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Role of aberrant Sonic hedgehog signaling pathway in cancers and developmental anomalies 被引量:3
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作者 Trupti N.Patel Pavan Kumar Dhanyamraju 《The Journal of Biomedical Research》 CAS CSCD 2022年第1期11-19,共9页
Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)pathway.Several important functions are executed by the Hh signaling cascade such as organogenesis,ti... Development is a sophisticated process maintained by various signal transduction pathways,including the Hedgehog(Hh)pathway.Several important functions are executed by the Hh signaling cascade such as organogenesis,tissue regeneration,and tissue homeostasis,among various others.Considering the multiple functions carried out by this pathway,any mutation causing aberrant Hh signaling may lead to myriad developmental abnormalities besides cancers.In the present review article,we explored a wide range of diseases caused by aberrant Hh signaling,including developmental defects and cancers.Finally,we concluded this mini-review with various treatment strategies for Hh-induced diseases. 展开更多
关键词 cancer developmental anomaly hedgehog signal transduction drug treatment
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Important Issues of Sustainable Development:Research of Nontraditional Mineral Resources
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作者 Zhao Pengda Chen Jianping Institute of High and New Techniques Applied to Land Resources, China University of Geosciences, Beijing 100083 《Journal of Earth Science》 SCIE CAS CSCD 2000年第2期3-7,共5页
Nontraditional resources refer to that potential mineral resources are unconsidered and unutilized under actual condition of technique, economic and environment, or some mineral resources are too difficult to find bec... Nontraditional resources refer to that potential mineral resources are unconsidered and unutilized under actual condition of technique, economic and environment, or some mineral resources are too difficult to find because of geological complexity. There are some signified problems about discovery and exploration of nontraditional mineral resources to be discussed in this paper. It is a very significant project next century, and makes development bases for offspring, which its research and practice the theory of nontraditional mineral resources need interactive combination. 展开更多
关键词 nontraditional mineral resources sustainable development geological anomaly.
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Hemispheric developmental venous anomaly draining into a vein of Galen varix:a case report and literature review
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作者 Hangzhe Xu Jun Zheng +1 位作者 Gao Chen Jingsen Chen 《Chinese Neurosurgical Journal》 CSCD 2017年第2期115-118,共4页
Background:Developmental venous anomaly (DVA),previously known as 'venous angioma',is the most common cerebral vascular malformation,but hemispheric DVA is extremely rare.Case presentation:In this article we p... Background:Developmental venous anomaly (DVA),previously known as 'venous angioma',is the most common cerebral vascular malformation,but hemispheric DVA is extremely rare.Case presentation:In this article we present a 21-year-old female with a large DVA draining the whole left hemisphere,combined with a vein of Galen varix and falcine sinus.To our knowledge,only 4 cases of hemispheric DVA have been reported before,however,none with a vein of Galen varix.This patient's digital subtraction angiography also revealed double straight sinus with severe stenosis of one of the sinuses,which was considered to be the possible reason of the venous varix.The patient was managed conservatively,and her clinical status was stable for 1 year.Conclusions:Because brain DVA drains the normal cerebral parenchyma and the hemorrhage risk is relatively low,hemispheric DVA is considered to be a benign anomaly,and conservative treatment is recommended. 展开更多
关键词 Cerebral hemisphere developmental venous anomaly Vein of Galen varix Venous malformation Digital subtraction angiography
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Thyroid dysfunction and developmental anomalies in first degree relatives of children with thyroid dysgenesis
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作者 Lakshminarasimhan Sindhuja Devi Dayal +2 位作者 Kushaljit Singh Sodhi Naresh Sachdeva Anish Bhattacharya 《World Journal of Pediatrics》 SCIE CSCD 2016年第2期215-218,共4页
Background: Familial clustering in patients withpermanent congenital hypothyroidism (CH) caused bythyroid dysgenesis (TD) has been reported in developedcountries. There is no information on familial TD fromdeveloping ... Background: Familial clustering in patients withpermanent congenital hypothyroidism (CH) caused bythyroid dysgenesis (TD) has been reported in developedcountries. There is no information on familial TD fromdeveloping countries.Methods: A total of 312 first degree relativesbelonging to 80 families of children with TD (group 1)and 40 families of age-matched normal children (group2) were screened by thyroid ultrasonography, serum totalthyroxine (T4) and thyroid stimulating hormone (TSH).Results: Thyroid scintigraphy revealed agenesis in78.7% of the patients, ectopic gland in 15%, and hypoplasiain 6.2%. The mean thyroid volumes were similar in parentsand siblings of both groups. Eight (10.6%) mothers in group1 were identified to have thyroid hypoplasia as comparedwith none in group 2 (P=0.03). Serum TSH was signifi cantlyhigher in group 1 than in group 2 (P=0.004). Sixteen (7.8%)subjects (6 mothers, 5 fathers, and 5 siblings) in group 1were found to have subclinical hypothyroidism as comparedto none in group 2 (P<0.05). Four families were identifiedto have thyroid developmental anomalies and abnormalthyroid functions accounting for 5% of cases of familial TDin our cohort.Conclusions: Thyroid developmental anomalies andthyroid function abnormalities are more frequent in firstdegree relatives of children with TD as compared with acontrol population. These findings suggest that possiblythere is a genetic component of TD in Indian patients. 展开更多
关键词 congenital hypothyroidism familial occurrence first degree relatives thyroid developmental anomalies thyroid dysgenesis
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