Macrophages have recently been characterized as having an M1 or M2 phenotype based on receptor expression, mechanism of activation and function. The effects of macrophage phenotype upon tissue remodeling following imp...Macrophages have recently been characterized as having an M1 or M2 phenotype based on receptor expression, mechanism of activation and function. The effects of macrophage phenotype upon tissue remodeling following implantation of an acellular dermal matrix (ADM) is largely unknown. The purpose of this study was to compare the macrophage phenotype and tissue remodeling elicited by four different ADMs (DermaMatrix, AlloDerm, Integra and Der mACELL). ADM samples were wrapped around the inferior epigastric vessels of a rat and were harvested on 7, 14, 21 and 42 days post implantation. Immunohistologic methods were used to identify macrophage surface markers CD68 (pan macrophage), CCR7 (M1 profile), and CD206 (M2 profile). All human derived ADMs showed a bell shaped curve for distribution of CD68+ macrophages with peaks for DermaMatrix occurring at day 14 and peak influx for AlloDerm occurring on day 21. In contrast, bovine derived Integra showed an increasing trend of macrophages with time. DermACELL had the highest influx of macro- phages while Integra had the lowest. A quantitative analysis of phenotype of macrophages in AlloDerm showed that the cells were predominantly M1 at 7, 14, 21 and 42 days post implantation. In contrast, Integra showed a mixed M1/M2 population of macrophages at all time points. The histopathologic evaluation showed that a predominantly M1 macrophage response was associated with a more inflamematory type tissue remodeling outcome in AlloDerm while a mixed M1/M2 macrophage response was associated with a more constructive tissue remodeling response seen in the other substrates.展开更多
Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal at...Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal attempts. The purpose of this study is two-fold: Firstly, to present and discuss vignettes of four young adolescents and secondly, to study the dynamics and characteristics of six derma-abusers who have attended Dual Group Therapy (DGT) concurrently with their parents for a six month period. Our findings suggest that patients involved in derma-abuse are generally non-suicidal but engage in comfort cutting for the psychological release of pain, tension reduction and anger management. There is a preponderance of females (80%) with an over-representation of mixed origin and borderline cultural states. In this small group, males amounted to 20% and were more bizarre, gruesome and brutal in their self-abuse. Of the total sample, 10% were of African origin, 60% were of Indian descent and 30% were of mixed ancestry. Psy- chodynamic factors explored in Dual Group Therapy (DGT) are the emphasis on non-suicidal intent, association with tension reduction, reclaiming power and mastery over self and others, life and death instincts, the significance of bloodletting in a socio-cultural context, trans- generational conflicts, dysfunctional family dynamics frequently with parental separation and sexual abuse and early sexual induction.展开更多
International Journal of Dermatology and Venereology是一本严格同行评审的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。目前已被Scopus、Embase、Ovid、DOAJ、中国科学引文数据库(CSCD)和中国科技核心期刊目录...International Journal of Dermatology and Venereology是一本严格同行评审的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。目前已被Scopus、Embase、Ovid、DOAJ、中国科学引文数据库(CSCD)和中国科技核心期刊目录等数据库收录,2023年Scopus全球排名进入Q3区。2023年网站累计浏览量超15万人次,其中国际读者比例超过80%。展开更多
International Journal of Dermatologyand Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤...International Journal of Dermatologyand Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。展开更多
International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮...International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。展开更多
International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮...International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。展开更多
International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮...International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。展开更多
International Journal of Dermatology and Venereology和全球五大出版商之一的荷兰威科出版集团于2018年12月24日正式签约,2019年开始由威科集团负责国际出版,通过其高端学术平台Lippincott向全球发布,全文实现开放获取,收录于Ovid数...International Journal of Dermatology and Venereology和全球五大出版商之一的荷兰威科出版集团于2018年12月24日正式签约,2019年开始由威科集团负责国际出版,通过其高端学术平台Lippincott向全球发布,全文实现开放获取,收录于Ovid数据库。展开更多
International Journal of Dermatology and Venereology是内地第一本皮肤性病学开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jfferon University的Jouni ...International Journal of Dermatology and Venereology是内地第一本皮肤性病学开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jfferon University的Jouni Litto教授担任名誉主编。展开更多
