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Trust beyond Technology Algorithms: A Theoretical Exploration of Consumer Trust and Behavior in Technological Consumption and AI Projects
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作者 David Oyekunle Ugochukwu Okwudili Matthew +1 位作者 David Preston David Boohene 《Journal of Computer and Communications》 2024年第6期72-102,共31页
In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing custome... In an era dominated by artificial intelligence (AI), establishing customer confidence is crucial for the integration and acceptance of AI technologies. This interdisciplinary study examines factors influencing customer trust in AI systems through a mixed-methods approach, blending quantitative analysis with qualitative insights to create a comprehensive conceptual framework. Quantitatively, the study analyzes responses from 1248 participants using structural equation modeling (SEM), exploring interactions between technological factors like perceived usefulness and transparency, psychological factors including perceived risk and domain expertise, and organizational factors such as leadership support and ethical accountability. The results confirm the model, showing significant impacts of these factors on consumer trust and AI adoption attitudes. Qualitatively, the study includes 35 semi-structured interviews and five case studies, providing deeper insight into the dynamics shaping trust. Key themes identified include the necessity of explainability, domain competence, corporate culture, and stakeholder engagement in fostering trust. The qualitative findings complement the quantitative data, highlighting the complex interplay between technology capabilities, human perceptions, and organizational practices in establishing trust in AI. By integrating these findings, the study proposes a novel conceptual model that elucidates how various elements collectively influence consumer trust in AI. This model not only advances theoretical understanding but also offers practical implications for businesses and policymakers. The research contributes to the discourse on trust creation and decision-making in technology, emphasizing the need for interdisciplinary efforts to address societal challenges associated with technological advancements. It lays the groundwork for future research, including longitudinal, cross-cultural, and industry-specific studies, to further explore consumer trust in AI. 展开更多
关键词 Consumer trust AI-Driven Projects TRANSPARENCY Ethical Accountability Structural Equation Modeling (SEM) Technology Acceptance Model (TAM) Interdisciplinary Study Organizational Factors Psychological Factors Behavioral Intention
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Static and Dynamic Structure Characteristics of a Trust Network and Formation of User Trust in an Online Society
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作者 Ying Li Hongduo Cao Ying Zhang 《Social Networking》 2018年第4期197-219,共23页
