Multi-Disease Prediction Based on Deep Learning: A Survey

In recent years, the development of artificial intelligence (AI) and the gradual beginning of AI’s research in themedical field have allowed people to see the excellent prospects of the integration of AI and healthcare. Amongthem, the hot deep learning field has shown greater potential in applications such as disease prediction and drugresponse prediction. From the initial logistic regression model to the machine learning model, and then to thedeep learning model today, the accuracy of medical disease prediction has been continuously improved, and theperformance in all aspects has also been significantly improved. This article introduces some basic deep learningframeworks and some common diseases, and summarizes the deep learning prediction methods correspondingto different diseases. Point out a series of problems in the current disease prediction, and make a prospect for thefuture development. It aims to clarify the effectiveness of deep learning in disease prediction, and demonstrates thehigh correlation between deep learning and the medical field in future development. The unique feature extractionmethods of deep learning methods can still play an important role in future medical research.

A Novel Early Warning Model for Hand, Foot and Mouth Disease Prediction Based on a Graph Convolutional Network

Objectives Hand,foot and mouth disease(HFMD)is a widespread infectious disease that causes a significant disease burden on society.To achieve early intervention and to prevent outbreaks of disease,we propose a novel warning model that can accurately predict the incidence of HFMD.Methods We propose a spatial-temporal graph convolutional network(STGCN)that combines spatial factors for surrounding cities with historical incidence over a certain time period to predict the future occurrence of HFMD in Guangdong and Shandong between 2011 and 2019.The 2011-2018 data served as the training and verification set,while data from 2019 served as the prediction set.Six important parameters were selected and verified in this model and the deviation was displayed by the root mean square error and the mean absolute error.Results As the first application using a STGCN for disease forecasting,we succeeded in accurately predicting the incidence of HFMD over a 12-week period at the prefecture level,especially for cities of significant concern.Conclusions This model provides a novel approach for infectious disease prediction and may help health administrative departments implement effective control measures up to 3 months in advance,which may significantly reduce the morbidity associated with HFMD in the future.

Data and Machine Learning Fusion Architecture for Cardiovascular Disease Prediction

Heart disease,which is also known as cardiovascular disease,includes various conditions that affect the heart and has been considered a major cause of death over the past decades.Accurate and timely detection of heart disease is the single key factor for appropriate investigation,treatment,and prescription of medication.Emerging technologies such as fog,cloud,and mobile computing provide substantial support for the diagnosis and prediction of fatal diseases such as diabetes,cancer,and cardiovascular disease.Cloud computing provides a cost-efficient infrastructure for data processing,storage,and retrieval,with much of the extant research recommending machine learning(ML)algorithms for generating models for sample data.ML is considered best suited to explore hidden patterns,which is ultimately helpful for analysis and prediction.Accordingly,this study combines cloud computing with ML,collecting datasets from different geographical areas and applying fusion techniques to maintain data accuracy and consistency for the ML algorithms.Our recommended model considered three ML techniques:Artificial Neural Network,Decision Tree,and Naïve Bayes.Real-time patient data were extracted using the fuzzy-based model stored in the cloud.

An Intelligent Forecasting Model for Disease Prediction Using Stack Ensembling Approach

This research work proposes a new stack-based generalization ensemble model to forecast the number of incidences of conjunctivitis disease.In addition to forecasting the occurrences of conjunctivitis incidences,the proposed model also improves performance by using the ensemble model.Weekly rate of acute Conjunctivitis per 1000 for Hong Kong is collected for the duration of the first week of January 2010 to the last week of December 2019.Pre-processing techniques such as imputation of missing values and logarithmic transformation are applied to pre-process the data sets.A stacked generalization ensemble model based on Auto-ARIMA(Autoregressive Integrated Moving Average),NNAR(Neural Network Autoregression),ETS(Exponential Smoothing),HW(Holt Winter)is proposed and applied on the dataset.Predictive analysis is conducted on the collected dataset of conjunctivitis disease,and further compared for different performance measures.The result shows that the RMSE(Root Mean Square Error),MAE(Mean Absolute Error),MAPE(Mean Absolute Percentage Error),ACF1(Auto Correlation Function)of the proposed ensemble is decreased significantly.Considering the RMSE,for instance,error values are reduced by 39.23%,9.13%,20.42%,and 17.13%in comparison to Auto-ARIMA,NAR,ETS,and HW model respectively.This research concludes that the accuracy of the forecasting of diseases can be significantly increased by applying the proposed stack generalization ensemble model as it minimizes the prediction error and hence provides better prediction trends as compared to Auto-ARIMA,NAR,ETS,and HW model applied discretely.

