Damaging Effect of Low Energy N^+ Implantation on Aspergillus niger Spores

The mutant effects of a keV range nitrogen ion （N＋） beam on enzyme-producing probiotics were studied, particularly with regard to the induction in the genome. The electron spin resonance （ESR） results showed that the signal of ESR spectrum existed in both implanted and non-implanted spores, and the yields of free radicals increased in a dose-dependent manner. The ionic etching and dilapidation of cell wall could be observed distinctly through the scanning electron microscope （SEM）. The mutagenic effect on genome indicated that N＋ implantation could make base mutation. This study provided an insight into the roles low-energy ions might play in inducing mutagenesis of micro-organisms.

Rockburst criterion and evaluation method for potential rockburst pit depth considering excavation damage effect

Excavation-induced disturbances in deep tunnels will lead to deterioration of rock properties and formation of excavation damaged zone(EDZ).This excavation damage effect may affect the potential rockburst pit depth.Taking two diversion tunnels of Jinping II hydropower station for example,the relationship between rockburst pit depth and excavation damage effect is first surveyed.The results indicate that the rockburst pit depth in tunnels with severe damage to rock masses is relatively large.Subsequently,the excavation-induced damage effect is characterized by disturbance factor D based on the Hoek-Brown criterion and wave velocity method.It is found that the EDZ could be further divided into a high-damage zone(HDZ)with D=1 and weak-damage zone(WDZ),and D decays from one to zero linearly.For this,a quantitative evaluation method for potential rockburst pit depth is established by presenting a three-element rockburst criterion considering rock strength,geostress and disturbance factor.The evaluation results obtained by this method match well with actual observations.In addition,the weakening of rock mass strength promotes the formation and expansion of potential rockburst pits.The potential rockburst pit depth is positively correlated with HDZ and WDZ depths,and the HDZ depth has a significant contribution to the potential rockburst pit depth.

Effect and mechanism of on-chip electrostatic discharge protection circuit under fast rising time electromagnetic pulse

The electrostatic discharge(ESD)protection circuit widely exists in the input and output ports of CMOS digital circuits,and fast rising time electromagnetic pulse(FREMP)coupled into the device not only interacts with the CMOS circuit,but also acts on the protection circuit.This paper establishes a model of on-chip CMOS electrostatic discharge protection circuit and selects square pulse as the FREMP signals.Based on multiple physical parameter models,it depicts the distribution of the lattice temperature,current density,and electric field intensity inside the device.At the same time,this paper explores the changes of the internal devices in the circuit under the injection of fast rising time electromagnetic pulse and describes the relationship between the damage amplitude threshold and the pulse width.The results show that the ESD protection circuit has potential damage risk,and the injection of FREMP leads to irreversible heat loss inside the circuit.In addition,pulse signals with different attributes will change the damage threshold of the circuit.These results provide an important reference for further evaluation of the influence of electromagnetic environment on the chip,which is helpful to carry out the reliability enhancement research of ESD protection circuit.

Comparison of displacement damage effects on the dark signal in CMOS image sensors induced by CSNS back-n and XAPR neutrons

This study investigates the effects of displacement damage on the dark signal of a pinned photodiode CMOS image sensor(CIS)following irradiation with back-streaming white neutrons from white neutron sources at the China spallation neutron source(CSNS)and Xi'an pulsed reactor(XAPR).The mean dark signal,dark signal non-uniformity(DSNU),dark signal distribution,and hot pixels of the CIS were compared between the CSNS back-n and XAPR neutron irradiations.The nonionizing energy loss and energy distribution of primary knock-on atoms in silicon,induced by neutrons,were calculated using the open-source package Geant4.An analysis combining experimental and simulation results showed a noticeable proportionality between the increase in the mean dark signal and the displacement damage dose(DDD).Additionally,neutron energies influence DSNU,dark signal distribution,and hot pixels.High neutron energies at the same DDD level may lead to pronounced dark signal non-uniformity and elevated hot pixel values.

