An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control...An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.展开更多
Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal batteries.However,the unclear mechanism for the fast capacity decay ...Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal batteries.However,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead Li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling life.To clarify the underlying mechanism,herein,the evolution of SEI and dead Li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical LiPF6-based polymer electrolyte.The results show that the initial capacity loss is attributed to the formation of SEI,while the dead Li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−1.To reduce the active Li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of Li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead Li generation by 2.3 and 20.1 folds,respectively.As a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in Li-Cu cells,which guides the rational design of high-performance AF-SSLBs.展开更多
In principle,the asynchronous measurement-device-independent quantum key distribution(AMDI-QKD)can surpass the key rate capacity without phase tracking and phase locking.However,practical imperfections in sources or d...In principle,the asynchronous measurement-device-independent quantum key distribution(AMDI-QKD)can surpass the key rate capacity without phase tracking and phase locking.However,practical imperfections in sources or detections would dramatically depress its performance.Here,we present an improved model on AMDI-QKD to reduce the influence of these imperfections,including intensity fluctuation,the afterpulse effect,and the dead time of detectors.Furthermore,we carry out corresponding numerical simulations.Simulation results show that,by implementing our present work,it can have more than 100 km longer secure transmission distance and one order of magnitude enhancement in the key generation rate after 320 km compared with the standard method.Moreover,our model can still break the Pirandola–Laurenza–Ottaviani–Banchi(PLOB)bound even under realistic experimental conditions.展开更多
The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the co...The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction curve.The uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of uncertainty.The MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical model.The results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the MCM.However,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.展开更多
Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulator...Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulatory transcriptional loop.The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes.Our in silico analysis of HNF1A,HNF4A.and FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrich-ment of these transcription factors specifically in the liver.Our previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma glycoproteins.Here,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype.We used the state-of-the-art clus-tered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9)molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell line.The results show that the downregulation of all three genes individually and in pairs affects the transcrip-tional activity of many glyco-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures.The effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantennary glycans.We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure.We also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.展开更多
This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This per...This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.展开更多
Research Background: The marketing of cosmetic products derived from Dead Sea (DS) mud has undergone significant evolution, transforming from simple souvenirs into a large-scale cosmetic industry offering a diverse ar...Research Background: The marketing of cosmetic products derived from Dead Sea (DS) mud has undergone significant evolution, transforming from simple souvenirs into a large-scale cosmetic industry offering a diverse array of products. DS mud is utilized both as pure mud for home spa treatments and as an active ingredient in cosmetic and cosmeceutical formulations. Its global appeal is largely due to its natural, health-oriented image, which aligns with consumer preferences and provides assurance regarding its use in skincare. Research Objectives: This review examines the published data related to the rationale for formulating DS mud in cosmetics, the biological and cosmetic effects of DS mud on the skin, and the speculated bio-mechanisms underlying these effects. Methods: We screened relevant literature on DS mud collected from the shores of the Dead Sea in Jordan and Israel. Publications on mineral muds excavated in different locations around the globe, as well as studies on the biological mechanisms of other DS minerals, were also reviewed as indications and supportive recommendations. Summarizing the vast collected data into a comprehensive review was undertaken to expose readers to the various aspects of DS mud in cosmetics. Results: The primary reason for formulating DS mud in skincare products is its deep cleansing and skin detoxification properties. Consequently, it is often incorporated into rinse-off masks, soaps, and scrubbing products. Additionally, DS mud is used in leave-on products and sheet masks. Cosmeceutical applications of DS mud, recommended for various skin conditions, offer