At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical comp...At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical company Trautec started pre-listing counseling.The first new raw material in the new year was registered.While on the other hand,the packaging material company Yiside declared bankruptcy.The beauty brand MAOGEPING failed to go public through an IPO again,after eight years’failure.Jinfa Labi,Watsons and Zhonghao Biology were all mired in recession.Hope and challenge hung over the first half month of 2024.With such a“magical”start,2024 will be definitely a year full of uncertainty.展开更多
Objective:Definitive chemoradiotherapy(dCRT)is the standard treatment for unresectable locally advanced esophageal cancer.However,this treatment is associated with substantial toxicity,and most malnourished or elderly...Objective:Definitive chemoradiotherapy(dCRT)is the standard treatment for unresectable locally advanced esophageal cancer.However,this treatment is associated with substantial toxicity,and most malnourished or elderly patients are unable to complete this therapy.Therefore,there is a need for a more suitable radiotherapy combination regimen for this population.This study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002)score.Methods:Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were enrolled.They were treated with S-1 and nimotuzumab with concurrent radiotherapy,followed by surgery or definitive radiotherapy.The primary endpoint was the locoregional control(LRC)rate.Results:A total of 55 patients who met the study criteria were enrolled.After completion of treatment,surgery was performed in 15 patients and radiotherapy was continued in 40 patients.The median follow-up period was 33.3[95%confidence interval(95%CI,31.4−35.1)]months.The LRC rate was 77.2%(95%CI,66.6%−89.4%)at 1 year in the entire population.The overall survival(OS)rate and event-free survival(EFS)rate were 57.5%and 51.5%at 3 years,respectively.Surgery was associated with better LRC[hazard ratio(HR)=0.16;95%CI,0.04−0.70;P=0.015],OS(HR=0.19;95%CI,0.04−0.80;P=0.024),and EFS(HR=0.25;95%CI,0.08−0.75;P=0.013).Most adverse events were of grade 1 or 2,and no severe adverse events occurred.Conclusions:For malnourished or elderly patients with locally advanced esophageal cancer,radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.展开更多
BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the compa...BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.展开更多
If one was to name the programmes that have been pushing development of the countries around the world for common prosperity in the past decade,the Belt and Road Initiative(BRI)would definitely be one of them.Also kno...If one was to name the programmes that have been pushing development of the countries around the world for common prosperity in the past decade,the Belt and Road Initiative(BRI)would definitely be one of them.Also known as the Silk Road Economic Belt and the 21st Century Maritime Silk Road.展开更多
为减轻人工审查MBD(model based definition)模型尺寸标注的劳动强度,对三维尺寸完备性的自动化审查进行了研究。将尺寸完备性问题归结为对相关几何要素是否定形定位的判断问题,建立了对应约束模型记录约束状态;建立了解析尺寸约束和拓...为减轻人工审查MBD(model based definition)模型尺寸标注的劳动强度,对三维尺寸完备性的自动化审查进行了研究。将尺寸完备性问题归结为对相关几何要素是否定形定位的判断问题,建立了对应约束模型记录约束状态;建立了解析尺寸约束和拓扑约束的约束传播规则,并总结了几何约束的解析算法;针对尺寸缺失造成的约束不足,采用打分策略,并以指定基准或指出尺寸缺失的方式主动添加约束;提出了三维尺寸完备性检查的总体算法。通过对3DDFM原型系统的继续开发,并用三维模型实例验证了方法的有效性。展开更多
BACKGROUND Brain arteriovenous malformations(bAVMs)remains one of the most prevalent causes of intracranial hemorrhage and stroke-like syndromes in the young adult population.Although it has been agreed upon that defi...BACKGROUND Brain arteriovenous malformations(bAVMs)remains one of the most prevalent causes of intracranial hemorrhage and stroke-like syndromes in the young adult population.Although it has been agreed upon that definitive treatment using either single or multi-modal approach is warranted for successful bAVM management,much debate still revolves regarding the optimal timing of definitive treatment.CASE SUMMARY In this report,we present a case of delayed,definitive endovascular treatment for ruptured bAVM in a 21-year-old female,3 mo post-ictus.The bAVM,with a left pericallosal feeding artery and cortical draining veins,was successfully obliterated through embolization using the Onyx 18.On follow-up the patient has recommenced her daily activities and experiences only mild occasional headaches with mild motor deficits.The report leads to our review on an important issue regarding the optimal timing of ruptured bAVM definitive management and bring forward the current evidence available on delayed vs immediate definitive bAVM intervention.We also highlight current issues that need to be addressed for clearer guidelines on definitive therapy initiation.CONCLUSION Current treatment paradigms of ruptured bAVM remains elusive,with substantial heterogeneity in the current literature.A consensus on the definition of“acute”vs“delayed”,management goal,follow-up length and outcome parameters are required to support formation of a clear paradigm.展开更多
