The dibutyltin 3,4-dimethoxybenzotate compound {[（3,4-（CH3O）2C6H3COO） Sn（Bu-n）2]2O}2 has been synthesized by the reaction of dibutyltin oxide with 3,4-dimethoxybenzoic acid. Its structure was determined by X-ray...The dibutyltin 3,4-dimethoxybenzotate compound {[（3,4-（CH3O）2C6H3COO） Sn（Bu-n）2]2O}2 has been synthesized by the reaction of dibutyltin oxide with 3,4-dimethoxybenzoic acid. Its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the triclinic system,space group P1 with a = 1.2003（2）,b = 1.2821（3）,c = 1.3666（3） nm,α = 80.50（3）,β = 65.56（3）,γ = 73.36（3）°,Z = 2,V = 1.8318（6） nm3,Dc = 1.530 Mg·m-3,μ（MoKa） = 1.413 mm-1,F（000） = 860,R = 0.0554 and wR = 0.1092. In the complex,each tin atom adopts a distorted tigonal bipyramidal structure,and the dimer structure is shaped by one Sn2O2 planar four-membered ring. The stabilities of the title complex,along with its orbital energies and composition characteristics of some frontier molecular orbitals have been investigated by means of quantum chemistry calculation methods.展开更多
Dibutyltin dilaurate functions as a stabilizer for polyvinyl chloride. In this study, experimental rats were intragastrically administered 5, 10, or 20 mg/kg dibutyltin dilaurate to model sub-chronic poisoning. After ...Dibutyltin dilaurate functions as a stabilizer for polyvinyl chloride. In this study, experimental rats were intragastrically administered 5, 10, or 20 mg/kg dibutyltin dilaurate to model sub-chronic poisoning. After exposure, our results showed the activities of superoxide dismutase and glutathione peroxidase decreased in rat brain tissue, while the malondialdehyde and nitric oxide content, as well as nitric oxide synthase activity in rat brain tissue increased. The cell cycle in the right parietal cortex was disordered and the rate of apoptosis increased. DNA damage was aggravated in the cerebral cortex, and the ultrastructure of the right parietal cortex tissues was altered. The above changes became more apparent with exposure to increasing doses of dibutyltin dilaurate. Our experimental findings confirmed the neurotoxicity of dibutyltin dilaurate in rat brain tissues, and demonstrated that the poisoning was dose-dependent.展开更多
Depolymerization of poly（ethylene terephthalate） （PET） was performed in the tubular bomb microreactor which contained the solution of PET in methanol and dibutyltin oxide at the temperature ranging from 433 K to 4...Depolymerization of poly（ethylene terephthalate） （PET） was performed in the tubular bomb microreactor which contained the solution of PET in methanol and dibutyltin oxide at the temperature ranging from 433 K to 473 K, the reaction time from 5 to 45 min and the catalyst-to-PET ratio of 0.3%-2% by weight. The optimal condition for PET depolymerization catalyzed by dibutyltin oxide is the temperature of 443-453 K, the reaction time of 20-25 min and 0.8% by weight of catalyst. By using differential methods, the activation energy for the depolymerization process was found to be 154.05 kJ/mol in the temperature range from 433-463 K.展开更多
Di-O-acetyl sucrose was regioselective synthesized by using dibutyltin oxide in about 60% yield. The structure of acetyl derivative was elucidated by 1H NMR, 13C NMR, 2D-NMR and MS spectral data.
