Ancient China recorded a wealth of astronomical observations,notably distinguished by the inclusion of empirical measurements of stellar observations.However,determining the precise observational epochs for these data...Ancient China recorded a wealth of astronomical observations,notably distinguished by the inclusion of empirical measurements of stellar observations.However,determining the precise observational epochs for these datasets poses a formidable challenge.This study employs the generalized Hough transform methodology to analyze two distinct sets of observational data originating from the Song and Yuan dynasties,allowing accurate estimation of the epochs of these stellar observations.This research introduces a novel and systematic approach,offering a scholarly perspective for the analysis of additional datasets within the domain of ancient astronomical catalogs in future investigations.展开更多
The study aimed to identify factors causing delays in scheduled gynaeco-obstetric surgeries at CHUMEFJE in Libreville from January 2019 to July 2020. Through a 16-month observational survey, it was found that out of 3...The study aimed to identify factors causing delays in scheduled gynaeco-obstetric surgeries at CHUMEFJE in Libreville from January 2019 to July 2020. Through a 16-month observational survey, it was found that out of 346 scheduled procedures, 128 (36.4%) were postponed. Organizational issues in the operating theatre were responsible for 80.3% of these delays, with 95.3% being preventable. To enhance efficiency, improvements in operating theatre organization are recommended.展开更多
Identifying state transition and determining the critical value of the Duffing oscillator are crucial to indicating external signal existence and have a great influence on detection accuracy in weak signal detection. ...Identifying state transition and determining the critical value of the Duffing oscillator are crucial to indicating external signal existence and have a great influence on detection accuracy in weak signal detection. A circular zone counting (CZC) method is proposed in this paper, by combining the Duffing oscillator's phase trajectory feature and numerical calculation for quickly and accurately identifying state transition and determining the critical value, to realize a high- efficiency weak signal detection. Detailed model analysis and method construction of the CZC method are introduced. Numerical experiments into the reliability of the proposed CZC method compared with the maximum Lyapunov exponent (MLE) method are carried out. The CZC method is demonstrated to have better detecting ability than the MLE method, and furthermore it is simpler and clearer in calculation to extend to engineering application.展开更多
In this study, a new parameter, S phase cell percentage (S fraction) normalized BrdU (SFN-BrdU) incorporation rate, was introduced to detect $ arrest. The results showed a positive linear correlation between the B...In this study, a new parameter, S phase cell percentage (S fraction) normalized BrdU (SFN-BrdU) incorporation rate, was introduced to detect $ arrest. The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells. Theoretical analysis indicated that only S arrest could result in a decrease in the SFN-BrdU incorporation rate. Additionally, the decrease in SFN-BrdU incorporation rate and the activation of DNA damage checkpoints further demonstrated that S arrest was induced by diethyl sulfate treatment of 16HBE cells. In conclusion, $FN-BrdU incorporation rate can be used to detecting S arrest.展开更多
Evaluating actual crop evapotranspiration(ET) variations and their determining factors under changing climates is crucial for agricultural irrigation management and crop productivity improvement in nonhumid regions.Th...Evaluating actual crop evapotranspiration(ET) variations and their determining factors under changing climates is crucial for agricultural irrigation management and crop productivity improvement in nonhumid regions.This study analyzed the spatiotemporal characteristics and detected the determining factors of ETfor winter wheat and summer maize rotation system from 2000 to 2017 in the North China Plain(NCP),by combining the FAO-56 dual crop coefficient approach with remotely sensed vegetation indices(VIs).The results indicated that daily air temperature increased in varying degrees while wind speed and sunshine hours decreased slightly during the growing season of winter wheat and summer maize over the study period.The trends of relative humidity and effective precipitation varied in crop growing seasons.Based on the validated relationship of dual crop coefficients and VIs,the estimated multi-year average ETof winter wheat(370.29±31.28 mm) was much higher than summer maize(281.85±20.14 mm),and the rotation cycle was 652.43±27.67 mm.Annual ETof winter wheat and the rotation cycle increased by 2.96 mm aand 1,77 mm a,respectively.However,the ETof summer maize decreased with distinct spatial variation.Spatially,winter wheat ETincreased significantly in the northeast NCP,covering the Beijing-Tianiin-Hebei areas.Meanwhile,significant increases in summer maize ETwere detected in the southwest NCP.The sensitivity and contribution analysis showed that ETof winter wheat and summer maize was positively sensitive to temperature,wind speed,and sunshine hours while negatively to relative humidity.Moreover,wind speed and sunshine hours contributed most to changes in ET(around 20%-40%).展开更多
