Digitalis Medication in Treatment of Heart Failure

In Mexico, digitalis was known since the 16th century and was used to treat patients with bloating, and it was not until the 20th century that it began to be used as a medicine for heart failure. In conjunction with diuretics. Digitalis was later used in combination individualized with the new medications, for this purpose and research has shown that the combination of medications on an individualized basis is what is currently successfully available for the medical treatment of heart failure.

Influence of the Trends Robotics and Digitalisation on Ladle Slide Gate Development

The article focuses on the influence of operator and process safety and the trends of robotics and digitalisation on a ladle slide gate that was introduced to the market 6 years ago[1].After more than 50 installations,customer experience was gathered and new features were added to a system upgrade.These upgrades are related to safety,ease of operation,and low operational costs.Especially a newly introduced“open check”feature increases the confidence level of the operators and can boost performance.With growing requirements to increase safety for people and processes in the ladle preparation area and on the continuous casting floor,automation has become increasingly important in steel plants.A slide gate prototype is currently underway to launch an innovative new gate design striving for full automation.Several critical process steps are already available and successfully used in the steel plants,such as cylinder connection,slag detection integration,and ladle gate preparation area automation.Fully automated operation will be followed by digitalisation,allowing for tracking of performance,safety,and quality.This paper summarises new features available for slide gates and outlines individual initiatives towards fully automated operation and data acquisition examples of digitalisation.

Combination of Pretreatments with Acetic Acid and Sodium Methoxide for Efficient Digoxin Preparation from Digitalis Glycosides in Digitalis lanata Leaves

We previously developed an HPLC method for determination of lanatoside C, digoxin and α-acetyldigoxin in digitalis glycosides isolated from Digitalis lanata leaves. Here, we present an improved HPLC-UV method to determine those compounds and deslanoside. We used the improved method to examine the effects of various pretreatments on the amounts of the four compounds isolated from the leaves, with the aim of maximizing the yield of digoxin. Leaves were extracted with 50% methanol, followed by clean-up on a Sep-Pak C18 cartridge prior to HPLC analysis. The amounts of lanatoside C, digoxin and α-acetyldigoxin per 100 mg of the leaves without pretreatment were 115.6, 7.45 and 23.8 μg, respectively (deslanoside was not detected). Pretreatment with acetic acid, which activated deglucosylation mediated by digilanidase present in the leaves, increased the amounts of digoxin and α-acetyldigoxin, while lanatoside C and deslanoside were not detected. Pretreatment with sodium methoxide, which hydrolyzed lanatoside C to deslanoside, increased the yields of deslanoside and digoxin, while lanatoside C and α-acetyldigoxin were not detected. The combination of both pretreatments afforded only digoxin in a yield of 115.1 μg/100 mg leaves. Use of the combined pretreatments appears to be effective for maximizing the yield of digoxin from the leaves.

The Practices and Experience of Digitalisation of Tax Administration in Singapore

Tax administrations around the world have been digitalising to improve services delivery and internal processes.This article provides an overview of the Inland Revenue Authority of Singapore’s digitalisation strategies,focusing on enhancing customers’experiences,modernising systems,adopting Artificial Intelligence and analytics,and empowering its people through capability building.

Evaluating Methods of Visual Assistance for Workers to Improve Quality and Usability in Individualized Kitchen Cabinet Assembly

In times of digitalisation, visual assistance systems in assembly are increasingly important. The design of these assembly systems needs to be highly complex to meet the requirements. Due to the increasing number of variants in production processes, as well as shorter innovation and product life cycles, assistance systems should improve quality and reduce complexity of assembly processes. However, many large kitchen manufacturers still assemble kitchen cabinets manually, due to the high variety of components, such as rails and fittings. This paper focuses on the analysis and evaluation of virtual assistance systems to improve quality and usability in individualised kitchen cabinet assembly processes at a large German manufacturer. A solution is identified and detailed.

