Mid-term outcomes of a kinematically designed cruciate retaining total knee arthroplasty

BACKGROUND Advances in implant material and design have allowed for improvements in total knee arthroplasty(TKA)outcomes.A cruciate retaining(CR)TKA provides the least constraint of TKA designs by preserving the native posterior cruciate ligament.Limited research exists that has examined clinical outcomes or patient reported outcome measures(PROMs)of a large cohort of patients undergoing a CR TKA utilizing a kinematically designed implant.It was hypothesized that the studied CR Knee System would demonstrate favorable outcomes and a clinically significant improvement in pain and functional scores.AIM To assess both short-term and mid-term clinical outcomes and PROMs of a novel CR TKA design.METHODS A retrospective,multi-surgeon study identified 255 knees undergoing a TKA utilizing a kinematically designed CR Knee System(JOURNEY™II CR;Smith and Nephew,Inc.,Memphis,TN)at an urban,academic medical institution between March 2015 and July 2021 with a minimum of two-years of clinical follow-up with an orthopedic surgeon.Patient demographics,surgical information,clinical outcomes,and PROMs data were collected via query of electronic medical records.The PROMs collected in the present study included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement(KOOS JR)and Patient-Reported Outcomes Measurement Information System(PROMIS■)scores.The significance of improvements in mean PROM scores from preoperative scores to scores collected at six months and two-years postoperatively was analyzed using Independent Samples t-tests.RESULTS Of the 255 patients,65.5%were female,43.8%were White,and patients had an average age of 60.6 years.Primary osteoarthritis(96.9%)was the most common primary diagnosis.The mean surgical time was 105.3 minutes and mean length of stay was 2.1 d with most patients discharged home(92.5%).There were 18 emergency department(ED)visits within 90 d of surgery resulting in a 90 d ED visit rate of 7.1%,including a 2.4%orthopedic-related ED visit rate and a 4.7%non-orthopedic-related ED visit rate.There were three(1.2%)hospital readmissions within 90 d postoperatively.With a mean time to latest follow-up of 3.3 years,four patients(1.6%)required revision,two for arthrofibrosis,one for aseptic femoral loosening,and one for peri-prosthetic joint infection.There were significant improvements in KOOS JR,PROMIS Pain Intensity,PROMIS Pain Interference,PROMIS Mobility,and PROMIS Physical Health from preoperative scores to six month and two-year postoperative scores.CONCLUSION The evaluated implant is an effective,novel design offering excellent outcomes and low complication rates.At a mean follow up of 3.3 years,four patients required revisions,three aseptic and one septic,resulting in an overall implant survival rate of 98.4%and an aseptic survival rate of 98.8%.The results of our study demonstrate the utility of this kinematically designed implant in the setting of primary TKA.

Three-dimensional calculation of roadway earthwork volume

To solve the inaccuracy problem caused by the two existing methods (averageend-area method and prismoidal method) used for the calculation of roadway earthwork volume, thispaper puts forward a new concept of the 3-dimensional algorithm that takes all the roadway geometricdesign procedures as a kind of geometrical operation between the ground model (original terrainmodel) and the roadway model (designed model) under certain constraints, and then presents acomplete 3-dimensional algorithm of roadway earthwork volume as well as its executable computerprogram. The algorithm benefits from the re-triangulation technique of constrained delaunaytriangulation (CDT), which can yield a true volume value theoretically. Through a number ofpractical testscovering varied intervals between adjacent cross sections, it is proven to possess ahigher accuracy compared with that of traditional methods. All the work involved in this paperindicates that the 3-dimensional calculation of roadway earthwork volumeis feasible, more accurateand should have further application in practice.