complementary treatments to improve the quality of life for people with skin diseases. The physicochemical and biological effects of DS mud are driven by its rich mineral ion composition, including magnesium, calcium, sodium, potassium, zinc, and strontium—elements known to improve skin barrier function, enhance hydration, and reduce inflammation. The high salt concentration induces moderate ionic osmotic stress, stimulating cellular growth and hydration pathways. Moreover, DS mud’s anti-microbial properties further contribute to its therapeutic potential. Ongoing innovations in formulation techniques continue to expand the applications of DS mud, including blending it with other active ingredients, developing novel application methods, and refining manufacturing processes to improve product quality and efficacy. Conclusions: DS mud remains a valuable ingredient in modern skincare due to its rich mineral content and therapeutic properties. Ongoing research and technological advancements promise further innovations, reinforcing its status as a natural and effective component in the global cosmetics industry.展开更多
Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot o...Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot objectively compare biddings: timber trade is a lottery game. Bucking is analyzed in terms of sawlog, pulp wood, log cylinder, sawn wood, value-weighted sawn wood, and chips. Sawn wood and its value are computed from top diameter of the sawlog. Profit maximization requires buyers to buck logs producing smaller than maximal value, causing dead weight loss. Nominal assortment prices have unpredictable relation to effective stumpage price. Assortment pricing does not meet requirements of market economy. If sawmills linked to pulp mills buck smaller sawlog percentages than independent sawmills, as generally believed, they use higher price for chips in their own harvests than they pay for independent sawmills, indicating imperfect competition for chips. Sawn wood potential pricing is suggested which gives prices for sawn wood and chips coming both from sawlogs and pulp wood in reference bucking which maximizes sawn wood for given minimum and maximum log length and minimum top diameter. Simple algorithm generates feasible bucking schedules from which optimum can be selected using any objective. Pricing produces unit price for all commercial wood utilizing ratio of theoretical sawn wood and commercial volume in stand. Unit price can be compared to stem pricing and could be compared to assortment pricing if assortment pricing would produce predictable sawlog percentages. Sawn wood potential pricing is concrete, transparent, easy to compute, considers stem size and tapering, reduces trading cost and is less risky to buyers than stem pricing. It meets requirements of market economy. Readers can repeat computations using open-source software Jlp22.展开更多
The Jordan River, also referred to as Nahr Al Sharieat in Arabic, is a long river in the Middle East that flows from north to south through the Sea of Galilee to the Dead Sea. The Jordan River is bordered by the Golan...The Jordan River, also referred to as Nahr Al Sharieat in Arabic, is a long river in the Middle East that flows from north to south through the Sea of Galilee to the Dead Sea. The Jordan River is bordered by the Golan Heights and the Hashemite Kingdom of Jordan in the east and by Israel and the Palestinian West Bank (Judea and Samaria) in the west. Soil tunnels, including those in the Jordan River watershed and on the Israel, Syria, and Lebanon borders, have a long history of use for warfare, as invasion pathways, smuggling, and storage of rockets, missiles and ordnance and are causes of serious political tension between the countries. Soil tunnel construction and destruction often has adverse environmental and human health impacts in the Jordan River landscape. Due to agricultural wastes, the discharge of untreated sewage, and diversion of saline springs into the river water there has been serious deterioration in the water quality in the lower courses of the Jordan River. The primary objective of this research is to encourage the development of a multi-country clean-up, mitigation, and protection plan for the Jordan River.展开更多
基金financially supported by the Sichuan Science and Technology Program(Grant No.2023NSFSC1980)。
文摘An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.
基金supported by the CAS Project of Young Scientists in Basic Research(YSBR-058)the National Natural Science Foundation of China(22279135)+2 种基金the Outstanding Youth Foundation of Liaoning Province(2023JH3/10200019)the Dalian Science and Technology Innovation Fund(2023JJ11CG004)the Energy Revolution S&T Program of Yulin Innovation Institute of Clean Energy(YIICE E411010316)。
文摘Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal batteries.However,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead Li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling life.To clarify the underlying mechanism,herein,the evolution of SEI and dead Li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical LiPF6-based polymer electrolyte.The results show that the initial capacity loss is attributed to the formation of SEI,while the dead Li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−1.To reduce the active Li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of Li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead Li generation by 2.3 and 20.1 folds,respectively.As a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in Li-Cu cells,which guides the rational design of high-performance AF-SSLBs.
