Modified inferior oblique anterior transposition for dissociated vertical deviation combined with superior oblique palsy:A case report

BACKGROUND Inferior oblique anterior transposition(IOAT)has emerged as an effective surgery in the management of dissociated vertical deviation(DVD)combined with superior oblique palsy(SOP).Traditional IOAT usually provides satisfactory primary position alignment and simultaneously restricts the superior floating phenomenon.However,it also increases the risk of the anti-elevation syndrome and narrowing of the palpebral fissure in straight-ahead gaze,especially after the unilateral operation.CASE SUMMARY We report the outcomes of the modified unilateral IOAT in two patients with unilateral DVD combined with SOP.The anterior-nasal fibers of the inferior oblique muscle were attached at 9 mm posterior to the corneal limbus along the temporal board of the inferior rectus muscle,the other fibers were attached a further 5 mm temporal to the anterior-nasal fibers.Postoperatively,both hypertropia and floating were improved,and no obvious complications occurred.CONCLUSION In these cases,the modified unilateral IOAT was an effective and safe surgical method for treating DVD with SOP.

The effects of simultaneous operation on dissociated vertical deviation with horizontal and torsional strabismus

AIM: To investigate the therapeutic effects of simultaneous horizontal and vertical operations on dissociated vertical deviation(DVD) associated with other deviations.METHODS: Forty-five cases of DVD with horizontal and torsional strabismus underwent combined operation were collected retrospectively. All clinical records were analyzed. All patients were followed up for 6 to 24 mo. Wilcoxon signed-ranks test was performed to evaluate the changes of vertical and horizontal deviation. χ~2 test was used to evaluate the changes of binocular visual function. RESULTS: Forty-five cases included 36 patients with intermittent exotropia and binocular inferior oblique overaction(IOOA), 5 patients with concomitant esotropia and binocular IOOA, 4 patients with intermittent exotropia and monocular superior oblique palsy. The superior rectus recession(SRR) combined with horizontal rectus recession and the myectomy of inferior oblique or anterior transposition were operated simultaneously to correct all types of strabismus. There were 43 cases who achieved normal eye position in vertical direction, while 2 cases were with undercorrection of 5~Δ to 6~Δ. In patients with horizontal strabismus, 2 cases of exotropia were with overcorrection of 6~Δ to 8~Δ, 1 case of esotropia was with undercorrection of 6~Δ, and 1 case of monocular superior oblique palsy with compensatory head posture was not significantly improved. The binocular visual function of most patients recovered after operation. The difference of the binocular visual function and eye position were significant compared with that before operation(P<0.05).CONCLUSION: The simultaneous operation on DVD with horizontal and torsional strabismus is successful.

Calculation of thermal physical parameters of dissociated air by the dissociation degree method

The high temperature gas occurs behind shock or near the wall surface of vehicle in the hypersonic flight. As the temperature exceeds 2 000 K, 4 000 K, respectively, O2 and N2 molecules are successively dissociated. Because of variable components at dif- ferent temperatures and pressures, the dissociated air is no longer a perfect gas, In this paper, a new method is developed to calculate accurate thermal physical parameters with the dissociation degree providing the thermochemical equilibrium procedure. Based on the dissociation degree, it is concluded that few numbers of equations and the solutions are easily obtained. In addition, a set of formulas relating the parameter to the dissociation degree are set up four-species, O2 molecule The thermodynamic properties of dissociated air containing and N2 molecule, O atom and N atom, are studied with the new method, and the results are consistent with those with the traditional equilibrium constant method. It is shown that this method is reliable for solving thermal physical parameters easily and directly.

EXTENDED CORE STRUCTURE OF DISSOCIATED EDGE DISLOCATIONS IN FCC CRYSTALS WITH CONSIDERATION OF DISCRETENESS

The extended core structure of the dissociated edge dislocation in Al, Au, Ag, Cu and Ni is determined within lattice theory of dislocation. The 2D dislocation equation governing the displacements is coupled by the restoring forces that are determined by the parameterization of the generalized stacking fault energies. The Ritz variational method is presented to solve the dislocation equation and the trial solution is constituted by two arctan-type functions with two undetermined parameters. The core widths of partial dislocations are wider than that obtained in generalized Peierls-Nabarro model due to the consideration of discreteness of crystal.

