Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupunctu...Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.展开更多
[Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation method.The morphology was ob...[Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation method.The morphology was observed by scanning electron microscopy and the particle size distribution was determined by Laser Diffraction Method.The encapsulation efficiency,drug loading capacity,and in vitro release were determined by HPLC.[Results]The prepared donepezil hydrochloride microspheres were spherical with the average particle diameter of 15.927 μm.The drug loading capacity was 35.62%.The encapsulation efficiency was 90.32%.The drug release in vitro lasted for14 d.The release curve accorded with the first-order kinetic equation.[Conclusions]The prepared donepezil hydrochloride microspheres performed good sustained release effect in vitro,and it was expected to be used for research on Parkinson's disease.展开更多
目的探讨远隔缺血预适应联合盐酸多奈哌齐片治疗脑小血管病(cerebral small vessel disease,CSVD)患者的临床效果。方法选取78例CSVD患者作为研究对象,观察组(盐酸多奈哌齐片联合远隔缺血预适应治疗)39例,对照组(盐酸多奈哌齐片治疗)39...目的探讨远隔缺血预适应联合盐酸多奈哌齐片治疗脑小血管病(cerebral small vessel disease,CSVD)患者的临床效果。方法选取78例CSVD患者作为研究对象,观察组(盐酸多奈哌齐片联合远隔缺血预适应治疗)39例,对照组(盐酸多奈哌齐片治疗)39例。治疗结束后比较2组的疗效,并比较2组治疗前后蒙特利尔认知量表(Montreal cognitive scale,MoCA)、简化36医疗结局研究量表(36-item short form survey instrument,SF-36)生活质量评分、脑血管灌注参数[平均通过时间(mean transit time,MTT)、脑血流量(cerebral blood flow,CVB)、血流速度(blood flow velocity,CBF)]、血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-8(interleukin-8,IL-8)、中枢神经特异性蛋白(central nervous system specific protein,S100β)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)水平。结果治疗前2组各参数比较差异均无统计学意义(P>0.05),治疗后2组MoCA、SF-36量表、CVB、CBF、BDNF、VEGF上升,MTT、TNF-α、IL-8、S100β水平下降(P<0.05);与对照组比较,观察组MoCA、SF-36量表、CVB、CBF、BDNF、VEGF及总有效率更高,MTT、TNF-α、IL-8、S100β更低(P<0.05)。治疗后观察组及对照组的总有效率分别为89.74%、71.79%,2组比较差异有统计学意义(P<0.05)。结论远隔缺血预适应联合盐酸多奈哌齐片可显著改善CSVD患者的认知功能障碍、脑血流灌注及炎性反应,并能提高患者的生活质量。展开更多
文摘Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.
基金Supported by National Innovative Training Program for College Students(201610443020)
文摘[Objectives]To prepare donepezil hydrochloride microspheres and evaluate their quality.[Methods]The donepezil hydrochloride microspheres were prepared by emulsification-solvent evaporation method.The morphology was observed by scanning electron microscopy and the particle size distribution was determined by Laser Diffraction Method.The encapsulation efficiency,drug loading capacity,and in vitro release were determined by HPLC.[Results]The prepared donepezil hydrochloride microspheres were spherical with the average particle diameter of 15.927 μm.The drug loading capacity was 35.62%.The encapsulation efficiency was 90.32%.The drug release in vitro lasted for14 d.The release curve accorded with the first-order kinetic equation.[Conclusions]The prepared donepezil hydrochloride microspheres performed good sustained release effect in vitro,and it was expected to be used for research on Parkinson's disease.