New dibutyltin(IV) complexes of Schiff base derived from 5-chloroindoline-2,3-dione, indoline- 2,3-dione with amino acids (tryptophan, alanine and valine) were synthesized and characterized by elemental analysis, IR, ...New dibutyltin(IV) complexes of Schiff base derived from 5-chloroindoline-2,3-dione, indoline- 2,3-dione with amino acids (tryptophan, alanine and valine) were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, and biological activity. The analytical data showed that the Schiff base ligand acts as bidentate towards metal ions via the azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of M:L (1:2) to form metal complexes. NMR (1H, 13C and 119Sn) spectral data of the ligands and metal complex agree with proposed structures. The conductivity values between 14 - 27 ohm-1cm2mol-1 in DMF imply the presence of non-electrolyte species. 3D molecular modeling and analysis of bond lengths and bond angles have also been conducted for a representative compound, [Bu2Sn(L2)2], to substantiate the proposed structures. Antibacterial results indicate that the metal complexes are more active than the free ligands.展开更多
Influences of lanthanum stearate （LaSt3） and calcium stearate/zinc stearate （Ca/Zn） stabilizers on stabilization efficiency of dibutyltin dilaurate （DBTDL） to polyvinyl chloride （PVC） in air were investigated....Influences of lanthanum stearate （LaSt3） and calcium stearate/zinc stearate （Ca/Zn） stabilizers on stabilization efficiency of dibutyltin dilaurate （DBTDL） to polyvinyl chloride （PVC） in air were investigated. The results revealed that the stabilization effect of DBTDL could be achieved by the La/Sn stabilizers with a ratio of 8/2. Addition of DBTDL could enhance thermal property and reduce dynamic storage modulus （G＇） at 180℃ for PVC containing LaSt3 or Ca/Zn stabilizers. On the other hand, incorporation of LaSh did not influence the stabilization efficiency of DBTDL markedly; while addition of Ca/Zn stabilizers could significantly decrease thermal property for the DBTDL stabilized PVC. Furthermore, the effects of LaSt3 and Ca/Zn stabilizers on the stabilization efficiency of DBTDL were explained in the framework of ionization potential.展开更多
Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C_(6)H_(5)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C_(6)H_(4)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)we...Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C_(6)H_(5)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C_(6)H_(4)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)were synthesized and characterized by IR,^(1)H,^(13)C and^(119)Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex I belongs to monoclinic system,space group P2_(1)/n with a=11.1942(8),b=10.4754(7),c=23.6700(17)?,?=101.529(2)?,Z=2,V=2719.6(3)?^(3),D_(c)=1.371 Mg·m^(–3),?(Mo Kα)=0.966 mm^(–1),F(000)=1152,R=0.0458and w R=0.1312.The crystal of complex II is of triclinic system,space group P1 with a=9.9960(4),b=11.2466(4),c=14.0509(5)?,α=69.4190(10)?,?=70.0600(10)?,γ=81.8090(10)?,Z=1,V=1389.69(9)?^(3),D_(c)=1.380 Mg·m^(–3),?(Mo Kα)=0.950 mm^(–1),F(000)=592,R=0.0284 and w R=0.0690.In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines(MCF7,NCI-H460 and Hep G2),and complex II exhibited better antitumor activity than I.The interaction between complexes and calf thymus DNA was studied by UV-vis,fluorescence spectroscopy and viscosity measurements.展开更多
A series of dibutyltin complexes,(Bu_(2)Sn)_(2)L,[(Bu_(2)Sn)_(2)L]3 and H_(2)LSnBu_(2),were synthesized by microwave-assisted methanolic solvothermal method,where H4L is[_(2)-(OH)-R-ArCH=NNH]_(2)CX,and X=O,R=4-NEt_(2)...A series of dibutyltin complexes,(Bu_(2)Sn)_(2)L,[(Bu_(2)Sn)_(2)L]3 and H_(2)LSnBu_(2),were synthesized by microwave-assisted methanolic solvothermal method,where H4L is[_(2)-(OH)-R-ArCH=NNH]_(2)CX,and X=O,R=4-NEt_(2)(Tl),5-Br(T_(2));X=S,R=H(T3);R=5-Br(T4).Their structures were characterized by elemental analysis,IR and(^(1)H,^(13)C)-NMR spectra.The molecular structure of T_(2) was confirmed by X-ray diffraction.The crystal of T_(2) belongs to monoclinic system,space group la.Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligand with two dibutyltins,thus forming a trimeric hexanuclear butyltin complex by the cross coordination of three units(Bu_(2)Sn)_(2)L with enol imines.The T_(2) and T4 exhibit fluorescence emission in DMF solvents and DMF-water mixture.The fluorescence intensity of T_(2)-DMF-H_(2)0 system decreases almost linearly with the increase of water volume fraction(WVF).The aggregation fluorescence enhancement effect of T4-DMF-H_(2)0 solution system increases with the increase of WVF at the range of 0-_(2)0%WVF.When WVF is more than _(2)0%,the fluorescence intensity decreases with the increase of WVF.In addition,T1〜T4 have broad growth activities on target plants,such as Portulaca oleracea L.,Amaranthus spinosus L.,Cassia tora L.,Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee,and Amaranthus tricolor L.,and can be used as a candidate herbicide for further research.展开更多
基金Project supported by the Key Foundation of Education Committee of Hunan Province (10A014,10K010)Key Subject Foundation of Hunan Province and SRTP Foundation of Hunan Province
文摘The dibutyltin 3,4-dimethoxybenzotate compound {[（3,4-（CH3O）2C6H3COO） Sn（Bu-n）2]2O}2 has been synthesized by the reaction of dibutyltin oxide with 3,4-dimethoxybenzoic acid. Its structure was determined by X-ray single-crystal diffraction. The crystal belongs to the triclinic system,space group P1 with a = 1.2003（2）,b = 1.2821（3）,c = 1.3666（3） nm,α = 80.50（3）,β = 65.56（3）,γ = 73.36（3）°,Z = 2,V = 1.8318（6） nm3,Dc = 1.530 Mg·m-3,μ（MoKa） = 1.413 mm-1,F（000） = 860,R = 0.0554 and wR = 0.1092. In the complex,each tin atom adopts a distorted tigonal bipyramidal structure,and the dimer structure is shaped by one Sn2O2 planar four-membered ring. The stabilities of the title complex,along with its orbital energies and composition characteristics of some frontier molecular orbitals have been investigated by means of quantum chemistry calculation methods.
文摘Dibutyltin dilaurate functions as a stabilizer for polyvinyl chloride. In this study, experimental rats were intragastrically administered 5, 10, or 20 mg/kg dibutyltin dilaurate to model sub-chronic poisoning. After exposure, our results showed the activities of superoxide dismutase and glutathione peroxidase decreased in rat brain tissue, while the malondialdehyde and nitric oxide content, as well as nitric oxide synthase activity in rat brain tissue increased. The cell cycle in the right parietal cortex was disordered and the rate of apoptosis increased. DNA damage was aggravated in the cerebral cortex, and the ultrastructure of the right parietal cortex tissues was altered. The above changes became more apparent with exposure to increasing doses of dibutyltin dilaurate. Our experimental findings confirmed the neurotoxicity of dibutyltin dilaurate in rat brain tissues, and demonstrated that the poisoning was dose-dependent.
文摘Depolymerization of poly（ethylene terephthalate） （PET） was performed in the tubular bomb microreactor which contained the solution of PET in methanol and dibutyltin oxide at the temperature ranging from 433 K to 473 K, the reaction time from 5 to 45 min and the catalyst-to-PET ratio of 0.3%-2% by weight. The optimal condition for PET depolymerization catalyzed by dibutyltin oxide is the temperature of 443-453 K, the reaction time of 20-25 min and 0.8% by weight of catalyst. By using differential methods, the activation energy for the depolymerization process was found to be 154.05 kJ/mol in the temperature range from 433-463 K.
文摘Di-O-acetyl sucrose was regioselective synthesized by using dibutyltin oxide in about 60% yield. The structure of acetyl derivative was elucidated by 1H NMR, 13C NMR, 2D-NMR and MS spectral data.
文摘New dibutyltin(IV) complexes of Schiff base derived from 5-chloroindoline-2,3-dione, indoline- 2,3-dione with amino acids (tryptophan, alanine and valine) were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, and biological activity. The analytical data showed that the Schiff base ligand acts as bidentate towards metal ions via the azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of M:L (1:2) to form metal complexes. NMR (1H, 13C and 119Sn) spectral data of the ligands and metal complex agree with proposed structures. The conductivity values between 14 - 27 ohm-1cm2mol-1 in DMF imply the presence of non-electrolyte species. 3D molecular modeling and analysis of bond lengths and bond angles have also been conducted for a representative compound, [Bu2Sn(L2)2], to substantiate the proposed structures. Antibacterial results indicate that the metal complexes are more active than the free ligands.
