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China's E-commerce Operators Ready for Double 11 Shopping Festival
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作者 Ada Wang 《China's Foreign Trade》 2024年第5期39-40,共2页
With one month until November 11,all major e-commerce platforms have started their preparations for this great event.The"Double 11"shopping festival was first initiated by Alibaba in 2009and is the world'... With one month until November 11,all major e-commerce platforms have started their preparations for this great event.The"Double 11"shopping festival was first initiated by Alibaba in 2009and is the world's largest online sales gala.This shopping festival is thus named due to the date of November11 and has extended from the original24 hours to several weeks in recent years.The pre-sales stage start from late October.Some new e-commerce companies like TikTok and Pinduoduo have also been involved in the event. 展开更多
关键词 COMPANIeS SHOPPING commerce
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Cross-border E-commerce Accelerates Diversely Abroad
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作者 Guo Yan 《China's Foreign Trade》 2024年第1期14-15,共2页
“Strength”and“vitality”are the comments that people in the industry have used to describe China’s cross-border e-commerce in 2023,which has been proven by the latest statistics.According to the General Administra... “Strength”and“vitality”are the comments that people in the industry have used to describe China’s cross-border e-commerce in 2023,which has been proven by the latest statistics.According to the General Administration of Customs,in 2023,the total volume of imports and exports was RMB 2.38 trillion,up by 15.6%.The volume of exports was RMB 1.83 billion,up by 19.6%,and the volume of imports was RMB 548.3 billion,up by 3.9%. 展开更多
关键词 IMPORTS BORDeR commerce
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More Options B2C e-commerce is evolving rapidly in China,moving towards live commerce
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《China Report ASEAN》 2024年第5期34-38,共5页
Way back in 1999,twelve volunteers locked themselves in hotel rooms in Beijing,Shanghai,and Guangzhou to participate in a“72-hour network survival experiment.”The goal was to stay in the room for three days and surv... Way back in 1999,twelve volunteers locked themselves in hotel rooms in Beijing,Shanghai,and Guangzhou to participate in a“72-hour network survival experiment.”The goal was to stay in the room for three days and survive on an allowance from the organizer,half in cash and half in electronic form,by purchasing food,bedding. 展开更多
关键词 B2C BeDDING commerce
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Predicting Purchasing Behavior on E-Commerce Platforms: A Regression Model Approach for Understanding User Features that Lead to Purchasing
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作者 Abraham Jallah Balyemah Sonkarlay J. Y. Weamie +2 位作者 Jiang Bin Karmue Vasco Jarnda Felix Jwakdak Joshua 《International Journal of Communications, Network and System Sciences》 2024年第6期81-103,共23页
