Objective： To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods： Pathogenic...Objective： To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods： Pathogenic bacteria identification and drug sensitivity tests were performed with a VITEK 2 compact automatic identification system and data were analyzed using WHONET5.6 software.Results： Of the 1,378 strains tested, 980 were Gram-negative bacilli, accounting for 71.1%, in which Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa were the dominant strains. We found 328 Gram-positive coccus, accounting for 23.8%, in which the amount of Staphylococcus aureus was the highest. We identified 46 fungi, accounting for 4.1%. According to the departmental distribution within the hospital, the surgical departments isolated the major strains, accounting for 49.7%. According to disease types, lung cancer, intestinal cancer and esophagus cancer were the top three, accounting for 20.9%, 17.3% and 14.2%, respectively. No strains were resistant to imipenem, ertapenem or vancomycin.Conclusions： Pathogenic bacteria isolated from the specialized cancer hospital have different resistance rates compared to commonly used antimicrobial agents; therefore antimicrobial agents to reduce the morbidity and mortality of infections should be used.展开更多
目的:探讨南阳市第一人民医院抗菌药物的使用情况及与常见的细菌耐药的相关性。方法:收集南阳市第一人民医院2018年1月至2021年12月临床患者送检的阳性标本,统计临床标本分离病原菌检出情况、常见抗菌药物消耗情况以及常见的革兰氏阴性...目的:探讨南阳市第一人民医院抗菌药物的使用情况及与常见的细菌耐药的相关性。方法:收集南阳市第一人民医院2018年1月至2021年12月临床患者送检的阳性标本,统计临床标本分离病原菌检出情况、常见抗菌药物消耗情况以及常见的革兰氏阴性杆菌、阳性球菌对抗菌药物产生的耐药率(%)与抗菌药物用药频度(Frequency of defined daily doses,DDDs)的相关性。结果:我院2018年至2021年抗菌药物DDDs较高的抗菌药物依次为美洛西林、头孢他啶、哌拉西林他唑巴坦,检出率较高的病原菌分别为大肠埃希氏菌、肺炎克雷伯菌、金黄色葡萄球菌等。大肠埃希菌产生的耐药率与哌拉西林他唑巴坦、头孢呋辛钠DDDs均有相关性(r=-0.107、0.432);肺炎克雷伯菌产生的耐药率与哌拉西林他唑巴坦、左氧氟沙星氯化钠、头孢呋辛钠DDDs呈正相关(r=0.410、0.720、0.420);铜绿假单胞菌与哌拉西林他唑巴坦、头孢哌酮舒巴坦钠DDDs呈正相关(r=0.716、0.933);金黄色葡萄球菌的耐药率与左氧氟沙星DDDs呈正相关(r=0.661);肺炎链球菌产生的耐药率与左氧氟沙星、头孢呋辛钠DDDs均存在正相关关系(r=0.416和0.482)。结论:抗菌药物的DDDs与常见细菌产生的耐药性具有一定的相关性,我院应严格控制抗菌药物的DDDs,根据感染性病种及药敏试验结果选择适当的抗菌药,加强常见病原菌的耐药监测。展开更多
目的探讨中老年脑卒中相关性肺炎的流行病学特征、危险因素及病原菌分布情况。方法回顾性选取2020年1月至2023年9月于丽水市第二人民医院治疗的822例中老年脑卒中患者,根据是否发生脑卒中相关性肺炎将其分为发生组(n=217)和未发生组(n=6...目的探讨中老年脑卒中相关性肺炎的流行病学特征、危险因素及病原菌分布情况。方法回顾性选取2020年1月至2023年9月于丽水市第二人民医院治疗的822例中老年脑卒中患者,根据是否发生脑卒中相关性肺炎将其分为发生组(n=217)和未发生组(n=605)。收集两组患者的临床资料、病原菌培养及药敏试验结果。结果两组患者的年龄、住院时间、吸烟史、糖尿病、高血压、意识障碍、吞咽障碍、入院时美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)评分、低蛋白血症、是否留置胃管比较差异均有统计学意义(P<0.05)。Logistic回归分析显示,年龄>65岁、住院时间≥15d、吸烟史、糖尿病、意识障碍、吞咽障碍、入院时NIHSS评分≥13分、留置胃管均是脑卒中相关性肺炎的危险因素(P<0.05)。217例脑卒中相关性肺炎患者的痰液中共培养出251株致病菌,包括革兰阴性菌168株,革兰阳性菌72株,真菌11株。主要病原菌为肺炎克雷伯菌68株(27.1%)、铜绿假单胞菌50株(19.9%)、金黄色葡萄球菌41株(16.3%)、鲍曼不动杆菌25株(10.0%)。肺炎克雷伯菌对氨苄西林、庆大霉素的耐药率较高,铜绿假单胞菌、金黄色葡萄球菌、鲍曼不动杆菌对氨苄西林、阿莫西林的耐药率均较高。结论中老年脑卒中相关性肺炎的发生和年龄、合并基础疾病、意识障碍、吞咽障碍、留置胃管等有关,且感染病原菌种类较多,临床上应加强识别高危因素,并根据药敏试验选择适当的抗菌药物治疗。展开更多
文摘Objective： To understand distribution and drug resistance of pathogenic bacteria from a specialized cancer hospital in 2013 in order to provide a basis for rational clinical antimicrobial agents. Methods： Pathogenic bacteria identification and drug sensitivity tests were performed with a VITEK 2 compact automatic identification system and data were analyzed using WHONET5.6 software.Results： Of the 1,378 strains tested, 980 were Gram-negative bacilli, accounting for 71.1%, in which Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa were the dominant strains. We found 328 Gram-positive coccus, accounting for 23.8%, in which the amount of Staphylococcus aureus was the highest. We identified 46 fungi, accounting for 4.1%. According to the departmental distribution within the hospital, the surgical departments isolated the major strains, accounting for 49.7%. According to disease types, lung cancer, intestinal cancer and esophagus cancer were the top three, accounting for 20.9%, 17.3% and 14.2%, respectively. No strains were resistant to imipenem, ertapenem or vancomycin.Conclusions： Pathogenic bacteria isolated from the specialized cancer hospital have different resistance rates compared to commonly used antimicrobial agents; therefore antimicrobial agents to reduce the morbidity and mortality of infections should be used.