Recently,some authors(Shen and Shi,2016)studied the generalized shiftsplitting(GSS)iteration method for singular saddle point problem with nonsymmetric positive definite(1,1)-block and symmetric positive semidefinite(...Recently,some authors(Shen and Shi,2016)studied the generalized shiftsplitting(GSS)iteration method for singular saddle point problem with nonsymmetric positive definite(1,1)-block and symmetric positive semidefinite(2,2)-block.In this paper,we further apply the GSS iteration method to solve singular saddle point problem with nonsymmetric positive semidefinite(1,1)-block and symmetric positive semidefinite(2,2)-block,prove the semi-convergence of the GSS iteration method and analyze the spectral properties of the corresponding preconditioned matrix.Numerical experiment is given to indicate that the GSS iteration method with appropriate iteration parameters is effective and competitive for practical use.展开更多
The Centers for Disease Control and Prevention(CDC)is monitoring an epidemic of monkeypox infection in the United States.The outbreak is now global and more than 6900 cases have already been reported.There are 83 conf...The Centers for Disease Control and Prevention(CDC)is monitoring an epidemic of monkeypox infection in the United States.The outbreak is now global and more than 6900 cases have already been reported.There are 83 confirmed cases among children and adolescents,as shown in the report published on November 3,2022,in the USA.However,monkeypox in pediatric patients is still infrequent(<0.3%of total cases).Among cases in the United States,16 cases were in children<5 years,12 in the age group 5-12 years,and 55 cases in adolescents 13-17 years old.In the adolescent age group,89%were male.For children<12 years of age,close physical contact with an adult household with monkeypox was the primary exposure,but for adolescents,male-to-male sexual contact was found more frequently.The CDC advised United States healthcare providers to remain vigilant for patients with a rash resembling monkeypox,even if there is no history of travel to a country with high risk.This article summarizes the history and epidemiology of monkeypox with a specific emphasis on clinical features and management in pediatric patients.展开更多
This paper discusses the necessary and sufficient conditions for the existence of Hermite positive definite solutions of the quaternion matrix equation X<sup>m</sup>+ B*XB = C (m > 0) and its iterative ...This paper discusses the necessary and sufficient conditions for the existence of Hermite positive definite solutions of the quaternion matrix equation X<sup>m</sup>+ B*XB = C (m > 0) and its iterative solution method. According to the characteristics of the coefficient matrix, a corresponding algebraic equation system is ingeniously constructed, and by discussing the equation system’s solvability, the matrix equation’s existence interval is obtained. Based on the characteristics of the coefficient matrix, some necessary and sufficient conditions for the existence of Hermitian positive definite solutions of the matrix equation are derived. Then, the upper and lower bounds of the positive actual solutions are estimated by using matrix inequalities. Four iteration formats are constructed according to the given conditions and existence intervals, and their convergence is proven. The selection method for the initial matrix is also provided. Finally, using the complexification operator of quaternion matrices, an equivalent iteration on the complex field is established to solve the equation in the Matlab environment. Two numerical examples are used to test the effectiveness and feasibility of the given method. .展开更多
SPEM(software process engineering metamodel)是国际标准化组织制定的标准元模型,正日益成为软件过程建模领域的行业标准,但在过程执行方面,SPEM还存在不足.将软件过程看作是一种特殊的工作流,提出了一种应用工作流运行机制支持软件...SPEM(software process engineering metamodel)是国际标准化组织制定的标准元模型,正日益成为软件过程建模领域的行业标准,但在过程执行方面,SPEM还存在不足.将软件过程看作是一种特殊的工作流,提出了一种应用工作流运行机制支持软件过程执行的方法.通过将SPEM模型转换为XPDL(XML process definition language)模型,利用XPDL引擎支持SPEM模型的执行.制定了SPEM和XPDL之间的映射规则,设计了转换算法并开发了转换引擎.该方法被应用在SoftPM项目中,成功地基于XPDL引擎Shark实现了对软件过程模型的执行支持.展开更多
文摘At the beginning of 2024,the cosmetic industry is bustling with prosperity and depression.On one hand,the perfume brand DOCUMENTS and the biotechnology company BIO-REGEN received financial investments.The medical company Trautec started pre-listing counseling.The first new raw material in the new year was registered.While on the other hand,the packaging material company Yiside declared bankruptcy.The beauty brand MAOGEPING failed to go public through an IPO again,after eight years’failure.Jinfa Labi,Watsons and Zhonghao Biology were all mired in recession.Hope and challenge hung over the first half month of 2024.With such a“magical”start,2024 will be definitely a year full of uncertainty.
