Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-di...Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration.展开更多
Jinping I hydropower station is one of the most challenging projects in China due to its highest arch dam and complex geological conditions for construction.After geological investigation into the dam foundation,a few...Jinping I hydropower station is one of the most challenging projects in China due to its highest arch dam and complex geological conditions for construction.After geological investigation into the dam foundation,a few large-scale weak discontinuities are observed.The rock masses in the left dam foundation are intensively unloaded,approximately to the depth of 150–300 m.These serious geological defects lead to a geological asymmetry on the left and right banks,and thus some major diffculties of dam construction are encountered.In this paper,the influences of geological defects on the project are analyzed,followed by the concepts and methods of treatment design.Based on the analysis,the treatment methods of the weak rock masses and discontinuities are carefully determined,including the concrete cushion,concrete replacement grids,and consolidation grouting.They work together to enhance the strength and integrity of the dam foundation.Evaluations and calibrations through geo-mechanical model tests in combination with feld monitoring results in early impoundment period show that the arch dam and its foundation are roughly stable,suggesting that the treatment designs are reasonable and effective.The proposed treatment methods and concepts in the context can be helpful for similar complex rock projects.展开更多
A direct strategy for the creation of defects on carbon nanofibers (CNFs) has been developed by steam treatment.Nitrogen physisorption,XRD,Raman spectra,SEM and TEM analyses proved the existence of the new defects on ...A direct strategy for the creation of defects on carbon nanofibers (CNFs) has been developed by steam treatment.Nitrogen physisorption,XRD,Raman spectra,SEM and TEM analyses proved the existence of the new defects on CNFs.BET surface area of CNFs after steam treatment was enhanced from 20 to 378 m2/g.Pd catalysts supported on CNFs were also prepared by colloidal deposition method.The different activity of Pd/CNFs catalysts in the partial hydrogenation of phenylacetylene further demonstrated the diverse surfaces of CNFs could be formed by steam treatment.展开更多
In the present paper, 32 cases of cutaneous defect were treated by using warm moxibustion. After 6 weeks’ treatment, 22 cases were cured, with the shortest cure duration being 12 days and the longest being 27 days; 6...In the present paper, 32 cases of cutaneous defect were treated by using warm moxibustion. After 6 weeks’ treatment, 22 cases were cured, with the shortest cure duration being 12 days and the longest being 27 days; 6 cases were markedly effective and 4 cases were effective. Of the 28 cases in the control group who were treated with routine medicated dressing, 6 were cured, 13 had marked improvement and 9 had improvement, with the shortest cure duration being 18 days and the longest being 36 days. Statistical analysis shows a significant difference between the two groups in the effective rate, indicating that moxibustion therapy is of an advantage in the duration of treatment and therapeutic effect.展开更多
Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdomina...Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdominal wall defect after malignant tumors resection(10 × 10 cm-32 cm×32 cm) were reviewed. The defectcontributed:Ⅰ region, 2 cases; twin-Ⅱ region, 2; Ⅲ region, 2; Ⅰ and Ⅱ region of one side, 1 and total abdominal wall,one case, The tissue flaps of transposition included: gracilis myocutaneous flaps, 4; retus abdominal myocutaneous flaps, 2; external abdominal obligue musculo-fascia flaps, 2; latissimus dorsi muscle, tensor fasciae latae muscle and retus femoris muscle flaps each, 1. One patient used MycroMesh also. Results In the course of peroperation, the incisions of 8 cases healed in first time; total tissue flaps survived and all pateints started exercise left the bed in 3 weeks. All 8 patients were followed up average of 2 years and 5 months: the success rate of reconstruction展开更多
Objective To investigate the clinical characteristics and therapeutic of head trauma patients with skull defect. Methods A retrospective study of clinical data of 47 brain injury patients with skull defect in our hosp...Objective To investigate the clinical characteristics and therapeutic of head trauma patients with skull defect. Methods A retrospective study of clinical data of 47 brain injury patients with skull defect in our hospital from Janary 1993 to Janary 2009 was performed. Results Compared with展开更多
基金the grant from the Ministry of Science and Technology of the People’s Republic of China(grant number 2016YFB1101501)Beijing Municipal Science&Technology Commission(Project Z181100001718195)。
文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration.
文摘Jinping I hydropower station is one of the most challenging projects in China due to its highest arch dam and complex geological conditions for construction.After geological investigation into the dam foundation,a few large-scale weak discontinuities are observed.The rock masses in the left dam foundation are intensively unloaded,approximately to the depth of 150–300 m.These serious geological defects lead to a geological asymmetry on the left and right banks,and thus some major diffculties of dam construction are encountered.In this paper,the influences of geological defects on the project are analyzed,followed by the concepts and methods of treatment design.Based on the analysis,the treatment methods of the weak rock masses and discontinuities are carefully determined,including the concrete cushion,concrete replacement grids,and consolidation grouting.They work together to enhance the strength and integrity of the dam foundation.Evaluations and calibrations through geo-mechanical model tests in combination with feld monitoring results in early impoundment period show that the arch dam and its foundation are roughly stable,suggesting that the treatment designs are reasonable and effective.The proposed treatment methods and concepts in the context can be helpful for similar complex rock projects.
基金supported by the National Natural Science Foundation of China(21073023 and 20906008)the Fundamental Research Funds for the Central Universities(DUT12YQ03)the CSC and DAAD for a Project Based Personnel Exchange Program
文摘A direct strategy for the creation of defects on carbon nanofibers (CNFs) has been developed by steam treatment.Nitrogen physisorption,XRD,Raman spectra,SEM and TEM analyses proved the existence of the new defects on CNFs.BET surface area of CNFs after steam treatment was enhanced from 20 to 378 m2/g.Pd catalysts supported on CNFs were also prepared by colloidal deposition method.The different activity of Pd/CNFs catalysts in the partial hydrogenation of phenylacetylene further demonstrated the diverse surfaces of CNFs could be formed by steam treatment.
文摘In the present paper, 32 cases of cutaneous defect were treated by using warm moxibustion. After 6 weeks’ treatment, 22 cases were cured, with the shortest cure duration being 12 days and the longest being 27 days; 6 cases were markedly effective and 4 cases were effective. Of the 28 cases in the control group who were treated with routine medicated dressing, 6 were cured, 13 had marked improvement and 9 had improvement, with the shortest cure duration being 18 days and the longest being 36 days. Statistical analysis shows a significant difference between the two groups in the effective rate, indicating that moxibustion therapy is of an advantage in the duration of treatment and therapeutic effect.
文摘Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdominal wall defect after malignant tumors resection(10 × 10 cm-32 cm×32 cm) were reviewed. The defectcontributed:Ⅰ region, 2 cases; twin-Ⅱ region, 2; Ⅲ region, 2; Ⅰ and Ⅱ region of one side, 1 and total abdominal wall,one case, The tissue flaps of transposition included: gracilis myocutaneous flaps, 4; retus abdominal myocutaneous flaps, 2; external abdominal obligue musculo-fascia flaps, 2; latissimus dorsi muscle, tensor fasciae latae muscle and retus femoris muscle flaps each, 1. One patient used MycroMesh also. Results In the course of peroperation, the incisions of 8 cases healed in first time; total tissue flaps survived and all pateints started exercise left the bed in 3 weeks. All 8 patients were followed up average of 2 years and 5 months: the success rate of reconstruction
文摘Objective To investigate the clinical characteristics and therapeutic of head trauma patients with skull defect. Methods A retrospective study of clinical data of 47 brain injury patients with skull defect in our hospital from Janary 1993 to Janary 2009 was performed. Results Compared with