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

Radiotherapy is widely used in the management of advanced colorectal cancer(CRC).However,the clinical efficacy is limited by the safe irradiated dose.Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the limitation.The BRCA1-BARD1 complex has been demonstrated to play a critical role in homologous recombination(HR)DSB repair,and its functions may be affected by HERC2 or BAP1.Accumulated evidence illustrates that the ubiquitination-deubiquitination balance is involved in these processes;however,the precise mechanism for the cross-talk among these proteins in HR repair following radiation hasn’t been defined.Through activity-based profiling,we identified PT33 as an active entity for HR repair suppression.Subsequently,we revealed that BAP1 serves as a novel molecular target of PT33 via a CRISPR-based deubiquitinase screen.Mechanistically,pharmacological covalent inhibition of BAP1 with PT33 recruits HERC2 to compete with BARD1 for BRCA1 interaction,interrupting HR repair.Consequently,PT33 treatment can substantially enhance the sensitivity of CRC cells to radiotherapy in vitro and in vivo.Overall,these findings provide a mechanistic basis for PT33-induced HR suppression and may guide an effective strategy to improve therapeutic gain.

Intrinsic correlation between the generalized phase equilibrium condition and mechanical behaviors in hydrate-bearing sediments

The phase equilibrium and mechanical behaviors of natural gas hydrate-bearing sediment are essential for gas recovery from hydrate reservoirs.In heating closed systems,the temperature-pressure path of hydrate-bearing sediment deviates from that of pure bulk hydrate,reflecting the porous media effect in phase equilibrium.A generalized phase equilibrium equation was established for hydrate-bearing sediments,which indicates that both capillary and osmotic pressures cause the phase equilibrium curve to shift leftward on the temperature-pressure plane.In contrast to bulk hydrate,hydrate-bearing sediment always contains a certain amount of unhydrated water,which keeps phase equilibrium with the hydrate within the hydrate stability field.With changes in temperature and pressure,a portion of pore hydrate and unhydrated water may transform into each other,affecting the shear strength of hydrate-bearing sediment.A shear strength model is proposed to consider not only hydrate saturation but also the change in temperature and pressure of hydrate-bearing sediment.The model is validated by experimental data with various hydrate saturation,temperature and pressure conditions.The deformation induced by partial dissociation was studied through depressurization tests under constant effective stress.The reduction in gas pressure within the hydrate stability field indeed caused sediment deformation.The dissociation-induced deformation can be reasonably estimated as the difference in volume between hydrate-bearing and hydrate-free sediments from the compression curves.

Semitransparent organic photovoltaics enabled by transparent p-type inorganic semiconductor and near-infrared acceptor

Semitransparent organic photovoltaics(STOPVs)have gained wide attention owing to their promising applications in building-integrated photovoltaics,agrivoltaics,and floating photovoltaics.Organic semiconductors with high charge carrier mobility usually have planar and conjugated structures,thereby showing strong absorption in visible region.In this work,a new concept of incorporating transparent inorganic semiconductors is proposed for high-performance STOPVs.Copper(I)thiocyanate(CuSCN)is a visible-transparent inorganic semiconductor with an ionization potential of 5.45 eV and high hole mobility.The transparency of CuSCN benefits high average visible transmittance(AVT)of STOPVs.The energy levels of CuSCN as donor match those of near-infrared small molecule acceptor BTP-eC9,and the formed heterojunction exhibits an ability of exciton dissociation.High mobility of CuSCN contributes to a more favorable charge transport channel and suppresses charge recombination.The control STOPVs based on PM6/BTP-eC9 exhibit an AVT of 19.0%with a power conversion efficiency(PCE)of 12.7%.Partial replacement of PM6 with CuSCN leads to a 63%increase in transmittance,resulting in a higher AVT of 30.9%and a comparable PCE of 10.8%.

MOF-assisted Synthesis of Dual-atom Palladium Catalysts for Acetylene Semi-hydrogenation

The selective removal of trace acetylene in ethylene feed gas is of great significance in the petrochemicalindustry;however, there are still challenges in designing and developing high-performance catalysts. Here, a MOFassistedencapsulation strategy was adopted for the precise synthesis of diatomic Pd2 sites on a ZnO support. When usedfor the acetylene semi-hydrogenation reaction, the dual-atom Pd2-ZnO catalyst exhibited improved catalytic performance,achieving complete conversion of acetylene at 125 °C with an 89% selectivity to ethene, as compared to Pd single-atom andnanoparticles. This enhancement was mainly attributed to the catalyst’s ability to dissociate H2 and facilitate the desorptionof intermediate C2H4. Moreover, the strong interaction between the support and the diatomic Pd sites was responsible for thecatalyst’s excellent stability during the long-term reaction.

