Duplicated chalcone synthase(CHS)genes modulate flavonoid production in tea plants in response to light stress

In tea plants,the abundant flavonoid compounds are responsible for the health benefits for the human body and define the astringent flavor profile.While the downstream mechanisms of flavonoid biosynthesis have been extensively studied,the role of chalcone synthase(CHS)in this secondary metabolic process in tea plants remains less clear.In this study,we compared the evolutionary profile of the flavonoid metabolism pathway and discovered that gene duplication of CHS occurred in tea plants.We identified three CsCHS genes,along with a CsCHS-like gene,as potential candidates for further functional investigation.Unlike the CsCHS-like gene,the CsCHS genes effectively restored flavonoid production in Arabidopsis chs-mutants.Additionally,CsCHS transgenic tobacco plants exhibited higher flavonoid compound accumulation compared to their wild-type counterparts.Most notably,our examination of promoter and gene expression levels for the selected CHS genes revealed distinct responses to UV-B stress in tea plants.Our findings suggest that environmental factors such as UV-B exposure could have been the key drivers behind the gene duplication events in CHS.

System of twice-gathering information and research of information fingerprint HashTrie

This paper presents a twice-gathering information interactive system prototype of e-government based on the condition that the Intranet and the Extranet are physical isolated.Users in the Extranet can gather links of the latest related information from client software which is previously collected by web alert in the Internet.Finally,through ferry-type transport devices,information is browsed by users in the Intranet,and it is transported to a storage device and synchronized with the web platform in the Intranet.During information gathering in the Extranet and data synchronization in the Intranet,it is essential to avoid repeated gathering and copying by means of comparing the extracted information fingerprints gathered from the web pages.This prototype uses HashTrie to store information fingerprints.During testing,the structure based on HashTrie is 2.28 times faster than the Darts（double array Trie）which is the fastest structure in the existing applied patent.The existing 12 types of high speed Hash functions serving for HashTrie are also implemented.When the dictionary content is larger than 5×105 words,the PJWHash or the SuperFastHush function can be adopted;when the dictionary content is 105 words, CalcStrCR32 and ELFHash functions can be adopted.

Different expression patterns of duplicated PHANTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf development

Recent studies on leaf development demonstrate that the mechanism on the adaxial-abaxial polarity pattern formation could be well conserved among the far-related species, in which PHANTASTICA （PAHN）-Iike genes play important roles. In this study, we explored the conservation and diversity on functions of PHAN-Iike genes during the compound leaf development in Lotusjaponicus, a papilionoid legume. Two PHAN-Iike genes in L. japonicus, LjPHANa and LjPHANb, were found to originate from a gene duplication event and displayed different expression patterns during compound leaf development. Two mutants, reduced leafletsl （rell） and reduced leaflets3 （rel3）, which exhibited decreased adaxial identity of leaflets and reduced leaflet initiation, were identified and investigated. The expression patterns of both LjPHANs in rel mutants were altered and correlated with abnormalities of compound leaves. Our data suggest that LjPHANa and LjPHANb play important but divergent roles in regulating adaxial-abaxial polarity of compound leaves in L. japonicus.

Duplicated appendix complicated by appendiceal cancer

A 37-year old male presented with an acute abdomen suggestive of an appendiceal perforation.Urgent laparotomy showed a duplicated appendix with one of the lumens involved with appendicitis and a focal periappendicular abscess while the other lumen had a localized appendiceal cancer.Recognition of congenital intestinal duplications in adults is important to avoid serious clinical consequences.

Availability Equivalence Factors of a General Repairable Parallel-Series System

The availability equivalence factors of a general repairable parallel-series system are discussed in this paper considering the availability function of the system. The system components are assumed to be repairable and independent but not identical. The life and repair times of the system components are exponentially distributed with different parameters. Two types of availability equivalent factors of the system are derived. The results derived in this paper generalize those given in the literature. A numerical example is introduced to illustrate how the idea of this work can be applied.

Anterior communicating artery aneurysm associated with duplicated hypoplastic right A1 segment

Variations of the anterior cerebral artery(ACA)-anterior communicating artery(ACo A) complex are commonly observed when associated with a symptomatic intracranial aneurysm. We report an asymptomatic ACo A aneurysm associated with duplicated hypoplastic A1 segment of the right ACA, observed in a 70-year-old female cadaver. Furthermore, the aneurysm, practically substituting the ACo A, caused a remarkable depression on the internal surface of the right frontal lobe, anterior to the optic chiasm. Aneurysms and other anomalies of the ACA and ACo A are common and their microvascular surgical management requires sound knowledge of the normal and variant vascular anatomy. Persistence of some embryonic vessels that normally disappear, disappearance of vessels that would normally persist or sprouting of new vessels due to hemodynamic and genetic factors are the usual causes for such anomalies. The high incidence of coexisting vascular anomalies and aneurysm suggests that such abnormalities predispose to aneurysm formation due to changes in the regional blood flow. A1 segment duplication has been reported to occur in 4% of subjects in cadaveric studies and in up to 0.5%-9.7% of cases of ACo A aneurysm surgery. Angiographic hypoplasias and aplasias of the A1 seg-ment have been also correlated with ACo A aneurysm patients.

