Objective:To study the effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke.Methods: The patients with insomnia after stroke who were tre...Objective:To study the effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke.Methods: The patients with insomnia after stroke who were treated in Linyi Rongjun Hospital between March 2015 and October 2017 were chosen and randomly divided into dexzopiclone group and estazolam group. The levels of neurotransmitters, nerve cytokines and stress indexes in serum were measured before treatment as well as 14 days and 28 days after treatment.Results: Compared with those before treatment, serum Glu,γ-GABA, 5-HT, 5-HIAA, BDNF and NGF levels of both groups significantly increased whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD and GSH levels significantly decreased after treatment, and serum Glu,γ-GABA, 5-HT, 5-HIAA, BDNF and NGF levels of dexzopiclone group after treatment were higher than those of estazolam group whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD and GSH levels were lower than those of estazolam group.Conclusion:Dexzopiclone is more effective than estazolam to regulate the secretion of neurotransmitters and nerve cytokines and reduce the stress state in patients with insomnia after stroke.展开更多
文摘Objective:To study the effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke.Methods: The patients with insomnia after stroke who were treated in Linyi Rongjun Hospital between March 2015 and October 2017 were chosen and randomly divided into dexzopiclone group and estazolam group. The levels of neurotransmitters, nerve cytokines and stress indexes in serum were measured before treatment as well as 14 days and 28 days after treatment.Results: Compared with those before treatment, serum Glu,γ-GABA, 5-HT, 5-HIAA, BDNF and NGF levels of both groups significantly increased whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD and GSH levels significantly decreased after treatment, and serum Glu,γ-GABA, 5-HT, 5-HIAA, BDNF and NGF levels of dexzopiclone group after treatment were higher than those of estazolam group whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD and GSH levels were lower than those of estazolam group.Conclusion:Dexzopiclone is more effective than estazolam to regulate the secretion of neurotransmitters and nerve cytokines and reduce the stress state in patients with insomnia after stroke.
