The aim of this study was to achieve on-demand controlled drug release from the dual-drug-loadedpoly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers by theapplication of ultrasoun...The aim of this study was to achieve on-demand controlled drug release from the dual-drug-loadedpoly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers by theapplication of ultrasound irradiation.Two drugs were loaded in different part of the composite fibrousmaterials,and it was found that ultrasound as an external stimulus was able to control releaseof drugs due to both its thermal effect and non-thermal effect.With the selective irradiation ofultrasound,the drug carrier enabled to realize controlled release,and because of different locationin fibers and sensitivity of two different kinds of drugs to ultrasound irradiation,the release rate oftwo drugs was different.These results indicated that ultrasound irradiation was a facile method torealize the on-demand controlled release of two drugs from the electrospun fibers.展开更多
The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to ...The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.展开更多
基金This work was supported by grants from Natural Science Foundation of China(grant no.:3073003481190132).
文摘The aim of this study was to achieve on-demand controlled drug release from the dual-drug-loadedpoly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers by theapplication of ultrasound irradiation.Two drugs were loaded in different part of the composite fibrousmaterials,and it was found that ultrasound as an external stimulus was able to control releaseof drugs due to both its thermal effect and non-thermal effect.With the selective irradiation ofultrasound,the drug carrier enabled to realize controlled release,and because of different locationin fibers and sensitivity of two different kinds of drugs to ultrasound irradiation,the release rate oftwo drugs was different.These results indicated that ultrasound irradiation was a facile method torealize the on-demand controlled release of two drugs from the electrospun fibers.
基金the National High Level Talents Special Support Plan(X.C.)the“Young Talent Support Plan”of Xi'an Jiaotong University(X.C.)+2 种基金the Natural Science Foundation of Shaanxi Province(No.2022JZ-48 to X.C.)the National Natural Science Foundation of China(No.82272141 to X.C.)the Shaanxi Provincial Key Research and Development Plan Project(No.2023-JC-QN-0260 to X.Q.).
文摘The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.