This research introduces a novel approach to improve and optimize the predictive capacity of consumer purchase behaviors on e-commerce platforms. This study presented an introduction to the fundamental concepts of the... This research introduces a novel approach to improve and optimize the predictive capacity of consumer purchase behaviors on e-commerce platforms. This study presented an introduction to the fundamental concepts of the logistic regression algorithm. In addition, it analyzed user data obtained from an e-commerce platform. The original data were preprocessed, and a consumer purchase prediction model was developed for the e-commerce platform using the logistic regression method. The comparison study used the classic random forest approach, further enhanced by including the K-fold cross-validation method. Evaluation of the accuracy of the model’s classification was conducted using performance indicators that included the accuracy rate, the precision rate, the recall rate, and the F1 score. A visual examination determined the significance of the findings. The findings suggest that employing the logistic regression algorithm to forecast customer purchase behaviors on e-commerce platforms can improve the efficacy of the approach and yield more accurate predictions. This study serves as a valuable resource for improving the precision of forecasting customers’ purchase behaviors on e-commerce platforms. It has significant practical implications for optimizing the operational efficiency of e-commerce platforms. 展开更多
关键词 e-commerce Platform Purchasing Behavior Prediction Logistic Regression Algorithm
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Electronic Commerce Security and Risk Management: An Important Part of College Curriculum
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作者 Yongchang Cai 《Journal of Educational Theory and Management》 2024年第1期18-22,共5页
With the rapid expansion of e-commerce,its security and risk management problems become increasingly prominent.In the current business environment,the ability to understand and apply e-commerce security and risk manag... With the rapid expansion of e-commerce,its security and risk management problems become increasingly prominent.In the current business environment,the ability to understand and apply e-commerce security and risk management has become an important criterion to measure a good person.Therefore,the importance of e-commerce security and risk management courses in college education is self-evident.This course can not only help students master the basic knowledge of e-commerce,but also enable them to understand how to deal with various risks in practical work and ensure the safe operation of e-commerce.At the same time,through the study of e-commerce security and risk management,students can better understand the operation mode and law of e-commerce,and lay a solid foundation for their future career.In general,e-commerce security and risk management occupy an important position in the curriculum of colleges and universities,and play a crucial role in cultivating e-commerce professionals with practical operation ability and innovative thinking. 展开更多
关键词 electronic commerce SeCURe Risk management College curriculum
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The Integration of Modern Electronic Technology and E-Commerce:the Driving Force of Innovation Development
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作者 Yongchang Cai 《Journal of Educational Theory and Management》 2024年第2期6-10,共5页