Analysis of displacement damage effects on the charge-coupled device induced by neutrons at Back-n in the China Spallation Neutron Source

Displacement damage effects on the charge-coupled device(CCD)induced by neutrons at the back-streaming white neutron source(Back-n)in the China Spallation Neutron Source(CSNS)are analyzed according to an online irradiation experiment.The hot pixels,random telegraph signal(RTS),mean dark signal,dark current and dark signal non-uniformity(DSNU)induced by Back-n are presented.The dark current is calculated according to the mean dark signal at various integration times.The single-particle displacement damage and transient response are also observed based on the online measurement data.The trends of hot pixels,mean dark signal,DSNU and RTS degradation are related to the integration time and irradiation fluence.The mean dark signal,dark current and DSNU2 are nearly linear with neutron irradiation fluence when nearly all the pixels do not reach saturation.In addition,the mechanisms of the displacement damage effects on the CCD are demonstrated by combining the experimental results and technology computer-aided design(TCAD)simulation.Radiation-induced traps in the space charge region of the CCD will act as generation/recombination centers of electron-hole pairs,leading to an increase in the dark signal.

Effects of Simulated Heat Wave and Ozone on High Fat Diet ApoE Deficient Mice

Objective To discuss the cardiac toxicities of a heat waves and ozone exposure on cardiovascular diseases（CVDs） and explore a possible mechanism. Methods The incidence of ozone exposure combined with heat wave was simulated in the Shanghai Meteorological and Environmental Animal Exposure System（Shanghai-METAS）. A total of 64 Apo E-/-mice, matched by weight, were randomly divided into 8 groups and exposed to heat wave conditions or ozone. The levels of creatine kinase（CK）, D-lactate dehydrogenase（D-LDH）, intercellular adhesion molecule 1（sICAM-1）, tumor necrosis factor alpha（TNF-α）, nitric oxide（NO）, endothelin-1（ET-1）, D-dimer（D2 D）, plasminogen activator inhibitor-1（PAI-1） and blood lipid in plasma and heat shock protein-60（HSP60）, hypoxia inducible factor 1 alpha（HIF-1α）, interleukin-6（IL-6）, C-reactive protein（CRP）, superoxide dismutase（SOD）, and malondialdehyde（MDA） in hearts were measured after exposure. Results The levels of all indicators, except for SOD, increased with the ozone-only exposure. However, cardiac damage was most significant when the heat wave conditions were combined with severe ozone exposure. Moreover, the levels of CK, D-LDH, NO, PAI-1, sICAM-1, and TNF-α in plasma increased significantly（P 〈 0.05）, and the contents of HSP60, HIF-1α, CRP, and MDA in hearts increased considerably（P 〈 0.05）, but the activity of SOD decreased significantly. In addition, the levels of four blood lipid items remarkably increased（except the level of HDL-C which decreased significantly） with ozone exposure. Conclusion A short-term exposure to a heat wave and ozone causes severe toxic effects on the heart. Cardiac damage was most significant under combined heat wave and severe ozone exposure simulations.

Damage effect and mechanism of the GaAs high electron mobility transistor induced by high power microwave

In this paper, we present the damage effect and mechanism of high power microwave （HPM） on AIGaAs/GaAs pseudomorphic high-electron-mobility transistor （pHEMT） of low-noise amplifier （LNA）. A detailed investigation is carried out by simulation and experiment study. A two-dimensional electro-thermal model of the typical GaAs pHEMT induced by HPM is established in this paper. The simulation result reveals that avalanche breakdown, intrinsic excitation, and thermal breakdown all contribute to damage process. Heat accumulation occurs during the positive half cycle and the cylinder under the gate near the source side is most susceptible to burn-out. Experiment is carried out by injecting high power microwave into GaAs pHEMT LNA samples. It is found that the damage to LNA is because of the burn-out at first stage pHEMT. The interiors of the damaged samples are observed by scanning electron microscopy （SEM） and energy dispersive spectrometer （EDS）. Experimental results accord well with the simulation of our model.