The principle, construction and application of two types of electrochemical sensors-amperometric and potentiometric are surveyed. Both types of sensors are very sensitive to changes in temperature. The accuracy of hyd...The principle, construction and application of two types of electrochemical sensors-amperometric and potentiometric are surveyed. Both types of sensors are very sensitive to changes in temperature. The accuracy of hydrogen measurement depends on both the precision of sensors developed and the reliable technique of installation and security of sensors. The two types of sensors have been used for in-situ determining hydrogen permeated in steels owing to a corrosive reaction, a hydrogen gas circumstance at elevated temperatures and high pressure or also a pretreatment process such as pickling and plating process, etc.展开更多
Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity...Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-展开更多
Evapotranspiration of a natural secondary white birch (Betula populifolia)forest in Maoershan Ecological Station was determined by water balance method, heat balance method and water and heat combination method. Resul...Evapotranspiration of a natural secondary white birch (Betula populifolia)forest in Maoershan Ecological Station was determined by water balance method, heat balance method and water and heat combination method. Results showed that the total evapotranspiration of the forest in the growing season was 3. 6mm/d. of which evapotrans piration from canopy xvas 2. 91 mm/d and that from forest floor was 0. 57 mm/d. and that in the non-growing season was 0. 8 mm/d.展开更多
One of the most commonly used non-invasive methods for assessing human exposure to pollution is the analysis of human milk.Human milk analyses help estimate the exposure of infants[1].This is why breast milk is receiv...One of the most commonly used non-invasive methods for assessing human exposure to pollution is the analysis of human milk.Human milk analyses help estimate the exposure of infants[1].This is why breast milk is receives scientific interest,and various methods for determining different pollutants from the environment are being developed[2,3].展开更多
A series of olefin hydroformylations over supported aqueous-phase rhodium catalyst with the substitUtion of CO/D2 for CO/H2 were cAned out to study the isotope effects of deuterium. The rate of aldehyde formation in C...A series of olefin hydroformylations over supported aqueous-phase rhodium catalyst with the substitUtion of CO/D2 for CO/H2 were cAned out to study the isotope effects of deuterium. The rate of aldehyde formation in CO/D2 was about 1.3 times faster than that in COns2, indicating that the aldehyde formation shows noticeable inverse deuterium isotope effect over SAP catalyst. The results of in-situIR stUdy of ethylene hydroformylation suggest that the reaction rate of acylhydrogenolysis forming aldehyde is the slowest one. It may be inferred from these results that the rate-determining step involved\in aldehyde formation is very probably astep ofhydrogenation.展开更多
The approach of estimating the number of signals based on information theoretic criteria has good performance in the assumption of white noise, but it always leads to false estimation of the coherent sources in colore...The approach of estimating the number of signals based on information theoretic criteria has good performance in the assumption of white noise, but it always leads to false estimation of the coherent sources in colored noise. An approach combining the combined information theoretic criteria and eigen- value correction, is presented to determine number of signals. The method uses maximum likelihood (ML) and information theoretic criteria to estimate coherent signals alternately, then eliminate the inequality of the eigenvalues caused by colored noise by correcting the noise eigenvalues. The computer simulation results prove the effective performance of the method.展开更多