教育数字化赋能乡村教师高质量发展的时代意涵、现实隐忧与推进路径

为了顺应数字化社会的发展趋势,实施教育数字化战略行动,推动教育数字化转型势在必行。教育数字化赋能乡村教师高质量发展意指依托数字技术的核心支撑与创新应用,推动数字技术与乡村教师发展各维度的深度整合,助力乡村教师的教育空间、教学范式、知识储备、能力结构与乡村教师队伍管理等多方面的转型与变革,打造适应教育数字化发展趋势的高质量乡村教师队伍。同时教育数字化赋能乡村教师高质量发展也面临着数字技术焦虑,压制乡村教师高质量发展动力;数字素养薄弱,制约乡村教师高质量发展行动;数字资源不均,加剧乡村教师高质量发展鸿沟;数字成本繁重,加重乡村教师高质量发展负担等现实问题。基于文化路径、素养路径、资源路径与管理路径等推进逻辑,通过培养乡村教师数字文化自觉观念、实施乡村教师数字素养提升工程、构建乡村教师数字资源共享群落与完善乡村教师数字负担管理体系等路径,促进乡村教师高质量发展。

数字化赋能家庭婴幼儿照护的趋势、挑战及建议

家庭是我国开展婴幼儿照护的主要场所。数字化技术在家庭场景应用的普及,对于优化婴幼儿照护服务内容、降低家庭养育成本、提高婴幼儿照护人科学养育水平、提升儿童早期发展水平具有积极的促进作用。然而,数字化家庭育儿也存在内容供给规范化不足、育儿需求与政策保障的衔接欠缺、过度使用后对亲子关系及家庭分工的负面影响以及代际、城乡、区域之间的数字鸿沟等现实挑战。为顺应数字化趋势,构建新时期家庭婴幼儿照护体系,需加强政策引领,逐步明确数字化赋能家庭婴幼儿照护工作的发展方向;制定行业规则,引导数字化赋能家庭婴幼儿照护工作相关技术生态健康发展;优化内容供给,丰富数字化赋能家庭婴幼儿照护工作的产品及渠道;提升照护人数字素养,缩小家庭婴幼儿照护层面的数字鸿沟。

数字化背景下智慧照明在城市建设中的发展现状

随着数字化时代的到来,新一代信息技术的特征就是智能化,其应用和发展越来越广泛,传统的照明系统已经不能满足城市发展的需求,城市的照明系统也在不断升级,新的技术手段为人们的生活带来了前所未有的便利。本文以数字化、智慧化发展为背景,通过对智慧照明当下的特点、发展现状和进展进行梳理和总结,分析智慧照明在城市建设中的实践应用和现实意义,并对未来智慧照明的发展趋势进行展望和探索。当前照明设施大量增加、照明控制需求愈加复杂,城市照明精细化管理依靠数字化、智慧化的手段能够满足当下的照明需求,同时在环保方面也更为便捷,使得城市生活照明进入“智慧”与“绿色”境界。

Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh

Objective: Digoxin is a therapeutic cardenolide widely used to treat various heart conditions such as atrial flutter, atrial fibrillation and heart failure in both Western as well as Chinese medicine. Digoxin is extracted from cultivated Digitalis lanata Ehrh. plants, known as Mao Hua Yang Di Huang in Chinese medicine. This manuscript presents two studies that were conducted to optimize the cultivation conditions for digoxin production in the TCM Mao Hua Yan Di Huang in a greenhouse under GAP conditions.Methods: Two experiments were designed in which 4 growth conditions were compared. Levels of digoxin, gitoxin, digitoxin, α-acetyldigoxin, β-acetyl-digoxin were measured using HPLC-UV and compared between the conditions.Results: Normal soil, no CO_2 enrichment combined with a cold shock was found to be the optimal condition for producing digoxin in the first experiment. Gitoxin content was significantly lower in plants grown in this condition. Mechanical stress as well as the time of harvesting showed no statistically significant differences in the production of cardenolides. In the second experiment the optimal condition was found to be a combination of cold nights, sun screen, fertilizer use and no milled soil.Conclusion: This study shows that digoxin production can be increased by controlling the growth conditions of D. lanata Ehrh. The effect of cold was important in both experiments for improving digoxin production. Cultivating Chinese herbal medicines in optimized greenhouse conditions might be an economically attractive alternative to regular open air cultivation.