In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovativ... In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovative development of e-commerce,but also brings unprecedented opportunities and challenges for enterprises.With the continuous development and popularization of Internet technology,more and more people choose to carry out shopping,payment and other consumption activities through e-commerce platforms,which also provides merchants with a broader market space and more sales channels.At the same time,e-commerce also brings more convenience and choice to consumers,making it easier for consumers to obtain the goods and services they need.However,the development of e-commerce has also brought some new challenges,such as how to ensure the quality of goods,how to protect consumer privacy and so on.Therefore,enterprises and government departments need to strengthen the supervision and management of e-commerce to ensure its healthy and orderly development.In general,the integration of electronic technology and e-commerce has become an important trend in today’s business field,which brings both opportunities and challenges to enterprises. 展开更多
关键词 electronic technology electronic commerce Innovation and development Driving force
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De Novo Synthesis of Biopaint Using Transformed Bacteria: Analysis of Spectral Intensity Trends and Comparison to Commercial Paint
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作者 Rathan Duggirala Prasamsi Mikkilineni Ivana Croghan 《Advances in Bioscience and Biotechnology》 CAS 2024年第10期543-555,共13页
Background: Commercial paint pigments contain toxic heavy metals that harm humans and pollute the environment. To mitigate these harms, ecologically safe pigments are necessary. Objective: This experiment aims to crea... Background: Commercial paint pigments contain toxic heavy metals that harm humans and pollute the environment. To mitigate these harms, ecologically safe pigments are necessary. Objective: This experiment aims to create a biopaint de-novo using transformed Escherichia coli bacteria and compare it to commercial paint. Methods: Genetically engineered E. coli bacteria producing magenta pigment were grown in petri dishes. The pigment protein was extracted, filtered, and dehydrated into a crystalline powder. This was mixed with acrylic medium to make biopaint. The biopaint and commercial paint were applied on acrylic paper;red, green, blue, and total spectral intensities were measured daily under different testing conditions. Spectral intensity variability was measured and compared using the Coefficient of Variation (CV). Trends in spectral intensity were analyzed using regression analysis. Results: The differences in the CV of biopaint to commercial paint were less than 20% under all testing conditions. Spectral intensities for both biopaint and commercial paint did not show any significant change during the testing period under the conditions of room temperature, heat, and humidity. However, under the cold testing condition, biopaint showed a slight but statistically significant (p-value Conclusion: This experiment proves that E. coli-derived pigments can be used to make biopaint which has a similar durability to commercial paint as measured by the spectral intensities. 展开更多
关键词 Synthetic Biology e. coli Protein Pigments Sustainable Paint BIOMATeRIALS Microbial Pigments Biogenic Paint Development
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A Certification Framework for E-Commerce Digital Competencies