This study investigated the characteristics and formation of the online social trust network of Epinions.com, a general consumer review site. An analysis of the static structure of this social trust network revealed a... This study investigated the characteristics and formation of the online social trust network of Epinions.com, a general consumer review site. An analysis of the static structure of this social trust network revealed a high clustering coefficient, short average path length, and power-law degree distribution;it is therefore a small-world and scale-free trust network. The dynamic evolutionary characteristics of the online social network (OSN) were also examined. The results showed that the scale of the network followed a sigmoidal curve;the average degree of the network was nonconstant and changed into a bell-shaped distribution;the density of the network decreased and subsequently stabilized;and user trust diffusion in the network conformed to the Bass model. Finally, the formation of trust within the network was researched at the overall network (macro) and individual user (micro) levels. Compared with their accumulated contribution and reputation, user activeness had a larger effect on trust formation in OSNs, indicating a “diminishing returns” phenomenon. This phenomenon contrasts with the Matthew effect (i.e. , the more reputation a person has, the more likely he or she is to be trusted) in real-world social networks. 展开更多
关键词 trust Network STATIC structure Dynamic Evolution trust FORMATION Diminishing Returns
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Antecedents of Social Network Trust in SNS Usage: The Moderating Role of Offline Familiarity
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作者 Yu Wang 《Social Networking》 2017年第2期107-134,共28页
With the rapid development of social networks, there is a focus on marketing strategies and business models that are based on social media. In the academic world, scholars believe that online trust is a key factor con... With the rapid development of social networks, there is a focus on marketing strategies and business models that are based on social media. In the academic world, scholars believe that online trust is a key factor contributing to online purchasing behavior. This article explored several factors in social media trust and verified the moderating role of offline familiarity by using relevant research on online trust in conjunction with a structure equation model. The results show that independent variables such as reputation, SNS interaction, information quality, reciprocity, satisfaction and shared values have a positive influence on trust, whereas perceived similarity does not, and information quality is the most important factor. In addition, offline familiarity significantly moderates the relations between information quality, reciprocity, reputation, shared values and social media trust. This information is important to assist companies in developing an effective social network marketing strategy. 展开更多
关键词 ofFLINE FAMILIARITY SOCIAL Network trust MODERATE structure Equation Modeling
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Trust-region based instantaneous optimal semi-active control of long-span spatially extended structures with MRF-04K damper 被引量:7
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作者 Lin Wei Li Zhongxian Ding Yang 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2008年第4期447-464,共18页