体育品牌体验与消费者品牌忠诚的关系研究——基于Designed to Move活动

本文以Designed to move活动为基础,分析体育品牌体验对消费者行为(品牌忠诚)的影响,这种形式的品牌体验能够给消费者的生命资产和生活价值观带来影响,具有研究价值。本文采用Brakus的SEMs模型测量品牌体验,通过实证分析,探究了感官体验、情感体验、行为体验和智力体验与品牌忠诚之间的作用关系。分析发现,感官体验、行为体验和智力体验对品牌忠诚有显著的正向影响作用,与以往研究不同的是,在体育品牌体验中情感体验对品牌忠诚影响不显著,这对体育企业的营销活动和体验手段具有现实的指导意义。

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress magnitude.To investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution method.The results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with depth.There is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and messy.Moreover,there is no obvious relationship between the rock quality designation(RQD)and depth.The maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same depth.In addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general.

Drilling Power Consumption and Soil Conveying Volume Performances of Lunar Sampling Auger

The sampling auger used in lunar sampling and return mission is to transmit power and convey soil, and its performance is the key factor of the whole mission. However, there is currently a lack of the optimization research on soil conveying volume and power consumption models in auger structure design. To provide the drilled object, the simulation lunar soil, whose physical and mechanical property is the same as the real soil, is made by reducing soil void ratio. The models are formulated to analyze the influence of auger structure parameters on power consumption and soil conveying volume. To obtain the optimized structure parameters of auger, the multi-objective optimization functions of the maximum soil conveying volume and minimum power consumption are developed. To verify the correctness of the models, the performances of different augers drilling simulation soil are tested. The test results demonstrate that the power consumption of optimized auger is the lowest both in theory and test, and the experimental results of soil conveying volume are in agreement with theoretical analysis. Consequently, a new method for designing a lunar sampling auger is proposed which includes the models of soil conveying volume and transportation power consumption, the optimization of structure parameters and the comparison tests. This method provides a reference for sampling auger designing of the Chinese Lunar Sample Mission.

Seismic fragility assessment of RC frame structure designed according to modern Chinese code for seismic design of buildings

Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete （RC） building sand studying the vulnerability of existing buildings. The Chinese Code for Seismic Design of Buildings （CCSDB） has evolved over time, however, there is still reported earthquake induced damage of newly designed RC buildings. Thus, to investigate modern Chinese seismic design code, three low-, mid- and high-rise RC frames were designed according to the 2010 CCSDB and the corresponding vulnerability curves were derived by computing a probabilistic seismic demand model （PSDM）.The PSDM was computed by carrying out nonlinear time history analysis using thirty ground motions obtained from the Pacific Earthquake Engineering Research Center. Finally, the PSDM was used to generate fragility curves for immediate occupancy, significant damage, and collapse prevention damage levels. Results of the vulnerability assessment indicate that the seismic demands on the three different frames designed according to the 2010 CCSDB meet the seismic requirements and are almost in the same safety level.

Reliability and sensitivity analysis of loop-designed security and stability control system in interconnected power systems

Security and stability control system(SSCS)in power systems involves collecting information and sending the decision from/to control stations at different layers;the tree structure of the SSCS requires more levels.Failure of a station or channel can cause all the execution stations(EXs)to be out of control.The randomness of the controllable capacity of the EXs increases the difficulty of the reliability evaluation of the SSCS.In this study,the loop designed SSCS and reliability analysis are examined for the interconnected systems.The uncertainty analysis of the controllable capacity based on the evidence theory for the SSCS is proposed.The bidirectional and loop channels are introduced to reduce the layers and stations of the existing SSCS with tree configuration.The reliability evaluation and sensitivity analysis are proposed to quantify the controllability and vulnerable components for the SSCS in different configurations.By aiming at the randomness of the controllable capacity of the EXs,the uncertainty analysis of the controllable capacity of the SSCS based on the evidence theory is proposed to quantify the probability of the SSCS for balancing the active power deficiency of the grid.