Damage effects and mechanism of the silicon NPN monolithic composite transistor induced by high-power microwaves

A two-dimensional model of the silicon NPN monolithic composite transistor is established for the first time by utilizing the semiconductor device simulator, Sentaurus-TCAD. By analyzing the internal distributions of electric field, current density, and temperature of the device, a detailed investigation on the damage process and mechanism induced by high-power microwaves （HPM） is performed. The results indicate that the temperature elevation occurs in the negative half-period and the temperature drop process is in the positive half-period under the HPM injection from the output port. The damage point is located near the edge of the base-emitter junction of T2, while with the input injection it exists between the base and the emitter of T2. Comparing these two kinds of injection, the input injection is more likely to damage the device than the output injection. The dependences of the damage energy threshold and the damage power threshold causing the device failure on the pulse-width are obtained, and the formulas obtained have the same form as the experimental equations, which demonstrates that more power is required to destroy the device if the pulse-width is shorter. Furthermore, the simulation result in this paper has a good coincidence with the experimental result.

Blasting cumulative damage effects of underground engineering rock mass based on sonic wave measurement

The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparatus. The blasting test was carried out for ten times at some tunnels of Changba Lead-Zinc Mine. The damage depth of surrounding rock caused by old blasting excavation （0.8-1.2 m） was confirmed. The relation between the cumulative damage degree and blast times was obtained. The results show that the sonic velocity decreases gradually with increasing blast times, hut the damage degree （D） increases. The damage cumulative law is non-linear. The damage degree caused by blast decreases with increasing distance, and damage effects become indistinct. The blasting damage of rock mass is anisotropic. The damage degree of rock mass within charging range is maximal. And the more the charge is, the more severe the damage degree of rock mass is. The test results provide references for researches of mechanical parameters of rock mass and dynamic stability analysis of underground chambers.

Radiation-hardened property of single-walled carbon nanotube film-based field-effect transistors under low-energy proton irradiation

Strong C-C bonds,nanoscale cross-section and low atomic number make single-walled carbon nanotubes(SWCNTs)a potential candidate material for integrated circuits(ICs)applied in outer space.However,very little work combines the simulation calculations with the electrical measurements of SWCNT field-effect transistors(FETs),which limits further understanding on the mechanisms of radiation effects.Here,SWCNT film-based FETs were fabricated to explore the total ionizing dose(TID)and displacement damage effect on the electrical performance under low-energy proton irradiation with different fluences up to 1×1015 p/cm2.Large negative shift of the threshold voltage and obvious decrease of the on-state current verified the TID effect caused in the oxide layer.The stability of the subthreshold swing and the off-state current reveals that the displacement damage caused in the CNT layer is not serious,which proves that the CNT film is radiation-hardened.Specially,according to the simulation,we found the displacement damage caused by protons is different in the source/drain contact area and channel area,leading to varying degrees of change for the contact resistance and sheet resistance.Having analyzed the simulation results and electrical measurements,we explained the low-energy proton irradiation mechanism of the CNT FETs,which is essential for the construction of radiation-hardened CNT film-based ICs for aircrafts.

Damage effect and mechanism of the GaAs pseudomorphic high electron mobility transistor induced by the electromagnetic pulse

The damage effect and mechanism of the electromagnetic pulse （EMP） on the GaAs pseudomorphic high electron mobility transistor （PHEMT） are investigated in this paper. By using the device simulation software, the distributions and variations of the electric field, the current density and the temperature are analyzed. The simulation results show that there are three physical effects, i.e., the forward-biased effect of the gate Schottky junction, the avalanche breakdown, and the thermal breakdown of the barrier layer, which influence the device current in the damage process. It is found that the damage position of the device changes with the amplitude of the step voltage pulse. The damage appears under the gate near the drain when the amplitude of the pulse is low, and it also occurs under the gate near the source when the amplitude is sufficiently high, which is consistent with the experimental results.

Damage effect analysis and experiment for electronic equipment in impact vibration environment

This paper analyzes the electronic equipment＇s effect factors such as structure characteristics and environment.The radar equipment is taken as an experimental subject.The damage laws of electro-products in vibration environment are analyzed.The experiment shows that the damage of electro-products in vibration environment has relations with both the type and amplitude of vibration and their structure.

