Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease(NAFLD) is defined as an excessive accumulation of triglycerides in h...Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease(NAFLD) is defined as an excessive accumulation of triglycerides in hepatocytes and includes a wide spectrum of liver conditions ranging from relatively benign steatosis to non-alcoholic steatohepatitis with fatty infiltration and lobular inflammation and to cirrhosis and endstage liver disease. Actually, psoriasis is considered a systemic diseases associated to comorbidities, as metabolic syndrome and NAFLD is seen the hepatic manifestation of the metabolic syndrome. The possible link between psoriasis, obesity and metabolic syndrome, which are known risk factors for NAFLD has beenrecently documented focusing in the crucial role of the adipose tissue in the development of the inflammatory background sharing by the above entities. According to recent data, patients with psoriasis show a greater prevalence of NAFLD and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple aspects linking NAFLD and psoriasis, only apparently far diseases.展开更多
Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature undersc...Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.展开更多
This paper reviews some of the nanoindentation research that has been done on teeth and discusses the usefulness of this technique in studying the structure-property-function relationship at the micro and nanometer sc...This paper reviews some of the nanoindentation research that has been done on teeth and discusses the usefulness of this technique in studying the structure-property-function relationship at the micro and nanometer scale. In particular, examples on the use of nanoindentation technique in investigating the effects of cleansing and bleaching agents as well as drinks on the micro- and nanostructures and mechanical properties of teeth are highlighted. Although nanoindentation on teeth is a relatively new area of research, it provides an excellent way of probing and relating the structures and mechanical properties of teeth at the submicron and nanometer scales that were previously not possible but which can now greatly benefit dental research. For example, a nanoindenter with a high resolution imaging capability can help to elucidate the mechanisms with which certain diseases can damage and compromise the structural integrity of teeth at the micro- and nanometer scale. With this information, clinicians and researchers can then work towards how best to tackle these problems or even preventing them.展开更多
目的 研究血清KL-6（Krebs von den lungen-6）作为生物标志物对CTD肺间质病变诊断、影像表现及活动性评估的价值。方法75例CTD患者分为合并肺间质病变组（44例）、不合并肺间质病变组（31例），而合并肺间质病变组再按肺CT影像分型及...目的 研究血清KL-6（Krebs von den lungen-6）作为生物标志物对CTD肺间质病变诊断、影像表现及活动性评估的价值。方法75例CTD患者分为合并肺间质病变组（44例）、不合并肺间质病变组（31例），而合并肺间质病变组再按肺CT影像分型及分级再分别分为3组，按肺间质病变活动与非活动分为2组。以ELISA法测定血清KL-6浓度，数据不服从正态分布，用独立样本非参数检验比较各组间的差异。结果CTD肺间质病变组的血清KL-6浓度[（1 118±877）U/ml]明显高于不合并肺间质病变组[（253±144）U/ml]，差异具有统计学意义（Z=-6.047，P〈0.01）。以500 U/ml为阳性标准，血清KL-6浓度对CTD合并肺间质病变诊断的敏感性、特异性、阳性预测值、阴性预测值分别为72.7%、87.1%、88.9%、69.2%。在合并肺间质病变组的影像分型中，寻常型间质性肺炎（UIP型，蜂窝病变为主）、非特异性间质性肺炎（NSIP型，毛玻璃与网格病变为主）与未定型分组间的血清KL-6浓度[分别为（1 104±843）U/ml、（1 242±1 039）U/ml、（815±400）U/ml]差异无统计学意义（χ2=0.35，P=0.84）。但合并肺间质病变组的影像病变累积分级中，病变分布范围广的患者血清KL-6浓度[（1 910±918）U/ml]较病变分布范围窄组的血清KL-6浓度[（459±268）U/ml]更高（Z=-4.364，P〈0.01）。肺间质病变活动组患者的血清KL-6浓度[（1 478±917）U/ml]也较肺间质病变非活动组[（598±475）U/ml]的高（Z=-3.915，P〈0.01）。结论血清KL-6浓度测定有利于CTD肺间质病变的诊断及肺病变范围及活动度的评估。展开更多
文摘Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease(NAFLD) is defined as an excessive accumulation of triglycerides in hepatocytes and includes a wide spectrum of liver conditions ranging from relatively benign steatosis to non-alcoholic steatohepatitis with fatty infiltration and lobular inflammation and to cirrhosis and endstage liver disease. Actually, psoriasis is considered a systemic diseases associated to comorbidities, as metabolic syndrome and NAFLD is seen the hepatic manifestation of the metabolic syndrome. The possible link between psoriasis, obesity and metabolic syndrome, which are known risk factors for NAFLD has beenrecently documented focusing in the crucial role of the adipose tissue in the development of the inflammatory background sharing by the above entities. According to recent data, patients with psoriasis show a greater prevalence of NAFLD and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple aspects linking NAFLD and psoriasis, only apparently far diseases.
文摘Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.
文摘This paper reviews some of the nanoindentation research that has been done on teeth and discusses the usefulness of this technique in studying the structure-property-function relationship at the micro and nanometer scale. In particular, examples on the use of nanoindentation technique in investigating the effects of cleansing and bleaching agents as well as drinks on the micro- and nanostructures and mechanical properties of teeth are highlighted. Although nanoindentation on teeth is a relatively new area of research, it provides an excellent way of probing and relating the structures and mechanical properties of teeth at the submicron and nanometer scales that were previously not possible but which can now greatly benefit dental research. For example, a nanoindenter with a high resolution imaging capability can help to elucidate the mechanisms with which certain diseases can damage and compromise the structural integrity of teeth at the micro- and nanometer scale. With this information, clinicians and researchers can then work towards how best to tackle these problems or even preventing them.