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作者 Antonia Stefani Bill Vassiliadis 《Open Journal of Applied Sciences》 CAS 2023年第5期758-774,共17页
In this paper, we introduce a comprehensive certification framework for digital competencies. This framework delineates the regulations, processes, and administration necessary for executing certification of a particu... In this paper, we introduce a comprehensive certification framework for digital competencies. This framework delineates the regulations, processes, and administration necessary for executing certification of a particular subset of competencies within the DigComp framework. It stipulates distinct requisites for the methodology employed, assessment instruments, evaluation criteria, and procedures for awarding certificates. The framework encompasses the enhancement of fundamental skills, particularly digital competencies, as well as involving digitally disenfranchised demographics with technology. It can be used to evaluate and certify varying degrees of digital proficiency and to instruct individuals in utilizing essential business-to-consumer e-commerce functionalities. 展开更多
关键词 Certification System DigComp electronic commerce
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Industrial E-commerce Develops in Full Swing
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作者 Jenny Hu 《China's Foreign Trade》 2023年第1期56-57,共2页
In 2022,the role of digital economy as a stabilizer and accelerator of the national economy was more prominent.Industry digitalization,which is driven by China’ s intelligent manufacturing,has become the main engine ... In 2022,the role of digital economy as a stabilizer and accelerator of the national economy was more prominent.Industry digitalization,which is driven by China’ s intelligent manufacturing,has become the main engine of China’ s digital economy development.As the core component of industrial digitalization,industrial e-commerce also developed in full swing.In the past three years,the COVID-19 pandemic has brought plenty of pressure to China’s industrial economy. 展开更多
关键词 plenty commerce SWING
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China's E-commerce Enterprises Tap Southeast Asian
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作者 Lily Wang 《China's Foreign Trade》 2023年第1期29-31,共3页
Driven by geographical and encouraging policy factors,Chinese e-commerce enterprises have always regarded Southeast Asia as the first stop of taking their business overseas.Although the Indonesian subsidiary of JD.com... Driven by geographical and encouraging policy factors,Chinese e-commerce enterprises have always regarded Southeast Asia as the first stop of taking their business overseas.Although the Indonesian subsidiary of JD.com announced that it would stop services on March 31,and JD.com Thailand had announced that it would be closed,the Chinese e-commerce platform Alibaba,and cross-border e-commerce operation platform TikTok Shop,said they would continue to expand businesses in Southeast Asia. 展开更多
关键词 SUBSIDIARY commerce SOUTHeAST
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Insights into B2C E-Commerce Quality Using ISO 25010
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作者 Antonia Stefani Eleni Vamvatsikou Bill Vassiliadis 《Journal of Software Engineering and Applications》 2023年第11期622-639,共18页