基金supported by Key Projects in the National Science & Technology Pillar Program(No. 2007BAE10B04)
文摘Influences of lanthanum stearate （LaSt3） and calcium stearate/zinc stearate （Ca/Zn） stabilizers on stabilization efficiency of dibutyltin dilaurate （DBTDL） to polyvinyl chloride （PVC） in air were investigated. The results revealed that the stabilization effect of DBTDL could be achieved by the La/Sn stabilizers with a ratio of 8/2. Addition of DBTDL could enhance thermal property and reduce dynamic storage modulus （G＇） at 180℃ for PVC containing LaSt3 or Ca/Zn stabilizers. On the other hand, incorporation of LaSh did not influence the stabilization efficiency of DBTDL markedly; while addition of Ca/Zn stabilizers could significantly decrease thermal property for the DBTDL stabilized PVC. Furthermore, the effects of LaSt3 and Ca/Zn stabilizers on the stabilization efficiency of DBTDL were explained in the framework of ionization potential.
基金Supported by the Scientific Research Fund of Hunan Provincial Education Department of China(No.19C0279)Functional Metal-organic Compounds of Hunan Science and Technology Innovation Team。
文摘Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C_(6)H_(5)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C_(6)H_(4)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)were synthesized and characterized by IR,^(1)H,^(13)C and^(119)Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex I belongs to monoclinic system,space group P2_(1)/n with a=11.1942(8),b=10.4754(7),c=23.6700(17)?,?=101.529(2)?,Z=2,V=2719.6(3)?^(3),D_(c)=1.371 Mg·m^(–3),?(Mo Kα)=0.966 mm^(–1),F(000)=1152,R=0.0458and w R=0.1312.The crystal of complex II is of triclinic system,space group P1 with a=9.9960(4),b=11.2466(4),c=14.0509(5)?,α=69.4190(10)?,?=70.0600(10)?,γ=81.8090(10)?,Z=1,V=1389.69(9)?^(3),D_(c)=1.380 Mg·m^(–3),?(Mo Kα)=0.950 mm^(–1),F(000)=592,R=0.0284 and w R=0.0690.In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines(MCF7,NCI-H460 and Hep G2),and complex II exhibited better antitumor activity than I.The interaction between complexes and calf thymus DNA was studied by UV-vis,fluorescence spectroscopy and viscosity measurements.
基金Supported by the Innovation Platform Open Foundation for Colleges and Universities of Hunan Province(No.16k011)the Foundation of Key Laboratory of Functional Metal-organic Compounds of Hunan Province。
文摘A series of dibutyltin complexes,(Bu_(2)Sn)_(2)L,[(Bu_(2)Sn)_(2)L]3 and H_(2)LSnBu_(2),were synthesized by microwave-assisted methanolic solvothermal method,where H4L is[_(2)-(OH)-R-ArCH=NNH]_(2)CX,and X=O,R=4-NEt_(2)(Tl),5-Br(T_(2));X=S,R=H(T3);R=5-Br(T4).Their structures were characterized by elemental analysis,IR and(^(1)H,^(13)C)-NMR spectra.The molecular structure of T_(2) was confirmed by X-ray diffraction.The crystal of T_(2) belongs to monoclinic system,space group la.Five-coordinated distorted triangular bipyramids and six-coordinated distorted octahedral configurations were formed by the coordination of oxygen and nitrogen atoms of ligand with two dibutyltins,thus forming a trimeric hexanuclear butyltin complex by the cross coordination of three units(Bu_(2)Sn)_(2)L with enol imines.The T_(2) and T4 exhibit fluorescence emission in DMF solvents and DMF-water mixture.The fluorescence intensity of T_(2)-DMF-H_(2)0 system decreases almost linearly with the increase of water volume fraction(WVF).The aggregation fluorescence enhancement effect of T4-DMF-H_(2)0 solution system increases with the increase of WVF at the range of 0-_(2)0%WVF.When WVF is more than _(2)0%,the fluorescence intensity decreases with the increase of WVF.In addition,T1〜T4 have broad growth activities on target plants,such as Portulaca oleracea L.,Amaranthus spinosus L.,Cassia tora L.,Brassica campestris L.ssp.chinensis var.utilis Tsen et Lee,and Amaranthus tricolor L.,and can be used as a candidate herbicide for further research.