Seismic resilience assessment of corroded reinforced concrete structures designed to the Chinese codes

The natural landscape in China exposes many existing RC buildings to aggressive environments.Such exposure can lead to deterioration in structural performance with regard to resisting events such as earthquakes.Corrosion of embedded reinforcement is one of the most common mechanisms by which such structural degradation occurs.There has been increasing attention in recent years toward seismic resilience in communities and their constituent construction;however,to date,studies have neglected the effect of natural aging.This study aims to examine the effect of reinforcement corrosion on the seismic resilience of RC frames that are designed according to Chinese seismic design codes.A total of twenty RC frames are used to represent design and construction that is typical of coastal China,with consideration given to various seismic fortification levels and elevation arrangements.Seismic fragility relationships are developed for case frames under varying levels of reinforcement corrosion,i.e.,corrosion rates are increased from 5%to 15%.Subsequently,the seismic resilience levels of uncorroded and corroded RC frames are compared using a normalized loss factor.It was found that the loss of resilience of the corroded frames is greater than that of their uncorroded counterparts.At the Rare Earthquake hazard level,the corrosioninduced increase in loss of resilience can be more than 200%,showing the significant effect of reinforcement corrosion on structural resilience under the influence of earthquakes.

Functionally Graded Cellular Structure Design Using the Subdomain Level Set Method with Local Volume Constraints

Functional graded cellular structure(FGCS)usually shows superiormechanical behaviorwith lowdensity and high stiffness.With the development of additivemanufacturing,functional graded cellular structure gains its popularity in industries.In this paper,a novel approach for designing functionally graded cellular structure is proposed based on a subdomain parameterized level set method(PLSM)under local volume constraints(LVC).In this method,a subdomain level set function is defined,parameterized and updated on each subdomain independently making the proposed approach much faster and more cost-effective.Additionally,the microstructures on arbitrary two adjacent subdomains can be connected perfectly without any additional constraint.Furthermore,the local volume constraint for each subdomain is applied by virtue of the augmented Lagrange multiplier method.Finally,several numerical examples are given to verify the correctness and effectiveness of the proposed approach in designing the functionally graded cellular structure.From the optimized results,it is also found that the number of local volume constraints has little influence on the convergence speed of the developed approach.

Characterization of Elastic Modulus of Granular Materials in a New Designed Uniaxial Oedometric System

A simple uniaxial oedometric system is developed to test the elastic modulus of granular materials. The stress- strain relationship is first measured under conditions of uniaxial compression with additional lateral stress and strain, then the elastic modulus of the material is determined by the linear fitting method. It is found that the modulus is positively correlated to the grain size and negatively correlated to the container size. Arching and dragging are revealed to be the mechanism of such correlations by using the digital image correlation method and the pressure film technology based on the statistical method.

A Wireless Sensor Network Ad-Hoc Designed as Anti-Theft Alarm System for Photovoltaic Panels

Photovoltaic (PV) systems have attracted increasing attention in last years as well as Wireless Sensor Networks (WSNs), which have been used in many application fields. In PV plants, especially in ground installations, a lot of thefts and damages occur due to the still high cost of the modules. A new experimental WSN ad-hoc has been designed to be an anti-theft alarm system. Each node of the network is directly installed under each PV string and it is equipped with an accelerometer sensor capable to detect a minimum displacement of the panel from its steady position. The WSN presents a star topology: a master node cyclically interrogates the slave nodes through RF link. It collects all the nodes responses and communicates though a RS-232 interface with a control PC checking the network status. When a slave node detects an alarm, continuous messages are sent to the control PC which turns on all the alarm signaling systems. The control PC is equipped with an open source operative system and software and provides for SMS, e-mail and sound-light signaling in case of alarm. It also communicates with a remote server where all the WSN information is stored. A first low cost experimental WSN has been already installed and it is working properly.