A method to determine the design value of the extreme wave height is introduced in this paper. The method is, based on the theoretical distribution of wave heights or the experiential probability distribution of wave ...A method to determine the design value of the extreme wave height is introduced in this paper. The method is, based on the theoretical distribution of wave heights or the experiential probability distribution of wave heights, to calculate the mode of the extreme wave height and the design value with good assuredness. In fitting the experiential distribution of the observed wave heights, the paper adopts the simulating function of F(x) = 1 - exp[ ?axb exp( -cxd )] and the non-linear parameter in the function is determined by the Non-Linear Least Square Method. The practical application of the method has proved that it is not only simple and convenient, but also very effective in engineering design practice.展开更多
The time-dependent Jones Wilkins-Lee equation products for aluminized explosives. To obtain the of state (JWL-EOS) is applied to describe detonation state time-dependent JWL-EOS parameters, cylinder tests and underw...The time-dependent Jones Wilkins-Lee equation products for aluminized explosives. To obtain the of state (JWL-EOS) is applied to describe detonation state time-dependent JWL-EOS parameters, cylinder tests and underwater explosion experiments are performed. According to the result of the wall radial velocity in cylinder tests and the shock wave pressures in underwater explosion experiments, the time-dependent JWL-EOS parameters are determined by iterating these variables in AUTODYN hydroeode simulations until the experimental values are reproduced. In addition, to verify the reliability of the derived JWL-EOS parameters, the aluminized explosive experiment is conducted in concrete. The shock wave pressures in the affected concrete bodies are measured by using manganin pressure sensors, and the rod velocity is obtained by using a high-speed camera. Simultaneously, the shock wave pressure and the rod velocity are calculated by using the derived time-dependent JWL equation of state. The calculated results are in good agreement with the experimental data.展开更多
BACKGROUND Sex determining region Y-box 2(SOX2) can promote squamous cell carcinoma(SSC) because it regulates the migration and invasion of several different types of squamous carcinoma cells.However,few studies have ...BACKGROUND Sex determining region Y-box 2(SOX2) can promote squamous cell carcinoma(SSC) because it regulates the migration and invasion of several different types of squamous carcinoma cells.However,few studies have examined the prognostic value of SOX2 and its effect on the epithelial-mesenchymal transition(EMT) in esophageal SSC(ESCC),a cancer characterized by high invasion and rapid metastasis.AIM To verify the relationship of SOX2 and the EMT in ESCC and determine the prognostic value and significance of SOX2 and protein markers of the EMT in ESCC.METHODS One hundred and eighty-five postsurgical ESCC patients were retrospectively examined.Immunohistochemistry was used to detect SOX2,E-cadherin,and vimentin in ESCC tissues.The chi-square test was used to determine the relationships of the expression of these proteins with clinical data.Kaplan-Meier survival curves were used to evaluate factors associated with overall survival(OS).RESULTS SOX2 and vimentin had high expression in ESCC tissues and correlated with the depth of local carcinoma invasion.SOX2 expression had positive correlations with tumor size,vimentin expression,and the EMT,and a negative correlation with Ecadherin expression.Expression of SOX2 and vimentin had negative correlations with OS.SOX2 expression was an independent prognostic risk factor for poor OS in patients with ESCC.CONCLUSION SOX2 expression was an independent risk factor for OS in patients with ESCC and its expression had a positive correlation with the expression of vimentin,a classic marker of the EMT.SOX2 promoted the migration and invasion of ESCC,and this may related to its effect on vimentin in promoting the EMT.展开更多
China, as a whole, is about to meet the Millennium Development Goals for reducing the maternal mortality ratio (MMR) and infant mortality rate (IMR), but the disparities between rural area and urban area still exists....China, as a whole, is about to meet the Millennium Development Goals for reducing the maternal mortality ratio (MMR) and infant mortality rate (IMR), but the disparities between rural area and urban area still exists. This study estimated the potential effectiveness of expanding coverage with high impact interventions using the Lives Saved Tool (LiST). It was found that gestational hypertension, antepartum and postpartum hemorrhage, preterm birth, neonatal asphyxia, and neonatal childhood pneumonia and diarrhea are still the major killers of mothers and children in rural area in China. It was estimated that 30% of deaths among 0-59 month old children and 25% of maternal deaths in 2008 could be prevented in 2015 if primary health care intervention coverage expanded to a feasible level. The LiST death cause framework, compared to data from the Maternal and Child Mortality Surveillance System, represents 60%-80% of neonatal deaths, 40%-50% of deaths in 1-59 month old children and 40%-60% of maternal deaths in rural areas of western China.展开更多
