AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospect...AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospective,single center,2-year clinical trial was conducted.Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.The primary endpoint was clinical relapse defi ned as the appearance of active symptoms of CD.Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous group.Remission rate with SVD was 100% at 1 year and 92% at 2 years.SVD showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD.展开更多
People are increasingly aware of the role of vegetarian diets in modulating human gut microbial abundance and intestinal physiology.A plant-based diet is thought to benefit host health by contributing to establish a d...People are increasingly aware of the role of vegetarian diets in modulating human gut microbial abundance and intestinal physiology.A plant-based diet is thought to benefit host health by contributing to establish a diverse and stable microbiome.In addition,microbe-derived metabolites of specific nutrients known to be abundant in vegetarian diets(such as indigestible carbohydrates,arginine,and others) are important to promote effective intestinal immune responses,maintain intestinal barrier function,and protect against pathogens.This review explores the characteristics of the gut microbiome formed by vegetarian diets and the effects of diet-associated nutrients on intestinal microbial abundance.The interactions between the microbe-derived metabolites of vegetarian diet-associated nutrients and intestinal physiology are also discussed.展开更多
Vegetarian diets are becoming increasingly popular as meat prices as well as health concerns rise. Many people are cutting down or cutting out meat in favor of a full vegetarian diet. In present study, the applicabili...Vegetarian diets are becoming increasingly popular as meat prices as well as health concerns rise. Many people are cutting down or cutting out meat in favor of a full vegetarian diet. In present study, the applicability of different vegetables for producing ready-to-use and ready-to-eat chickpea-based ovo-vegetarian diets (OVDs) was investigated. Herein, six different vegetables (cauliflower, taro, green zucchini, pea, bean and spinach) were formulated with 25% chickpea and additional edible ingredients to produce ready-to-use OVDs. Subsequently, chemical composition, minerals content, bioactive compounds and antioxidant activity of those OVDs were investigated. However, ready-to-eat OVDs were organoleptically evaluated after frying as common cooking method. Results of composite analysis indicated 67.73% to 73.17%, 23.20% to 37.12%, 1.86% to 2.63%, 7.63% to 9.53%, 9.06% to 9.82% and 39.24% to 55.28% for moisture, crude protein, lipids, ash, fiber, and carbohydrates contents in ready-to-use OVDs, respectively. After frying, lipid content was increased in fried diets which changed the chemical composition and caloric value. Significant differences (p < 0.05) were found between macro- and micro-nutrients content of ready- to-use and ready-to-eat OVDs. The ready-to-use OVDs exhibit appropriate content of ascorbic acid, chlorophylls, carotenoids, flavonoids, and flavonols which basically depends on their ingredients. Frying process dramatically affected the ascorbic acid, chlorophylls, flavonoids, flavonols, and carotenoids contents. High organoleptic acceptability of ready-to-eat OVDs was recorded to confirm theconsumer attractiveness further. In conclusion, the possibility of producing healthy ready-to-eatand ready-to-use OVDs incorporated with common consumed vegetables could provide a promising approach for improving human health and dietary pattern as well as for selecting the optimum processing conditions for innovative OVDs.展开更多
Background: There is convincing evidence that vegetarians have lower incidence of coronary heart disease, but there is a debate as to why this is the case. Objective: The aim of the study was to investigate whether a ...Background: There is convincing evidence that vegetarians have lower incidence of coronary heart disease, but there is a debate as to why this is the case. Objective: The aim of the study was to investigate whether a shift from a mixed diet to a lacto-vegetarian diet would lead to a decrease in risk for coronary heart diseases indicated by surrogate markers. Design: Twenty volunteers participated in the study (4 men and 16 women, mean age 44 years, range 27 - 61) from a town in western Sweden. Clinical examinations were performed, blood samples were drawn and dietary survey, i.e. repeated 24-h recalls were carried out before (0 months) and 3, 6 and 12 months after the change from a mixed diet to a lacto-vegetarian diet. A dietician educated the volunteers with regard to the vegetarian dietary regimen, organized and taught the vegetarian cooking courses. Results: The dietary shift lead to an increase in the intake of total carbohydrates and fibre and a decrease in fat, protein and sucrose. The coronary heart disease risk markers body weight, body mass index, systolic and diastolic blood pressure, total cholesterol and low-density lipoptrotein cholesterol decreased significantly. Conclusions: There was a decrease in disease risk markers even though the ratio polyunsaturated to saturated fatty acids was unchanged. The main finding in this study is that there was a weight loss, sustained for one year, without any recommendation to decrease the energy intake or any focus on weight reduction.展开更多
The goal of this paper is to review the evidence related to the effect of plant-based dietary pattems on obesity and weight loss, includingboth observational and intervention trials. Literature from plant-based diets ...The goal of this paper is to review the evidence related to the effect of plant-based dietary pattems on obesity and weight loss, includingboth observational and intervention trials. Literature from plant-based diets （PBDs） epidemiological and clinical trial research was used toinform this review. In addition, data on dietary quality, adherence, and acceptability were evaluated and are presented. Both clinical trials andobservational research indicate an advantage to adoption of PBDs for preventing overweight and obesity and promoting weight loss. PBDsmay also confer higher levels of diet quality than are observed with other therapeutic diet approaches, with similar levels of adherence andacceptability. Future studies should utilize health behavior theory to inform intervention development and delivery of PBDs studies and newtechnologies to bring interventions to scale for greater public health impact. Research examining PBDs and weight loss is also needed withmore diverse populations, including older adults. Based on the available evidence, PBDs should be considered a viable option for the treat-ment and prevention of overweight and obesity.展开更多
Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and...Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and approximately 80million Americans 20 years of age and older are hyperten-sive.展开更多
Heart failure is associated with high rates of morbidityand mortality, and is a burden to the healthcare system.There is a growing appreciation for the role diet may play inthe development and treatment of heart failure.