In the field of civil engineering, magnetorheological fluid (MRF) damper-based semi-active control systems have received considerable attention for use in protecting structures from natural hazards such as strong ea... In the field of civil engineering, magnetorheological fluid (MRF) damper-based semi-active control systems have received considerable attention for use in protecting structures from natural hazards such as strong earthquakes and high winds. In this paper, the MRF damper-based semi-active control system is applied to a long-span spatially extended structure and its feasibility is discussed. Meanwhile, a _trust-region method based instantaneous optimal semi-active control algorithm (TIOC) is proposed to improve the performance of the semi-active control system in a multiple damper situation. The proposed TIOC describes the control process as a bounded constraint optimization problem, in which an optimal semi- active control force vector is solved by the trust-region method in every control step to minimize the structural responses. A numerical example of a railway station roof structure installed with MRF-04K dampers is presented. First, a modified Bouc- Wen model is utilized to describe the behavior of the selected MRF-04K damper. Then, two semi-active control systems, including the well-known clipped-optimal controller and the proposed TIOC controller, are considered. Based on the characteristics of the long-span spatially extended structure, the performance of the control system is evaluated under uniform earthquake excitation and travelling-wave excitation with different apparent velocities. The simulation results indicate that the MR fluid damper-based semi-active control systems have the potential to mitigate the responses of full-scale long-span spatially extended structures under earthquake hazards. The superiority of the proposed TIOC controller is demonstrated by comparing its control effectiveness with the clipped-optimal controller for several different cases. 展开更多
关键词 long-span spatially extended structure instantaneous optimal control semi-active control trust-regionmethod magnetorheological (MR) damper bounded constraint optimization modified Bouc-Wen model clipped-optimal control
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Attitudes Toward Dysfunctional Audit Behavior: The Effect of Budget Emphasis, Leadership Behavior, and Effectiveness of Audit Review
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作者 Halil Paino Azlan Thani Syed Iskandar Zulkarnain Syid Idris 《Journal of Modern Accounting and Auditing》 2011年第12期1344-1351,共8页
Dysfunctional audit behavior (DAB) is an accepted problem, associated with decreased audit quality. This study develops and tests a theoretical model that identifies factors contributing to DAB. Budget emphasis, lea... Dysfunctional audit behavior (DAB) is an accepted problem, associated with decreased audit quality. This study develops and tests a theoretical model that identifies factors contributing to DAB. Budget emphasis, leadership behavior structure and consideration, and effectiveness of audit review were examined as antecedents of attitudes toward DAB. The findings produced consistent evidence in support of the theoretical model. It is not an emphasis on meeting budgets that leads to undesirable behavior, but contextual variables, such as leadership behavior structure and effectiveness of audit review. 展开更多
关键词 attitudes towards dysfunctional audit behavior budget emphasis leadership behavior structure andconsideration audit review
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Structural equation modeling analysis of factors influencing architects' trust in project design teams 被引量:1
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作者 丁志坤 NG Fung-fai 《Journal of Chongqing University》 CAS 2009年第1期32-36,共5页