This paper introduces an innovative Software Quality Assurance framework tailored for B2C e-commerce systems, seamlessly integrating software quality with business objectives. Drawing from elements of the ISO 25000 se... This paper introduces an innovative Software Quality Assurance framework tailored for B2C e-commerce systems, seamlessly integrating software quality with business objectives. Drawing from elements of the ISO 25000 series and ISO 20000 standards, this framework specifically addresses challenges inherent to e-commerce. By establishing business-relevant KPIs, the framework ensures that ongoing improvement initiatives resonate with the company’s strategic goals. Additionally, the paper presents a Dynamic Bayesian Network model as a hands-on tool for implementing the framework within e-commerce organisations. 展开更多
关键词 electronic commerce Software Quality Business to Consumer Targeted Software Design ISO 25010
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Effects of cooperative mechanisms in mobile commerce value chain 被引量:1
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作者 蒋丽丽 梅姝娥 仲伟俊 《Journal of Southeast University(English Edition)》 EI CAS 2011年第3期335-339,共5页
In order to analyze the effects of different cooperative mechanisms between a mobile device manufacturer and a mobile network operator ( MNO ), a Stackelberg structure is constructed. The manufacturer acts as a lead... In order to analyze the effects of different cooperative mechanisms between a mobile device manufacturer and a mobile network operator ( MNO ), a Stackelberg structure is constructed. The manufacturer acts as a leader, while the MNO acts as a follower, i. e., a traditional retailer. Three cooperative mechanisms are considered: the manufacturer does not invest in developing the propriety function and software to support the infrastructure capacity of the MNO; the manufacturer invests in the development; the MNO offers a subsidy to encourage the manufacturer to invest in development. The results reveal that investing in the development can increase the profits of both the manufacturer and the MNO. Furthermore, if the MNO shares certain investment costs with the manufacturer, the MNO may charge higher prices of mobile connection services and mobile value-added services, and the profits of the two players may be enhanced. 展开更多
关键词 mobile commerce supply chain model PRICING ame theory
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RCEP协定下跨境电商对贸易影响的时间差异性研究 被引量:1
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作者 胡艳英 赵家琪 田刚 《对外经贸》 2024年第6期15-19,共5页
为了拓宽双循环渠道,打开外循环新思路,以中国与RCEP成员国在2010年至2021年间进出口面板数据结合中国跨境电商交易额建立VAR模型,研究跨境电子商务发展对我国进出口贸易的动态影响。结果表明,在长期,跨境电商的发展使得发展中国家与我... 为了拓宽双循环渠道,打开外循环新思路,以中国与RCEP成员国在2010年至2021年间进出口面板数据结合中国跨境电商交易额建立VAR模型,研究跨境电子商务发展对我国进出口贸易的动态影响。结果表明,在长期,跨境电商的发展使得发展中国家与我国双边贸易弹性系数高于发达国家,跨境电商的发展有利于我国同发展中国家进行贸易往来;在短期,跨境电商的发展对中国与韩国等部分国家的进出口存在逐渐增强的正向影响;跨境电商的发展对我国与多国贸易存在双向动态交互关系。 展开更多
关键词 RCeP 进出口贸易 跨境电商 VAR模型
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牛病毒性腹泻病毒E2蛋白的真核表达及间接ELISA抗体检测方法的建立 被引量:1
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作者 刘丹 黄小洁 +5 位作者 吴华伟 孙淼 陈延飞 秦义娴 侯力丹 薛麒 《动物医学进展》 北大核心 2024年第4期51-56,共6页
为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重... 为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重复性试验。结果表明,在昆虫细胞中表达了BVDV E2蛋白,Western blot证实目的蛋白可与BVDV阳性血清发生特异性反应。ELISA优化结果显示,E2蛋白最佳包被浓度为0.5μg/mL,最佳封闭液为1%明胶,最佳血清稀释度为1∶400,最佳血清作用方式为37℃作用30 min,酶标抗体的最佳作用方式为1∶2000稀释、37℃作用30 min,最佳底物作用时间为室温20 min,阳性临界值为OD 450≥0.423。与血清中和试验法进行比较,总符合率为97.8%,板内和板间重复性试验的变异系数均小于10%。该方法与牛常见病毒阳性血清均无交叉反应。说明建立的间接ELISA抗体检测方法特异性、敏感性和重复性良好,可用于大批量样本的临床检测和流行病学研究。 展开更多