A practical approach to improve alarm system performance: Application to power plant

Process safety in chemical industries is considered to be one of the important goals towards sustainable development. This is due to the fact that, major accidents still occur and continue to exert significant reputational and financial impacts on process industries. Alarm systems constitute an indispensable component of automation as they draw the attention of process operators to any abnormal conditi on in the plant. Therefore, if deployed properly, alarm systems can play a critical role in helping plant operators ensure process safety and profitability. How-ever, in practice, many process plants suffer from poor alarm system configuration which leads to nuisance alarms and alarm floods that compromise safety. A vast amount of research has primarily focused on developing sophisticated alarm management algorithms to address specific issues. In this article, we provide a simple, practical, systematic approach that can be applied by plant engineers (i.e., non-experts) to improve industrial alarm system performance. The proposed approach is demonstrated using an industrial power plant case study.

An Automatic Threshold Selection Using ALO for Healthcare Duplicate Record Detection with Reciprocal Neuro-Fuzzy Inference System

ESystems based on EHRs(Electronic health records)have been in use for many years and their amplified realizations have been felt recently.They still have been pioneering collections of massive volumes of health data.Duplicate detections involve discovering records referring to the same practical components,indicating tasks,which are generally dependent on several input parameters that experts yield.Record linkage specifies the issue of finding identical records across various data sources.The similarity existing between two records is characterized based on domain-based similarity functions over different features.De-duplication of one dataset or the linkage of multiple data sets has become a highly significant operation in the data processing stages of different data mining programmes.The objective is to match all the records associated with the same entity.Various measures have been in use for representing the quality and complexity about data linkage algorithms,and many other novel metrics have been introduced.An outline of the problem existing in themeasurement of data linkage and de-duplication quality and complexity is presented.This article focuses on the reprocessing of health data that is horizontally divided among data custodians,with the purpose of custodians giving similar features to sets of patients.The first step in this technique is about an automatic selection of training examples with superior quality from the compared record pairs and the second step involves training the reciprocal neuro-fuzzy inference system(RANFIS)classifier.Using the Optimal Threshold classifier,it is presumed that there is information about the original match status for all compared record pairs(i.e.,Ant Lion Optimization),and therefore an optimal threshold can be computed based on the respective RANFIS.Febrl,Clinical Decision(CD),and Cork Open Research Archive(CORA)data repository help analyze the proposed method with evaluated benchmarks with current techniques.

Pedicle complex tissue flap transfer for reconstruction of duplicated thumbs with unequal size

BACKGROUND Thumb polydactyly is one of the most common congenital hand deformities,and the Bilhaut-Cloquet procedure or a modified one is often used.However,controversy remains over the rare instances in which both thumbs are not of similar length or far apart in distance.AIM To evaluate the clinical outcomes of pedicle complex tissue flap transfer in the treatment of duplicated thumbs with unequal size.METHODS From January 2014 to December 2020,15 patients underwent duplicated thumb reconstruction by pedicle complex tissue flap transfer at our hand surgery center.The technique was used when it was necessary to combine different tissues from both severed and preserved thumbs that were not of similar length or far apart in distance.Subjective parents’evaluations and functional outcomes(ALURRA and TATA criteria)were obtained.The alignment deviation,instability,range of motion(percent of opposite thumb)of the interphalangeal and metacarpophalangeal joints,and the aesthetic aspects,including circumference,length,nail size,and nail deformity,were used to assess the clinical outcomes.RESULTS The average age of patients at the time of surgery was 13 mo,and the mean final follow-up occurred at 42 mo.An appropriate volume with a stable joint and good appearance was obtained in 14 reconstructed thumbs.An unstable interphalangeal joint occurred in one thumb.The flexion-extension arc at the metacarpophalangeal joint was good,while that at the interphalangeal joint was poor.Most of the parents were satisfied with the cosmetic and functional results of the reconstructed thumbs.The mean ALURRA score was 21.8(range:20-24),and the Tada score was 6.9(range:5-8).Compared with the non-operated side,the length of the operated thumb was approximately 95%,the girth was 89%,and the nail width was 82.9%.The mean ranges of motion were 62.1%of that of the unaffected thumb in the interphalangeal joint and 78.3%in the metacarpophalangeal joint.CONCLUSION Harvesting a pedicle flap from a severed thumb is a safe and reliable procedure.Defects of the preserved thumb,such as the skin,nail,and bone,can be effectively restored using the complex tissue flap.

