Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,a...Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,anti-ischemia and anti-cancer,daurisoline has attracted wide attention of researchers.In this paper,the pharmacological effects and action mechanism of daurisoline were reviewed in combination with relevant research literature,to provide a theoretical basis for the development and clinical application of daurisoline.展开更多
Cytosolic free Ca([Ca]i)was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in[Ca]i occurred rapidly following explsure of the cells to 50 mmol/L KCI,1...Cytosolic free Ca([Ca]i)was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in[Ca]i occurred rapidly following explsure of the cells to 50 mmol/L KCI,10mol/L Bayk 8644 or 200μmol/L glutamate（Glu）.[Ca]i elevated by展开更多
Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectr...Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectra with the stereochemistry of synthetic RR-(1),SS-(2),RS-daurisoline(3) and SR-daurisoline(4).By comparision of the CD spectrum of natural daurisoline(1)from Menis- permum dauricum(Menispermaceae)with those of synthetic enantiomers,the absolute configuration was established as RR-daurisoline(1).展开更多
基金Supported by Central Government Supporting Local College Reform and Development Fund Talent Training Project (2020GSP16)
文摘Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,anti-ischemia and anti-cancer,daurisoline has attracted wide attention of researchers.In this paper,the pharmacological effects and action mechanism of daurisoline were reviewed in combination with relevant research literature,to provide a theoretical basis for the development and clinical application of daurisoline.
文摘Cytosolic free Ca([Ca]i)was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in[Ca]i occurred rapidly following explsure of the cells to 50 mmol/L KCI,10mol/L Bayk 8644 or 200μmol/L glutamate（Glu）.[Ca]i elevated by
基金This work was supported by the National Natural Science Foundation of China.
文摘Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectra with the stereochemistry of synthetic RR-(1),SS-(2),RS-daurisoline(3) and SR-daurisoline(4).By comparision of the CD spectrum of natural daurisoline(1)from Menis- permum dauricum(Menispermaceae)with those of synthetic enantiomers,the absolute configuration was established as RR-daurisoline(1).
