A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alco...A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling reagents.Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.展开更多
Since most of the central regions of the European part of Russia are considered selenium and iodine deficient, the assessment of modern real consumption of chlorine, bromine, iodine and selenium by population of these...Since most of the central regions of the European part of Russia are considered selenium and iodine deficient, the assessment of modern real consumption of chlorine, bromine, iodine and selenium by population of these regions with different diets is an important constituent part of medical monitoring. In this paper, a brief analysis of the impact of these elements on the human body is given. A number of consumed foodstuffs in different food rations (diets) were assessed. Six selected basic food rations, which most fully reflect the specific features of nutrition in the Russian Federation, were chosen. The analysis of the concentration of chlorine, bromine, iodine and selenium in a wide range of food and agricultural products was carried out. The daily intake of these elements in the human body from the selected diets was calculated. A comparison of the real income of chlorine, bromine, iodine and selenium in the human body with a physiologically needed intake was performed. It is proposed to use the coefficient of Kr, which is the ratio of actual intake of the element in the human body to physiologically needed intake. Based on this analysis assessed insufficient or excess supply of chlorine, bromine, iodine and selenium in the human body with these diets in the central regions of the European part of Russia was evaluated.展开更多
Disinfection by-products（DBPs） are a complex mixture of compounds unintentionally formed as a result of disinfection processes used to treat drinking water. Effects of long-term exposure to DBPs are mostly unknown a...Disinfection by-products（DBPs） are a complex mixture of compounds unintentionally formed as a result of disinfection processes used to treat drinking water. Effects of long-term exposure to DBPs are mostly unknown and were the subject of recent epidemiological studies. However,most bioanalytical methods focus on a select few DBPs. In this study, a new comprehensive bioanalytical method has been developed that can quantify mixtures of organic halogenated compounds, including DBPs, in human urine as total organic chlorine（TOCl）, total organic bromine（TOBr）, and total organic iodine（TOI）. The optimized method consists of urine dilution, adsorption to activated carbon, pyrolysis of activated carbon, absorption of gases in an aqueous solution, and halide analysis with ion chromatography and inductively coupled plasma-mass spectrometry. Spike recoveries for TOCl, TOBr, and TOI measurements ranged between 78% and 99%. Average TOCl, TOBr, and TOI concentrations in five urine samples from volunteers who consumed tap water were 1850, 82, and 21.0 μg/L as X^-, respectively.Volunteers who consumed spring water（control） had TOCl, TOBr, and TOI average concentrations in urine of 1090, 88, and 10.3 μg/L as X^-, respectively. TOCl and TOI in the urine samples from tap water consumers were higher than the control. However, TOBr was slightly lower in tap water urine samples compared to mineral water urine samples, indicating other sources of environmental exposure other than drinking water. A larger sample population that consumes tap water from different cities and mineral water is needed to determine TOCl, TOBr, and TOI exposure from drinking water.展开更多
基金supported the Natural Science Foundation of Higher Education Institutions in Anhui Province(2022AH030133,2022AH051340)National Natural Science Foundation of China(22231003,22271008)+6 种基金Shenzhen Science and Technology Program(Grant No.KQTD20190929174023858)Shenzhen Science and Technology Innovation Committee(GXWD20201231165807007-20200812100115001)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2023SHIBS0004)Horizontal Cooperation Project of Fuyang Municipal Government(SXHZ202201)Key Projects of the Support Program for Outstanding Young Talents in Anhui Province Colleges and Universities(gxyqZD2020030)Yifan Pharmaceutical Co.,Ltd.(HX2019033)Innovative Drug Design&Development Collaborative Team(TDYY2021009).
文摘A metal-free,green,and sustainable functionalization of unactivated alkyl sp^(3) C—H bonds is reported using iodine(III)as a feasible dehydrogenation agent under visible light or KBr,and alkyl chlorides,bromides,alcohols,and ketones could be constructed by addition of different coupling reagents.Cheap and safe iodobenzene diacetate was used to form a radical to activate the alkyl sp^(3) C—H bond in a highly efficient manner,which can construct different alkylation products by adding corresponding coupling reagents.
文摘Since most of the central regions of the European part of Russia are considered selenium and iodine deficient, the assessment of modern real consumption of chlorine, bromine, iodine and selenium by population of these regions with different diets is an important constituent part of medical monitoring. In this paper, a brief analysis of the impact of these elements on the human body is given. A number of consumed foodstuffs in different food rations (diets) were assessed. Six selected basic food rations, which most fully reflect the specific features of nutrition in the Russian Federation, were chosen. The analysis of the concentration of chlorine, bromine, iodine and selenium in a wide range of food and agricultural products was carried out. The daily intake of these elements in the human body from the selected diets was calculated. A comparison of the real income of chlorine, bromine, iodine and selenium in the human body with a physiologically needed intake was performed. It is proposed to use the coefficient of Kr, which is the ratio of actual intake of the element in the human body to physiologically needed intake. Based on this analysis assessed insufficient or excess supply of chlorine, bromine, iodine and selenium in the human body with these diets in the central regions of the European part of Russia was evaluated.
文摘Disinfection by-products（DBPs） are a complex mixture of compounds unintentionally formed as a result of disinfection processes used to treat drinking water. Effects of long-term exposure to DBPs are mostly unknown and were the subject of recent epidemiological studies. However,most bioanalytical methods focus on a select few DBPs. In this study, a new comprehensive bioanalytical method has been developed that can quantify mixtures of organic halogenated compounds, including DBPs, in human urine as total organic chlorine（TOCl）, total organic bromine（TOBr）, and total organic iodine（TOI）. The optimized method consists of urine dilution, adsorption to activated carbon, pyrolysis of activated carbon, absorption of gases in an aqueous solution, and halide analysis with ion chromatography and inductively coupled plasma-mass spectrometry. Spike recoveries for TOCl, TOBr, and TOI measurements ranged between 78% and 99%. Average TOCl, TOBr, and TOI concentrations in five urine samples from volunteers who consumed tap water were 1850, 82, and 21.0 μg/L as X^-, respectively.Volunteers who consumed spring water（control） had TOCl, TOBr, and TOI average concentrations in urine of 1090, 88, and 10.3 μg/L as X^-, respectively. TOCl and TOI in the urine samples from tap water consumers were higher than the control. However, TOBr was slightly lower in tap water urine samples compared to mineral water urine samples, indicating other sources of environmental exposure other than drinking water. A larger sample population that consumes tap water from different cities and mineral water is needed to determine TOCl, TOBr, and TOI exposure from drinking water.