关键词 牛病毒性腹泻病毒 e2蛋白 间接eLISA 抗体检测
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基于ADDIE模型的沉浸式电子商务教学实践探索 被引量:1
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作者 蒋益 《湖北开放职业学院学报》 2024年第4期182-184,共3页
我国电子商务行业方兴未艾,其专业人才的需求旺盛,因而许多高职院校都开设有电子商务专业。但与此同时,高职电子商务专业的毕业生往往就业率偏低且专业不对口的问题一直存在。不少民营企业来校园招聘电子商务人才往往找不到匹配工作岗... 我国电子商务行业方兴未艾,其专业人才的需求旺盛,因而许多高职院校都开设有电子商务专业。但与此同时,高职电子商务专业的毕业生往往就业率偏低且专业不对口的问题一直存在。不少民营企业来校园招聘电子商务人才往往找不到匹配工作岗位的人才。本文分析了造成这样问题的原因,并提出了通过ADDIE模型进行沉浸式教学设计的应对措施。 展开更多
关键词 电子商务 ADDIe模型 沉浸式教学
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人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响 被引量:1
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作者 王建新 王琳茜 +3 位作者 朱波 时沛 孙义长 韩立 《中国药理学通报》 CAS CSCD 北大核心 2024年第5期853-858,共6页
目的探究人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响。方法MTT测定不同浓度人参皂苷Rg3(0、80、160、320μmol·L^(-1))对细胞增殖影响;流式细胞术测定不同浓度人参皂苷Rg3对细胞凋亡的影响;划痕愈合实验和Trans... 目的探究人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响。方法MTT测定不同浓度人参皂苷Rg3(0、80、160、320μmol·L^(-1))对细胞增殖影响;流式细胞术测定不同浓度人参皂苷Rg3对细胞凋亡的影响;划痕愈合实验和Transwell实验测定不同浓度人参皂苷Rg3对细胞迁移及侵袭的影响;Western blot测定不同浓度人参皂苷Rg3对E2F1、MMP-2、MMP-9、BCL-2、Bax表达的影响。结果80、160、320μmol·L^(-1)人参皂苷Rg3组细胞存活率与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞凋亡率与空白对照组比较明显增加,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞迁移数目与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞侵袭数目与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组E2F1 mRNA与E2F1蛋白表达量相较空白对照组明显减少且,呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞中MMP-2、MMP-9、BCL-2蛋白表达量与空白对照组比较明显降低,BCL-2与空白对照组比较明显升高,且呈浓度依赖性(P<0.05)。结论人参皂苷Rg3能降低胃癌SGC-7901细胞增殖能力,抑制细胞迁移及侵袭能力,同时还促进SGC-7901细胞凋亡,且具有浓度依赖性,其作用机制可能通过E2F1因子下调MMP-2、MMP-9、BCL-2表达,上调Bax表达有关。 展开更多
关键词 人参皂苷RG3 e2F1 胃癌 增殖 迁移和侵袭 凋亡
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载脂蛋白E联合临床相关指标预测阿尔兹海默病模型的建立与验证
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作者 吴天晨 杨卉 +1 位作者 梁艳 杨永刚 《中国卫生统计》 CSCD 北大核心 2024年第1期23-27,共5页
目的 以载脂蛋白E(ApoE)为基础,结合阿尔茨海默病发病危险因素及临床常见指标,构建阿尔兹海默病发病风险的临床预测模型。方法 从南京市中医院大数据平台中,检索时间为2019年1月至2021年1月两年时间内,阿尔兹海默病患者61例,模糊匹配健... 目的 以载脂蛋白E(ApoE)为基础,结合阿尔茨海默病发病危险因素及临床常见指标,构建阿尔兹海默病发病风险的临床预测模型。方法 从南京市中医院大数据平台中,检索时间为2019年1月至2021年1月两年时间内,阿尔兹海默病患者61例,模糊匹配健康体检者111例。利用LASSO回归筛选危险因素,构建logistic回归预测模型,10折交叉进行区分度验证,bootstrap法进行校准度验证,临床决策曲线评判预测模型的临床指导性,最后以列线图可视化呈现临床预测模型。结果 筛选出12个变量,最终纳入4个危险因素:年龄、游离三碘甲状腺素(FT3)、性别、ApoE。全样本ROC曲线下面积为0.879,10折交叉9次验证后ROC曲线下平均面积为0.864;采用Bootstrap法抽样及Hosmer-Lemeshow校准度检验,结果χ^(2)=6.496,P=0.592>0.05。临床决策曲线阈值概率区间为1%~88.6%。结论 利用年龄、游离三碘甲状腺素、性别、 ApoE构建的临床预测模型对患者进行个体化评估,可以预警阿尔兹海默病,开展早期预防干预,减缓该病的发生发展。 展开更多
关键词 痴呆 阿尔兹海默病 预测模型 载脂蛋白e
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创伤性颅脑损伤患者血清锌、维生素E与病情程度及预后的关系
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作者 张春满 梁晨 +4 位作者 曹慧琴 杨延庆 胡国良 折刚刚 韦玮 《疑难病杂志》 CAS 2024年第8期902-907,共6页
目的探讨创伤性颅脑损伤(TBI)患者血清锌、维生素E与病情程度及预后的关系。方法选取2020年1月—2023年8月延安大学附属医院神经外科收治的TBI患者135例为TBI组,根据格拉斯哥昏迷量表(GCS)评分分为轻度TBI亚组(GCS评分13~15分,54例)、中... 目的探讨创伤性颅脑损伤(TBI)患者血清锌、维生素E与病情程度及预后的关系。方法选取2020年1月—2023年8月延安大学附属医院神经外科收治的TBI患者135例为TBI组,根据格拉斯哥昏迷量表(GCS)评分分为轻度TBI亚组(GCS评分13~15分,54例)、中度TBI亚组(GCS评分9~12分,45例)、重度TBI亚组(GCS评分3~8分,36例),再根据患者90 d预后分为不良预后亚组(35例)和良好预后亚组(100例),另选同期体检健康者100例为健康对照组。采用锌比色法与高效液相色谱法检测血清锌、维生素E水平;比较TBI组与健康对照组和不同病情程度TBI患者血清锌、维生素E水平;采用Spearman相关系数分析血清锌、维生素E水平与GCS评分的相关性;多因素Logistic回归分析影响TBI患者不良预后的因素;绘制受试者工作特征(ROC)曲线评价血清锌、维生素E水平对TBI患者90 d死亡的预测价值。