基金supported by grants from Beijing Xisike Clinical Oncology Research Foundation(No.YYoung2023-0114).
文摘Objective:Definitive chemoradiotherapy(dCRT)is the standard treatment for unresectable locally advanced esophageal cancer.However,this treatment is associated with substantial toxicity,and most malnourished or elderly patients are unable to complete this therapy.Therefore,there is a need for a more suitable radiotherapy combination regimen for this population.This study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002)score.Methods:Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were enrolled.They were treated with S-1 and nimotuzumab with concurrent radiotherapy,followed by surgery or definitive radiotherapy.The primary endpoint was the locoregional control(LRC)rate.Results:A total of 55 patients who met the study criteria were enrolled.After completion of treatment,surgery was performed in 15 patients and radiotherapy was continued in 40 patients.The median follow-up period was 33.3[95%confidence interval(95%CI,31.4−35.1)]months.The LRC rate was 77.2%(95%CI,66.6%−89.4%)at 1 year in the entire population.The overall survival(OS)rate and event-free survival(EFS)rate were 57.5%and 51.5%at 3 years,respectively.Surgery was associated with better LRC[hazard ratio(HR)=0.16;95%CI,0.04−0.70;P=0.015],OS(HR=0.19;95%CI,0.04−0.80;P=0.024),and EFS(HR=0.25;95%CI,0.08−0.75;P=0.013).Most adverse events were of grade 1 or 2,and no severe adverse events occurred.Conclusions:For malnourished or elderly patients with locally advanced esophageal cancer,radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.
基金Supported by the Guangdong Esophageal Cancer Institute Science and Technology Program,No.M202013Guangdong Medical Research Foundation,No.A2021369.
文摘BACKGROUND Endoscopic submucosal dissection(ESD)and surgical resection are the standard of care for cT1N0M0 esophageal cancer(EC),whereas definitive chemoradiotherapy(d-CRT)is a treatment option.Nevertheless,the comparative efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC remain unclear.AIM To compare the efficiency and safety of ESD,surgery and d-CRT for cT1N0M0 EC.METHODS We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th,2022.We analyzed demographic,medical recorded,histopathologic characteristics,imaging and endoscopic,and follow-up data.The Kaplan-Meier method and Cox proportional hazards modeling were used to analyze the difference of survival outcome by treatments.Inverse probability of treatment weighting(IPTW)was used to minimize potential confounding factors.RESULTS We retrospectively analyzed patients who underwent ESD(n=99)or surgery(n=220)or d-CRT(n=16)at the Sun Yat-sen University Cancer Center from 2017 to 2019.The median follow-up time for the ESD group,the surgery group,and the d-CRT group was 42.0 mo(95%CI:35.0-60.2),45.0 mo(95%CI:34.0-61.75)and 32.5 mo(95%CI:28.3-40.0),respectively.After adjusting for background factors using IPTW,the highest 3-year overall survival(OS)rate and 3-year recurrence-free survival(RFS)rate were observed in the ESD group(3-year OS:99.7% and 94.7% and 79.1%;and 3-year RFS:98.3%,87.4% and 79.1%,in the ESD,surgical,and d-CRT groups,respectively).There was no difference of severe complications occurring between the three groups(P≥0.05).Multivariate analysis showed that treatment method,histology and depth of infiltration were independently associated with OS and RFS.CONCLUSION For cT1N0M0 EC,ESD had better long-term survival and lower hospitalization costs than those who underwent d-CRT and surgery,with a similar rate of severe complications occurring.
文摘If one was to name the programmes that have been pushing development of the countries around the world for common prosperity in the past decade,the Belt and Road Initiative(BRI)would definitely be one of them.Also known as the Silk Road Economic Belt and the 21st Century Maritime Silk Road.