Deep Learning Approach for Automatic Cardiovascular Disease Prediction Employing ECG Signals

Cardiovascular problems have become the predominant cause of death worldwide and a rise in the number of patients has been observed lately.Currently,electrocardiogram(ECG)data is analyzed by medical experts to determine the cardiac abnormality,which is time-consuming.In addition,the diagnosis requires experienced medical experts and is error-prone.However,automated identification of cardiovascular disease using ECGs is a challenging problem and state-of-the-art performance has been attained by complex deep learning architectures.This study proposes a simple multilayer perceptron(MLP)model for heart disease prediction to reduce computational complexity.ECG dataset containing averaged signals with window size 10 is used as an input.Several competing deep learning and machine learning models are used for comparison.K-fold cross-validation is used to validate the results.Experimental outcomes reveal that the MLP-based architecture can produce better outcomes than existing approaches with a 94.40%accuracy score.The findings of this study show that the proposed system achieves high performance indicating that it has the potential for deployment in a real-world,practical medical environment.

An Online Chronic Disease Prediction System Based on Incremental Deep Neural Network

Many chronic disease prediction methods have been proposed to predict or evaluate diabetes through artificial neural network.However,due to the complexity of the human body,there are still many challenges to face in that process.One of them is how to make the neural network prediction model continuously adapt and learn disease data of different patients,online.This paper presents a novel chronic disease prediction system based on an incremental deep neural network.The propensity of users suffering from chronic diseases can continuously be evaluated in an incremental manner.With time,the system can predict diabetes more and more accurately by processing the feedback information.Many diabetes prediction studies are based on a common dataset,the Pima Indians diabetes dataset,which has only eight input attributes.In order to determine the correlation between the pathological characteristics of diabetic patients and their daily living resources,we have established an in-depth cooperation with a hospital.A Chinese diabetes dataset with 575 diabetics was created.Users’data collected by different sensors were used to train the network model.We evaluated our system using a real-world diabetes dataset to confirm its effectiveness.The experimental results show that the proposed system can not only continuously monitor the users,but also give early warning of physiological data that may indicate future diabetic ailments.

A Convolutional Neural Network Model for Wheat Crop Disease Prediction

Wheat is the most important cereal crop,and its low production incurs import pressure on the economy.It fulfills a significant portion of the daily energy requirements of the human body.The wheat disease is one of the major factors that result in low production and negatively affects the national economy.Thus,timely detection of wheat diseases is necessary for improving production.The CNN-based architectures showed tremendous achievement in the image-based classification and prediction of crop diseases.However,these models are computationally expensive and need a large amount of training data.In this research,a light weighted modified CNN architecture is proposed that uses eight layers particularly,three convolutional layers,three SoftMax layers,and two flattened layers,to detect wheat diseases effectively.The high-resolution images were collected from the fields in Azad Kashmir(Pakistan)and manually annotated by three human experts.The convolutional layers use 16,32,and 64 filters.Every filter uses a 3×3 kernel size.The strides for all convolutional layers are set to 1.In this research,three different variants of datasets are used.These variants S1-70%:15%:15%,S2-75%:15%:10%,and S3-80%:10%:10%(train:validation:test)are used to evaluate the performance of the proposed model.The extensive experiments revealed that the S3 performed better than S1 and S2 datasets with 93%accuracy.The experiment also concludes that a more extensive training set with high-resolution images can detect wheat diseases more accurately.

An Improved Ensemble Learning Approach for Heart Disease Prediction Using Boosting Algorithms

Cardiovascular disease is among the top five fatal diseases that affect lives worldwide.Therefore,its early prediction and detection are crucial,allowing one to take proper and necessary measures at earlier stages.Machine learning(ML)techniques are used to assist healthcare providers in better diagnosing heart disease.This study employed three boosting algorithms,namely,gradient boost,XGBoost,and AdaBoost,to predict heart disease.The dataset contained heart disease-related clinical features and was sourced from the publicly available UCI ML repository.Exploratory data analysis is performed to find the characteristics of data samples about descriptive and inferential statistics.Specifically,it was carried out to identify and replace outliers using the interquartile range and detect and replace the missing values using the imputation method.Results were recorded before and after the data preprocessing techniques were applied.Out of all the algorithms,gradient boosting achieved the highest accuracy rate of 92.20%for the proposed model.The proposed model yielded better results with gradient boosting in terms of precision,recall,and f1-score.It attained better prediction performance than the existing works and can be used for other diseases that share common features using transfer learning.