This paper describes a structural equation modeling (SEM) analysis of factors influencing architects' trust in project design teams. We undertook a survey of architects, during which we distributed 193 questionnair... This paper describes a structural equation modeling (SEM) analysis of factors influencing architects' trust in project design teams. We undertook a survey of architects, during which we distributed 193 questionnaires in 29 A-level architectural design institutes selected radomly from the altogether 59 ones in Shenzhen, P. R. China, and received 130 valid questionnaires. We used Amos 6.0 for SEM to identify significant personal construct based factors affecting interpersonal trust. The results show that only social interaction between architects significantly affects their interpersonal trust. The explained variance of trus~ is not very high in the model. Therefore, future research should add more factors into the current model. The practical implication is that team managers should promote the social interactions between team members such that the interpersonal trust level between team members can be improved. 展开更多
关键词 architect trust project design team cluster sampling structural equation modeling
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Perceived Trust and Payment Methods: An Empirical Study of MarkaVIP Company
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作者 Mahmoud Maqableh Ra’ed Moh’d Taisir Masa’deh +1 位作者 Rifat O. Shannak Khalid M. Nahar 《International Journal of Communications, Network and System Sciences》 2015年第11期409-427,共19页
This empirical study focused on investigating the perceived trust surrogated by a number of hy-pothesized factors and its effect on the choice of method of payment. The data were collected using a questionnaire, as th... This empirical study focused on investigating the perceived trust surrogated by a number of hy-pothesized factors and its effect on the choice of method of payment. The data were collected using a questionnaire, as the instrument for the primary data collection, with total collected back responses of 214 from customers of MarkaVIP. Structural equation modeling technique was used to fully analyze the data in order to determine what level of the relationship between the constituting factors of the perceived trust and the method of payment. The main findings were related to confirming the seven main hypotheses of the research that were related to testing if some factors were important to forming perceived trust by customers. Four factors (reputation, security, familiarity, and ease of use) were found to have a positive effect and the remaining three were not (privacy, size and usefulness). In addition, having perceived trust meant no preference to any method of payment by the customers. 展开更多
关键词 E-PAYMENT PERCEIVED trust EPS E-COMMERCE Security Structural Equation Modeling
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Trust Model Based on Structured Protection for High Level Security System 被引量:1
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作者 Liao Jianhua Zhao Yong Zhan Jing 《China Communications》 SCIE CSCD 2012年第11期70-77,共8页