基金Project supported by Natural Science Foundation of Jiangsu Province(Grant Nos.BE2022071 and BK20192001)the National Natural Science Foundation of China(Grant Nos.12074194,62101285,62471248,and 12104240)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX220954).
文摘In principle,the asynchronous measurement-device-independent quantum key distribution(AMDI-QKD)can surpass the key rate capacity without phase tracking and phase locking.However,practical imperfections in sources or detections would dramatically depress its performance.Here,we present an improved model on AMDI-QKD to reduce the influence of these imperfections,including intensity fluctuation,the afterpulse effect,and the dead time of detectors.Furthermore,we carry out corresponding numerical simulations.Simulation results show that,by implementing our present work,it can have more than 100 km longer secure transmission distance and one order of magnitude enhancement in the key generation rate after 320 km compared with the standard method.Moreover,our model can still break the Pirandola–Laurenza–Ottaviani–Banchi(PLOB)bound even under realistic experimental conditions.
文摘The aim of this study is to evaluate the uncertainty of 2πα and 2πβ surface emission rates using the windowless multiwire proportional counter method.This study used the Monte Carlo method (MCM) to validate the conventional Guide to the Expression of Uncertainty in Measurement (GUM) method.A dead time measurement model for the two-source method was established based on the characteristics of a single-channel measurement system,and the voltage threshold correction factor measurement function was indirectly obtained by fitting the threshold correction curve.The uncertainty in the surface emission rate was calculated using the GUM method and the law of propagation of uncertainty.The MCM provided clear definitions for each input quantity and its uncertainty distribution,and the simulation training was realized with a complete and complex mathematical model.The results of the surface emission rate uncertainty evaluation for four radioactive plane sources using both methods showed the uncertainty’s consistency E_(n)<0.070 for the comparison of each source,and the uncertainty results of the GUM were all lower than those of the MCM.However,the MCM has a more objective evaluation process and can serve as a validation tool for GUM results.
基金the European Structural and Investment Funded Grant"Cardio Metabolic"(#KK.01.2.1.02.0321)the Croatian National Centre of Research Excellence in Personalized Healthcare Grant(#KK.01.1.1.01.0010)+2 种基金the European Regional Development Fund Grant,project"CRISPR/Cas9-CasMouse"(#KK.01.1.1.04.0085)the European Structural and Investment Funded Project of Centre of Competence in Molecular Diagnostics(#KK.01.2.2.03.0006)the Croatian National Centre of Research Excellence in Personalized Healthcare Grant(#KK.01.1.1.01.0010).
文摘Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulatory transcriptional loop.The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes.Our in silico analysis of HNF1A,HNF4A.and FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrich-ment of these transcription factors specifically in the liver.Our previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma glycoproteins.Here,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype.We used the state-of-the-art clus-tered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9)molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell line.The results show that the downregulation of all three genes individually and in pairs affects the transcrip-tional activity of many glyco-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures.The effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantennary glycans.We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure.We also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.
文摘This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.