Explainable Heart Disease Prediction Using Ensemble-Quantum Machine Learning Approach

Nowadays,quantum machine learning is attracting great interest in a wide range offields due to its potential superior performance and capabilities.The massive increase in computational capacity and speed of quantum computers can lead to a quantum leap in the healthcarefield.Heart disease seriously threa-tens human health since it is the leading cause of death worldwide.Quantum machine learning methods can propose effective solutions to predict heart disease and aid in early diagnosis.In this study,an ensemble machine learning model based on quantum machine learning classifiers is proposed to predict the risk of heart disease.The proposed model is a bagging ensemble learning model where a quantum support vector classifier was used as a base classifier.Further-more,in order to make the model’s outcomes more explainable,the importance of every single feature in the prediction is computed and visualized using SHapley Additive exPlanations(SHAP)framework.In the experimental study,other stand-alone quantum classifiers,namely,Quantum Support Vector Classifier(QSVC),Quantum Neural Network(QNN),and Variational Quantum Classifier(VQC)are applied and compared with classical machine learning classifiers such as Sup-port Vector Machine(SVM),and Artificial Neural Network(ANN).The experi-mental results on the Cleveland dataset reveal the superiority of QSVC compared to the others,which explains its use in the proposed bagging model.The Bagging-QSVC model outperforms all aforementioned classifiers with an accuracy of 90.16%while showing great competitiveness compared to some state-of-the-art models using the same dataset.The results of the study indicate that quantum machine learning classifiers perform better than classical machine learning classi-fiers in predicting heart disease.In addition,the study reveals that the bagging ensemble learning technique is effective in improving the prediction accuracy of quantum classifiers.

An Improved Machine Learning Technique with Effective Heart Disease Prediction System

Heart disease is the leading cause of death worldwide.Predicting heart disease is challenging because it requires substantial experience and knowledge.Several research studies have found that the diagnostic accuracy of heart disease is low.The coronary heart disorder determines the state that influences the heart valves,causing heart disease.Two indications of coronary heart disorder are strep throat with a red persistent skin rash,and a sore throat covered by tonsils or strep throat.This work focuses on a hybrid machine learning algorithm that helps predict heart attacks and arterial stiffness.At first,we achieved the component perception measured by using a hybrid cuckoo search particle swarm optimization(CSPSO)algorithm.With this perception measure,characterization and accuracy were improved,while the execution time of the proposed model was decreased.The CSPSO-deep recurrent neural network algorithm resolved issues that state-of-the-art methods face.Our proposed method offers an illustrative framework that helps predict heart attacks with high accuracy.The proposed technique demonstrates the model accuracy,which reached 0.97 with the applied dataset.

Improving Prediction Efficiency of Machine Learning Models for Cardiovascular Disease in IoST-Based Systems through Hyperparameter Optimization

This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)device.Ten distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter tuning.Significant improvements were observed across various models,with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score,recall,and precision.The study underscores the critical role of tailored hyperparameter tuning in optimizing these models,revealing diverse outcomes among algorithms.Decision Trees and Random Forests exhibited stable performance throughout the evaluation.While enhancing accuracy,hyperparameter optimization also led to increased execution time.Visual representations and comprehensive results support the findings,confirming the hypothesis that optimizing parameters can effectively enhance predictive capabilities in cardiovascular disease.This research contributes to advancing the understanding and application of machine learning in healthcare,particularly in improving predictive accuracy for cardiovascular disease management and intervention strategies.

Development of Machine Learning Methods for Accurate Prediction of Plant Disease Resistance

The traditional method of screening plants for disease resistance phenotype is both time-consuming and costly.Genomic selection offers a potential solution to improve efficiency,but accurately predicting plant disease resistance remains a challenge.In this study,we evaluated eight different machine learning(ML)methods,including random forest classification(RFC),support vector classifier(SVC),light gradient boosting machine(lightGBM),random forest classification plus kinship(RFC_K),support vector classification plus kinship(SVC_K),light gradient boosting machine plus kinship(lightGBM_K),deep neural network genomic prediction(DNNGP),and densely connected convolutional networks(DenseNet),for predicting plant disease resistance.Our results demonstrate that the three plus kinship(K)methods developed in this study achieved high prediction accuracy.Specifically,these methods achieved accuracies of up to 95%for rice blast(RB),85%for rice black-streaked dwarf virus(RBSDV),and 85%for rice sheath blight(RSB)when trained and applied to the rice diversity panel I(RDPI).Furthermore,the plus K models performed well in predicting wheat blast(WB)and wheat stripe rust(WSR)diseases,with mean accuracies of up to 90%and 93%,respectively.To assess the generalizability of our models,we applied the trained plus K methods to predict RB disease resistance in an independent population,rice diversity panel II(RDPII).Concurrently,we evaluated the RB resistance of RDPII cultivars using spray inoculation.Comparing the predictions with the spray inoculation results,we found that the accuracy of the plus K methods reached 91%.These findings highlight the effectiveness of the plus K methods(RFC_K,SVC_K,and lightGBM_K)in accurately predicting plant disease resistance for RB,RBSDV,RSB,WB,and WSR.The methods developed in this study not only provide valuable strategies for predicting disease resistance,but also pave the way for using machine learning to streamline genome-based crop breeding.