In order to ensure the security of information systems, it's essential to make sure that system behaviors are trusted. By analyzing threats that exist in executing procedures, a trust model based on structured pro... In order to ensure the security of information systems, it's essential to make sure that system behaviors are trusted. By analyzing threats that exist in executing procedures, a trust model based on structured protection is proposed. We consider that functional components, system actions and message flows between components are three key factors of information systems. Structured protection requirements on components, connections and action parameters are also provided. Four trusted properties of the model are deducted through formal analysis, and trusted system behavior is defined based on these properties. Furthermore, decision theorem of trusted system behavior is proved. The developed prototype system indicates the model is practical. It is a general theory model built on logic deduction and independent on specific environment and the behaviors of the system designed and implemented following the model are trusted. 展开更多
关键词 trusted computing security assurance structured protection
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Transformation of myocardial energy metabolism pattern during myocardial remodeling caused by volume overload
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作者 Yongchun Cui Bo Li +4 位作者 Xiaokang Luo Lei Qi Chengliang Luo Xiuyu Shi Yue Tang 《中国循环杂志》 CSCD 北大核心 2018年第S01期132-132,共1页
Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even rev... Objective To elucidate the transformation of energy metabolism patterns in the process of myocardial remodeling induced by volumeoverload and to explore a novel intervention target for the prevention,delay or even reversal of structural heart dysfunction.Methods Thirty C57/BL6 mice,20-30 g,half male and half female,were randomly divided into model group(n=15)and sham operation group(n=15).Each group was divided into subacute phase(2 weeks after surgery,n=5),cardiac functional compensation phase(5 weeks after surgery,n=5)and decompensation phase(15 weeks after surgery,n=5). 展开更多
关键词 volume OVERLOAD energy METABOLISM patterns structural HEART dysfunction
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结合TAM与Trust的移动内容服务采纳因素变化分析 被引量:1
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作者 黄浩 《经济与管理评论》 2016年第4期60-66,共7页
针对移动内容服务的特点,结合信任因素对TAM进行了扩展,提出了移动内容服务采纳因素变化的比较模型,并利用结构方程模型的方法,对影响用户采纳移动内容服务的因素进行实证研究。在验证假设模型的过程中,把样本区分为潜在消费者和忠实消... 针对移动内容服务的特点,结合信任因素对TAM进行了扩展,提出了移动内容服务采纳因素变化的比较模型,并利用结构方程模型的方法,对影响用户采纳移动内容服务的因素进行实证研究。在验证假设模型的过程中,把样本区分为潜在消费者和忠实消费者,分别验证不同类型消费者对于理论模型的适应性,通过比较分析揭示采纳因素的变化趋势。研究发现,感知有用性是消费者采纳移动内容服务的必要而非充分条件,信任和信息质量因素起到了关键作用,潜在消费者向忠实消费者转化的过程中,个人信任倾向和企业声誉对消费者信任信念的作用在弱化。 展开更多
关键词 采纳 移动商务 移动内容服务 信任 结构方程模型
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老年认知功能障碍与高尿酸血症及脑灰质结构改变的关系研究
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作者 王晓 杨牧 +1 位作者 余雯晴 苏雪娟 《中国CT和MRI杂志》 2024年第1期18-20,共3页
目的分析老年认知功能障碍与高尿酸血症的关系,观测患者脑灰质结构改变情况,探讨相关脑机制。方法前瞻性选取在本院住院或门诊就医的老年认知功能障碍患者392例,根据认知功能障碍分类诊断标准及认知评定量表分为轻度认知障碍组224例,痴... 目的分析老年认知功能障碍与高尿酸血症的关系,观测患者脑灰质结构改变情况,探讨相关脑机制。方法前瞻性选取在本院住院或门诊就医的老年认知功能障碍患者392例,根据认知功能障碍分类诊断标准及认知评定量表分为轻度认知障碍组224例,痴呆组168例;另取同期在本院健康体检的老年人182例为对照组。比较各组血尿酸水平,收集并分析可能的影响因素。采用基于体素的形态测量学方法对患者全脑容积进行分割,在Matlab 6.5环境下运行spm5,分析简易精神状态检查表(MMSE)分级与全脑灰质容积的相关性。结果痴呆组患者血尿酸水平[(419.47±32.51)μmol/L]明显高于轻度认知障碍组[(354.80±27.63)μmol/L]和对照组[(226.48±32.15)μmol/L];轻度认知障碍组血尿酸水平明显高于对照组(均P<0.01)。多因素Logistic回归分析显示,年龄(B=1.821,OR=2.134,95%CI=1.296~4.830,P=0.000)、受教育程度(B=1.559,OR=1.607,95%CI=0.971~3.519,P=0.001)、高尿酸血症(B=2.671,OR=3.641,95%CI=1.695~7.831,P=0.000)是老年认知功能障碍的独立影响因素。其中高尿酸血症发生认知功能障碍的风险高出尿酸正常者的3.641倍。老年认知功能障碍患者MMSE分级与灰质容积成负相关的脑区包括:左侧前扣带回、左内侧额上回、两侧海马旁回、两侧岛叶、两侧舌回、两侧小脑皮层、左侧尾状核、右侧颞中回、左侧后扣带回、左侧枕中回(均P<0.005);成正相关的脑区包括:左侧颞中回、左侧颞下回、两侧丘脑和豆状苍白球、右侧背外侧额上回、左侧缘上回、右侧枕上回和中回、左侧楔前叶(均P<0.005)。结论高尿酸血症是老年认知功能障碍的危险因素;情绪、记忆及默认网络脑灰质结构异常与老年认知功能障碍的发生、发展相关。 展开更多
