After reading the review by An et al“Biological factors driving colorectal cancer metastasis”,which covers the problem of the metastasis of colorectal cancer(CRC),I had a desire to discuss with readers one of the ex...After reading the review by An et al“Biological factors driving colorectal cancer metastasis”,which covers the problem of the metastasis of colorectal cancer(CRC),I had a desire to discuss with readers one of the exciting problems associated with dormant metastases.Most deaths from CRCs are caused by metastases,which can be detected both at diagnosis of the primary tumor and several years or even decades after treatment.This is because tumor cells that enter the bloodstream can be destroyed by the immune system,cause metastatic growth,or remain dormant for a long time.Dormant tumor cells may not manifest themselves throughout a person’s life or,after some time and under appropriate conditions,may give rise to the growth of metastases.In this editorial,we will discuss the most important features of dormant metastases and the mechanisms of premetastatic niche formation,as well as factors that contribute to the activation of dormant metastases in CRCs.We will pay special attention to the possible mechanisms involved in the formation of circulating tumor cell complexes and the choice of therapeutic strategies that promote the dormancy or destruction of tumor cells in CRCs.展开更多
Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ul...Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.展开更多
为实现休眠期枣树选择性修剪,针对自动化剪枝过程中枣树枝干识别与参数提取困难的问题,提出一种基于实例分割神经网络的枝干识别与参数自动提取的方法。首先,通过前期搭建的视觉系统获取2个角度下的点云,并基于骨架点重建完整的枣树点云...为实现休眠期枣树选择性修剪,针对自动化剪枝过程中枣树枝干识别与参数提取困难的问题,提出一种基于实例分割神经网络的枝干识别与参数自动提取的方法。首先,通过前期搭建的视觉系统获取2个角度下的点云,并基于骨架点重建完整的枣树点云,利用CloudCompare V 2.11软件对枣树三维点云进行手工标注,构建带语义信息的枣树点云数据集,将标注完的376棵枣树,按照8∶2的比例分为训练集和验证集;其次,结合JSNet实例分割网络对枣树点云进行分割,同时对比分析不同自然环境对实例分割精度的影响;最后,提出枣树修剪枝直径和长度参数自动提取的方法。试验结果表明:休眠期枣树主干的分割精度为96%,而修剪枝的分割精度为77%,并且不同自然环境对分割精度影响较小。枣树修剪枝的直径拟合值与实际测量值误差范围在2 mm以内,且其长度拟合值与实际值的误差范围在1 cm以内,为后续准确确定枣树剪枝点的位置提供数据依据。展开更多
文摘After reading the review by An et al“Biological factors driving colorectal cancer metastasis”,which covers the problem of the metastasis of colorectal cancer(CRC),I had a desire to discuss with readers one of the exciting problems associated with dormant metastases.Most deaths from CRCs are caused by metastases,which can be detected both at diagnosis of the primary tumor and several years or even decades after treatment.This is because tumor cells that enter the bloodstream can be destroyed by the immune system,cause metastatic growth,or remain dormant for a long time.Dormant tumor cells may not manifest themselves throughout a person’s life or,after some time and under appropriate conditions,may give rise to the growth of metastases.In this editorial,we will discuss the most important features of dormant metastases and the mechanisms of premetastatic niche formation,as well as factors that contribute to the activation of dormant metastases in CRCs.We will pay special attention to the possible mechanisms involved in the formation of circulating tumor cell complexes and the choice of therapeutic strategies that promote the dormancy or destruction of tumor cells in CRCs.
文摘Nearly half of the global population are carriers of Helicobacter pylori(H. pylori),a Gram-negative bacterium that persists in the healthy human stomach. H. pylori can be a pathogen and causes development of peptic ulcer disease in a certain state of the macroorganism. It is well established that H. pylori infection is the main cause of chronic gastritis and peptic ulcer disease(PUD). Decontamination of the gastric mucosa with various antibiotics leads to H. pylori elimination and longer remission in this disease. However,the reasons for repeated detection of H. pylori in recurrent PUD after its successful eradication remain unclear. The reason for the redetection of H. pylori in recurrent PUD can be either reinfection or ineffective anti-Helicobacter therapy. The administration of antibacterial drugs can lead not only to the emergence of resistant strains of microorganisms,but also contribute to the conversion of H. pylori into the resting(dormant) state. The dormant forms of H. pylori have been shown to play a potential role in the development of relapses of PUD. The paper discusses morphological H. pylori forms,such as S-shaped,C-shaped,U-shaped,and coccoid ones. The authors proposes the classification of H. pylori according to its morphological forms and viability.
文摘为实现休眠期枣树选择性修剪,针对自动化剪枝过程中枣树枝干识别与参数提取困难的问题,提出一种基于实例分割神经网络的枝干识别与参数自动提取的方法。首先,通过前期搭建的视觉系统获取2个角度下的点云,并基于骨架点重建完整的枣树点云,利用CloudCompare V 2.11软件对枣树三维点云进行手工标注,构建带语义信息的枣树点云数据集,将标注完的376棵枣树,按照8∶2的比例分为训练集和验证集;其次,结合JSNet实例分割网络对枣树点云进行分割,同时对比分析不同自然环境对实例分割精度的影响;最后,提出枣树修剪枝直径和长度参数自动提取的方法。试验结果表明:休眠期枣树主干的分割精度为96%,而修剪枝的分割精度为77%,并且不同自然环境对分割精度影响较小。枣树修剪枝的直径拟合值与实际测量值误差范围在2 mm以内,且其长度拟合值与实际值的误差范围在1 cm以内,为后续准确确定枣树剪枝点的位置提供数据依据。
