This article is a theoretical note on de-growth debate. The article includes an analysis of economic growth and alternative growth paths. The article is focused on the concepts of de-linking, re-linking and de-growth....This article is a theoretical note on de-growth debate. The article includes an analysis of economic growth and alternative growth paths. The article is focused on the concepts of de-linking, re-linking and de-growth. We connected linking analysis (de-linking and re-linking) analytically to the de-growth debate. On the basis of our framework, special cases of de-growth in the linking process relate to strong re-linking, weak re-linking and recessive de-linking. This kind of theoretical approach helps us to define the special nature of de-growth. Key finding of us is that only the de-growth case of recessive de-linking meets the condition of environmental sustainability. However, this case does not fulfil the criteria of sustainable development defined in the WCSD context. In the linking process, the WCSD conditions of sustainable development are met in the strong de-linking process only. In our analytical framework, the theoretical concepts of de-growth and sustainable development seem to conflict by definition.展开更多
目的:探讨静脉用低剂量米诺环素对局灶性脑缺血再灌注大鼠认知功能障碍及缺血侧海马生长相关蛋白-43(growth associated protein-43,GAP-43)和突触后致密物质-95(postsynaptic density 95,PSD-95)表达的影响。方法:采用线栓法建立Spragu...目的:探讨静脉用低剂量米诺环素对局灶性脑缺血再灌注大鼠认知功能障碍及缺血侧海马生长相关蛋白-43(growth associated protein-43,GAP-43)和突触后致密物质-95(postsynaptic density 95,PSD-95)表达的影响。方法:采用线栓法建立Sprague-Dawley大鼠大脑中动脉阻塞再灌注模型,将45只雄性大鼠随机分为假手术组、模型组及米诺环素组(n=15)。分别采用免疫组织化学及免疫印迹法检测术后2周大鼠缺血侧海马GAP-43和PSD-95蛋白的表达,Morris水迷宫实验评价大鼠的行为学改变。结果:同假手术组相比,模型组大鼠缺血侧海马GAP-43(0.49±0.03)和PSD-95(0.92±0.04)表达明显增高(P=0.000);大鼠逃避潜伏期明显延长[(44.2±10.0)s],穿过原平台次数(2.6±0.9)和在目标象限探索时间百分率明显降低[(19.2±2.1)%,P=0.000)]。同模型组相比,尾静脉给予3 mg/kg米诺环素治疗后,大鼠缺血侧海马GAP-43(0.72±0.05)表达明显增加,PSD-95表达降低(0.67±0.05,P=0.000),大鼠逃避潜伏期明显缩短[(30.8±7.6)s,P=0.020]、穿过原平台次数(4.4±1.1,P=0.012)和在目标象限探索时间百分率明显增加[(30.4±2.7)%,P=0.000)]。结论:低剂量米诺环素能显著改善脑缺血再灌注后大鼠学习记忆能力,其机制可能与上调GAP-43和下调PSD-95表达有关。展开更多
文摘This article is a theoretical note on de-growth debate. The article includes an analysis of economic growth and alternative growth paths. The article is focused on the concepts of de-linking, re-linking and de-growth. We connected linking analysis (de-linking and re-linking) analytically to the de-growth debate. On the basis of our framework, special cases of de-growth in the linking process relate to strong re-linking, weak re-linking and recessive de-linking. This kind of theoretical approach helps us to define the special nature of de-growth. Key finding of us is that only the de-growth case of recessive de-linking meets the condition of environmental sustainability. However, this case does not fulfil the criteria of sustainable development defined in the WCSD context. In the linking process, the WCSD conditions of sustainable development are met in the strong de-linking process only. In our analytical framework, the theoretical concepts of de-growth and sustainable development seem to conflict by definition.
