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Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets 被引量:1
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作者 Xin-Xia Li Yan Wang +6 位作者 Ping-Ping Xu Qi-Zhou Zhang Kun Nie Xu Hu Bin Kong Li Li Jian Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS 2013年第1期71-74,共4页
The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)〈 1.0 is required when using a fiber-optic dissolution test system. The detection wa... The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)〈 1.0 is required when using a fiber-optic dissolution test system. The detection wavelength of 2 (218 nm) was replaced by 244 nm to carry out this test. The absorbance of Cimetidine solution at different temperature showed an obvious change. Calibration of Cimetidine solution should be tested at the same temperature (37° C) with the test solution. A suitable wavelength with smaller tangent slope could be chosen for in-situ dissolution test of Cimetidine tablets. 展开更多
关键词 Cimetidine tablets Drug dissolution test In-situ dissolution test UV-VIS
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Monitoring the hydrolyzation of aspirin during the dissolution testing for aspirin delayed-release tablets with a fiber-optic dissolution system 被引量:4
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作者 Yan Wang Ping-Ping Xu +4 位作者 Xin-Xia Li Kun Nie Ming-Fu Tuo Bin Kong Jian Chen 《Journal of Pharmaceutical Analysis》 CAS 2012年第5期386-389,共4页
The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effec... The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution testing in situ. The results showed that the hydrolyzation of aspirin made the percentage of salicylic acid exceed the limit of free salicylic acid (4.0), and the hydrolyzation may affect the quality detection of aspirin delayed-release tablets. 展开更多
关键词 Aspirin delayed-releasetablets Drug dissolution test Fiber-optic dissolution system UV-vis spectrum
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Bioassay-based dissolution test of Shuanghuanglian tablet
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作者 肖珑 韩晋 +3 位作者 黄雪 张媛媛 袁海龙 肖小河 《Journal of Chinese Pharmaceutical Sciences》 CAS 2011年第1期77-82,共6页
It has been difficult to perform dissolution test on solid preparations of traditional Chinese medicines (TCMs). TCMs are different from chemical drugs in that their chemical compositions are complicated. The measur... It has been difficult to perform dissolution test on solid preparations of traditional Chinese medicines (TCMs). TCMs are different from chemical drugs in that their chemical compositions are complicated. The measurement method based on chemical approach alone is incomplete. In order to solve this problem, in this study a bioassay-based dissolution test was developed. Microcalorimetry was used to obtain growth power-time curves and biothermodynamic parameters of Staphylococcus aureus inhibited by the solution of ShuangHuangLian (SHL) tablet, which was dissolved in phosphate buffer (pH 6.8) for different times. The results of the bioassay-based dissolution test of SHL tablet demonstrated that the bioassay method might be a promising alternative for its quality control. 展开更多
关键词 dissolution test Shuanghuanglian tablet BIOASSAY Traditional Chinese medicines
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Monolithic LC method applied to fesoterodine fumarate low dose extended-release tablets:Dissolution and release kinetics 被引量:2
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作者 Maximiliano S.Sangoi Vítor Todeschini Martin Steppe 《Journal of Pharmaceutical Analysis》 CAS 2015年第2期137-141,共5页
A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic(LC) method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically a... A dissolution test for fesoterodine low dose extended-release tablets using liquid chromatographic(LC) method equipped with a C18 monolithic column was developed and validated. LC system was operated isocratically at controlled temperature(40 1C) using a mobile phase of acetonitrile:methanol:0.03 M ammonium acetate(p H 3.8)(30:15:55, v/v/v), run at a flow rate of 1.5 m L/min and detected at 208 nm. The best dissolution conditions for this formulation were achieved using a USP apparatus 2(paddle) at 100 rpm and 900 m L of phosphate buffer at p H 6.8 as the dissolution medium.Validation parameters such as the specificity, linearity, accuracy, precision, and robustness were evaluated according to international guidelines, giving results within the acceptable range. The kinetic parameters of drug release were also investigated using model-dependent methods and the dissolution profiles were best described by the Higuchi model. The validated dissolution test can be applied for quality control of this formulation. 展开更多
关键词 FESOTERODINE dissolution test Low dose extendedrelease tablets Monolithic LC Release kinetics
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Portable and automated analyzer for rapid and high precision in vitro dissolution of drugs 被引量:1
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作者 Zhongmei Chi Siqi Zhao +2 位作者 Xiujun Cui Yunxiang Feng Li Yang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2021年第4期490-498,共9页