Stroke is a leading cause of death and disability in theUnited States and globally. Each year, approxirnately 795,000Americans experience a stroke.Total annual costs of stroke,both direct and indirect, amount to $33 b...Stroke is a leading cause of death and disability in theUnited States and globally. Each year, approxirnately 795,000Americans experience a stroke.Total annual costs of stroke,both direct and indirect, amount to $33 billion. Ischemicstroke is predicted to cost more than $2.2 trillion between2005 and 2050. In the United States, 87% of all strokesare ischemic, 10% are due to intracerebral hemorrhage, and3% are due to subarachnoid hemorrhage.展开更多
Chronic kidney disease (CKD) is a common health problem worldwide. CKD staging or classification, together with patients’ prognosis and treatment plan depend on the patients’ kidney function which is assessed by mea...Chronic kidney disease (CKD) is a common health problem worldwide. CKD staging or classification, together with patients’ prognosis and treatment plan depend on the patients’ kidney function which is assessed by measurement of glomerular filtration rate (GFR). Estimated GFR can be obtained using serum or plasma creatinine as a main variable in equations or formulae such as Cockcroft-Gault equation, MDRD equation (Modification of Diet in Renal Disease), the Schwartz and Counahan-Barratt formulae. These equations, though widely accepted, still have to be adjusted or validated among different groups of patients according to the variation in some factors such as race, diet, and genetic heterogenicity. Diet, especially the high protein load, can affect GFR representing the renal functional reserve. A high protein diet can cause an increase in GFR that lasts for many hours. Long-term consumption of vegetarian diet which is low in protein and contains only protein from plant sources can cause a low baseline GFR while the renal functional reserve is still preserved. This paper aims to remind of the role of protein diet effect on GFR measurement especially when assessing the renal function in vegetarians or individuals on long-term low-protein intake.展开更多
文摘AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospective,single center,2-year clinical trial was conducted.Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.The primary endpoint was clinical relapse defi ned as the appearance of active symptoms of CD.Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous group.Remission rate with SVD was 100% at 1 year and 92% at 2 years.SVD showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD.
基金supported by the National Natural Science Foundation of China Program [No. 31871773 and No. 31820103010]Projects of Innovation and Development Pillar Program for Key Industries in Southern Xinjiang of Xinjiang Production and Construction Corps [2018DB002]National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]。
文摘People are increasingly aware of the role of vegetarian diets in modulating human gut microbial abundance and intestinal physiology.A plant-based diet is thought to benefit host health by contributing to establish a diverse and stable microbiome.In addition,microbe-derived metabolites of specific nutrients known to be abundant in vegetarian diets(such as indigestible carbohydrates,arginine,and others) are important to promote effective intestinal immune responses,maintain intestinal barrier function,and protect against pathogens.This review explores the characteristics of the gut microbiome formed by vegetarian diets and the effects of diet-associated nutrients on intestinal microbial abundance.The interactions between the microbe-derived metabolites of vegetarian diet-associated nutrients and intestinal physiology are also discussed.
文摘Vegetarian diets are becoming increasingly popular as meat prices as well as health concerns rise. Many people are cutting down or cutting out meat in favor of a full vegetarian diet. In present study, the applicability of different vegetables for producing ready-to-use and ready-to-eat chickpea-based ovo-vegetarian diets (OVDs) was investigated. Herein, six different vegetables (cauliflower, taro, green zucchini, pea, bean and spinach) were formulated with 25% chickpea and additional edible ingredients to produce ready-to-use OVDs. Subsequently, chemical composition, minerals content, bioactive compounds and antioxidant activity of those OVDs were investigated. However, ready-to-eat OVDs were organoleptically evaluated after frying as common cooking method. Results of composite analysis indicated 67.73% to 73.17%, 23.20% to 37.12%, 1.86% to 2.63%, 7.63% to 9.53%, 9.06% to 9.82% and 39.24% to 55.28% for moisture, crude protein, lipids, ash, fiber, and carbohydrates contents in ready-to-use OVDs, respectively. After frying, lipid content was increased in fried diets which changed the chemical composition and caloric value. Significant differences (p < 0.05) were found between macro- and micro-nutrients content of ready- to-use and ready-to-eat OVDs. The ready-to-use OVDs exhibit appropriate content of ascorbic acid, chlorophylls, carotenoids, flavonoids, and flavonols which basically depends on their ingredients. Frying process dramatically affected the ascorbic acid, chlorophylls, flavonoids, flavonols, and carotenoids contents. High organoleptic acceptability of ready-to-eat OVDs was recorded to confirm theconsumer attractiveness further. In conclusion, the possibility of producing healthy ready-to-eatand ready-to-use OVDs incorporated with common consumed vegetables could provide a promising approach for improving human health and dietary pattern as well as for selecting the optimum processing conditions for innovative OVDs.