结果与健康对照组比较,TBI组血清锌、维生素E水平降低(t/P=10.836/<0.001、10.160/<0.001);不同病情程度TBI患者血清锌、维生素E水平比较,轻度TBI亚组>中度TBI亚组>重度TBI亚组(F/P=41.858/<0.001、104.911/<0.001)。135例TBI患者90 d不良预后发生率为25.93%(35/135);血清锌、维生素E水平与GCS评分均呈正相关(r s=0.709/<0.001、0.698/<0.001);GCS评分增加、血清锌升高、维生素E升高为TBI患者不良预后的独立保护因素[OR(95%CI)=0.809(0.690~0.950)、0.706(0.590~0.845)、0.726(0.599~0.880)],基底池异常、中线移位≥5 mm为TBI患者不良预后的独立危险因素[OR(95%CI)=5.989(1.492~24.036)、3.378(1.045~10.922)];血清锌、维生素E水平及二者联合预测TBI患者不良预后的AUC分别为0.783、0.774、0.856,二者联合的AUC大于血清锌、维生素E水平单独预测(Z/P=2.580/0.010、2.727/0.006)。结论TBI患者血清锌、维生素E水平降低,与病情程度加重和预后不良有关,二者联合对TBI患者不良预后有良好的预测价值。 展开更多
关键词 创伤性颅脑损伤 血清锌 维生素e 病情程度 预后
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LncRNA ZEB1-AS1和LncRNA SOX2OT在糖尿病肾病患者中的表达及与肾功能的相关性研究 被引量:1
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作者 何德娇 凌娜 +3 位作者 李正翔 乔玲 张淼淼 夏露 《疑难病杂志》 CAS 2024年第7期809-813,共5页
目的探究长链非编码RNA锌指E盒结合同源盒蛋白1反义链1(LncRNA ZEB1-AS1)和长链非编码RNA性别决定相关基因簇2重叠转录本(LncRNA SOX2OT)在糖尿病肾病(DN)患者中的表达及与肾功能的相关性。方法选取于2021年11月—2023年12月在武汉大学... 目的探究长链非编码RNA锌指E盒结合同源盒蛋白1反义链1(LncRNA ZEB1-AS1)和长链非编码RNA性别决定相关基因簇2重叠转录本(LncRNA SOX2OT)在糖尿病肾病(DN)患者中的表达及与肾功能的相关性。方法选取于2021年11月—2023年12月在武汉大学人民医院肾内科收治的DN患者106例为DN组,并根据24 h尿蛋白定量(24 h Upro)水平分为正常蛋白尿亚组43例(<30 mg)、微量蛋白尿亚组39例(30~<300 mg)、大量蛋白尿亚组24例(≥300 mg),另选取同期医院单纯糖尿病患者106例作对照组,检测患者血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平;Pearson法分析LncRNA ZEB1-AS1和LncRNA SOX2OT与肾功能指标的相关性;Logistic分析影响DN患者肾功能损伤的因素。结果DN组血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平低于对照组(t=11.471、10.257,P均<0.001)。血清LncRNA ZEB1-AS1、LncRNA SOX2OT比较,正常尿蛋白亚组>微量尿蛋白亚组>大量尿蛋白亚组(F=58.720、117.722,P均<0.001),BUN、SCr、UA水平比较,正常尿蛋白亚组<微量尿蛋白亚组<大量尿蛋白亚组,差异均有统计学意义(F=122.493、595.589、53.178,P均<0.001);LncRNA ZEB1-AS1、LncRNA SOX2OT分别与BUN、SCr、UA呈负相关(r=-0.487、-0.498、-0.521,-0.527、-0.515、-0.534,P均<0.001);Logistic回归分析显示,糖尿病病程长及高BUN、SCr、UA水平是影响DN患者肾功能损伤的危险因素[OR(95%CI)=1.672(1.128~2.479)、2.839(1.534~5.253)、2.754(1.512~5.017)、2.693(1.464~4.954)],高LncRNA ZEB1-AS1、LncRNA SOX2OT是保护因素[OR(95%CI)=0.875(0.798~0.959)、0.898(0.832~0.969)]。结论血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平与DN患者肾功能有关,可能是评估DN患者肾功能的潜在指标。 展开更多
关键词 糖尿病肾病 长链非编码RNA锌指e盒结合同源盒蛋白1反义链1 长链非编码RNA性别决定相关基因簇2重叠转录本 肾功能 相关性
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TCT联合HPV E6/E7 mRNA检测对子宫颈癌前早期病变诊断价值的meta分析 被引量:1
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作者 陈君君 郭培培 +4 位作者 路红春 梁宇鸣 沈婧 刘腾 王润洁 《齐齐哈尔医学院学报》 2024年第2期175-182,共8页
目的系统评价液基薄层细胞学检查(thinprep cytologic test,TCT)联合人乳头瘤病毒(human papillomavirus,HPV)E6/E7 mRNA检测对子宫颈癌前早期病变的诊断价值。方法计算机检索CNKI、维普数据库(VIP)、万方数据库、中国生物医学文献数据... 目的系统评价液基薄层细胞学检查(thinprep cytologic test,TCT)联合人乳头瘤病毒(human papillomavirus,HPV)E6/E7 mRNA检测对子宫颈癌前早期病变的诊断价值。方法计算机检索CNKI、维普数据库(VIP)、万方数据库、中国生物医学文献数据库(CBM)、PubMed、The Cochrane Library、Embase、Science数据库中关于TCT联合HPV E6/E7 mRNA检测诊断子宫颈癌前早期病变的相关文献,检索时限均为建库至2023年1月。由2位评价员按纳入标准和排除标准各自筛选文献、提取资料和评价质量后,应用RevMan 5.3、Stata 15.0、Meta-Disc 1.4统计软件分析TCT联合HPV E6/E7 mRNA检测对子宫颈癌前早期病变的诊断价值,计算诊断敏感性的Spearman相关系数验证阈值效应,进行异质性检验;计算合并敏感性、特异性、阳性似然比和阴性似然比、诊断比值比、SROC曲线下面积。结果共纳入15篇文献,合计6620例患者。Meta分析显示,合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值比均不存在明显异质性(I^(2)=31.6%、14.2%、10.9%、16.7%、17.2%,P=0.1162、0.2947、0.3311、0.2663、0.2610),采用固定效应模型进行统计分析,其结果分别为0.95(95%CI:0.94~0.96)、0.87(95%CI:0.86~0.88)、6.86(95%CI:6.26~7.51)、0.06(95%CI:0.05~0.07)、113.23(95%CI:86.44~148.31)。SROC曲线下面积为0.9414。结论TCT联合HPV E6/E7 mRNA检测对诊断子宫颈癌前早期病变有重要价值。 展开更多
关键词 TCT HPV e6/e7 mRNA 子宫颈癌前早期病变 诊断
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