07)pg/ml]明显升高,CCK[(4.66±0.54)pg/ml]明显下降,与对照组的胃排空率[(37.0±8.8)%]、MFC[(2.90±0.39)次/min]、AC[(168.11±24.65)μV]、MTL[(300.44±35.39)pg/ml]、CCK[(6.04±0.69)pg/ml]比较,差异有统计学意义(P<0.05)。结论达立通颗粒可升高MTL水平,降低CCK水平,提高胃排空率,达立通颗粒联合治疗胆囊切除术后BRG,疗效优于单纯的雷贝拉唑、铝镁加混悬液治疗。