A single three point bend specimen compliance method for determining JIC of high strength high fracture toughness steels is presented and a formula for calculatinff J-integral is proposed as follows.It is simple and v...A single three point bend specimen compliance method for determining JIC of high strength high fracture toughness steels is presented and a formula for calculatinff J-integral is proposed as follows.It is simple and valid for high strength high fracture toughness steels. The values of JIC and KIC measured by this method are in good agreement with those measured by standard test method.展开更多
We consider the initial-boundary value problem for a nonlinear wave equation with strong structural damping and nonlinear source terms in IR. We prove the global existence and uniqueness of weak solutions of the probl...We consider the initial-boundary value problem for a nonlinear wave equation with strong structural damping and nonlinear source terms in IR. We prove the global existence and uniqueness of weak solutions of the problem and then we will study the determining modes on the phase space by using energy methods and the concept of the completeness defect.展开更多
Housing is both good and investment assets so that it plays an important role in the economy. Housing also can be characterized the most complex economic good because of its durability, heterogeneity, locational fixit...Housing is both good and investment assets so that it plays an important role in the economy. Housing also can be characterized the most complex economic good because of its durability, heterogeneity, locational fixity, the possibility to raise loans against housing collateral, and the effect on well-developed secondary markets. On the other hand, income distribution, socio-economic justice, and regional disparities imply that housing market is an important concept for social and cultural transformation. In this study, the determinants of housing demand were compared for countries. These countries are selected according to economic situation: Turkey, Hungary, and United Kingdom. As a scope of this, the dynamic relationship between the housing demand and variables determining the housing demand in Turkey, Hungary, and UK has been analyzed. The model estimated uses quarterly data from January 2002 to January 2014. Building permits has been considered as housing demand. The other variables used for determining the housing demand are GDP, monetary aggregate, interest rate, and share prices. The long term relationship among variables has been analyzed with Vector Autoregressive Model (VAR) as impulse response and variance decomposition. The findings indicate that determining of housing demand changes according to economic and financial components such as government policies, mortgage system, consumer choice, tax, and subsidy in selected countries. All variables play an important role in housing demand, although the level of their impacts varies.展开更多
While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics. Analyzing the genes for CYP2A6 from t...While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics. Analyzing the genes for CYP2A6 from the three subjects, we discovered that the three subjects possessed the whole CYP2A6 gene deletion (CYP2A6*4C), a novel genetic polymorphism of the CYP2A6 gene. Genetically engineered Salmonella YG7108 cells expressing human CYP2A6 or CYP2E1 together with the NADPH-CYP reductase were established in our laboratory to compare the mutagen-producing capacity of these enzymes for various N-nitrosamines. We found that CYP2E1 was responsible for the metabolic activation of N-nitrosamines with relatively short alkyl chains, whereas CYP2A6 was involved in the metabolic activation of N-nitrosamines possessing relatively bulky alkyl chains such as a tobacco-specific nitrosamine, NNK, which has been known to cause lung tumor in rodents. Thus, to examine a hypothesis that individuals possessing the CYP2A6*4C have the reduced risk of lung cancer due to the lack of the capacity of the metabolic activation of certain carcinogens in tobacco smoke, a case-control study was performed.展开更多
文摘Ancient China recorded a wealth of astronomical observations,notably distinguished by the inclusion of empirical measurements of stellar observations.However,determining the precise observational epochs for these datasets poses a formidable challenge.This study employs the generalized Hough transform methodology to analyze two distinct sets of observational data originating from the Song and Yuan dynasties,allowing accurate estimation of the epochs of these stellar observations.This research introduces a novel and systematic approach,offering a scholarly perspective for the analysis of additional datasets within the domain of ancient astronomical catalogs in future investigations.
