Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verd...Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H-NMR, </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.05). The same observation was effective in Malme-3M melanin production with a significant daniellic acid action than kojic acid (p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05) without reducing cell viabilities. This bioactive daniellic acid could explain the traditional uses of oleoresins from </span><i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> for genitor-urinary tract diseases treatments, wound healing, and skin ailments in Burkina Faso.</span></span></span></span>展开更多
Various resources of the so-called traditional Chinese medicine, such as taijiquan, massage, diets, or acupuncture, have become widely available in the everyday therapeutic culture of contemporary Argentina. While the...Various resources of the so-called traditional Chinese medicine, such as taijiquan, massage, diets, or acupuncture, have become widely available in the everyday therapeutic culture of contemporary Argentina. While these resources can be found in the first half of the 20th century, it is evident that from the 1960s onward their presence is more evident, with a strong emphasis from the 1980s on. This article aims to describe the reception and popularization of body and therapeutic techniques of traditional Chinese medicine in Argentina in the 1980s through the case of Daniel Alegre, a key figure in the dissemination of Chinese therapeutic techniques. To do so, it focuses on certain key mediators in the popularization of techniques such as taijiquan and Chinese massage: teachers, promoters, and specialized magazines. All these mediators are key artifacts in the processes of massification and dissemination of traditional Chinese medicine in a broader emerging horizon associated with two simultaneous processes, the Chinese cultural transnationalization and the boom of new forms of holistic management of personal well-being.展开更多
心理学家Daniel Kahneman被授予2002年诺贝尔经济学奖。他遵循1978年诺贝尔经济学奖获得者Herbert A. Simon的“有限理性”理论和启发式的思想,提出3种常见的启发式:代表性、可得性以及锚定和调整。Kahneman发现人类的决策行为常常是非...心理学家Daniel Kahneman被授予2002年诺贝尔经济学奖。他遵循1978年诺贝尔经济学奖获得者Herbert A. Simon的“有限理性”理论和启发式的思想,提出3种常见的启发式:代表性、可得性以及锚定和调整。Kahneman发现人类的决策行为常常是非理性和有偏差的,这与传统经济学理论 (期望效用理论)的预期不符,而且这种偏差是有规律的。Kahneman提出前景理论以解释人类在不确定条件下的判断和决策行为。他获得诺贝尔经济学奖是因为他“把心理学的,特别是关于不确定条件下人的判断和决策的研究思想,结合到了经济科学中。”该文列举实例简单介绍了Daniel Kahneman对心理学和经济学的贡献。展开更多
文摘Over the past years, natural products have been used as useful candidates for prevention and treatment of skin disorders such as skin darkening. In this current research, <i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> which was a potential source of cosmeceutical agent was selected to investigate its active components. Daniellic acid isolated from the oleoresin was characterized by using data from </span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H-NMR, </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C-NMR, HSQC, IR, and online chemo-informatic analysis. The daniellic acid antioxidant, anti-proliferative, and tyrosinase inhibition capabilities were evaluated. This compound possessed an anti-DPPH and iron (III) reducing effect compared to quercetin. It was able to inhibit 9 tumor cells with IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;"> going from 0.03 mM (U373) to 0.14 mM (Malme-3M). Interestingly daniellic acid inhibit</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> tyrosinase activity with 1.20 mM as IC</span><sub><span style="font-family:Verdana;">50</span></sub><span style="font-family:Verdana;">. The tyrosinase inhibition mechanism was noncompetitive mixed-type with un-significant effect on cell melanogenesis. Daniellic acids induced a half-reduction of melanin production in B16F10 cell in IBMX stimulation (p</span></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.05). The same observation was effective in Malme-3M melanin production with a significant daniellic acid action than kojic acid (p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">0.05) without reducing cell viabilities. This bioactive daniellic acid could explain the traditional uses of oleoresins from </span><i><span style="font-family:Verdana;">Daniellia oliveri</span></i><span style="font-family:Verdana;"> for genitor-urinary tract diseases treatments, wound healing, and skin ailments in Burkina Faso.</span></span></span></span>
基金financed by The National Scientific and Technical Research Council of Argentina (CONICET)。
文摘Various resources of the so-called traditional Chinese medicine, such as taijiquan, massage, diets, or acupuncture, have become widely available in the everyday therapeutic culture of contemporary Argentina. While these resources can be found in the first half of the 20th century, it is evident that from the 1960s onward their presence is more evident, with a strong emphasis from the 1980s on. This article aims to describe the reception and popularization of body and therapeutic techniques of traditional Chinese medicine in Argentina in the 1980s through the case of Daniel Alegre, a key figure in the dissemination of Chinese therapeutic techniques. To do so, it focuses on certain key mediators in the popularization of techniques such as taijiquan and Chinese massage: teachers, promoters, and specialized magazines. All these mediators are key artifacts in the processes of massification and dissemination of traditional Chinese medicine in a broader emerging horizon associated with two simultaneous processes, the Chinese cultural transnationalization and the boom of new forms of holistic management of personal well-being.