关键词 认知功能障碍 老年人 高尿酸血症 脑灰质 结构变化
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基于eHMI的车外人机交互信任影响因素研究
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作者 徐娟芳 陈子昂 《包装工程》 CAS 北大核心 2024年第14期225-232,共8页
目的更好地发挥车外人机交互界面(eHMI)的潜在优势,研究车外人机交互过程中的信任影响机制。方法首先基于自动化信任理论,提出感知可靠性、感知透明度、感知熟悉度、感知车辆性能、感知品牌信誉和感知主观倾向等6个车外人机交互信任影... 目的更好地发挥车外人机交互界面(eHMI)的潜在优势,研究车外人机交互过程中的信任影响机制。方法首先基于自动化信任理论,提出感知可靠性、感知透明度、感知熟悉度、感知车辆性能、感知品牌信誉和感知主观倾向等6个车外人机交互信任影响因素,然后使用结构方程模型的方法对305名被调查者进行数据分析,由此建立车外人机交互信任影响因素的理论模型。结果行人通过对eHMI信号感知而形成的信任能够影响对自动驾驶汽车的信任,行人对eHMI的信任一定程度上转移成为行人对车辆的信任,eHMI的辅助作用得到体现。强调了eHMI设计中感知可靠性的重要性,这能够被熟悉度、透明度和品牌信誉所影响。同时,行人的主观倾向和对车辆性能的感知也是影响信任水平的重要因素。结论研究结果为车外人机交互信任对于自动驾驶汽车在未来道路上使用的重要性提供了证据,同时也为eHMI的设计提供了参考和建议。 展开更多
关键词 自动化信任 自动驾驶汽车 车外人机交互界面 结构方程模型 交互设计
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结构需求作用下感知公平对员工离职倾向的双路径影响
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作者 周燕华 李子龙 《经济论坛》 2024年第3期142-152,共11页
公平感是组织领域一个经久不衰的研究议题。已有研究表明组织公平感是员工行为和态度的强预测变量,但较少研究从双元路径探讨公平感如何作用于员工离职倾向的产生。文章以情感事件理论和社会交换理论为基础探讨了“情绪反应”和“认知... 公平感是组织领域一个经久不衰的研究议题。已有研究表明组织公平感是员工行为和态度的强预测变量,但较少研究从双元路径探讨公平感如何作用于员工离职倾向的产生。文章以情感事件理论和社会交换理论为基础探讨了“情绪反应”和“认知驱动”的双元路径模式,并基于补偿性控制理论讨论了结构需求度不同的员工如何体现出对组织公平的差异性感知。运用层级回归、Bootstrap等分析方法,得出如下结论:组织公平感与工作倦怠显著负相关、与管理者信任显著正相关;组织公平感通过工作倦怠和管理者信任的中介效应对员工离职倾向产生影响。同时,结构需求削弱了组织公平感与工作倦怠间的负向关系,增强了组织公平感与管理者信任间的正向关系。最后,基于研究结论,提出了相关的管理措施建议。 展开更多
关键词 组织公平感 结构需求 工作倦怠 管理者信任 离职倾向
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苓桂气化2号方对射血分数保留心力衰竭大鼠心脏结构和舒张功能的影响 被引量:1
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作者 乔文博 董国菊 +6 位作者 李知轩 张贺 石玉姣 杨晨光 刘永成 梁小雨 刘思雨 《环球中医药》 CAS 2024年第6期991-998,共8页
目的观察苓桂气化2号方对射血分数保留心力衰竭(heart failure with preserved ejection fraction,HFpEF)大鼠心脏结构和舒张功能的影响。方法10只7周龄的威斯塔京都大鼠作为正常组,40只自发性高血压大鼠建立复合糖尿病、高血压、高血脂... 目的观察苓桂气化2号方对射血分数保留心力衰竭(heart failure with preserved ejection fraction,HFpEF)大鼠心脏结构和舒张功能的影响。方法10只7周龄的威斯塔京都大鼠作为正常组,40只自发性高血压大鼠建立复合糖尿病、高血压、高血脂的HFpEF大鼠模型,造模期间死亡3只。造模成功后,所有造模成功的大鼠随机分为模型组(9只)、恩格列净组(10只)、低剂量组(9只)和高剂量组(9只)。正常组和模型组给予等量生理盐水,恩格列净组给予恩格列净1.8 mg/(kg·d),低、高剂量组分别给予苓桂气化2号方浸膏8.1 g/(kg·d)和16.2 g/(kg·d),持续4周。给药结束后,使用超声心动图测量每组大鼠的左室舒末内径(left ventricular end diastolic diameter,LVEDD)、左房内径(left atrial diameter,LAD)、右房内径(right atrial diameter,RAD)、室间隔厚度(interventricular septal thickness,IVST)、左室射血分数(left ventricular ejection fraction,LVEF)、等容舒张时间(isovolumic relaxation time,IVRT)、舒张早期二尖瓣血流速度(left ventricular early diastolic filling peak velocity,E)与二尖瓣环心肌运动速度(early diastolic lateral mitral annulus velocity,e′)的值。使用酶联免疫吸附法检测心钠素(atrial natriuretic peptide,ANP)和脑钠肽(B-type brain natriuretic peptide,BNP)水平。苏木精—伊红染色观察左房心肌组织病理变化,马松染色染色观察心肌组织纤维化。结果与正常组比较,模型组大鼠出现呼吸急促、食欲下降、易怒等情况,心脏超声检测显示LVEDD、LAD、RAD显著增大(P<0.01),IVST、E/e′、IVRT显著增加(P<0.01);血清ANP、BNP水平显著升高(P<0.01)。与模型组相比,各给药组大鼠精神佳、反应灵敏、纳食饮水相对较多,心脏超声相关参数显示LVEDD、LAD、RAD、IVST以及E/e′、IVRT均有明显改善(P<0.05);血清ANP、BNP水平均明显降低(P<0.05)。结论苓桂气化2号方可能通过减轻心肌肥厚及纤维化改善HFpEF大鼠的心脏重构和舒张功能障碍,是治疗HFpEF的潜在有效方剂。 展开更多
关键词 苓桂气化2号方 射血分数保留的心力衰竭 心脏结构和功能 舒张功能障碍 心钠素 脑钠肽 病理形态
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基于在线信任模型的患者对移动医疗服务信任的 影响因素研究
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作者 周颖 张启华 刘畅 《卫生软科学》 2024年第8期18-22,共5页
