On Software Application Database Constraint-driven Design and Development

This paper presents a methodology driven by database constraints for designing and developing(database)software applications.Much needed and with excellent results,this paradigm guarantees the highest possible quality of the managed data.The proposed methodology is illustrated with an easy to understand,yet complex medium-sized genealogy software application driven by more than 200 database constraints,which fully meets such expectations.

Design and Development of Composite Plywood that Integrates Fire Resistance,Water Resistance and Wear Resistance

In order to improve the fire resistance,water resistance and wear resistance of ordinary plywood products in the wood processing industry,three composite structures of plywood products S1,S2 and S3 were designed in this paper,and a reasonable production process was proposed.Through the physical and mechanical properties and fire resistance testing and technical and economic analysis,the applicability of composite plywood was evaluated.The results of the study showed that the physical mechanics of the three kinds of composite structure plywood met the standard requirements,and their fire resistance was far better than that of ordinary plywood.Among them,the S1 structural board had the best overall physical and mechanical properties.The S3 structural board showed the best fire resistance,which was about 1.9 times more than that of ordinary plywood,and the added cost was the lowest.The thin cork board added to the S2 structural board had poor fire performance since the air in the cork board cavities had a certain combustion-supporting effect,which inhibited the fire resistance of high-pressure laminate(HPL)layer.Moreover,the additional cost of the S2 board was the highest,and its comprehensive performance was the worst.The S3 structural plywood product composed of HPL fireproof board with a thickness of about 1 mm in the surface layer and ordinary plywood with a thickness of about 12 mm in the core layer was the most cost-effective product,which could meet the needs of various fields such as construction,home furnishing,decoration and transportation.

Design and Development of TGPSIS Based on SuperMap—Map Subsystem

The Three Gorges Project (TGP for short) is the key project to train and develop the Yangtze River of China,with multi-objects of flood defence,electricity generation,shipping,etc.However,sediment plays an important role in beth constructing of engineering and exerting efficiency of TGP.Special attention,there- fore,has been paid to sediment problem of TGP since the very beginning of this engineering's pregnancy.Up to now,much observed data and fruitful researches about TGP have come into being,and a sci...

Analysis of the Design and Development Path of the Cultural and Creative Derivatives of Marquis of Haihun Site

This paper firstly analyzes the culture of Marquis of Haihun site and explores the cultural and creative derivatives,followed by the value of these cultural and creative derivatives of Marquis of Haihun site and the design and development path of the cultural and creative derivatives of Marquis of Haihun site for the reference of relevant scholars.

Future of the current anticoronaviral agents: A viewpoint on thevalidation for the next COVIDs and pandemics

Despite the global decline in the severity of the coronavirus disease 2019 (COVID-19) cases, the disease stillrepresents a major concern to the relevant scientific and medical communities. The primary concern of drug scientists,virologists, and other concerned specialists in this respect is to find ready-to-use suitable and potent anticoronaviraltherapies that are broadly effective against the different species/strains of the coronaviruses in general, not only againstthe current and previous coronaviruses (e.g., the recently-appeared severe acute respiratory syndrome coronavirus 2“SARS-CoV-2”), i.e., effective antiviral agents for treatment and/or prophylaxis of any coronaviral infections, includingthose of the coming ones from the next species and strains (if any). As an expert in this field, I tried, in this up-to-dateperspective “viewpoint” article, to evaluate the suitability and applicability of using the currently-availableanticoronaviral agents for the next coronavirus diseases (COVIDs) and coronaviral pandemics, highlighting the mostimportant general guidelines that should be considered in the next pandemics from the therapeutic points of view.