We developed a novel portable and automated dissolution test analyzer for rapid and high precision in vitro dissolution testing of drugs.The analyzer consists of a flow-through-cell drug dissolution system,an automate... We developed a novel portable and automated dissolution test analyzer for rapid and high precision in vitro dissolution testing of drugs.The analyzer consists of a flow-through-cell drug dissolution system,an automated sequential sampling system,a high-speed capillary electrophoresis(HSCE)system,and a data acquisition system.Combining the high-temporal resolution flow-gating sampling approach with HSCE,which has outstanding advantages of efficient separation and resolution,the analyzer can achieve rapid analysis and exhibits the ability in miniaturization for on-site assessment of different active pharmaceutical ingredients.To integrate the flow-through-cell dissolution system with HSCE,a specially designed flow-gating-injection(FGI)interface was employed.The performance of the analyzer was investigated by analyzing the dissolution of immediate-release drugs including single dose(amoxicillin dispersible tablets)and fixed dose combination(amoxicillin and clavulanate potassium)drug tablets with the high-temporal resolutions of 12 s and 20 s,respectively.The dissolution profiles of different active pharmaceutical ingredients could be simultaneously and automatically monitored with high repeatability and accuracy.The analyzer was successfully utilized for the pharmaceutical quality control and bio-relevant dissolution testing,as well as in vivo-in vitro correlation analysis.Our portable analyzer is miniaturized,convenient and of low-cost,and will provide a valuable tool for dissolution testing in pharmaceutical research and development. 展开更多
关键词 dissolution test analyzer PORTABLE AUTOMATED Immediate-release drug Fixed dose combination drug
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Solid dispersion in the development of a nimodipine delayed-release tablet formulation 被引量:1
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作者 Yang Zhao Tiegang Xin +2 位作者 Tiantian Ye Xinggang Yang Weisan Pan 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2014年第1期35-41,共7页
Nimodipine(NMD)is a dihydropyridine calcium channel blocker with selectivity for cerebral blood vessels and the major therapeutic indication of NMD is for the prevention and treatment of delayed ischemic neurological... Nimodipine(NMD)is a dihydropyridine calcium channel blocker with selectivity for cerebral blood vessels and the major therapeutic indication of NMD is for the prevention and treatment of delayed ischemic neurological disorders and other cerebrovascular disorders,such as stroke which is associated with biological rhythm.This study was mainly designed to solve the drawback of conventional NMD solid dosage form,low bioavailability and limited clinical efficacy,by preparing enteric solid dispersion(SD)and the SD was prepared via melting method.The physical state of the dispersed NMD in the polymer matrix was characterized by differential scanning calorimetry(DSC),powder X-ray diffraction(PXRD)and dissolution studies.Compared with pure drug and physical mixture,the dissolution of NMD-SD was enhanced dramatically(about 80%).Furthermore,in consideration of the biological rhythm of stroke,we first obtained a delayed-release tablet containing NMD-SD by a direct powder compression method.As shown in the dissolution studies,the tablet released less than 10%in the artificial gastric acid in the initial 2 h and released 32.1%,75%,more than 90%at 4,10 and 14 h respectively in the artificial intestinal fluid.This investigation has solved the problems of oral solid dosage forms of NMD,and it has the good industry prospect. 展开更多
关键词 NIMODIPINE Solid dispersion Delayed-release dissolution test
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Quality Evaluation of Carnitine for Proper Use of Supplement
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作者 Yuka Miyachi Chika Nakayama Taeyuki Oshima 《Pharmacology & Pharmacy》 2021年第2期55-62,共8页
<span style="font-family:Verdana;">In</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdan... <span style="font-family:Verdana;">In</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">recent years, consumers are becoming more health-conscious. Supplements are becoming popular as they can be purchased easily. In Japan, the “Food with Function Claims” system began in 2015;the market for supplements is expected to continue to expand. However, the use of some supplements has not been supported with sufficient scientific evidence;some products have even caused health problems. </span><span style="font-family:Verdana;">In addition</span><span style="font-family:Verdana;">, consumers may not be able to make correct decisions based on the information from the Internet. Unlike medicine, the instruction on the usage of supplements is not precise. Therefore, improving the quality of the information on the supplements will become more necessary in the future. This study aims to improve the quality of the information on supplements by surveying the disintegration and dissolution behavior of the carnitine-containing supplements and evaluated the</span><span style="font-family:Verdana;">ir quality. The products tested here were supplements containing commercial carnitine. Disintegration test and dissolution test were conducted according to the Japanese Pharmacopoeia. Carnitine was quantified by high-performa</span><span style="font-family:Verdana;">nce liquid chr</span><span style="font-family:Verdana;">omatography. The disintegration tests revealed that the products </span><span style="font-family:Verdana;">had different disintegration times, varying from 35 to 100 minutes;some products took more than 5 hours to disintegrate. Thus, some products had a slow rise in their dissolution rate. These results suggest that the carnitine-containing supplements used in this study may affect the absorption process. Therefore, in the case of oral administration, the expected effect might not </span><span style="font-family:Verdana;">be achieved depending on the product.</span></span> 展开更多
关键词 SUPPLEMENT Disintegration test dissolution test CARNITINE
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