文摘The study aimed to identify factors causing delays in scheduled gynaeco-obstetric surgeries at CHUMEFJE in Libreville from January 2019 to July 2020. Through a 16-month observational survey, it was found that out of 346 scheduled procedures, 128 (36.4%) were postponed. Organizational issues in the operating theatre were responsible for 80.3% of these delays, with 95.3% being preventable. To enhance efficiency, improvements in operating theatre organization are recommended.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61172047 and 61071025)
文摘Identifying state transition and determining the critical value of the Duffing oscillator are crucial to indicating external signal existence and have a great influence on detection accuracy in weak signal detection. A circular zone counting (CZC) method is proposed in this paper, by combining the Duffing oscillator's phase trajectory feature and numerical calculation for quickly and accurately identifying state transition and determining the critical value, to realize a high- efficiency weak signal detection. Detailed model analysis and method construction of the CZC method are introduced. Numerical experiments into the reliability of the proposed CZC method compared with the maximum Lyapunov exponent (MLE) method are carried out. The CZC method is demonstrated to have better detecting ability than the MLE method, and furthermore it is simpler and clearer in calculation to extend to engineering application.
基金supported by the National Nature Science Foundation of China(Nos.81370079 and 81001253)the Beijing Natural Science Foundation(No.7132122)
文摘In this study, a new parameter, S phase cell percentage (S fraction) normalized BrdU (SFN-BrdU) incorporation rate, was introduced to detect $ arrest. The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells. Theoretical analysis indicated that only S arrest could result in a decrease in the SFN-BrdU incorporation rate. Additionally, the decrease in SFN-BrdU incorporation rate and the activation of DNA damage checkpoints further demonstrated that S arrest was induced by diethyl sulfate treatment of 16HBE cells. In conclusion, $FN-BrdU incorporation rate can be used to detecting S arrest.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA28060200)the National Science Fund for Excellent Young Scholars (42122003)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA20040301)the Youth Innovation Promotion Association,CAS (Y202016)。
文摘Evaluating actual crop evapotranspiration(ET) variations and their determining factors under changing climates is crucial for agricultural irrigation management and crop productivity improvement in nonhumid regions.This study analyzed the spatiotemporal characteristics and detected the determining factors of ETfor winter wheat and summer maize rotation system from 2000 to 2017 in the North China Plain(NCP),by combining the FAO-56 dual crop coefficient approach with remotely sensed vegetation indices(VIs).The results indicated that daily air temperature increased in varying degrees while wind speed and sunshine hours decreased slightly during the growing season of winter wheat and summer maize over the study period.The trends of relative humidity and effective precipitation varied in crop growing seasons.Based on the validated relationship of dual crop coefficients and VIs,the estimated multi-year average ETof winter wheat(370.29±31.28 mm) was much higher than summer maize(281.85±20.14 mm),and the rotation cycle was 652.43±27.67 mm.Annual ETof winter wheat and the rotation cycle increased by 2.96 mm aand 1,77 mm a,respectively.However,the ETof summer maize decreased with distinct spatial variation.Spatially,winter wheat ETincreased significantly in the northeast NCP,covering the Beijing-Tianiin-Hebei areas.Meanwhile,significant increases in summer maize ETwere detected in the southwest NCP.The sensitivity and contribution analysis showed that ETof winter wheat and summer maize was positively sensitive to temperature,wind speed,and sunshine hours while negatively to relative humidity.Moreover,wind speed and sunshine hours contributed most to changes in ET(around 20%-40%).
文摘The principle, construction and application of two types of electrochemical sensors-amperometric and potentiometric are surveyed. Both types of sensors are very sensitive to changes in temperature. The accuracy of hydrogen measurement depends on both the precision of sensors developed and the reliable technique of installation and security of sensors. The two types of sensors have been used for in-situ determining hydrogen permeated in steels owing to a corrosive reaction, a hydrogen gas circumstance at elevated temperatures and high pressure or also a pretreatment process such as pickling and plating process, etc.
文摘Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-
文摘Evapotranspiration of a natural secondary white birch (Betula populifolia)forest in Maoershan Ecological Station was determined by water balance method, heat balance method and water and heat combination method. Results showed that the total evapotranspiration of the forest in the growing season was 3. 6mm/d. of which evapotrans piration from canopy xvas 2. 91 mm/d and that from forest floor was 0. 57 mm/d. and that in the non-growing season was 0. 8 mm/d.
基金supported by the Bilateral Scientific-research Project between the Republic of Croatia and Serbia 2019-2020[337-00-205/2019-09/22]Croatian Science Foundation[Project OPENTOX,No.8366]the Ministry of Education,Science and Technological Development of the Republic of Serbia[Project No.III43007].