Multiple sclerosis：integration of modeling with biology,clinical and imaging measures to provide better monitoring of disease progression and prediction of outcome

Multiple Sclerosis（MS） is a major cause of neurological disability in adults and has an annual cost of approximately $28 billion in the United States. MS is a very complex disorder as demyelination can happen in a variety of locations throughout the brain; therefore, this disease is never the same in two patients making it very hard to predict disease progression. A modeling approach which combines clinical, biological and imaging measures to help treat and fight this disorder is needed. In this paper, I will outline MS as a very heterogeneous disorder, review some potential solutions from the literature, demonstrate the need for a biomarker and will discuss how computational modeling combined with biological, clinical and imaging data can help link disparate observations and decipher complex mechanisms whose solutions are not amenable to simple reductionism.

Updated roles of the gut microbiota in exploring shrimp etiology, polymicrobial pathogens, and disease incidence

Litopenaeus vannamei is the most extensively cultured shrimp species globally,recognized for its scale,production,and economic value.However,its aquaculture is plagued by frequent disease outbreaks,resulting in rapid and massive mortality.etiological research often lags behind the emergence of new diseases,leaving the causal agents of some shrimp diseases unidentified and leading to nomenclature based on symptomatic presentations,especially in cases involving co-and polymicrobial pathogens.Comprehensive data on shrimp disease statuses remain limited.In this review,we summarize current knowledge on shrimp diseases and their effects on the gut microbiome.Furthermore,we also propose a workflow integrating primary colonizers,“driver”taxa in gut networks from healthy to diseased states,disease-discriminatory taxa,and virulence genes to identify potential polymicrobial pathogens.We examine both abiotic and biotic factors(e.g.,external and internal sources and specific-disease effects)that influence shrimp gut microbiota,with an emphasis on the“holobiome”concept and common features of gut microbiota response to diverse diseases.After excluding the effects of confounding factors,we provide a diagnosis model for quantitatively predicting shrimp disease incidence using disease common-discriminatory taxa,irrespective of the causal agents.Due to the conservation of functional genes used in designing specific primers,we propose a practical strategy applying qPCR-assayed abundances of disease common-discriminatory functional genes.This review updates the roles of the gut microbiota in exploring shrimp etiology,polymicrobial pathogens,and disease incidence,offering a refined perspective for advancing shrimp aquaculture health management.

Prediction of presence and severity of coronary artery disease using prediction for atherosclerotic cardiovascular disease risk in China scoring system

BACKGROUND Coronary artery disease(CAD)is one of the leading causes of death and disease burden in China and worldwide.A practical and reliable prediction scoring system for CAD risk and severity evaluation is urgently needed for primary prevention.AIM To examine whether the prediction for atherosclerotic cardiovascular disease risk in China(China-PAR)scoring system could be used for this purpose.METHODS A total of 6813 consecutive patients who underwent diagnostic coronary angiography were enrolled.The China-PAR score was calculated for each patient and CAD severity was assessed by the Gensini score(GS).RESULTS Correlation analysis demonstrated a significant relationship between China-PAR and GS(r=0.266,P<0.001).In receiver operating characteristic curve analysis,the cut-off values of China-PAR for predicting the presence and the severity of CAD were 7.55%with a sensitivity of 55.8%and specificity of 71.8%[area under the curve(AUC)=0.693,95%confidence interval:0.681 to 0.706,P<0.001],and 7.45%with a sensitivity of 58.8%and specificity of 67.2%(AUC=0.680,95%confidence interval:0.665 to 0.694,P<0.001),respectively.CONCLUSION The China-PAR scoring system may be useful in predicting the presence and severity of CAD.