Damage effectiveness assessment method for anti-ship missiles based on double hierarchy linguistic term sets and evidence theory

The research on the damage effectiveness assessment of anti-ship missiles involves system science and weapon science, and has essential strategic research significance. With comprehensive analysis of the specific process of the damage assessment process of anti-missile against ships, a synthetic damage effectiveness assessment process is proposed based on the double hierarchy linguistic term set and the evidence theory. In order to improve the accuracy of the expert ’s assessment information, double hierarchy linguistic terms are used to describe the assessment opinions of experts. In order to avoid the loss of experts ’ original information caused by information fusion rules, the evidence theory is used to fuse the assessment information of various experts on each case. Good stability of the assessment process can be reflected through sensitivity analysis, and the fluctuation of a certain parameter does not have an excessive influence on the assessment results. The assessment process is accurate enough to be reflected through comparative analysis and it has a good advantage in damage effectiveness assessment.

Fracture evolution and localization effect of damage in rock based on wave velocity imaging technology

By utilizing wave velocity imaging technology,the uniaxial multi-stage loading test was conducted on siltstone to attain wave velocity imagings during rock fracture.Based on the time series parameters of acoustic emissions(AE),joint response characteristics of the velocity field and AE during rock fracture were analyzed.Moreover,the localization effect of damage during rock fracture was explored by applying wave velocity imagings.The experimental result showed that the wave velocity imagings enable three-dimensional(3-D)visualization of the extent and spatial position of damage to the rock.A damaged zone has a low wave velocity and a zone where the low wave velocity is concentrated tends to correspond to a severely damaged zone.AE parameters and wave velocity imagings depict the changes in activity of cracks during rock fracture from temporal and spatial perspectives,respectively:the activity of cracks is strengthened,and the rate of AE events increases during rock fracture;correspondingly,the low-velocity zones are gradually aggregated and their area gradually increases.From the wave velocity imagings,the damaged zones in rock were divided into an initially damaged zone,a progressively damaged zone,and a fractured zone.During rock fracture,the progressively damaged zone and the fractured zone both develop around the initially damaged zone,showing a typical localization effect of the damage.By capturing the spatial development trends of the progressively damaged zone and fractured zone in wave velocity imagings,the development of microfractures can be predicted,exerting practical significance for determining the position of the main fracture.

EFFECT OF DAMAGE ON NONLINEAR DYNAMIC PROPERTIES OF VISCOELASTIC RECTANGULAR PLATES

The nonlinear dynamic behaviors of viscoelastic rectangular plates including the damage effects under the action of a transverse periodic load were studied. Using the von Karman equations, Boltzmann superposition principle and continuum damage mechanics, the nonlinear dynamic equations in terms of the mid_plane displacements for the viscoelastic thin plates with damage effect were derived. By adopting the finite difference method and Newmark method, these equations were solved. The results were compared with the available data. In the numerical calculations, the effects of the external loading parameters and geometric dimensions of the plate on the nonlinear dynamic responses of the plate were discussed. Research results show that the nonlinear dynamic response of the structure will change remarkably when the damage effect is considered.

Damage Effects of Overload Axes on Pavement Structures

This paper established the axle load distribution model of overload axes by practical axle-meter investigations. To study the effects of overload axes on pavement distress, deflection and deflection basin tests with axle load from 60kN to 190kN were conducted on different pavement structures. The relationship between axle load and its deflection as well as its deflection basin curvature was obtained by statistical analyses. A methodology for deriving the equivalent conversion factors of overload axes to equivalent standard axle loads (ESAL) of 100kN is developed, obtaining the relationship between the equivalent conversion factors and the axle loads. Comparing the calculated defiections with the measured deflections, that elastic layered system theory is suitable for analyzing overload vehicles was verified. Consequently, the stresses and strains caused by overload axes were calculated by elastic layered system theory. The results showed that overload axes led to greater stresses and strains causing premature pavement fatigue distress. To guarantee the expected performance in overload axes pavement, the structure thickness needed increasing was obtained. The results are of referential values in the control of semi-rigid pavement overloadings.