文摘One of the most commonly used non-invasive methods for assessing human exposure to pollution is the analysis of human milk.Human milk analyses help estimate the exposure of infants[1].This is why breast milk is receives scientific interest,and various methods for determining different pollutants from the environment are being developed[2,3].
文摘A series of olefin hydroformylations over supported aqueous-phase rhodium catalyst with the substitUtion of CO/D2 for CO/H2 were cAned out to study the isotope effects of deuterium. The rate of aldehyde formation in CO/D2 was about 1.3 times faster than that in COns2, indicating that the aldehyde formation shows noticeable inverse deuterium isotope effect over SAP catalyst. The results of in-situIR stUdy of ethylene hydroformylation suggest that the reaction rate of acylhydrogenolysis forming aldehyde is the slowest one. It may be inferred from these results that the rate-determining step involved\in aldehyde formation is very probably astep ofhydrogenation.
文摘The approach of estimating the number of signals based on information theoretic criteria has good performance in the assumption of white noise, but it always leads to false estimation of the coherent sources in colored noise. An approach combining the combined information theoretic criteria and eigen- value correction, is presented to determine number of signals. The method uses maximum likelihood (ML) and information theoretic criteria to estimate coherent signals alternately, then eliminate the inequality of the eigenvalues caused by colored noise by correcting the noise eigenvalues. The computer simulation results prove the effective performance of the method.
文摘A method to determine the design value of the extreme wave height is introduced in this paper. The method is, based on the theoretical distribution of wave heights or the experiential probability distribution of wave heights, to calculate the mode of the extreme wave height and the design value with good assuredness. In fitting the experiential distribution of the observed wave heights, the paper adopts the simulating function of F(x) = 1 - exp[ ?axb exp( -cxd )] and the non-linear parameter in the function is determined by the Non-Linear Least Square Method. The practical application of the method has proved that it is not only simple and convenient, but also very effective in engineering design practice.
基金Supported by the National Natural Science Foundation of China under Grant No 11172042
文摘The time-dependent Jones Wilkins-Lee equation products for aluminized explosives. To obtain the of state (JWL-EOS) is applied to describe detonation state time-dependent JWL-EOS parameters, cylinder tests and underwater explosion experiments are performed. According to the result of the wall radial velocity in cylinder tests and the shock wave pressures in underwater explosion experiments, the time-dependent JWL-EOS parameters are determined by iterating these variables in AUTODYN hydroeode simulations until the experimental values are reproduced. In addition, to verify the reliability of the derived JWL-EOS parameters, the aluminized explosive experiment is conducted in concrete. The shock wave pressures in the affected concrete bodies are measured by using manganin pressure sensors, and the rod velocity is obtained by using a high-speed camera. Simultaneously, the shock wave pressure and the rod velocity are calculated by using the derived time-dependent JWL equation of state. The calculated results are in good agreement with the experimental data.
基金Supported by National Natural Science Foundation of China,No. 81860422。
文摘BACKGROUND Sex determining region Y-box 2(SOX2) can promote squamous cell carcinoma(SSC) because it regulates the migration and invasion of several different types of squamous carcinoma cells.However,few studies have examined the prognostic value of SOX2 and its effect on the epithelial-mesenchymal transition(EMT) in esophageal SSC(ESCC),a cancer characterized by high invasion and rapid metastasis.AIM To verify the relationship of SOX2 and the EMT in ESCC and determine the prognostic value and significance of SOX2 and protein markers of the EMT in ESCC.METHODS One hundred and eighty-five postsurgical ESCC patients were retrospectively examined.Immunohistochemistry was used to detect SOX2,E-cadherin,and vimentin in ESCC tissues.The chi-square test was used to determine the relationships of the expression of these proteins with clinical data.Kaplan-Meier survival curves were used to evaluate factors associated with overall survival(OS).RESULTS SOX2 and vimentin had high expression in ESCC tissues and correlated with the depth of local carcinoma invasion.SOX2 expression had positive correlations with tumor size,vimentin expression,and the EMT,and a negative correlation with Ecadherin expression.Expression of SOX2 and vimentin had negative correlations with OS.SOX2 expression was an independent prognostic risk factor for poor OS in patients with ESCC.CONCLUSION SOX2 expression was an independent risk factor for OS in patients with ESCC and its expression had a positive correlation with the expression of vimentin,a classic marker of the EMT.SOX2 promoted the migration and invasion of ESCC,and this may related to its effect on vimentin in promoting the EMT.