An Approach Using Fuzzy Sets and Boosting Techniques to Predict Liver Disease

The aim of this research is to develop a mechanism to help medical practitioners predict and diagnose liver disease.Several systems have been proposed to help medical experts by diminishing error and increasing accuracy in diagnosing and predicting diseases.Among many existing methods,a few have considered the class imbalance issues of liver disorder datasets.As all the samples of liver disorder datasets are not useful,they do not contribute to learning about classifiers.A few samples might be redundant,which can increase the computational cost and affect the performance of the classifier.In this paper,a model has been proposed that combines noise filter,fuzzy sets,and boosting techniques(NFFBTs)for liver disease prediction.Firstly,the noise filter(NF)eliminates the outliers from the minority class and removes the outlier and redundant pair from the majority class.Secondly,the fuzzy set concept is applied to handle uncertainty in datasets.Thirdly,the AdaBoost boosting algorithm is trained with several learners viz,random forest(RF),support vector machine(SVM),logistic regression(LR),and naive Bayes(NB).The proposed NFFBT prediction system was applied to two datasets(i.e.,ILPD and MPRLPD)and found that AdaBoost with RF yielded 90.65%and 98.95%accuracy and F1 scores of 92.09%and 99.24%over ILPD and MPRLPD datasets,respectively.

Real-Time Multi-Class Infection Classification for Respiratory Diseases

Real-time disease prediction has emerged as the main focus of study in the field of computerized medicine.Intelligent disease identification framework can assist medical practitioners in diagnosing disease in a way that is reliable,consistent,and timely,successfully lowering mortality rates,particularly during endemics and pandemics.To prevent this pandemic’s rapid and widespread,it is vital to quickly identify,confine,and treat affected individuals.The need for auxiliary computer-aided diagnostic(CAD)systems has grown.Numerous recent studies have indicated that radiological pictures contained critical information regarding the COVID-19 virus.Utilizing advanced convolutional neural network(CNN)architectures in conjunction with radiological imaging makes it possible to provide rapid,accurate,and extremely useful susceptible classifications.This research work proposes a methodology for real-time detection of COVID-19 infections caused by the Corona Virus.The purpose of this study is to offer a two-way COVID-19(2WCD)diagnosis prediction deep learning system that is built on Transfer Learning Methodologies(TLM)and features customized fine-tuning on top of fully connected layered pre-trained CNN architectures.2WCD has applied modifications to pre-trained models for better performance.It is designed and implemented to improve the generalization ability of the classifier for binary and multi-class models.Along with the ability to differentiate COVID-19 and No-Patient in the binary class model and COVID-19,No-Patient,and Pneumonia in the multi-class model,our framework is augmented with a critical add-on for visually demonstrating infection in any tested radiological image by highlighting the affected region in the patient’s lung in a recognizable color pattern.The proposed system is shown to be extremely robust and reliable for real-time COVID-19 diagnostic prediction.It can also be used to forecast other lung-related disorders.As the system can assist medical practitioners in diagnosing the greatest number of patients in the shortestamount of time, radiologists can also be used or published online to assistany less-experienced individual in obtaining an accurate immediate screeningfor their radiological images.

Heart Disease Classification Using Multiple K-PCA and Hybrid Deep Learning Approach

One of the severe health problems and the most common types of heartdisease (HD) is Coronary heart disease (CHD). Due to the lack of a healthy lifestyle, HD would cause frequent mortality worldwide. If the heart attack occurswithout any symptoms, it cannot be cured by an intelligent detection system.An effective diagnosis and detection of CHD should prevent human casualties.Moreover, intelligent systems employ clinical-based decision support approachesto assist physicians in providing another option for diagnosing and detecting HD.This paper aims to introduce a heart disease prediction model including phaseslike (i) Feature extraction, (ii) Feature selection, and (iii) Classification. At first,the feature extraction process is carried out, where the features like a time-domainindex, frequency-domain index, geometrical domain features, nonlinear features,WT features, signal energy, skewness, entropy, kurtosis features are extractedfrom the input ECG signal. The curse of dimensionality becomes a severe issue.This paper provides the solution for this issue by introducing a new ModifiedPrincipal Component Analysis known as Multiple Kernel-based PCA for dimensionality reduction. Furthermore, the dimensionally reduced feature set is thensubjected to a classification process, where the hybrid classifier combining bothRecurrent Neural Network (RNN) and Restricted Boltzmann Machine (RBM)is used. At last, the performance analysis of the adopted scheme is compared overother existing schemes in terms of specific measures.

An Efficient Disease Detection Technique of Rice Leaf Using AlexNet

As nearly half of the people in the world live on rice, so the rice leaf disease detection is very important for our agricultural sector. Many researchers worked on this problem and they achieved different results according to their applied techniques. In this paper, we applied AlexNet technique to detect the three prevalence rice leaf diseases termed as bacterial blight, brown spot as well as leaf smut and got a remarkable outcome rather than the previous works. AlexNet is a special type of classification technique of deep learning. This paper shows more than 99% accuracy due to adjusting an efficient technique and image augmentation.