Dermatofibromas are benign soft tissue tumors that predominantly affect the limbs, and more rarely the chest.Keloidal dermatofibroma is a rare subtype with distinct clinicopathological features and an aggressive clini...Dermatofibromas are benign soft tissue tumors that predominantly affect the limbs, and more rarely the chest.Keloidal dermatofibroma is a rare subtype with distinct clinicopathological features and an aggressive clinical course. By researching the evolution of the disease in this study, we aimed to summarize our experience of managing a rare patient who underwent five surgeries for keloidal dermatofibroma that developed sequentially in the upper arm and chest and propose a novel treatment for keloidal dermatofibroma. We concluded that keloidal dermatofibroma involving larger areas, high tension sites, and multiple localizations can be treated using the principles of pathological scar management.展开更多
目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a ...目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a l lung tissue,NL)中p53和PCNA的蛋白表达。结果:p53及PCNA蛋白在35例PSH组织中的阳性表达率分别为45.71%(16/35)和62.86%(22/35),在8例PP组织中的阳性表达率分别为0%(0/8)和25%(2/8),而8例NL组织中均呈阴性表达。p53、PCNA在PSH组织的阳性表达率显著高于NL和PP组织(P<0.05)。结论:p53、PCNA蛋白的过表达可能与PSH发生发展有关。展开更多
文摘Dermatofibromas are benign soft tissue tumors that predominantly affect the limbs, and more rarely the chest.Keloidal dermatofibroma is a rare subtype with distinct clinicopathological features and an aggressive clinical course. By researching the evolution of the disease in this study, we aimed to summarize our experience of managing a rare patient who underwent five surgeries for keloidal dermatofibroma that developed sequentially in the upper arm and chest and propose a novel treatment for keloidal dermatofibroma. We concluded that keloidal dermatofibroma involving larger areas, high tension sites, and multiple localizations can be treated using the principles of pathological scar management.
文摘目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a l lung tissue,NL)中p53和PCNA的蛋白表达。结果:p53及PCNA蛋白在35例PSH组织中的阳性表达率分别为45.71%(16/35)和62.86%(22/35),在8例PP组织中的阳性表达率分别为0%(0/8)和25%(2/8),而8例NL组织中均呈阴性表达。p53、PCNA在PSH组织的阳性表达率显著高于NL和PP组织(P<0.05)。结论:p53、PCNA蛋白的过表达可能与PSH发生发展有关。