文摘目的:探讨南阳市第一人民医院抗菌药物的使用情况及与常见的细菌耐药的相关性。方法:收集南阳市第一人民医院2018年1月至2021年12月临床患者送检的阳性标本,统计临床标本分离病原菌检出情况、常见抗菌药物消耗情况以及常见的革兰氏阴性杆菌、阳性球菌对抗菌药物产生的耐药率(%)与抗菌药物用药频度(Frequency of defined daily doses,DDDs)的相关性。结果:我院2018年至2021年抗菌药物DDDs较高的抗菌药物依次为美洛西林、头孢他啶、哌拉西林他唑巴坦,检出率较高的病原菌分别为大肠埃希氏菌、肺炎克雷伯菌、金黄色葡萄球菌等。大肠埃希菌产生的耐药率与哌拉西林他唑巴坦、头孢呋辛钠DDDs均有相关性(r=-0.107、0.432);肺炎克雷伯菌产生的耐药率与哌拉西林他唑巴坦、左氧氟沙星氯化钠、头孢呋辛钠DDDs呈正相关(r=0.410、0.720、0.420);铜绿假单胞菌与哌拉西林他唑巴坦、头孢哌酮舒巴坦钠DDDs呈正相关(r=0.716、0.933);金黄色葡萄球菌的耐药率与左氧氟沙星DDDs呈正相关(r=0.661);肺炎链球菌产生的耐药率与左氧氟沙星、头孢呋辛钠DDDs均存在正相关关系(r=0.416和0.482)。结论:抗菌药物的DDDs与常见细菌产生的耐药性具有一定的相关性,我院应严格控制抗菌药物的DDDs,根据感染性病种及药敏试验结果选择适当的抗菌药,加强常见病原菌的耐药监测。
文摘目的探讨中老年脑卒中相关性肺炎的流行病学特征、危险因素及病原菌分布情况。方法回顾性选取2020年1月至2023年9月于丽水市第二人民医院治疗的822例中老年脑卒中患者,根据是否发生脑卒中相关性肺炎将其分为发生组(n=217)和未发生组(n=605)。收集两组患者的临床资料、病原菌培养及药敏试验结果。结果两组患者的年龄、住院时间、吸烟史、糖尿病、高血压、意识障碍、吞咽障碍、入院时美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)评分、低蛋白血症、是否留置胃管比较差异均有统计学意义(P<0.05)。Logistic回归分析显示,年龄>65岁、住院时间≥15d、吸烟史、糖尿病、意识障碍、吞咽障碍、入院时NIHSS评分≥13分、留置胃管均是脑卒中相关性肺炎的危险因素(P<0.05)。217例脑卒中相关性肺炎患者的痰液中共培养出251株致病菌,包括革兰阴性菌168株,革兰阳性菌72株,真菌11株。主要病原菌为肺炎克雷伯菌68株(27.1%)、铜绿假单胞菌50株(19.9%)、金黄色葡萄球菌41株(16.3%)、鲍曼不动杆菌25株(10.0%)。肺炎克雷伯菌对氨苄西林、庆大霉素的耐药率较高,铜绿假单胞菌、金黄色葡萄球菌、鲍曼不动杆菌对氨苄西林、阿莫西林的耐药率均较高。结论中老年脑卒中相关性肺炎的发生和年龄、合并基础疾病、意识障碍、吞咽障碍、留置胃管等有关,且感染病原菌种类较多,临床上应加强识别高危因素,并根据药敏试验选择适当的抗菌药物治疗。