Coverage Dependent Dissociative Adsorption of HCl on Au(111)

Dissociative adsorption of HCl on Au(111)has become one of unsolved puzzles in surface chemistry.Despite tremendous efforts in the past years,varioustheoretical models still greatly overestimate the zero-coverage initial sticking probabilities(So).To find the origin of the large experiment-theory discrepancy,we have revisited the dissociative adsorption of HCl on Au(111)with a newly designed molecular beam-surface apparatus.The zero-coverage So derived from Cl-coverage measurements with varying HCl doses agree well with previous ones.However,we notice a sharp change of the coverage/dose slope with the HCl dosage at the low coverage regime,which may result in some uncertainties to the fitted So value.This seems consistent with a coverage-dependence of the dissociation barrier predicted by density functional theory at low Cl-coverages.Our results reveal the potential inconsistency of utilizing simulations with finite coverage to compare against experimental data with zero coverage in this system,and provide guidance for improving both experiment and theory in this regard.

Structure transformation induced bi-component Co–Mo/A-Co(OH)_(2)as highly efficient hydrogen evolution catalyst in alkaline media

Elucidating the inherent origins of the sluggish hydrogen evolution reaction(HER)kinetics in alkaline media and developing high-performance electrocatalysts are fundamental for the advances of conventional alkaline water electrolyzers and emerging anion exchange membrane(AEM)electrolyzers.Here we present a facile electrochemical modification strategy for the synthesis of bi-component Co–Mo_((18%))/A-Co(OH)_(2)catalyst toward efficient HER catalysis in alkaline media.Porous Co–Mo alloys with adjustable Mo/Co atomic ratio are first prepared by H2-assisted cathodic electrodeposition.By virtue of the appropriate electronic structure and hydrogen binding energy,Co–Mo_((18%))is the most HER active among the alloys and is further activated by a constant-current electrochemical modification process.Physical characterizations reveal the formation of amorphous Co(OH)_(2)nanoparticles on the surface.Electrokinetic analysis combined with theoretical calculations reveal that the in-situ formed Co(OH)_(2)can efficiently promote the water dissociation,resulting in accelerated Volmer-step kinetics.As a result,the Co–Mo_((18%))/A-Co(OH)_(2)simultaneously achieves the optimization of the two factors dominating alkaline HER activity,i.e.,water dissociation and hydrogen adsorption/desorption via the bifunctional synergy of the bi-components.The high HER activity(η10 of 47 mV at 10 mA cm^(-2))of Co–Mo_((18%))/A-Co(OH)_(2)is close to benchmark Pt/C catalyst and comparable or superior to the most active non-noble metal catalysts.

Clinical, scientific and stakeholders’ caring about identity perturbations

In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways.This is an upcoming problem in the society as not only school children are affected.Adolescents and young people suffer from uncertainty in gender identity,in self-image,migration effects due to chronic crises caused by war,pandemic disruptions or climate change.We show how such chronic uncertainty can be cared for,treated,and contained.The key is affective holding,reflection and to provide adequate affective mentalizing in a close concomitant way.These key features also depend on ambient conditions,such as psychotherapeutic care.In a qualitative interview study carried out in a cyclical research design with a comparative analysis on the basis of thematic coding using Grounded Theory Methodology we found institu-tionalized defenses in health policies.Professionals request better training and adequat academic knowledge as well as research into unresolved areas for improvement of the ambient conditions for adequat development of the self.Practice points for further clinical and scientific development are given and discussed.

Double-gating mechanism and diversity of an adenosine triphosphate (ATP)-sensitive K^+ channel in neurons acutely dissociated from rat neocortex

Classically, ion channels are classified into 2 groups: chemical-sensitive (ligand-gated) and voltage-sensitive channels. Single ATP-sensitive K+ (K-ATP) channel currents were recorded in acutely dissociated rat neo-cortical neurons using patch clamp technique. A type of K-ATP channel has been found to be gated not only by intra-cellular ATP, but also by membrane potential ( Vm) , and proved to be a novel mechanism underlying the gating of ion channels, namely bi-gating mechanism. The results also show that the K-ATP channels possess heterogeneity and di-versity. These types of K-ATP channels have been identified in 40.12% of all patches, which are different in activa-tion-threshold and voltage-sensitivity. The present experiment studied the type-3 K-ATP channel with a unitary con-ductance of about 80 pS in detail ( n = 15). Taking account of all the available data, a variety of K-ATP channels are suggested to exist in body, and one type of them is bi-gated by both chemical substances and membrane potentials. This property of the K-ATP channels may be related to their pathophysiblogical function.