高质量发展下数字化赋能河南省制造业绿色转型升级研究

随着全球经济的快速发展,数字化技术已经成为推动制造业转型升级的重要力量。数字化技术有助于提高生产效率、降低成本、优化资源配置,为制造业的高质量发展提供有力支持。河南省作为中国的重要制造业基地,如何借助数字化技术实现高质量发展,是当前亟待解决的问题。从数字化赋能的角度,从加强政策引导、注重数字化人才培养、数字化基础设施建设等方面探讨了河南省制造业绿色转型升级的路径和政策建议,以期望为河南省制造业的绿色转型升级提供一定的参考和借鉴。

双轮驱动下重型装备制造业价值共创路径分析——以Z重工企业为例

随着数字革命的深入推进,数字化已经成为驱动高质量发展的重要引擎,而实现碳中和碳达峰是一场广泛而深刻的经济社会变革,两者相互交融,推动数字经济和绿色发展联动增效对重型装备制造企业价值格局的创造有着指引意义。以Z重工企业为对象,结合数字化和绿色化双轮驱动的机制,通过对Z重工企业特点及价值创造现状进行分析,从社会价值、战略合作等方面探讨了重型装备制造企业价值创造策略。

代州黄酒产业数字化转型发展分析

2022年9月,山西省公布首批十大省级重点专业镇名单,代州黄酒位列其中。在全面摸底调研的基础上,总结呈现了代州黄酒产业数字化转型的现状、问题和需求,提出了代州黄酒产业数字化转型思考和建议,为代州黄酒专业镇数字化转型生态体系构建提供借鉴。

数字化水平、技术创新效率与区域经济高质量发展——对面板数据的实证检验

收集2015-2020年中国34个省、自治区、直辖市中30个的面板数据,通过面板数据回归探索数字化水平对区域经济高质量发展的影响机理,同时分析技术创新效率的中介作用和吸收能力的调节作用。结果表明:数字化水平对区域经济高质量发展具有显著正向影响;存在“数字化水平提高→技术创新效率提升→区域经济高质量发展”的影响路径,即数字化水平的提高先作用于技术创新效率,进而间接推动区域经济高质量发展;数字化水平对区域经济高质量发展的提升幅度会受当地人力资本吸收能力的影响,人力资本吸收能力在此过程中发挥着调节作用。

Digitalisation of Tax Administrations:A Business Perspective

The rapid trend of digitalisation in government services,and in particular for tax administrations,is a key strategic business topic with great potential to increase the efficiency and effectiveness of business and government operations in general.As many tax administrations digitalise their processes,businesses are faced with interesting dynamics where they need to adapt their systems and processes to information and communication technology systems designed by the public sector,which could increase administrative complexity and compliance costs for businesses.ICC supports continued efforts to ensure that digitalisation enhances the efficiency and effectiveness of processes for both businesses and tax administrations and is of the view that closer collaboration with all stakeholders,and the consideration and application of key principles in digitalisation strategies and processes,will help ensure that these systems are a benefit,rather than a hindrance,to business supply chains and government operations.This article explores COVID-19 implications on tax digitalisation;key principles and objectives for digitalisation,as well as the key components of a successful digital transformation and the pre-requisites from a business perspective.It highlights how these steps will play an integral role in realising optimal benefits of efficient digitalisation for tax administrations and businesses.