Design and technology review of the solar X-ray detector onboard the Macao Science Satellite-1B

On May 21,2023,the Macao Science Satellite-1B(MSS-1B),a low-inclination,low-latitude,and high-precision scientific exploration satellite for geomagnetic fields and space environments,was successfully launched.The solar X-ray detector(SXD),one of the two major scientific payloads onboard the MSS-1B,has obtained a large amount of solar X-ray radiation data,which reveals the distribution law of the magnetic field in the low Earth orbit,as well as the coupling law of the Earth's magnetic field and the solar radiation and energy particle distributions.First,the overall design of the multi-detection-unit,broad-energy-range,small-volume,and low-power SXD was implemented to achieve the scientific objectives of the mission.Second,the technical indicators of the instrument were decomposed into various components,and the key technologies,such as collimator,processing circuit,thermal,and payload dataset designs,were reviewed.Third,the backgrounds,including electronic noise,cosmic diffuse X-ray background,and high-energy background in the Earth's radiation belts in and out of the field of view,were analyzed for the instrument.Then,the ground calibrations of the energy response,detection efficiency,and temperature-dependent peak drift of the SXD flight model were conducted.Finally,the in-orbit temperature,energy spectrum data,background,and solar flare process observation of the instrument in the in-orbit test stage are presented,verifying the instrument design,analysis,and ground calibration,providing a foundation for obtaining accurate solar X-ray radiation data,and achieving the scientific objectives of the satellite.

System for the Management of the Continuity of Use of Medical Devices in Hospitals

The Technical Services and the Medical Administration of the Hospitals of Trieste have been working for years to ensure the optimal functioning of the Surgery, Intensive Care, Diagnostics and Research Services offered to the Patients and to the University in an 800-bed hospital complex, transforming and innovating the buildings and support installations. We have dedicated special attention to the technologies necessary to guarantee the continuity of the power supply to the electromedical devices, increasingly numerous in highly specialized hospitals. We report the power of the generator sets and the UPS and our opinion that their power must be related to the overall consumption of the hospital, with a reserve margin.

An Analysis of a Writing Test in a Chinese Senior High School

This paper analyzes the design and implementation of a normal writing test in a senior high school. In line with theories of test evaluation, an effective writing test should try to meet the balance of the six usefulness, which will be discussed in this paper; thereafter, pedagogical implications will be mentioned with an emphasis on how a test affects the teachers in changing their teaching approaches and motivates the learners in achieving higher goals in their writing proficiency.

Fluorine-containing pharmaceuticals approved by the FDA in 2020:Synthesis and biological activity

Thirteen new fluorine-containing drugs,which have been granted approval by the US Food and Drug Administration(FDA)in 2020,are profiled in this review.Therapeutic areas of these new fluorinated pharmaceuticals include medicines and diagnostic agents for Cushing's disease,neurofibromatosis,migraine,Alzheimer's disease,myelodysplastic syndromes,hereditary angioedema attacks,and various cancers.Molecules of these approved drugs feature aromatic fluorine(Ar-F)(11 compounds),aromatic Ar-CF_(3)(1),aliphatic CHF(1)and CF_(2)(1)groups.For each compound,we provide a spectrum of biological activity,medicinal chemistry discovery,and synthetic approaches.

Fluorine-containing drugs approved by the FDA in 2021

Nine new fluorine-containing drugs have been approved by the US Food and Drug Administration(FDA)in 2021,which are presented in this review article.These small molecular drugs feature aromatic fluorine,trifluoromethyl and chlorodifluoro groups.The therapeutic areas of these fluorine-containing drugs include multiple myeloma,lymphoma,HIV,chronic heart failure,chronic myeloid leukemia,(ANCA)-associated vasculitis,migraines,von Hippel-Lindau disease,and non-small cell lung cancer.The brief biological activities and the synthetic methods have been discussed in this review for each of these nine drugs.

FDA approved fluorine-containing drugs in 2023

This review profiles twelve fluorine-containing drugs approved by the US Food and Drug Administration(FDA) for the clinic in 2023.These small molecule drugs represent such therapeutic areas as cancer,neuromuscular disorder,immunodeficiency,virology,and infectious diseases.Medicinal chemistry discovery,biological activity,and synthetic routes have been discussed for each drug.Also,new trends in structural positioning,functionality,and degree of fluorination are discussed.Besides fluorination,the importance of amino acid residues and chirality in the design of new pharmaceuticals is highlighted.