[目的]了解影响患者对移动医疗服务信任的因素及其作用机制,为提升在线患者信任提供参考依据。[方法]采用问卷调查法对具有移动医疗服务使用经验的600位患者进行调查,构建结构方程模型,探讨在线患者信任的影响因素。[结果]除个人信任倾... [目的]了解影响患者对移动医疗服务信任的因素及其作用机制,为提升在线患者信任提供参考依据。[方法]采用问卷调查法对具有移动医疗服务使用经验的600位患者进行调查,构建结构方程模型,探讨在线患者信任的影响因素。[结果]除个人信任倾向对在线患者信任不存在显著影响外,其他因素对在线患者信任的总效应依次为制度保障(0.725)、医生可信度(0.491)、医院可信度(0.319)、网站可信度(0.221)和感知风险(-0.119)。[结论]制度保障、医生可信度、医院可信度、网站可信度对在线患者信任产生正向影响,感知风险产生负向影响,且制度保障对在线患者信任的总效应最大,应有针对性地从以上5个方面提升在线患者信任,进而促进移动医疗发展。 展开更多
关键词 移动医疗服务 在线信任模型 在线患者信任 调查问卷法 结构方程模型
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Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Model of Parkinson's Disease 被引量:15
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作者 LIU Shu-min LI Xu-zhao +5 位作者 ZHANG Shuai-nan YANG Zhi-ming WANG Ke-xin LU Fang WANG Chong-zhi YUAN Chun-su 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2018年第11期835-843,共9页
Objective: To investigate the neuro-protective effects of Acanthopanax senticosus Harms(EAS) on mesencephalic mitochondria and the mechanism of action, using a mouse model of Parkinson's disease(PD). Methods: T... Objective: To investigate the neuro-protective effects of Acanthopanax senticosus Harms(EAS) on mesencephalic mitochondria and the mechanism of action, using a mouse model of Parkinson's disease(PD). Methods: The chemical fingerprint analysis of the extract of Acanthopanax senticosus Harms(EAS) was performed using the ultra performance liquid chromatograph and time of flight mass spectrometry. Thirty mice were randomly divided into the control group, the MPTP model group, and the EAS treated group with MPTP(MPTP+EAS group, 10 in each group). The MPTP model group and the MPTP+EAS group received MPTP-HCl(30 mg/kg i.p) once a day for 5 days. The control group received an equal volume of saline(20 m L/kg i.p) once a day for 5 days. Induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride daily(MPTP-HCl, 30 mg/kg) for 5 days, the PD mice were treated with EAS at 45.5 mg/kg daily for 20 days. The behavioral testing of mice was carried out using the pole-climbing test. The integrity and functions of neurons were examined in mesencephalic mitochondria in a PD mouse model, including nicotinamide adenine dinucleotide dehydrogenase ubiquinone flavoprotein 2(NDUFV2), mitochondrially encoded nicotinamide adenine dinucleotide dehydrogenase 1(MT-ND1), succinate dehydrogenase complex subunit A(SDHA), and succinate dehydrogenase cytochrome b560 subunit(SDHC). Results: After treatment with EAS, the behavioral changes induced by MPTP were attenuated significantly(P〈0.05). EAS protected the mesencephalic mitochondria from swelling and attenuated the decreases in their membrane potential(both P〈0.05), which was supported by an ultra-structural level analysis. The changes in reactive oxygen species(ROS), malonic dialdehyde(MDA), oxidative phosphorylation(OXPHOS) system 4 subunits levels and PD-related proteins expressions(parkin, Pink1, DJ-1, α-synuclein, and Lrrk2) reverted to near normal levels(all P〈0.05), based on the results of immune-histological and Western blotting observations. Conclusions: The neuro-protective effects of EAS are linked to protecting mice against MPTPinduced mitochondrial dysfunction and structuraldamage.Therefore,EAS is a promising candidate for the prevention or treatment of mitochondrial neurodegenerative disorders,such as PD. 展开更多
关键词 Acanthopanax senticosus Harms Parkinson's disease mitochondrial dysfunction mitochondrial structural damage oxidative phosphorylation system
