Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied the...Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied theory and method of comparative salinology, it is determined that the palaeoclimate framework of Dong Co during early\|middle Holocene, and reckoned the range of the temperature variation. Furthermore, after completing regional analogue, discovered that the palaeoclimate environment is fully comparative and consistent with the synchronous lake\|water retreating trace of Zhaduixiong spits in Zabuye Lake basin, with palaeoclimate changes recorded by pollen in adjacent Zabuye Lake, with Holocene plaeoclimate environment indicated by drilling\|hole in Bangong Co,with palaeoclimate significance traced by δ 18 O value in Qinghai Lake and Siling Co and with the palaeoclimate framework during the 5th Level Arid (Salinization) Extension Period of Quaternary arid center of Western China.展开更多
目的:通过环芳香烃受体(cyclic aromatic hydrocarbon receptor,AhR)/白细胞介素22(interleukin-22,IL-22)/信号转导和转录激活因子3(signal transducer and activator of transcription3,STAT3)通路探讨董氏奇穴联合丁沉扶正汤对胃癌...目的:通过环芳香烃受体(cyclic aromatic hydrocarbon receptor,AhR)/白细胞介素22(interleukin-22,IL-22)/信号转导和转录激活因子3(signal transducer and activator of transcription3,STAT3)通路探讨董氏奇穴联合丁沉扶正汤对胃癌患者术后肠道菌群紊乱的影响,并探讨其具体作用机制。方法:选择接受腹腔镜下胃癌根治术的患者120例,随机分为对照组和针药联合组,每组60例。对照组接受董氏奇穴针灸治疗,针药联合组在对照组的基础上给予丁沉扶正汤治疗。比较两组术中指标、T淋巴细胞亚群、D-乳酸(D-Lactic acid,D-LA)、炎性因子、肠道细菌以及肠黏膜组织AhR/IL-22/STAT3通路转录和翻译水平。结果:两组干预前指标比较,差异无统计学意义(P>0.05)。干预后两组乳酸杆菌、双歧杆菌含量、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比值均升高(P<0.05),且上述指标针药联合组均高于对照组(P<0.05)。干预后两组肠道中大肠杆菌、梭菌、拟杆菌、柔嫩梭菌水平及血清中D-乳酸、降钙素原、C反应蛋白(C-reactive protein,CRP)和白细胞介素-6(interleukin-6,IL-6)水平均降低(P<0.05),且以上指标针药联合组均显著低于对照组(P<0.05)。针药联合组住院时间显著短于对照组(P<0.05)。与干预前比较,两组AhR、IL-22和STAT3 mRNA及蛋白水平均升高(P<0.05),针药联合组高于对照组(P<0.05)。结论:董氏奇穴联合丁沉扶正汤可能通过促进AhR/IL-22/STAT3通路保护肠黏膜屏障,进而改善胃癌患者术后的细胞免疫功能、缓解肠道菌群失衡,促进患者恢复。展开更多
目的观察双e疗法刺激董氏奇穴治疗2型糖尿病患者口服降糖药继发性失效的临床疗效及安全性。方法将120例口服降糖药继发性失效的2型糖尿病患者随机分为治疗组和对照组,每组60例,在口服基础降糖药的基础上,治疗组给予针挑结合放血刺激董...目的观察双e疗法刺激董氏奇穴治疗2型糖尿病患者口服降糖药继发性失效的临床疗效及安全性。方法将120例口服降糖药继发性失效的2型糖尿病患者随机分为治疗组和对照组,每组60例,在口服基础降糖药的基础上,治疗组给予针挑结合放血刺激董氏奇穴,对照组给予二甲双胍,并进行疗效评价。结果治疗后,两组患者的空腹血糖值(FPG)、2 h血糖值(2 h PG)、糖化血红蛋白(Hb A1c)等指标较治疗前都有明显下降(P<0.05),组间比较治疗组优于对照组(P<0.05);治疗后治疗组总有效率93.33%明显优于对照组85%(P<0.05)。结论双e疗法刺激董氏奇穴与二甲双胍对继发性磺脲类降糖药失效的2型糖尿病患者均有效,可以改善胰岛素抵抗,此外"双e疗法"的副作用小,绿色经济,有良好的临床推广前景。展开更多
文摘Based on the sedimentary characteristics study of Holocene borax\|bearing mirabilite beds of Dong Co(lake) two sections, DZ01 and DZ02, in the center of North\|Tibetan Plateau,combined with dating of 14 C, applied theory and method of comparative salinology, it is determined that the palaeoclimate framework of Dong Co during early\|middle Holocene, and reckoned the range of the temperature variation. Furthermore, after completing regional analogue, discovered that the palaeoclimate environment is fully comparative and consistent with the synchronous lake\|water retreating trace of Zhaduixiong spits in Zabuye Lake basin, with palaeoclimate changes recorded by pollen in adjacent Zabuye Lake, with Holocene plaeoclimate environment indicated by drilling\|hole in Bangong Co,with palaeoclimate significance traced by δ 18 O value in Qinghai Lake and Siling Co and with the palaeoclimate framework during the 5th Level Arid (Salinization) Extension Period of Quaternary arid center of Western China.
文摘目的观察双e疗法刺激董氏奇穴治疗2型糖尿病患者口服降糖药继发性失效的临床疗效及安全性。方法将120例口服降糖药继发性失效的2型糖尿病患者随机分为治疗组和对照组,每组60例,在口服基础降糖药的基础上,治疗组给予针挑结合放血刺激董氏奇穴,对照组给予二甲双胍,并进行疗效评价。结果治疗后,两组患者的空腹血糖值(FPG)、2 h血糖值(2 h PG)、糖化血红蛋白(Hb A1c)等指标较治疗前都有明显下降(P<0.05),组间比较治疗组优于对照组(P<0.05);治疗后治疗组总有效率93.33%明显优于对照组85%(P<0.05)。结论双e疗法刺激董氏奇穴与二甲双胍对继发性磺脲类降糖药失效的2型糖尿病患者均有效,可以改善胰岛素抵抗,此外"双e疗法"的副作用小,绿色经济,有良好的临床推广前景。