Protective Effect of Vitamin E on Liver Damage Induced by 2-Chloro-1, 3-butadiene

The present study was performed to determine the influence of lipid peroxidation and perturbance of Ca2+ homeostasis on liver damage induced by 2-chloro-1, 3-butadiene (CBD) and the protective effects of vitamin E in Wistar rats. Animals were given intraperitoneally different doses (8,40 or 200 mg·kg-1 daily) of CBD for 21 days, and the following dose-dependent events were observed: liver damage, significant increase in liver lipid peroxides, and decreases in activities of erythrocytic glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD). The pretreatment of rats with vitamin E (po 150 mg·kg-1) before administering CBD (iP 60 mg·kg-1 ) daily for 21 days prevented the following CBD-induced changes, the increase in serum cholylglycine (CG), hepatic LP, hepatic mitochondrion LP, hepatic oxidized glutathione (GSSG) (while the significant increase of reduced glutathione (GSH) was not affected) and the decrease in activities of erythrocytic SOD and hepatic mitochondrial calcium sequestration. These results suggest that lipid peroxidation and perturbance of Ca2+ homeostasis appear to contribute to the hepatotoxicity of CBD, and vitamin E might prevent the liver damage induced by CBD. The decrease in activities of GSH-Px and SOD in erythrocytes might be used as biomarkers for adverse effects of CBD on defense system against lipid peroxidation.

Effects of low dose Glibenclamide on secondary damage after acute spinal cord injury in rats

Objective To investigate the effects of Glibenclamide on reduction of secondary damage after acute spinal cord injury in rats.Methods Ninety rats were randomly divided into control group(laminectomy alone),spinal cord injury group(injury group),and treatment group(treated

Experimental investigation on enhanced damage to fuel tanks by reactive projectiles impact

Enhanced damage to the full-filled fuel tank,impacted by the cold pressed and sintered PTFE/Al/W reactive material projectile(RMP)with a density of 7.8 g/cm3,is investigated experimentally and theoretically.The fuel tank is a rectangular structure,welded by six pieces of 2024 aluminum plate with a thickness of 6 mm,and filled with RP-3 aviation kerosene.Experimental results show that the kerosene is ignited by the RMP impact at a velocity above 1062 m/s,and a novel interior ignition phenomenon which is closely related to the rupture effect of the fuel tank is observed.However,the traditional steel projectile with the same mass and dimension requires a velocity up to 1649 m/s to ignite the kerosene.Based on the experimental results,the radial pressure field is considered to be the main reason for the shear failure of weld.For mechanism considerations,the chemical energy released by the RMP enhances the hydrodynamic ram(HRAM)effect and provides additional ignition sources inside the fuel tank,thereby enhancing both rupture and ignition effects.Moreover,to further understand the enhanced ignition effect of RMP,the reactive debris temperature inside the kerosene is analyzed theoretically.The initiated reactive debris with high temperature provides effective interior ignition sources to ignite the kerosene,resulting in the enhanced ignition of the kerosene.

Dose-dependent Cardiac Dysfunction and Structural Damage in Rats after Shortwave Radiation

Objective To detect the effects of shortwave radiation on dose-dependent cardiac structure and function in rats after radiation and to elucidate the mechanism of shortwave radiation induced cardiac injury to identify sensitive indicators and prophylactic treatment.Methods One hundred Wistar rats were either exposed to 27 MHz continuous shortwave at a power density of 5,10,and 30 mW/cm^2 for 6 min or undergone sham exposure for the control(the rats had to be placed in the exposure system with the same schedules as the exposed animals,but with an inactive antenna).The Ca^2+,glutamic oxaloacetic transaminase(AST),creatine kinase(CK)and lactate dehydrogenase(LDH)content in the peripheral serum of the rats were detected by an automatic blood biochemical analyser.The electrocardiogram(ECG)of standard lead II was recorded by a multi-channel physiological recording and analysis system.The cardiac structure of rats was observed by light and electron microscopy.Results The results showed that the 5,10,and 30 mW/cm^2 shortwave radiation caused a significant increased in the levels of Ca2+,AST,CK,and LDH in the peripheral serum of rats.The cardiac structure was damaged by radiation and showed a disordered arrangement of myocardial fibres,the cavitation and swelling of myocardial mitochondria.These injuries were most significant 7 d after radiation and were not restored until 28 d after radiation.Conclusion Shortwave radiation of 5,10,and 30 mW/cm^2 can damage rat cardiac function,including damage to the tissue structure and ultrastructure,especially at the level of the myocardial fibres and mitochondria.Shortwave radiation at 5,10,and 30 mW/cm^2 induced damage to rat heart function and structure with a dose-effect relationship,i.e.,the greater the radiation dose was,the more significant the damage was.