International Journal of Dermatology and Venereology是中国大陆第一本皮肤性病学方面的开放获取英文期刊,旨在搭建-个高水平的国际学术交流平台,本刊由中国医学科学院整形外科医院党委书记王宝玺教授担任主编,美国Thomas Jefferson ...International Journal of Dermatology and Venereology是中国大陆第一本皮肤性病学方面的开放获取英文期刊,旨在搭建-个高水平的国际学术交流平台,本刊由中国医学科学院整形外科医院党委书记王宝玺教授担任主编,美国Thomas Jefferson University的Jouni Uitt。展开更多
International Journal of Dermatology and Venereology是中国内地第一本皮肤性病学方面的开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jefferson Univer...International Journal of Dermatology and Venereology是中国内地第一本皮肤性病学方面的开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jefferson University的Jouni Uitto教授担任名誉主编。展开更多
文摘Macrophages have recently been characterized as having an M1 or M2 phenotype based on receptor expression, mechanism of activation and function. The effects of macrophage phenotype upon tissue remodeling following implantation of an acellular dermal matrix (ADM) is largely unknown. The purpose of this study was to compare the macrophage phenotype and tissue remodeling elicited by four different ADMs (DermaMatrix, AlloDerm, Integra and Der mACELL). ADM samples were wrapped around the inferior epigastric vessels of a rat and were harvested on 7, 14, 21 and 42 days post implantation. Immunohistologic methods were used to identify macrophage surface markers CD68 (pan macrophage), CCR7 (M1 profile), and CD206 (M2 profile). All human derived ADMs showed a bell shaped curve for distribution of CD68+ macrophages with peaks for DermaMatrix occurring at day 14 and peak influx for AlloDerm occurring on day 21. In contrast, bovine derived Integra showed an increasing trend of macrophages with time. DermACELL had the highest influx of macro- phages while Integra had the lowest. A quantitative analysis of phenotype of macrophages in AlloDerm showed that the cells were predominantly M1 at 7, 14, 21 and 42 days post implantation. In contrast, Integra showed a mixed M1/M2 population of macrophages at all time points. The histopathologic evaluation showed that a predominantly M1 macrophage response was associated with a more inflamematory type tissue remodeling outcome in AlloDerm while a mixed M1/M2 macrophage response was associated with a more constructive tissue remodeling response seen in the other substrates.
文摘Cutting or self inflicted epidermal damage (derma-abuse) describes a number of blood- letting behaviours among adolescents. Unlike suicidal behaviour, it is associated with low lethality and the absence of suicidal attempts. The purpose of this study is two-fold: Firstly, to present and discuss vignettes of four young adolescents and secondly, to study the dynamics and characteristics of six derma-abusers who have attended Dual Group Therapy (DGT) concurrently with their parents for a six month period. Our findings suggest that patients involved in derma-abuse are generally non-suicidal but engage in comfort cutting for the psychological release of pain, tension reduction and anger management. There is a preponderance of females (80%) with an over-representation of mixed origin and borderline cultural states. In this small group, males amounted to 20% and were more bizarre, gruesome and brutal in their self-abuse. Of the total sample, 10% were of African origin, 60% were of Indian descent and 30% were of mixed ancestry. Psy- chodynamic factors explored in Dual Group Therapy (DGT) are the emphasis on non-suicidal intent, association with tension reduction, reclaiming power and mastery over self and others, life and death instincts, the significance of bloodletting in a socio-cultural context, trans- generational conflicts, dysfunctional family dynamics frequently with parental separation and sexual abuse and early sexual induction.
文摘International Journal of Dermatology and Venereology是一本严格同行评审的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。目前已被Scopus、Embase、Ovid、DOAJ、中国科学引文数据库(CSCD)和中国科技核心期刊目录等数据库收录,2023年Scopus全球排名进入Q3区。2023年网站累计浏览量超15万人次,其中国际读者比例超过80%。
文摘International Journal of Dermatologyand Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。
文摘International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。
文摘International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。
文摘International Journal of Dermatology and Venereology是一本开放获取的皮肤性病学专业英文期刊,旨在搭建一个高水平的国际学术交流平台。该刊由中国医学科学院整形外科医院王宝玺教授担任主编。国际编委会由来自11个国家22位知名皮肤病学专家组成,覆盖遗传学、皮肤病理、疱病、黑色素瘤、皮肤镜等众多领域。
文摘International Journal of Dermatology and Venereology和全球五大出版商之一的荷兰威科出版集团于2018年12月24日正式签约,2019年开始由威科集团负责国际出版,通过其高端学术平台Lippincott向全球发布,全文实现开放获取,收录于Ovid数据库。
文摘International Journal of Dermatology and Venereology是内地第一本皮肤性病学开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jfferon University的Jouni Litto教授担任名誉主编。
文摘International Journal of Dermatology and Venereology是中国大陆第一本皮肤性病学方面的开放获取英文期刊,旨在搭建-个高水平的国际学术交流平台,本刊由中国医学科学院整形外科医院党委书记王宝玺教授担任主编,美国Thomas Jefferson University的Jouni Uitt。
文摘International Journal of Dermatology and Venereology是中国内地第一本皮肤性病学方面的开放获取英文期刊,旨在搭建一个高水平的国际学术交流平台。本刊由中国医学科学院整形外科医院王宝玺教授担任主编,美国Thomas Jefferson University的Jouni Uitto教授担任名誉主编。