基金supported jointly by WHO(CHN-12-MCN-005007)UNICEF(YH702H&N)Chinese Post-doctoral Foundation(2012M510295)
文摘China, as a whole, is about to meet the Millennium Development Goals for reducing the maternal mortality ratio (MMR) and infant mortality rate (IMR), but the disparities between rural area and urban area still exists. This study estimated the potential effectiveness of expanding coverage with high impact interventions using the Lives Saved Tool (LiST). It was found that gestational hypertension, antepartum and postpartum hemorrhage, preterm birth, neonatal asphyxia, and neonatal childhood pneumonia and diarrhea are still the major killers of mothers and children in rural area in China. It was estimated that 30% of deaths among 0-59 month old children and 25% of maternal deaths in 2008 could be prevented in 2015 if primary health care intervention coverage expanded to a feasible level. The LiST death cause framework, compared to data from the Maternal and Child Mortality Surveillance System, represents 60%-80% of neonatal deaths, 40%-50% of deaths in 1-59 month old children and 40%-60% of maternal deaths in rural areas of western China.
文摘A single three point bend specimen compliance method for determining JIC of high strength high fracture toughness steels is presented and a formula for calculatinff J-integral is proposed as follows.It is simple and valid for high strength high fracture toughness steels. The values of JIC and KIC measured by this method are in good agreement with those measured by standard test method.
文摘We consider the initial-boundary value problem for a nonlinear wave equation with strong structural damping and nonlinear source terms in IR. We prove the global existence and uniqueness of weak solutions of the problem and then we will study the determining modes on the phase space by using energy methods and the concept of the completeness defect.
文摘Housing is both good and investment assets so that it plays an important role in the economy. Housing also can be characterized the most complex economic good because of its durability, heterogeneity, locational fixity, the possibility to raise loans against housing collateral, and the effect on well-developed secondary markets. On the other hand, income distribution, socio-economic justice, and regional disparities imply that housing market is an important concept for social and cultural transformation. In this study, the determinants of housing demand were compared for countries. These countries are selected according to economic situation: Turkey, Hungary, and United Kingdom. As a scope of this, the dynamic relationship between the housing demand and variables determining the housing demand in Turkey, Hungary, and UK has been analyzed. The model estimated uses quarterly data from January 2002 to January 2014. Building permits has been considered as housing demand. The other variables used for determining the housing demand are GDP, monetary aggregate, interest rate, and share prices. The long term relationship among variables has been analyzed with Vector Autoregressive Model (VAR) as impulse response and variance decomposition. The findings indicate that determining of housing demand changes according to economic and financial components such as government policies, mortgage system, consumer choice, tax, and subsidy in selected countries. All variables play an important role in housing demand, although the level of their impacts varies.
文摘While we studied pharmacokinetics of SM-12502 which was under development as an anti-PAF agent, we found three subjects showing a slow metabolic phenotype in its pharmacokinetics. Analyzing the genes for CYP2A6 from the three subjects, we discovered that the three subjects possessed the whole CYP2A6 gene deletion (CYP2A6*4C), a novel genetic polymorphism of the CYP2A6 gene. Genetically engineered Salmonella YG7108 cells expressing human CYP2A6 or CYP2E1 together with the NADPH-CYP reductase were established in our laboratory to compare the mutagen-producing capacity of these enzymes for various N-nitrosamines. We found that CYP2E1 was responsible for the metabolic activation of N-nitrosamines with relatively short alkyl chains, whereas CYP2A6 was involved in the metabolic activation of N-nitrosamines possessing relatively bulky alkyl chains such as a tobacco-specific nitrosamine, NNK, which has been known to cause lung tumor in rodents. Thus, to examine a hypothesis that individuals possessing the CYP2A6*4C have the reduced risk of lung cancer due to the lack of the capacity of the metabolic activation of certain carcinogens in tobacco smoke, a case-control study was performed.