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue cultures in vitro

The purpose of this study was to compare cell growth characteristics,ciliated cell differentiation,and function of human nasal epithelial cells established as explant outgrowth cultures or dissociated tissue cultures.Human nasal mucosa of the uncinate process was obtained by endoscopy and epithelial cell cultures were established by explant outgrowth or dissociated tissue culture methods.Epithelial cell growth characteristics were observed by inverted phase contrast microscopy.Ciliated cell differentiation was detected byβ-tubulin IV and ZO-1 immunocytochemistry.Basal and ATP-stimulated ciliary beat frequency(CBF)was measured using a high-speed digital microscopic imaging system.Both the explant and dissociated tissue cultures established as monolayers with tight junctions and differentiated cell composition,with both types of cultures comprising ciliated and non-ciliated epithelial cells.Fibroblasts were also frequently found in explant cultures but rarely seen in dissociated tissue cultures.In both culture systems,the highest ciliated cell density appeared at 7th–10th culture day and declined with time,with the lifespan of ciliated cells ranging from 14 to 21 days.Overall,10%of the cells in explant cultures and 20%of the cells in the dissociated tissue cultures were ciliated.These two cultures demonstrated similar ciliary beat frequency values at baseline(7.78±1.99 Hz and 7.91±2.52 Hz,respectively)and reacted equivalently following stimulation with 100μM ATP.The results of this study indicate that both the explant outgrowth and dissociated tissue culture techniques are suitable for growing well-differentiated nasal ciliated and non-ciliated cells,which have growth characteristics and ciliary activity similar to those of nasal epithelial cells in vivo.

Cancer and diet: significance of diet in a patient whose life expectancy was 4 to 5 months

Clinical summary:The patient,62 years old,a professional laboratory technician specialist,married with two children who in the month of January 2017,came to the emergency department for presenting problems of metrorrhagia and severe pain in left hip that prevented her from ambulation.Once the appropriate tests were performed,the clinical judgment was moderately differentiated endometroid adenocarcinoma with squamous metaplasia infiltrating the cervix,M1(bone and lung metastases);image compatible with left femoral DVT and PET in the right lower lobar branch,and her life expectancy at that time was four to five months.Objective:Given the situation in which the patient was,the few posibilties of a restorative treatment,and the short life expectancy expected for the patient,the only objective was to seek help through a special diet focusing the interest mainly on the nutritional aspect so that it could help to control especially the metastases,the tumor cell and the activation and reinforcement of the immune system.Method:In 2017,when the study was started,a systematic literature review was conducted in search of information related to diets,cancer and metastasis.In this study,the references used for the establishment of the diet have been taken into account and updated to the last five years,where we have been able to confront and confirm the same results obtained in 2017.For the reviews,databases related to health sciences on published articles that related alkaline diets with cancer and metastasis have been used.Results:The patient was recommended a special alkaline dissociated diet based mainly on a nutritional point of view that she started from the first day of treatment with the intention that she could be controlled and favor her recovery;after six months,both tumors and metastases and the problems of DVT and PTE had practically disappeared.Conclusions:The results(although it is only one case)make us think about nutrition's importance,especally in this type of disease.We know this disease is not specific to a single cause but that various factors such as diet,environment,and especially the emotional state can intervene.It is necessary to carry out more studies,such as the one that has been carried out to ensure its importance in the state of health.

Comprehensive utilization of complex rubidium ore resources:Mineral dissociation and selective leaching of rubidium and potassium

Currently,the process of extracting rubidium from ores has attracted a great deal of attention due to the increasing application of rubidium in high-technology field.A novel process for the comprehensive utilization of rubidium ore resources is proposed in this paper.The process consists mainly of mineral dissociation,selective leaching,and desilication.The results showed that the stable silicon–oxygen tetrahedral structure of the rubidium ore was completely disrupted by thermal activation and the mineral was completely dissociated,which was conducive to subsequent selective leaching.Under the optimal conditions,extractions of 98.67% Rb and 96.23%K were obtained by leaching the rubidium ore.Moreover,the addition of a certain amount of activated Al(OH)_(3) during leaching can effectively inhibit the leaching of silicon.In the meantime,the leach residue was sodalite,which was successfully synthesized to zeolite A by hydrothermal conversion.The proposed process provided a feasible strategy for the green extraction of rubidium and the sustainable utilization of various resources.

