A Study on the Multi-Compartment Linear Circulation Pharmacokinetic Model for the Targeting Drug Delivery System

By analyzing the observed phenomena and the data collected in the study, a multi-compartment linear circulation model for targeting drug delivery system was developed and the function formulas of the drug concentration-time in blood and target organ by computing were figured out. The drug concentration-time curve for target organ can be plotted with reference to the data of drug concentration in blood according to the model. The pharmacokinetic parameters of the drug in target organ could also be obtained. The practicability of the model was further checked by the curves of drug concentration-time in blood and target organ(liver) of liver-targeting nanoparticles in animal tests. Based on the liver drug concentration-time curves calculated by the function formula of the drug in target organ, the pharmacokinetic behavior of the drug in target organ(liver) was analyzed by statistical moment, and its pharmacokinetic parameters in liver were obtained. It is suggested that the (relative targeting index( can be used for quantitative evaluation of the targeting drug delivery systems.

A 3-D in vitro tumor model for investigation of bacteria-mediated gene delivery

Introduction Cancer is an attractive target of gene therapy and currently represents the disease in most clinical trials[1]. Strategies for cancer gene therapy include: (1) stimulation of immune responses to tumor cells,(2) delivery of specific enzymes

Modeling of Raw Materials Management on the Example of Textile Production Company

The aim of this paper is to propose a discussion about inventory control and to present a new method for testing the control process in terms of uncertainty. The subject matter is modelling for optimal control that ultimately provides the basic parameters for the level of safety stock and the cycle of deliveries. An optimisation criterion is a function minimising the total costs of storage and production coming to a halt because of depleted stock of inputs. Considering the results of the study, it is found that appropriate management process of textile companies requires determining raw materials stocks and its costs very precisely. The stream management process in the enterprise includes an element of fluctuations in demand. This is the source of ＂a conflict＂ that appears in two sub-systems： storage and production. At the same time, a systemic approach to the optimal coordination of supply/production calls for effective management of the whole system. Implementation of modem information technologies is one of the factors that support the effective control.

Performance improvement of licklider transmission protocol in complex deep space networks based on parameter optimization

A reasonable parameter configuration helps improve the data transmission performance of the Licklider Transmission Protocol(LTP).Previous research has focused mainly on parameter optimization for LTP in simplified scenarios with one to two hops or multihop scenarios with a custody mechanism of the Bundle Protocol(BP).However,the research results are not applicable to communications in Complex Deep Space Networks(CDSNs)without the custody mechanism of BP that are more suitable for deep space communications with LTP.In this paper,we propose a model of file delivery time for LTP in CDSNs.Based on the model,we propose a Parameter Optimization Design Algorithm for LTP(LTP-PODA)of configuring reasonable parameters for LTP.The results show that the accuracy of the proposed model is at least 6.47%higher than that of the previously established models based on simple scenarios,and the proposed model is more suitable for CDSNs.Moreover,the LTP parameters are optimized by the LTP-PODA algorithm to obtain an optimization plan.Configuring the optimization plan for LTP improves the protocol transmission performance by at least 18.77%compared with configuring the other parameter configuration plans.