Dose–response experiments and data analyses are often carried out according to an optimal design under a model assumption.A two-parameter logistic model is often used because of its nice mathematical properties and p...Dose–response experiments and data analyses are often carried out according to an optimal design under a model assumption.A two-parameter logistic model is often used because of its nice mathematical properties and plausible stochastic response mechanisms.There is an extensive literature on its optimal designs and data analysis strategies.However,a model is at best a good approximation in a real-world application,and researchers must be aware of the risk of model mis-specification.In this paper,we investigate the effectiveness of the sequential EDdesign,the D-optimal design,and the up-and-down design under the three-parameter logistic regression model,and we develop a numerical method for the parameter estimation.Simulations show that the combination of the proposed model and the data analysis strategy performs well.When the logistic model is correct,this more complex model has hardly any efficiency loss.The three-parameter logistic model works better than the two-parameter logistic model in the presence of model mis-specification.展开更多
基金fundings from the National Natural Science foundation of China[Grant Number 11871419]the Natural Science and Engineering Research Council of Canada.
文摘Dose–response experiments and data analyses are often carried out according to an optimal design under a model assumption.A two-parameter logistic model is often used because of its nice mathematical properties and plausible stochastic response mechanisms.There is an extensive literature on its optimal designs and data analysis strategies.However,a model is at best a good approximation in a real-world application,and researchers must be aware of the risk of model mis-specification.In this paper,we investigate the effectiveness of the sequential EDdesign,the D-optimal design,and the up-and-down design under the three-parameter logistic regression model,and we develop a numerical method for the parameter estimation.Simulations show that the combination of the proposed model and the data analysis strategy performs well.When the logistic model is correct,this more complex model has hardly any efficiency loss.The three-parameter logistic model works better than the two-parameter logistic model in the presence of model mis-specification.