文摘为减轻人工审查MBD(model based definition)模型尺寸标注的劳动强度,对三维尺寸完备性的自动化审查进行了研究。将尺寸完备性问题归结为对相关几何要素是否定形定位的判断问题,建立了对应约束模型记录约束状态;建立了解析尺寸约束和拓扑约束的约束传播规则,并总结了几何约束的解析算法;针对尺寸缺失造成的约束不足,采用打分策略,并以指定基准或指出尺寸缺失的方式主动添加约束;提出了三维尺寸完备性检查的总体算法。通过对3DDFM原型系统的继续开发,并用三维模型实例验证了方法的有效性。
文摘BACKGROUND Brain arteriovenous malformations(bAVMs)remains one of the most prevalent causes of intracranial hemorrhage and stroke-like syndromes in the young adult population.Although it has been agreed upon that definitive treatment using either single or multi-modal approach is warranted for successful bAVM management,much debate still revolves regarding the optimal timing of definitive treatment.CASE SUMMARY In this report,we present a case of delayed,definitive endovascular treatment for ruptured bAVM in a 21-year-old female,3 mo post-ictus.The bAVM,with a left pericallosal feeding artery and cortical draining veins,was successfully obliterated through embolization using the Onyx 18.On follow-up the patient has recommenced her daily activities and experiences only mild occasional headaches with mild motor deficits.The report leads to our review on an important issue regarding the optimal timing of ruptured bAVM definitive management and bring forward the current evidence available on delayed vs immediate definitive bAVM intervention.We also highlight current issues that need to be addressed for clearer guidelines on definitive therapy initiation.CONCLUSION Current treatment paradigms of ruptured bAVM remains elusive,with substantial heterogeneity in the current literature.A consensus on the definition of“acute”vs“delayed”,management goal,follow-up length and outcome parameters are required to support formation of a clear paradigm.
基金Supported by Guangxi Science and Technology Department Specific Research Project of Guangxi for Research Bases and Talents(Grant No.GHIKE-AD23023001)Natural Science Foundation of Guangxi Minzu University(Grant No.2021KJQD01)Xiangsi Lake Young Scholars Innovation Team of Guangxi University for Nationalities(Grant No.2021RSCXSHQN05)。
文摘Recently,some authors(Shen and Shi,2016)studied the generalized shiftsplitting(GSS)iteration method for singular saddle point problem with nonsymmetric positive definite(1,1)-block and symmetric positive semidefinite(2,2)-block.In this paper,we further apply the GSS iteration method to solve singular saddle point problem with nonsymmetric positive semidefinite(1,1)-block and symmetric positive semidefinite(2,2)-block,prove the semi-convergence of the GSS iteration method and analyze the spectral properties of the corresponding preconditioned matrix.Numerical experiment is given to indicate that the GSS iteration method with appropriate iteration parameters is effective and competitive for practical use.
文摘The Centers for Disease Control and Prevention(CDC)is monitoring an epidemic of monkeypox infection in the United States.The outbreak is now global and more than 6900 cases have already been reported.There are 83 confirmed cases among children and adolescents,as shown in the report published on November 3,2022,in the USA.However,monkeypox in pediatric patients is still infrequent(<0.3%of total cases).Among cases in the United States,16 cases were in children<5 years,12 in the age group 5-12 years,and 55 cases in adolescents 13-17 years old.In the adolescent age group,89%were male.For children<12 years of age,close physical contact with an adult household with monkeypox was the primary exposure,but for adolescents,male-to-male sexual contact was found more frequently.The CDC advised United States healthcare providers to remain vigilant for patients with a rash resembling monkeypox,even if there is no history of travel to a country with high risk.This article summarizes the history and epidemiology of monkeypox with a specific emphasis on clinical features and management in pediatric patients.
文摘This paper discusses the necessary and sufficient conditions for the existence of Hermite positive definite solutions of the quaternion matrix equation X<sup>m</sup>+ B*XB = C (m > 0) and its iterative solution method. According to the characteristics of the coefficient matrix, a corresponding algebraic equation system is ingeniously constructed, and by discussing the equation system’s solvability, the matrix equation’s existence interval is obtained. Based on the characteristics of the coefficient matrix, some necessary and sufficient conditions for the existence of Hermitian positive definite solutions of the matrix equation are derived. Then, the upper and lower bounds of the positive actual solutions are estimated by using matrix inequalities. Four iteration formats are constructed according to the given conditions and existence intervals, and their convergence is proven. The selection method for the initial matrix is also provided. Finally, using the complexification operator of quaternion matrices, an equivalent iteration on the complex field is established to solve the equation in the Matlab environment. Two numerical examples are used to test the effectiveness and feasibility of the given method. .
基金Supported by the National Natural Science Foundation of China under Grant No.60273026(国家自然科学基金)the National High-Tech Research and Development Plan of China under Grant No.2002AA116060(国家高技术研究发展计划(863))
文摘SPEM(software process engineering metamodel)是国际标准化组织制定的标准元模型,正日益成为软件过程建模领域的行业标准,但在过程执行方面,SPEM还存在不足.将软件过程看作是一种特殊的工作流,提出了一种应用工作流运行机制支持软件过程执行的方法.通过将SPEM模型转换为XPDL(XML process definition language)模型,利用XPDL引擎支持SPEM模型的执行.制定了SPEM和XPDL之间的映射规则,设计了转换算法并开发了转换引擎.该方法被应用在SoftPM项目中,成功地基于XPDL引擎Shark实现了对软件过程模型的执行支持.
