Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the devel...Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer disease.Today,the presence of H.pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications.Whether NSAID intake in the presence of H.pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate.Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years.In addition,the interaction between H.pylori infection and low-dose ASA remains even more controversial.In real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors.These huge variety of possible combinations greatly hinder the decision making process of physicians.展开更多
Fifteen patients with unresectable hepatocellular carcinoma were treated with unresectable hepatocellular carcinoma were treated with high dose MMC or ADR via hepatic artery with drug filtration in our hospital from A...Fifteen patients with unresectable hepatocellular carcinoma were treated with unresectable hepatocellular carcinoma were treated with high dose MMC or ADR via hepatic artery with drug filtration in our hospital from April to December 1988. Among them, 11 cases (73%) had symptoms relief, 3 cases (20%) tumor minimal remission and AFP decreased in 4 cases (33%). One case dide of hep'atoma 8 months after HAI-F and another case was followed up only 2 months after treatment, the remaining 13 cases are alive for 5 to 10 months after HAI-F. The reasons of unsatisfactory results were analyzed and possible ways of improvement were suggested.展开更多
Urban populations in Morocco receive free medical drugs as prescribed by doctors in district health centres.To explore the exposure pathway of ^(238)U and^(232)Th and their decay products on the skin of patients,these...Urban populations in Morocco receive free medical drugs as prescribed by doctors in district health centres.To explore the exposure pathway of ^(238)U and^(232)Th and their decay products on the skin of patients,these radionuclides were measured in various medical drugs by using solid-state nuclear track detectors(SSNTDs).The measured concentrations range of ^(238)U and ^(232)Th in the medical drug samples of interest vary from(4.3±0.3) to(11.1±0.7) mBq 1^(-1) and(0.49±0.03) to(1.3±0.1)mBq 1^(-1),respectively.A new dosimetric model,based on the concept of specific alpha-dose and alpha-particle residual energy,was developed for evaluating radiation doses to skin following the application of different medical drugs by patients.The maximum total equivalent effective dose to skin due to the ^(238)U and ^(232)Th series from cutaneous application of different medical drugs by patients was found to be 2.8 mSv year^(-1) cm^(-2).展开更多
文摘Previous reports clearly demonstrated that Helicobacter pylori(H.pylori)infection,nonsteroidal anti-inflammatory drugs(NSAID)or low dose aspirin(ASA)use significantly and independently increased the risk for the development of peptic ulcer disease.Today,the presence of H.pylori infection associated with low dose ASA and/or NSAID use in the same patient is becoming more frequent and therefore the potential interaction between these factors and the consequences of it has important implications.Whether NSAID intake in the presence of H.pylori infection may further increase the risk of peptic ulcer carried by the presence of only one risk factor is still a matter of debate.Studies on the interaction between the two risk factors yielded conflicting data and no consensus has been reached in the last years.In addition,the interaction between H.pylori infection and low-dose ASA remains even more controversial.In real clinical practice,we can find different clinical scenarios involving these three factors associated with the presence of different gastrointestinal and cardiovascular risk factors.These huge variety of possible combinations greatly hinder the decision making process of physicians.
文摘Fifteen patients with unresectable hepatocellular carcinoma were treated with unresectable hepatocellular carcinoma were treated with high dose MMC or ADR via hepatic artery with drug filtration in our hospital from April to December 1988. Among them, 11 cases (73%) had symptoms relief, 3 cases (20%) tumor minimal remission and AFP decreased in 4 cases (33%). One case dide of hep'atoma 8 months after HAI-F and another case was followed up only 2 months after treatment, the remaining 13 cases are alive for 5 to 10 months after HAI-F. The reasons of unsatisfactory results were analyzed and possible ways of improvement were suggested.
基金under an URAC-15 research contract with the CNRST,Rabat,Morocco
文摘Urban populations in Morocco receive free medical drugs as prescribed by doctors in district health centres.To explore the exposure pathway of ^(238)U and^(232)Th and their decay products on the skin of patients,these radionuclides were measured in various medical drugs by using solid-state nuclear track detectors(SSNTDs).The measured concentrations range of ^(238)U and ^(232)Th in the medical drug samples of interest vary from(4.3±0.3) to(11.1±0.7) mBq 1^(-1) and(0.49±0.03) to(1.3±0.1)mBq 1^(-1),respectively.A new dosimetric model,based on the concept of specific alpha-dose and alpha-particle residual energy,was developed for evaluating radiation doses to skin following the application of different medical drugs by patients.The maximum total equivalent effective dose to skin due to the ^(238)U and ^(232)Th series from cutaneous application of different medical drugs by patients was found to be 2.8 mSv year^(-1) cm^(-2).