Duplicated inferior vena cava in a patient undergoing right transumbilical laparoendoscopic single-site (LESS) radical nephrectomy

LaparoEndoscopic Single-site(LESS) renal surgery emerging as a potential alternative to conventional laparoscopy,is technically challenging and the major vascular anomaly may increase the risk of intraoperative haemorrhage.Herein,we present a case of right transumbilical LESS radical nephrectomy which was successfully performed in the presence of double inferior vena cava and duplicated the standard laparoscopic techniques.Most importantly,to bring such an aberrant vascular anatomy to the attention of laparoscopic,especially LESS surgeons with high resolution pictorial illustrations.

A case of duplicated inferior vena cava with bilateral iliac vein compression

Duplicated inferior vena cava with bilateral iliac vein compression is extremely rare.We report a case of an 87-year-old man presented with bilateral lower extremity swelling,who was noted to have duplicated inferior vena cava,as revealed by computed tomography angiography(CTA).This revealed bilateral iliac vein compression caused by surrounding structures.Anticoagulant treatment combined with stent implantation completely alleviated this chronic debilitating condition during the follow-up of 2 months with no recurrence.

TCP Karak: A New TCP AIMD Algorithm Based on Duplicated Acknowledgements for MANET

Transmission Control Protocol (TCP) performance over MANET is an area of extensive research. Congestion control mechanisms are major components of TCP which affect its performance. The improvement of these mechanisms represents a big challenge especially over wireless environments. Additive Increase Multiplicative Decrease (AIMD) mechanisms control the amount of increment and decrement of the transmission rate as a response to changes in the level of contention on routers buffer space and links bandwidth. The role of an AIMD mechanism in transmitting the proper amount of data is not easy, especially over MANET. This is because MANET has a very dynamic topology and high bit error rate wireless links that cause packet loss. Such a loss could be misinterpreted as severe congestion by the transmitting TCP node. This leads to unnecessary sharp reduction in the transmission rate which could degrades TCP throughput. This paper introduces a new AIMD algorithm that takes the number of already received duplicated ACK, when a timeout takes place, into account in deciding the amount of multiplicative decrease. Specifically, it decides the point from which Slow-start mechanism should begin its recovery of the congestion window size. The new AIMD algorithm has been developed as a new TCP variant which we call TCP Karak. The aim of TCP Karak is to be more adaptive to mobile wireless networks conditions by being able to distinguish between loss due to severe congestion and that due to link breakages or bit errors. Several simulated experiments have been conducted to evaluate TCP Karak and compare its performance with TCP NewReno. Results have shown that TCP Karak is able to achieve higher throughput and goodput than TCP NewReno under various mobility speeds, traffic loads, and bit error rates.

DETECTION OF PRIMARY TISSUE FAILURE POTENTIAL OF BIOPROSTHETIC HEART VALVES IN A STERILE PULSE DUPLICATOR SYSTEM

This paper discusses results of anatomic analogy and transmission line model for designing a sterile pulse duplication system for bioprostheses. By simulating physiological flow and pressure pulses as well as the input impedance of the human arterial system Pulsatile function testing allows us to study the hydrodynamic performances and the leaflet action of each valve. This inspection enables us to identify and reject those valves exhibiting leaflet prolapse or lazy leaflet or others believed to contribute to Primary tissue failure. Consequently, the risk of valve complications is reduced

Duplicates in systematic reviews: A critical, but often neglected issue

The number of systematic reviews is gradually increas-ing over time. Also, the methods to perform a systematic review are being improved. However, little attention has been paid for the issue regarding how to fnd duplicates in systematic reviews. On the basis of the survey and systematic reviews by our team and others, we review the prevalence, significance and classification of duplicates and the method to fnd duplicates in a systematic review. Notably, although a preliminary method to fnd duplicates is established, its usefulness and convenience need to be further confrmed.

