We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by ph...We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by phos-photungstic acid at room temperature.For this reaction,a simple 'one-pot'ball-milling operation was conducted,readily available starting materials were employed,'one-pot'conditions were applied,and the most important was to use inexpensive and environmentally friendly catalyst phosphotungstic acid.Various tetrahvdroquinolines,which might be potentially applicable in the pharmaceutical and biochemical areas,were conveniently synthesized in moderate to excellent yields.展开更多
Glycyrrhizic acid(GA),as a traditional herbal,can self-assemble into helical nanofiber in the water.The formed helical nanostructures can be employed as scaffolds for asymmetric Diels-Alder reaction.Through co-assembl...Glycyrrhizic acid(GA),as a traditional herbal,can self-assemble into helical nanofiber in the water.The formed helical nanostructures can be employed as scaffolds for asymmetric Diels-Alder reaction.Through co-assembling with a series of achiral copper-ligands,the chirality of GA helical nanostructures can be transferred to catalytic site,and resulted assemblies showed moderated enantioselectivity toward catalysis of Diels-Alder reaction.展开更多
Diels-Alder reactions of N-functionalized acryloyl α-pyrrolidone derivatives were investigated, which were catalyzed by FeCl3·6H2O as an efficient catalyst under solvent-free conditions at room temperature. The ...Diels-Alder reactions of N-functionalized acryloyl α-pyrrolidone derivatives were investigated, which were catalyzed by FeCl3·6H2O as an efficient catalyst under solvent-free conditions at room temperature. The corresponding cycloadducts with functionalized-pyrrolidone were prepared in high yield with high stereoselectivity by a green chemistry procedure. N-Functionalized acryloyl pyrrolidone derivatives, a kind of pyrrolidone-functionalized chelating α,β-unsaturated ketone usable as a dienophile in Diels-Alder reaction, were synthesized by N-acylation procedure in ionic liquid as a novel synthetic method.展开更多
基金Supported by the Natural Science Foundation of Shandong Province,China(Nos.ZR2019QB022,ZR2019MB043).
文摘We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by phos-photungstic acid at room temperature.For this reaction,a simple 'one-pot'ball-milling operation was conducted,readily available starting materials were employed,'one-pot'conditions were applied,and the most important was to use inexpensive and environmentally friendly catalyst phosphotungstic acid.Various tetrahvdroquinolines,which might be potentially applicable in the pharmaceutical and biochemical areas,were conveniently synthesized in moderate to excellent yields.
基金the National Natural Science Foundation of China(Nos.21861132002,21773043)Chinese Academy of Sciences(Nos.XDB12020200,QYZDJ-SSW-SLH044)for the financial support
文摘Glycyrrhizic acid(GA),as a traditional herbal,can self-assemble into helical nanofiber in the water.The formed helical nanostructures can be employed as scaffolds for asymmetric Diels-Alder reaction.Through co-assembling with a series of achiral copper-ligands,the chirality of GA helical nanostructures can be transferred to catalytic site,and resulted assemblies showed moderated enantioselectivity toward catalysis of Diels-Alder reaction.
文摘Diels-Alder reactions of N-functionalized acryloyl α-pyrrolidone derivatives were investigated, which were catalyzed by FeCl3·6H2O as an efficient catalyst under solvent-free conditions at room temperature. The corresponding cycloadducts with functionalized-pyrrolidone were prepared in high yield with high stereoselectivity by a green chemistry procedure. N-Functionalized acryloyl pyrrolidone derivatives, a kind of pyrrolidone-functionalized chelating α,β-unsaturated ketone usable as a dienophile in Diels-Alder reaction, were synthesized by N-acylation procedure in ionic liquid as a novel synthetic method.