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动脉瘤蛛网膜下腔出血术后认知功能障碍患者的脑结构及功能的MRI研究进展
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作者 张钤军 刘倩 +1 位作者 李瑞利 卢洁 《磁共振成像》 CAS CSCD 北大核心 2024年第1期194-198,共5页
动脉瘤蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)在年轻人中常见,致残致死率高,且超过50%的患者术后会出现认知功能障碍,表现在多个领域:语言、记忆、视觉感知能力、信息处理、注意力以及执行功能,严重影响患者的生存质... 动脉瘤蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)在年轻人中常见,致残致死率高,且超过50%的患者术后会出现认知功能障碍,表现在多个领域:语言、记忆、视觉感知能力、信息处理、注意力以及执行功能,严重影响患者的生存质量,给患者、家庭及社会带来沉重的精神和经济负担。早期诊断和治疗有助于患者的功能恢复和生活质量的提高,但其诊断需要一系列神经认知量表的评估,耗时且具有主观性。MRI具有无创、无辐射的优势,应用不同的颅脑影像序列(3D T1WI、扩散张量成像、功能MRI)能够从不同角度获取脑微观结构和功能的改变,为aSAH患者术后认知功能障碍的早期诊断、疾病监测、预后评估及病理机制提供影像学的独特见解。本研究对aSAH患者术后认知功能障碍的脑结构及功能MRI研究进展进行综述,旨在探索aSAH早期诊断、患者术后认知功能障碍评估的相关MRI参数,以期有益于早期治疗及改善预后。 展开更多
关键词 动脉瘤蛛网膜下腔出血 认知功能障碍 磁共振成像 脑结构 脑功能
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轻度认知功能障碍与PD患者脑结构改变的相关性
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作者 陈晓菲 黄辉 王超 《中国实用神经疾病杂志》 2024年第8期1003-1007,共5页
目的探讨轻度认知功能障碍与帕金森病(PD)患者脑结构改变的相关性。方法选取2020-01—2023-04淮北市人民医院收治的83例PD患者为研究对象,将其分为认知功能正常组(PD-N,n=28)、轻度认知功能障碍组(PD-M,n=28)、痴呆组(PDD,n=27)。比较... 目的探讨轻度认知功能障碍与帕金森病(PD)患者脑结构改变的相关性。方法选取2020-01—2023-04淮北市人民医院收治的83例PD患者为研究对象,将其分为认知功能正常组(PD-N,n=28)、轻度认知功能障碍组(PD-M,n=28)、痴呆组(PDD,n=27)。比较各组患者MoCA评分、汉密尔顿抑郁量表、睡眠质量、疲劳严重度、脑叶萎缩评分、运动症状与非运动症状评分。结果PD-N组MoCA评分(26.34±2.15)、睡眠质量评分(7.25±1.67)高于PD-M组与PDD组,PD-M组MoCA评分(20.46±3.23)、睡眠质量评分(4.68±1.19)高于PDD组(P<0.05);PD-N组汉密尔顿抑郁量表评分(12.82±4.34)、疲劳严重度评分(3.13±0.81)低于PD-M组与PDD组,PD-M组汉密尔顿抑郁量表评分(18.67±5.20)、疲劳严重度评分(4.68±1.19)低于PDD组(P<0.05)。PD-N组前额叶萎缩评分(1.21±0.45)、颞叶萎缩评分(1.13±0.37)、顶叶萎缩评分(1.06±0.24)、枕叶萎缩评分(1.05±0.26)低于PD-M组与PDD组(P<0.05),PD-M组前额叶萎缩评分(1.84±0.56)、颞叶萎缩评分(1.62±0.48)、顶叶萎缩评分(1.49±0.31)、枕叶萎缩评分(1.43±0.37)低于PDD组(P<0.05)。PD-N组运动症状评分(18.52±6.24)、非运动症状评分(24.39±7.15)低于PD-M组与PDD组(P<0.05)。结论轻度认知功能障碍与PD患者的脑结构改变存在显著相关性。随着PD患者认知功能障碍的加重,其脑结构改变的程度也相应增加,这可能进一步加剧了认知功能的衰退,这一发现对于深入理解PD的病理生理机制以及早期识别和治疗PD患者的认知功能障碍具有重要意义。 展开更多
关键词 认知功能障碍 帕金森病 脑结构 相关性 脑叶萎缩评分
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神经源性肠道功能障碍对脊髓损伤患者生存质量影响的结构方程分析
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作者 苟昕雨 吴静 +3 位作者 韦翠翠 詹水荣 杜培云 吴爱荣 《护理学报》 2024年第20期13-18,共6页
目的通过构建结构方程模型探讨神经源性肠道功能障碍对脊髓损伤患者生存质量的影响及其作用关系。方法采用整群抽样方法,于2021年3月—2022年2月选取上海市4家医院脊髓损伤科患者作为研究对象。调查内容包含一般资料调查表、生存质量测... 目的通过构建结构方程模型探讨神经源性肠道功能障碍对脊髓损伤患者生存质量的影响及其作用关系。方法采用整群抽样方法,于2021年3月—2022年2月选取上海市4家医院脊髓损伤科患者作为研究对象。调查内容包含一般资料调查表、生存质量测定量表简表、神经源性肠道功能障碍量表、焦虑自评量表和患者积极度量表。采用AMOS 28.0软件构建结构方程模型。结果脊髓损伤患者生存质量总得分为(47.39±10.04),神经源性肠道功能障碍得分为8.00(3.00,11.00)。结构方程模型分析显示,神经源性肠道功能障碍对生存质量有直接消极作用(β=-0.146,P=0.021),并以积极度(β=0.202,P<0.05)、焦虑度(β=-0.007,P<0.05)为中介变量可间接预测生存质量。结论本研究脊髓损伤患者的生存质量水平呈现低水平,神经源性肠道功能障碍负向直接影响患者的生存质量。积极度、焦虑度在神经源性肠道功能障碍与生存质量之间发挥中介作用。医护人员需重视脊髓损伤患者的肠道护理与管理,关注患者的心理状态,提供积极的综合支持。 展开更多
关键词 脊髓损伤 神经源性肠道功能障碍 生存质量 结构方程模型
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农地信托化趋势下农村居民收入结构优化研究 被引量:1
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作者 管延芳 张紫雯 《当代农村财经》 2024年第6期44-49,共6页
农地信托化是新一轮土地制度变革的必然趋势,在推进过程中会改变农村居民收入结构。本文提出农村居民收入的“四元结构”,从理论上分析农地信托化对农村居民收入结构的影响机理,基于2000年至2021年数据,运用对比分析方法,从实际出发分... 农地信托化是新一轮土地制度变革的必然趋势,在推进过程中会改变农村居民收入结构。本文提出农村居民收入的“四元结构”,从理论上分析农地信托化对农村居民收入结构的影响机理,基于2000年至2021年数据,运用对比分析方法,从实际出发分析农村居民收入规模变化和农村居民收入结构变化,得出结论:优化农村居民收入结构才能提高农民收入的韧性,随着农地信托化的发展,农村居民收入结构得到优化,但仍存在一些问题,还需进一步优化。最后,提出优化建议:破除路径依赖,完善土地流转机制;打破小农意识,重建土地情结与农民收入之间的关系;注重农民文化素质教育,完善职业技能培训体系;实现农村社会保障全覆盖,提高社保缴费灵活性。 展开更多
关键词 土地信托化 农村居民 收入结构 土地流转
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