Seismic performance evaluation of typical dampers designed by Chinese building code

Adding dampers is a commonly adopted seismic risk mitigation strategy for modern buildings, and the corresponding design procedure of dampers has been well established by the Chinese Building Code. Even though all types of dampers are designed by the same procedure, actual seismic performance of the building may differ from one to the others. In this study, a nine-story benchmark steel building is established, and three different and typical types of dampers are designed according to the Chinese Building Code to realize structural vibration control under strong earthquake excitation. The seismic response of the prototype building equipped with a viscoelastic damper, viscous damper and buckling-restrained brace(BRB) subjected to 10 earthquake records are calculated, and Incremental Dynamic Analysis(IDA) is performed to describe progressive damage of the structure under increasing earthquake intensity. In the perspective of fragility, it shows that the viscoelastic damper has the highest collapse margin ratio(CMR), and the viscous damper provides the best drift control. Both the BRB and viscoelastic dampers can effectively reduce the floor acceleration responses in the mid-rise building.

High-strength Ti-Al-V-Zr cast alloys designed using α and β cluster formulas

Ti-Al-V-Zr quaternary titanium alloys were designed followingα-{[Al-Ti12](AlTi2)}17-n+β-{[Al-Ti12Zr2](V3)}n,where n=1-7(the number ofβunits),on the basis of the dual-cluster formula of popular Ti-6Al-4V alloy.Such an alloying strategy aims at strengthening the alloy via Zr and V co-alloying in theβ-Ti unit,based on the originalβformula[Al-Ti14](V2Ti)of Ti-6Al-4V alloy.The microstructures of the as-cast alloys by copper-mold suction-casting change from pureα(n=1)toα+α’martensite(n=7).When n is 6,Ti-5.6Al-6.8V-8.1Zr alloy reaches the highest ultimate tensile strength of 1,293 MPa and yield strength of 1,097 MPa,at the expense of a low elongation of 2%,mainly due to the presence of a large amount of acicularα’martensite.Its specific strength far exceeds that of Ti-6Al-4V alloy by 35%.

Inelastic displacement ratio of low-to mid-rise BRBFs designed under variable levels of seismicity

Buckling-restrained braces(BRBs)have shown their capability to provide building structures with stiffness,strength,and ductility.Estimating the seismic drifts of buckling-restrained braced frames(BRBFs)is an important design step to control structural and non-structural damage.In current practice of seismic design,the estimation of seismic drifts of BRBFs is performed by using empirical calculations that are independent upon either the type of the structural system or the design level of seismicity.In these empirical calculations,the seismic drifts are estimated by amplifying the reduced elastic drifts obtained under design lateral loading with a displacement amplification factor(DAF).The value of DAF is considered equal to the product of the response modification factor R and the inelastic displacement ratioρ.The goal of the current research is to assess the value ofρfor low-to mid-rise BRBFs designed under low and high levels of seismicity.This goal has been achieved by conducting a series of elastic and inelastic time-history analyses pertaining to an ensemble of earthquake records on 3-,6-and 9-story BRBFs.The results indicate that theρ-ratio increases with an increase in design seismic intensity and an increase in experienced inelasticity.The range ofρfor low seismicity designs ranges from 0.63 to 0.9,while for high seismicity designs this range stretches from 0.83 to 1.29.It has been found that the consideration of a generalρ-ratio of 1.0 is a reasonable estimation for the design of the BRBFs considered in this study.

A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy designed using cluster-plus-glue-atom model for laser additive manufacturing

A novel Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy was designed using the cluster formula approach(cluster-plus-glue-atom model)and prepared by laser melting deposition(LMD).Its composition formula 12[Al-Ti_(12)](AlTi_(2))+5[Al_(0.8)Si_(0.2)-Ti_(12)Zr_(2)](V_(0.8)Mo_(0.2)Nb_(1)Ti)features an enhancedβ-Ti via co-alloying of Zr,V,Mo,Nb and Si.The experimental results show that the cluster formula ofαandβphases in the novel alloy are respectivelyα-[Al-Ti_(11.5)Zr_(0.5)](Al_(1)Ti_(2))andβ-[Al_(0.8)Si_(0.2)-Ti_(13.2)Zr_(0.8)](V_(1)Mo_(0.4)Nb_(1.6)),both containing Zr elements.The fitted composition via the α andβphase cluster formulas has little difference with the actual alloy composition,suggesting that the validity of cluster-plus-glue-atom model in the alloy composition design.After hot isostatic pressing(HIP),both the Ti-6Al-4V and the novel alloy by LMD are characterized by prior-βcolumnar grains,while the typical<100>texture disappears.Compared with Ti-6Al-4V,Ti-5.55Al-6.70Zr-1.50V-0.70Mo-3.41Nb-0.21Si alloy exhibits a combination of higher strength(1,056 MPa)and higher ductility(14%)at room temperature and higher strength(580 MPa)at 550℃ after HIP,and can potentially serves as LMD materials.