基金The Swed- ish Board for Planning and Coordination of Research The Swedish Medical Research Council+1 种基金The Swedish Foundation for Scientific Re- search without Animal Experiments The Ekhaga Foundation and Hal- sokostradet.
文摘Background: There is convincing evidence that vegetarians have lower incidence of coronary heart disease, but there is a debate as to why this is the case. Objective: The aim of the study was to investigate whether a shift from a mixed diet to a lacto-vegetarian diet would lead to a decrease in risk for coronary heart diseases indicated by surrogate markers. Design: Twenty volunteers participated in the study (4 men and 16 women, mean age 44 years, range 27 - 61) from a town in western Sweden. Clinical examinations were performed, blood samples were drawn and dietary survey, i.e. repeated 24-h recalls were carried out before (0 months) and 3, 6 and 12 months after the change from a mixed diet to a lacto-vegetarian diet. A dietician educated the volunteers with regard to the vegetarian dietary regimen, organized and taught the vegetarian cooking courses. Results: The dietary shift lead to an increase in the intake of total carbohydrates and fibre and a decrease in fat, protein and sucrose. The coronary heart disease risk markers body weight, body mass index, systolic and diastolic blood pressure, total cholesterol and low-density lipoptrotein cholesterol decreased significantly. Conclusions: There was a decrease in disease risk markers even though the ratio polyunsaturated to saturated fatty acids was unchanged. The main finding in this study is that there was a weight loss, sustained for one year, without any recommendation to decrease the energy intake or any focus on weight reduction.
文摘The goal of this paper is to review the evidence related to the effect of plant-based dietary pattems on obesity and weight loss, includingboth observational and intervention trials. Literature from plant-based diets （PBDs） epidemiological and clinical trial research was used toinform this review. In addition, data on dietary quality, adherence, and acceptability were evaluated and are presented. Both clinical trials andobservational research indicate an advantage to adoption of PBDs for preventing overweight and obesity and promoting weight loss. PBDsmay also confer higher levels of diet quality than are observed with other therapeutic diet approaches, with similar levels of adherence andacceptability. Future studies should utilize health behavior theory to inform intervention development and delivery of PBDs studies and newtechnologies to bring interventions to scale for greater public health impact. Research examining PBDs and weight loss is also needed withmore diverse populations, including older adults. Based on the available evidence, PBDs should be considered a viable option for the treat-ment and prevention of overweight and obesity.
文摘Hypertension is an insidious, common, and deadly dis-ease, often detected incidentally at a routine doctor＇s visit orworkplace health screening. Worldwide, it is estimated thatone billion people have hypertension and approximately 80million Americans 20 years of age and older are hyperten-sive.
文摘Heart failure is associated with high rates of morbidityand mortality, and is a burden to the healthcare system.There is a growing appreciation for the role diet may play inthe development and treatment of heart failure.
文摘Stroke is a leading cause of death and disability in theUnited States and globally. Each year, approxirnately 795,000Americans experience a stroke.Total annual costs of stroke,both direct and indirect, amount to $33 billion. Ischemicstroke is predicted to cost more than $2.2 trillion between2005 and 2050. In the United States, 87% of all strokesare ischemic, 10% are due to intracerebral hemorrhage, and3% are due to subarachnoid hemorrhage.
文摘Chronic kidney disease (CKD) is a common health problem worldwide. CKD staging or classification, together with patients’ prognosis and treatment plan depend on the patients’ kidney function which is assessed by measurement of glomerular filtration rate (GFR). Estimated GFR can be obtained using serum or plasma creatinine as a main variable in equations or formulae such as Cockcroft-Gault equation, MDRD equation (Modification of Diet in Renal Disease), the Schwartz and Counahan-Barratt formulae. These equations, though widely accepted, still have to be adjusted or validated among different groups of patients according to the variation in some factors such as race, diet, and genetic heterogenicity. Diet, especially the high protein load, can affect GFR representing the renal functional reserve. A high protein diet can cause an increase in GFR that lasts for many hours. Long-term consumption of vegetarian diet which is low in protein and contains only protein from plant sources can cause a low baseline GFR while the renal functional reserve is still preserved. This paper aims to remind of the role of protein diet effect on GFR measurement especially when assessing the renal function in vegetarians or individuals on long-term low-protein intake.