Coupling interface engineering with electronic interaction toward high-efficiency H_(2) evolution in pH-universal electrolytes

Herein,the merits of heterojunction,CeO_(2),and W are employed to design and prepare the PtCoW@CeO_(2)heterojunction catalyst,which can accelerate water dissociation and improve the desorption of OHad,displaying efficient hydrogen evolution reaction(HER)performance in pH-universal conditions.Density functional theory calculation results reveal that the electronic structure of Pt is regulated by CeO_(2)and W,which tunes the Pt-Hadbond strength to boost HER intrinsic activity.Consequently,electrochemical results display that it has low potentials of-26,-25,and-23 mV at-10 mA cm^(-2)in alkaline,neutral,and acidic solutions,respectively,and it can stably cycle for 50,000 cycles.Thus,this work provides the guidance for developing high-performance Pt-based catalysts in pH-universal environments.

Static and dynamic evolution of CO adsorption onγ-U(100)surface with different levels of Mo doping using DFT and AIMD calculations

Alloys of uranium and molybdenum are considered as the future of nuclear fuel and defense materials.However,surface corrosion is a fundamental problem in practical applications and storage.In this study,the static and dynamic evolution of carbon monoxide(CO)adsorption and dissociation onγ-U(100)surface with different Mo doping levels was investigated based on density functional theory and ab initio molecular dynamics.During the static calculation phase,parameters,such as adsorption energy,configuration,and Bader charge,were evaluated at all adsorption sites.Furthermore,the time-dependent behavior of CO molecule adsorption were investigated at the most favorable sites.The minimum energy paths for CO molecu-lar dissociation and atom migration were investigated using the transition state search method.The results demonstrated that the CO on the uranium surface mainly manifests as chemical adsorption before dissociation of the CO molecule.The CO molecule exhibited a tendency to rotate and tilt upright adsorption.However,it is difficult for CO adsorption on the surface in one of the configurations with CO molecule in vertical direction but oxygen(O)is closer to the surface.Bader charge illustrates that the charge transfers from slab atoms to the 2π*antibonding orbital of CO molecule and particularly occurs in carbon(C)atoms.The time is less than 100 fs for the adsorptions that forms embryos with tilt upright in dynamics evolution.The density of states elucidates that the overlapping hybridization of C and O 2p orbitals is mainly formed via the d orbitals of uranium and molybdenum(Mo)atoms in the dissociation and re-adsorption of CO molecule.In conclusion,Mo doping of the surface can decelerate the adsorption and dissociation of CO molecules.A Mo-doped surface,created through ion injection,enhanced the resistance to uranium-induced surface corrosion.

Engineering Vacancy-Atom Ensembles to Boost Catalytic Activity toward Hydrogen Evolution

The dissociation of water is the rate-determining step of several energy-relating reactions due to high energy barrier in homolysis of H-O bond.Herein,engineering vacancy-atom ensembles via injecting oxygen vacancy(V O)into single facet-exposed TiO_(2)-Pd catalyst to form V_(O)-Pd ensemble is proposed and implemented.The outstanding activity of as-prepared catalyst,1.5-PdTV_(O),toward water dissociation is established with a turnover frequency of 240 min^(−1) in ammonia borane hydrolysis at 298 K.Density functional theory simulation suggests that the V_(O)-Pd ensemble is responsible for the high intrinsic catalytic activity.Water molecules tend to be dissociated on V_(O) sites and ammonia borane molecules on Pd atoms.Those H atoms from water dissociation on V_(O) combine with H atoms from ammonia borane on Pd atoms to generate H_(2).This insights into engineering vacancy-atom ensembles catalysis provide a new avenue to design catalytic materials for important energy chemical reactions.

Density Functional Theory Study of Marine Polybrominated Diphenyl Ethers in Anaerobic Degradation

Polybrominated diphenyl ethers(PBDEs)are a kind of serious pollutants in the ocean.Biodegradation is considered as an economical and safe way for PBDEs removal and reductive debromination dominates the initial pathway of anaerobic degradation.On the basis of experimental study,Octa-BDE 197,Hepta-BDE 183,Hexa-BDE 153,Penta-BDE 99 and Tetra-BDE 47 were selected as the initial degradation objects,and their debromination degradation were studied using density functional theory.The structures were optimized by Gaussian 09 program.Furthermore,the molecular orbitals and charge distribution were analyzed.All C-Br bond dissociation energies at different positions including ortho,meta and para bromine atoms were calculated and the sequence of debromination was obtained.There is a close relationship between molecular structure,charge,molecular orbital and C-Br bond.All PBDEs exhibited similar debromination pathways with preferential removal of meta and para bromines.