Parameters Distribution Along the Channel Axis in the Scaling Designed Stationary Plasma Thruster

The study of the parameters＇ distribution along the channel axis in a stationary plasma thruster（SPT） helps One to understand the physical characteristics of the SPT＇s operation. In this paper, the axial distribution of the desired SPT parameters are predicted by combining the improved scaling theory and a one-dimensional hybrid model. The simulation indicates that the SPT parameters＇ distribution along the channel axis changes with scaling index variable ~. If ~ is set properly, the similarity of the parameters~ axial distribution between the model and a desired thruster can be ensured. In addition, the operation characteristics of the desired thruster, such as the ionization and acceleration processes, are also similar to those of the model. When ζ is set, the improved SPT scaling theory and the one-dimensional hybrid model can be used to predict the axial distribution of the desired SPT parameters with the same propellant （such as Xe）.

Mechanical and Acoustic Performance Test of New Designed Metal Noise Barrier Unit Plate with No Riveted Connection

The modern transportation system is increasingly developed during recent years.It is an effective solution to set the noise barriers to reduce the traffic noise pollution caused by different kinds of transportation systems.Many deficiencies on concrete noise barriers and metal noise barriers with rivet structure can be eliminated by a new kind of noise barrier with no-riveted structure.The mechanical performance examination and acoustic performance test are conducted on the new-designed noise barrier with no-riveted structure.The results indicate that the maximum stress is 1.74 MPa and the maximum deformation is 1.04 mm with load acting on the unit plate.The noise reduction coefficient of this kind of no-riveted noise barrier unit plate is 0.75 and its noise insulation is 40 dB,which were conform to or superior to the standard requirements.Therefore,this new designed noise barrier meets the field application requirements of mechanical and acoustic performance,which demonstrates the noise barriers can be widely promoted.

A Review of the DCP-DN Pavement Design Method for Low Volume Sealed Roads: Development and Applications

Widespread implementation of the DCP-DN design method for low volume roads has been promoted internationally over the past decade or so. The method has progressed from a simple determination of the in situ CBR investigation based on DCP-CBR correlations with respective cover requirements to a more sophisticated method using the DCP penetration data directly and omitting any need to use correlations with the CBR. This paper summarises the development of the method, and some of its advantages and compares the design structures with other recognised and widely implemented designs.

Hydrogen-based direct reduction of industrial iron ore pellets:Statistically designed experiments and computational simulation

As part of efforts to reduce anthropogenic CO_(2) emissions by the steelmaking industry,this study investigated the direct reduction of industrially produced hematite pellets with H_(2) using the Doehlert experimental design to evaluate the effect of pellet diameter(10.5-16.5 mm),porosity(0.36-0.44),and temperature(600-1200℃).A strong interactive effect between temperature and pellet size was observed,indicating that these variables cannot be considered independently.The increase in temperature and decrease in pellet size considerably favor the reduction rate,while porosity did not show a relevant effect.The change in pellet size during the reduction was negligible,except at elevated temperatures due to crack formation.A considerable decrease in mechanical strength at high temperatures suggests a maximum process operating temperature of 900℃.Good predictive capacity was achieved using the modified grain model to simulate the three consecutive non-catalytic gas-solid reactions,considering different pellet sizes and porosities,changes during the reaction from 800 to 900℃.However,for other temperatures,different mechanisms of structural modifications must be considered in the modeling.These results represent significant contributions to the development of ore pellets for CO_(2)-free steelmaking technology.