文摘Research Background: The marketing of cosmetic products derived from Dead Sea (DS) mud has undergone significant evolution, transforming from simple souvenirs into a large-scale cosmetic industry offering a diverse array of products. DS mud is utilized both as pure mud for home spa treatments and as an active ingredient in cosmetic and cosmeceutical formulations. Its global appeal is largely due to its natural, health-oriented image, which aligns with consumer preferences and provides assurance regarding its use in skincare. Research Objectives: This review examines the published data related to the rationale for formulating DS mud in cosmetics, the biological and cosmetic effects of DS mud on the skin, and the speculated bio-mechanisms underlying these effects. Methods: We screened relevant literature on DS mud collected from the shores of the Dead Sea in Jordan and Israel. Publications on mineral muds excavated in different locations around the globe, as well as studies on the biological mechanisms of other DS minerals, were also reviewed as indications and supportive recommendations. Summarizing the vast collected data into a comprehensive review was undertaken to expose readers to the various aspects of DS mud in cosmetics. Results: The primary reason for formulating DS mud in skincare products is its deep cleansing and skin detoxification properties. Consequently, it is often incorporated into rinse-off masks, soaps, and scrubbing products. Additionally, DS mud is used in leave-on products and sheet masks. Cosmeceutical applications of DS mud, recommended for various skin conditions, offer complementary treatments to improve the quality of life for people with skin diseases. The physicochemical and biological effects of DS mud are driven by its rich mineral ion composition, including magnesium, calcium, sodium, potassium, zinc, and strontium—elements known to improve skin barrier function, enhance hydration, and reduce inflammation. The high salt concentration induces moderate ionic osmotic stress, stimulating cellular growth and hydration pathways. Moreover, DS mud’s anti-microbial properties further contribute to its therapeutic potential. Ongoing innovations in formulation techniques continue to expand the applications of DS mud, including blending it with other active ingredients, developing novel application methods, and refining manufacturing processes to improve product quality and efficacy. Conclusions: DS mud remains a valuable ingredient in modern skincare due to its rich mineral content and therapeutic properties. Ongoing research and technological advancements promise further innovations, reinforcing its status as a natural and effective component in the global cosmetics industry.
文摘Dominant Finnish assortment pricing gives prices for sawlog and pulp wood volumes. Buyers buck stems to sawlogs using secret price matrices. Agreed dimensions allow wide range of sawlog volumes. Forest owners cannot objectively compare biddings: timber trade is a lottery game. Bucking is analyzed in terms of sawlog, pulp wood, log cylinder, sawn wood, value-weighted sawn wood, and chips. Sawn wood and its value are computed from top diameter of the sawlog. Profit maximization requires buyers to buck logs producing smaller than maximal value, causing dead weight loss. Nominal assortment prices have unpredictable relation to effective stumpage price. Assortment pricing does not meet requirements of market economy. If sawmills linked to pulp mills buck smaller sawlog percentages than independent sawmills, as generally believed, they use higher price for chips in their own harvests than they pay for independent sawmills, indicating imperfect competition for chips. Sawn wood potential pricing is suggested which gives prices for sawn wood and chips coming both from sawlogs and pulp wood in reference bucking which maximizes sawn wood for given minimum and maximum log length and minimum top diameter. Simple algorithm generates feasible bucking schedules from which optimum can be selected using any objective. Pricing produces unit price for all commercial wood utilizing ratio of theoretical sawn wood and commercial volume in stand. Unit price can be compared to stem pricing and could be compared to assortment pricing if assortment pricing would produce predictable sawlog percentages. Sawn wood potential pricing is concrete, transparent, easy to compute, considers stem size and tapering, reduces trading cost and is less risky to buyers than stem pricing. It meets requirements of market economy. Readers can repeat computations using open-source software Jlp22.
文摘The Jordan River, also referred to as Nahr Al Sharieat in Arabic, is a long river in the Middle East that flows from north to south through the Sea of Galilee to the Dead Sea. The Jordan River is bordered by the Golan Heights and the Hashemite Kingdom of Jordan in the east and by Israel and the Palestinian West Bank (Judea and Samaria) in the west. Soil tunnels, including those in the Jordan River watershed and on the Israel, Syria, and Lebanon borders, have a long history of use for warfare, as invasion pathways, smuggling, and storage of rockets, missiles and ordnance and are causes of serious political tension between the countries. Soil tunnel construction and destruction often has adverse environmental and human health impacts in the Jordan River landscape. Due to agricultural wastes, the discharge of untreated sewage, and diversion of saline springs into the river water there has been serious deterioration in the water quality in the lower courses of the Jordan River. The primary objective of this research is to encourage the development of a multi-country clean-up, mitigation, and protection plan for the Jordan River.