Unruptured Aneurysm at the Origin of the Duplicated Middle Cerebral Artery Treated by Coil Embolization: A Case Report

Aneurysm at the origin of a duplication of the middle cerebral artery (DMCA) is very rare, and only 29 treated cases have been reported. All of the cases were treated by direct surgery except a ruptured case treated by intentional partial coil embolization. We report the first unruptured case treated by coil embolization and review the previously published cases. Coil embolization can be alternative treatment for an unruptured aneurysm at the origin of the DMCA. Stable framing to spare the origin of it and prevention of thromboembolic complications are keys for safe treatment.

Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

Content Caching Algorithms in Drone-Aided Ad Hoc Networks

Content delivery networks(CDNs)lead to fast content distribution through content caching at specific CDN servers near end users.However,existing CDNs based on infrastructure cannot be employed in special cases,such as military operations.Thus,a temporary CDN without an existing infrastructure is required.To achieve this goal,we introduce a new CDN for drone-aided ad hoc networks,whereby multiple drones form ad hoc networks and quickly store specific content according to new caching algorithms.Unlike the typical CDN server,the content-caching algorithm in the proposed architecture considers the limited storage capacity of the drone.We present three content distribution algorithms that consider the constraints and mobility of drones.The main contribution of content caching for drone-aided ad hoc networks is to keep partial segments rather than whole content as well as move the drone near to area with a high volume of requests.The proposed scheme is evaluated to demonstrate its feasibility in terms of content acquisition time and utilization in several practical scenarios through simulations.Consequently,acquisition time in CDN to support drone movement is improved by approximately 50%and 40%rather than one in the proposed naive greedy approach as a function of content request interval and size,respectively.

Multiple thoracic and abdominal foregut duplication cysts:A case report

BACKGROUND Congenital enteric duplication cysts are tubular or cystic structures that normally lie alongside the gastrointestinal(GI)tract.Enteric duplication cysts are typically solitary lesions that occur anywhere near the GI tract from the neck to the rectum,but having multiple duplication cysts is rare,and presentation within the pancreas is extremely rare.CASE SUMMARY We herein demonstrate a case of esophageal,gastric,and gastric-type duplication cyst of the pancreas in a seventeen-month-old girl who presented with failure to thrive,abdominal pain,vomiting,hematemesis,and melena since the age of three months.The cysts were excised by thoracoscopy and laparoscopy in the same setting.To our knowledge,no such case has been published.CONCLUSION Enteric duplications can occur throughout the entire alimentary tract.When they occur in the pancreas,they present a formidable challenge in both diagnosis and treatment.Due to the risk of complications and malignant transformation,surgical removal is the recommended treatment of all duplication cysts.

Comparative analysis of SIMILAR to RCD ONE(SRO)family from tetraploid cotton species and their diploid progenitors depict their significance in cotton growth and development

Background SRO(Similar to RCD1)genes family is largely recognized for their importance in the growth,develop-ment,and in responding to environmental stresses.However,genome-wide identification and functional characteri-zation of SRO genes from cotton species have not been reported so far.Results A total of 36 SRO genes were identified from four cotton species.Phylogenetic analysis divided these genes into three groups with distinct structure.Syntenic and chromosomal distribution analysis indicated uneven distribu-tion of GaSRO,GrSRO,GhSRO,and GbSRO genes on A2,D5 genomes,Gh-At,Gh-Dt,Gb-At,and Gb-Dt subgenomes,respectively.Gene duplication analysis revealed the presence of six duplicated gene pairs among GhSRO genes.In promoter analysis,several elements responsive to the growth,development and hormones were found in GhSRO genes,implying gene induction during cotton growth and development.Several miRNAs responsive to plant growth and abiotic stress were predicted to target 12 GhSRO genes.Organ-specific expression profiling demonstrated the roles of GhSRO genes in one or more tissues.In addition,specific expression pattern of some GhSRO genes dur-ing ovule development depicted their involvement in these developmental processes.Conclusion The data presented in this report laid a foundation for understanding the classification and functions of SRO genes in cotton.

Critical issues in the characteristics and assessment of China's water resources

This study provides a comprehensive analysis of the concepts and assessment processes of water resources in China,focusing on the characteristics of water resources and variations in water cycle fluxes.It reveals that the distribution of water resources in China is uneven,with more south and less north,and human activities have led to a decline in water resources,particularly in northern arid and semi-arid regions.Further analysis shows that duplicated measurements of surface water and groundwater significantly affect water balance calculation and water resource assessments,serving as a crucial factor guiding water resource development and utilization.The study also finds that consistency correction of runoff series is insufficient to meet the requirements of accurate water resource assessment.It is urgent to strengthen fundamental research in hydrology and hydrogeology,and to establish a dynamic assessment system for the efficient management and rational use of surface water and groundwater in the current changing environment.