数字化智能化制造车间的建设与思考

简要介绍了数字化、智能化制造车间及其建设思路,重点阐述了数字化、智能化车间的建设要点,从车间布局与虚拟车间的建设、数字化装备及产线建设、物联网建设、数字化生产管控平台建设和数字孪生车间建设等五个方面进行深入探讨,在数字化装备和信息化软件的基础上,将信息车间和物理车间深度融合,通过构造精益生产的数字化体系,为车间各业务活动提供科学决策支持,实现精益生产,真正实现车间的数字化和智能化。

中小企业数字化发展困境与对策研究

数字化已经成为国家重点发展战略,而中小企业的数字化发展决定着数字化战略能否平稳落地,因此,研究中小企业数字化发展所存在的困境具有现实意义。但中小企业数字化发展存在数字化认识不足、缺乏数字化转型资源、难以分析数字化发展预期成效、数字化战略不明晰以及难以获得政府政策精准支持等困境。基于此,针对性地提出中小企业数字化高质量发展的策略。

基于数字化转型的现代物流管理课程思政建设探析——以"智能物流技术"课程为例

随着《数字中国建设整体布局规划》的发布,为中国企业数字化转型吹响了号角,也为企业的创新发展指明了方向。企业数字化发展的关键是人才,培养德才兼备的高素质技术技能人才是职业教育的重要任务,高职现代物流管理专业人才培养体系从技术、工艺和标准方面都需要跟随企业的发展不断演进,课程思政建设必然要与之相适应。以"智能物流技术"课程为例,从课程思政设计、元素、载体、实施和评价等方面,探析数字化转型背景下课程思政建设与实施,为现代物流管理专业人才培养的课程思政提供参考。

Homo Faber Scapegoated, or Apocalyptic Artificial Intelligence: Rethinking the Technological Singularity Concept From the Synergetic Historicism Position

The article is focused on discussing a new methodological approach to the study on specifics of transferring human beings to the posthuman cyber society.The approach in question assists in rethinking interconnected problems both of human origins in the universe and mankind’s digital future.And,besides,such an approach allows to deal with self-organising interconversions between the poles of the cardinal dual opposition of the Global Noosphere Brain and the Artificial General Intelligence.Herewith such phenomena of digital social life as Global Digitalisation,Digital Immortality,Mindcloning,and Technological Zombification being the constituents of Technological Singularity Concept,are rethought as paving the way for oncoming Posthuman Digital Era.This concept is evidently exemplified by a bifurcation resulting in two alternatives to be chosen by human beings,to wit,either to be undergone Mindcloning and become digitally immortal or being destroyed by powerful intelligent machines.The investigation in question is based on such a progressive methodology as the Law of Self-Organizing Ideals,as well as on the Method of Dual Oppositions.Rethinking interrelationships between the problem of a sense of social history and the meaning-of-life of local societies members which any intelligent machine is devoid of permits to substantiate specific regularities of Self-Transforming Homo Faber into Homo Digitalis and Technological Zombies ready to be transferred to posthuman cyberspace.

顺德智造新模式的数字化升级路径研究

目的在于为制造业企业探索一个灵活应用“互联网+制造”技术进行数字化转型和升级的研究路径。选取了多个佛山顺德的“三个一批”企业作为中国制造数字化的典型样本,再跨案例分析的研究方法对其中三个样本进行比较,归纳出顺德智造的龙头企业在数字化升级过程中的不同路径,研究成果将为中国传统制造业企业尤其是中小型企业提供借鉴价值。

海塘智慧建管系统电子档案管理技术研究与应用

为解决传统水利工程建设档案信息共享不充分、业务管理不规范、双套制电子档案不方便等问题,结合海宁市百里钱塘综合整治提升工程,开展电子文件单套制归档、流程驱动信息流转等关键技术研究。通过海塘智慧建管系统的电子签章、流程引擎等技术,实现web端在线签章与管理业务标准化协同,在质量管理、文件管理、投资管理等领域达到良好的应用成效。形成了全生命周期的电子档案管理体系,可为水利工程数字化管理、数字化档案提供借鉴。